The role of glioma stem cells in chemotherapy resistance and glioblastoma multiforme recurrence

RNA interference targeting hypoxia-inducible factor 1α via a novel multifunctional surfactant attenuates glioma growth in an intracranial mouse model

(2015) David L. Gillespie et al.   JOURNAL OF NEUROSURGERY

Conversion of differentiated cancer cells into cancer stem-like cells in a glioblastoma model after primary chemotherapy

(2014) B Auffinger et al.   CELL DEATH AND DIFFERENTIATION

Localized increase of tissue oxygen tension by magnetic targeted drug delivery

(2014) Celine Liong et al.   NANOTECHNOLOGY

Downregulation of ABCG2 protein inhibits migration and invasion in U251 glioma stem cells

(2014) Weiyi Gong et al.   NEUROREPORT

Brain Tumor Stem-Like Cells Identified by Neural Stem Cell Marker CD15

(2014) Xing-gang Mao et al.   Translational Oncology

Ionizing radiations sustain glioblastoma cell dedifferentiation to a stem-like phenotype through survivin: possible involvement in radioresistance

(2014) P Dahan et al.   Cell Death & Disease

Combined PDK1 and CHK1 inhibition is required to kill glioblastoma stem-like cells in vitro and in vivo

(2014) M Signore et al.   Cell Death & Disease

Side population in human glioblastoma is non-tumorigenic and characterizes brain endothelial cells

(2013) Anna Golebiewska et al.   BRAIN

Melatonin-induced methylation of the ABCG2/BCRP promoter as a novel mechanism to overcome multidrug resistance in brain tumour stem cells

(2013) V Martín et al.   BRITISH JOURNAL OF CANCER

The Somatic Genomic Landscape of Glioblastoma

(2013) Cameron W. Brennan et al.   CELL

Sorafenib selectively depletes human glioblastoma tumor-initiating cells from primary cultures

(2013) Elisa Carra et al.   CELL CYCLE

Understanding glioma stem cells: rationale, clinical relevance and therapeutic strategies

(2013) Atique U Ahmed et al.   Expert Review of Neurotherapeutics

Predictability, efficacy and safety of radiosensitization of glioblastoma-initiating cells by the ATM inhibitor KU-60019

(2013) Donatella Vecchio et al.   INTERNATIONAL JOURNAL OF CANCER

The Implications of Clonal Genome Evolution for Cancer Medicine

(2013) Samuel Aparicio et al.   NEW ENGLAND JOURNAL OF MEDICINE

Delineating the Cytogenomic and Epigenomic Landscapes of Glioma Stem Cell Lines

(2013) Simona Baronchelli et al.   PLoS One

Mesenchymal glioma stem cells are maintained by activated glycolytic metabolism involving aldehyde dehydrogenase 1A3

(2013) P. Mao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Aberrant Transcription Factor Network Essential for Wnt Signaling and Stem Cell Maintenance in Glioblastoma

(2013) Esther Rheinbay et al.   Cell Reports

Adoptive Cell Therapies for Glioblastoma

(2013) Kevin Bielamowicz et al.   Frontiers in Oncology

Laminin alpha 2 enables glioblastoma stem cell growth

(2012) Justin D. Lathia et al.   ANNALS OF NEUROLOGY

The cancer stem cell niche(s): The crosstalk between glioma stem cells and their microenvironment

(2012) Alina Filatova et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Hotspot Mutations in H3F3A and IDH1 Define Distinct Epigenetic and Biological Subgroups of Glioblastoma

(2012) Dominik Sturm et al.   CANCER CELL

Glioblastoma Cancer Stem-Like Cells

(2012) Edjah Kweku-Ebura Nduom et al.   CANCER JOURNAL

Receptor Tyrosine Kinase Genes Amplified in Glioblastoma Exhibit a Mutual Exclusivity in Variable Proportions Reflective of Individual Tumor Heterogeneity

