Nascent peptide assists the ribosome in recognizing chemically distinct small molecules

The ribosome can discriminate the chirality of amino acids within its peptidyl-transferase center

(2015) Michael T. Englander et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drug Sensing by the Ribosome Induces Translational Arrest via Active Site Perturbation

(2014) Stefan Arenz et al.   MOLECULAR CELL

The general mode of translation inhibition by macrolide antibiotics

(2014) Krishna Kannan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macrolide antibiotics allosterically predispose the ribosome for translation arrest

(2014) Shanmugapriya Sothiselvam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sequence selectivity of macrolide-induced translational attenuation

(2014) A. R. Davis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular basis for erythromycin-dependent ribosome stalling during translation of the ErmBL leader peptide

(2014) Stefan Arenz et al.   Nature Communications

GROMACS 4.5: a high-throughput and highly parallel open source molecular simulation toolkit

(2013) Sander Pronk et al.   BIOINFORMATICS

Regulation of Gene Expression by Macrolide-Induced Ribosomal Frameshifting

(2013) Pulkit Gupta et al.   MOLECULAR CELL

Deregulation of translation due to post-transcriptional modification of rRNA explains why erm genes are inducible

(2013) Pulkit Gupta et al.   Nature Communications

Selective Protein Synthesis by Ribosomes with a Drug-Obstructed Exit Tunnel

(2012) Krishna Kannan et al.   CELL

The 2′-OH group of the peptidyl-tRNA stabilizes an active conformation of the ribosomal PTC

(2011) Hani S Zaher et al.   EMBO JOURNAL

Nascent Peptide in the Ribosome Exit Tunnel Affects Functional Properties of the A-Site of the Peptidyl Transferase Center

(2011) Haripriya Ramu et al.   MOLECULAR CELL

Role of antibiotic ligand in nascent peptide-dependent ribosome stalling

(2011) N. Vazquez-Laslop et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Binding and Action of CEM-101, a New Fluoroketolide Antibiotic That Inhibits Protein Synthesis

(2010) B. Llano-Sotelo et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The key function of a conserved and modified rRNA residue in the ribosomal response to the nascent peptide

(2010) Nora Vázquez-Laslop et al.   EMBO JOURNAL

The Role of L1 Stalk–tRNA Interaction in the Ribosome Elongation Cycle

(2010) Leonardo G. Trabuco et al.   JOURNAL OF MOLECULAR BIOLOGY

Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action

(2010) J. A. Dunkle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Revisiting the structures of several antibiotics bound to the bacterial ribosome

(2010) D. Bulkley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular dynamics flexible fitting: A practical guide to combine cryo-electron microscopy and X-ray crystallography

(2009) Leonardo G. Trabuco et al.   METHODS

Programmed drug-dependent ribosome stalling

(2009) Haripriya Ramu et al.   MOLECULAR MICROBIOLOGY

Insights into substrate stabilization from snapshots of the peptidyl transferase center of the intact 70S ribosome

(2009) Rebecca M Voorhees et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Molecular Mechanism of Drug-Dependent Ribosome Stalling

(2008) Nora Vazquez-Laslop et al.   MOLECULAR CELL

tRNAdb 2009: compilation of tRNA sequences and tRNA genes

(2008) F. Juhling et al.   NUCLEIC ACIDS RESEARCH

Flexible Fitting of Atomic Structures into Electron Microscopy Maps Using Molecular Dynamics

(2008) Leonardo G. Trabuco et al.   STRUCTURE