(2012) S. E. Little et al.   CANCER RESEARCH

Drug Transport across the Blood–Brain Barrier

(2012) William M Pardridge   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

ATM inhibitor KU-55933 increases the TMZ responsiveness of only inherently TMZ sensitive GBM cells

(2012) Aditi Nadkarni et al.   JOURNAL OF NEURO-ONCOLOGY

IDH mutation impairs histone demethylation and results in a block to cell differentiation

(2012) Chao Lu et al.   NATURE

Clonal evolution in cancer

(2012) Mel Greaves et al.   NATURE

Drug Resistance in Glioblastoma: A Mini Review

(2012) Catherine P. Haar et al.   NEUROCHEMICAL RESEARCH

Knockdown of Checkpoint Kinase 1 Is Associated with the Increased Radiosensitivity of Glioblastoma Stem-Like Cells

(2012) Jun Wu et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

The ABCG2 transporter is a key molecular determinant of the efficacy of sonodynamic therapy with Photofrin in glioma stem-like cells

(2012) Zhong-Ye Xu et al.   ULTRASONICS

Elevated invasive potential of glioblastoma stem cells

(2011) Lin Cheng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mosaic Amplification of Multiple Receptor Tyrosine Kinase Genes in Glioblastoma

(2011) Matija Snuderl et al.   CANCER CELL

Endothelial Cells Create a Stem Cell Niche in Glioblastoma by Providing NOTCH Ligands That Nurture Self-Renewal of Cancer Stem-Like Cells

(2011) T. S. Zhu et al.   CANCER RESEARCH

Secreted factors from brain endothelial cells maintain glioblastoma stem-like cell expansion through the mTOR pathway

(2011) Eva Maria Galan-Moya et al.   EMBO REPORTS

Cancer stem cells: the development of new cancer therapeutics

(2011) Roberto Scatena et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

The antitumor effect of mesenchymal stem cells transduced with a lentiviral vector expressing cytosine deaminase in a rat glioma model

(2011) Song Fei et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Chemoresistance of glioblastoma cancer stem cells - much more complex than expected

(2011) Dagmar Beier et al.   Molecular Cancer

Tumour evolution inferred by single-cell sequencing

(2011) Nicholas Navin et al.   NATURE

Hypoxia Potentiates Glioma-Mediated Immunosuppression

(2011) Jun Wei et al.   PLoS One

A hypoxic niche regulates glioblastoma stem cells through hypoxia inducible factor 2α

(2010) Sascha Seidel et al.   BRAIN

A Hierarchy of Self-Renewing Tumor-Initiating Cell Types in Glioblastoma

(2010) Ruihuan Chen et al.   CANCER CELL

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

(2010) Roel G.W. Verhaak et al.   CANCER CELL

The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype

(2010) John M. Heddleston et al.   CELL CYCLE

Acidic stress promotes a glioma stem cell phenotype

(2010) A B Hjelmeland et al.   CELL DEATH AND DIFFERENTIATION

Glioma-Associated Cancer-Initiating Cells Induce Immunosuppression

(2010) J. Wei et al.   CLINICAL CANCER RESEARCH

Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastoma

(2010) M.-d.-M. Inda et al.   GENES & DEVELOPMENT

BMI1 Confers Radioresistance to Normal and Cancerous Neural Stem Cells through Recruitment of the DNA Damage Response Machinery

(2010) S. Facchino et al.   JOURNAL OF NEUROSCIENCE

Photothermolysis of glioblastoma stem-like cells targeted by carbon nanotubes conjugated with CD133 monoclonal antibody

(2010) Chung-Hao Wang et al.   Nanomedicine-Nanotechnology Biology and Medicine

Genome remodelling in a basal-like breast cancer metastasis and xenograft

(2010) Li Ding et al.   NATURE

Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells

(2010) Lucia Ricci-Vitiani et al.   NATURE

Sensitivity to temozolomide in brain tumor initiating cells

(2010) M. D. Blough et al.   NEURO-ONCOLOGY

Glioma cancer stem cells induce immunosuppressive macrophages/microglia

(2010) Adam Wu et al.   NEURO-ONCOLOGY

Replication stress and oxidative damage contribute to aberrant constitutive activation of DNA damage signalling in human gliomas

(2010) J Bartkova et al.   ONCOGENE

De-repression of CTGF via the miR-17-92 cluster upon differentiation of human glioblastoma spheroid cultures

(2010) A Ernst et al.   ONCOGENE

Cancer stem cells in glioblastoma—molecular signaling and therapeutic targeting

(2010) Zhi Huang et al.   Protein & Cell

Enhanced radiosensitivity and radiation-induced apoptosis in glioma CD133-positive cells by knockdown of SirT1 expression

(2009) Charn-Jung Chang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Malignant Astrocytomas Originate from Neural Stem/Progenitor Cells in a Somatic Tumor Suppressor Mouse Model

(2009) Sheila Alcantara Llaguno et al.   CANCER CELL

PTEN/PI3K/Akt Pathway Regulates the Side Population Phenotype and ABCG2 Activity in Glioma Tumor Stem-like Cells

(2009) Anne-Marie Bleau et al.   Cell Stem Cell

The Neuropharmacokinetics of Temozolomide in Patients with Resectable Brain Tumors: Potential Implications for the Current Approach to Chemoradiation

(2009) J. Portnow et al.   CLINICAL CANCER RESEARCH

MSH6 Mutations Arise in Glioblastomas during Temozolomide Therapy and Mediate Temozolomide Resistance

(2009) S. Yip et al.   CLINICAL CANCER RESEARCH

Gli1 is a potential target for alleviating multidrug resistance of gliomas

(2009) Daming Cui et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Comparative Analysis of DNA Repair in Stem and Nonstem Glioma Cell Cultures

(2009) M. Ropolo et al.   MOLECULAR CANCER RESEARCH

Biology of glioma cancer stem cells

(2009) Deric M. Park et al.   MOLECULES AND CELLS

Tumour-initiating cells: challenges and opportunities for anticancer drug discovery

(2009) Bin-Bing S. Zhou et al.   NATURE REVIEWS DRUG DISCOVERY

Tie2-mediated multidrug resistance in malignant gliomas is associated with upregulation of ABC transporters

(2009) V Martin et al.   ONCOGENE

Regulation of Mammary Stem/Progenitor Cells by PTEN/Akt/β-Catenin Signaling

(2009) Hasan Korkaya et al.   PLOS BIOLOGY

MIR-451 and Imatinib mesylate inhibit tumor growth of Glioblastoma stem cells

(2008) Hilah Gal et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells

(2008) Joachim Silber et al.   BMC Medicine

CD133/prominin-1 is a potential therapeutic target for antibody-drug conjugates in hepatocellular and gastric cancers

(2008) L M Smith et al.   BRITISH JOURNAL OF CANCER

Temozolomide Preferentially Depletes Cancer Stem Cells in Glioblastoma

(2008) D. Beier et al.   CANCER RESEARCH

A New Model for Prediction of Drug Distribution in Tumor and Normal Tissues: Pharmacokinetics of Temozolomide in Glioma Patients

(2008) L. Rosso et al.   CANCER RESEARCH

DNA repair and cancer stem-like cells – Potential partners in glioma drug resistance?

(2008) Tor-Christian Aase Johannessen et al.   CANCER TREATMENT REVIEWS

Identification of cells initiating human melanomas

(2008) Tobias Schatton et al.   NATURE

Subclonal phylogenetic structures in cancer revealed by ultra-deep sequencing

(2008) P. J. Campbell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD133 negative glioma cells form tumors in nude rats and give rise to CD133 positive cells

(2007) Jian Wang et al.   INTERNATIONAL JOURNAL OF CANCER