Cancer stem cells: the development of new cancer therapeutics

Neural Tumor-Initiating Cells Have Distinct Telomere Maintenance and Can be Safely Targeted for Telomerase Inhibition

(2011) P. Castelo-Branco et al.   CLINICAL CANCER RESEARCH

Treatment-emergent hypertension and outcomes in patients with advanced non-small-cell lung cancer receiving chemotherapy with or without the vascular endothelial growth factor receptor inhibitor cediranib: NCIC Clinical Trials Group Study BR24

(2010) R. Goodwin et al.   ANNALS OF ONCOLOGY

Notch signaling: Emerging molecular targets for cancer therapy

(2010) Ling Yin et al.   BIOCHEMICAL PHARMACOLOGY

Gemtuzumab ozogamicin: is there room for salvage?

(2010) W. T. Clarke et al.   BLOOD

The cancer stem cell selective inhibitor salinomycin is a p-glycoprotein inhibitor

(2010) Roberta Riccioni et al.   BLOOD CELLS MOLECULES AND DISEASES

Antitumor and antiangiogenic effect of the dual EGFR and HER-2 tyrosine kinase inhibitor lapatinib in a lung cancer model

(2010) Roque Diaz et al.   BMC CANCER

Resveratrol suppresses IGF-1 induced human colon cancer cell proliferation and elevates apoptosis via suppression of IGF-1R/Wnt and activation of p53 signaling pathways

(2010) Jairam Vanamala et al.   BMC CANCER

Combined bezafibrate and medroxyprogesterone acetate have efficacy without haematological toxicity in elderly and relapsed acute myeloid leukaemia (AML)

(2010) Jim A. Murray et al.   BRITISH JOURNAL OF HAEMATOLOGY

Sunitinib rechallenge in metastatic renal cell carcinoma patients

(2010) Ivan N. Zama et al.   CANCER

Side-by-side analysis of five clinically tested anti-EpCAM monoclonal antibodies

(2010) Markus Münz et al.   Cancer Cell International

HGF/c-Met Acts as an Alternative Angiogenic Pathway in Sunitinib-Resistant Tumors

(2010) F. Shojaei et al.   CANCER RESEARCH

The Telomerase Inhibitor Imetelstat Depletes Cancer Stem Cells in Breast and Pancreatic Cancer Cell Lines

(2010) I. Joseph et al.   CANCER RESEARCH

Novel therapeutic approach to eradicate tyrosine kinase inhibitor resistant chronic myeloid leukemia stem cells

(2010) Kazuhito Naka et al.   CANCER SCIENCE

Celecoxib enhances radiosensitivity in medulloblastoma-derived CD133-positive cells

(2010) Kuan-Hsuan Chen et al.   CHILDS NERVOUS SYSTEM

Nitric Oxide-Donating Acetylsalicylic Acid Induces Apoptosis in Chronic Lymphocytic Leukemia Cells and Shows Strong Antitumor Efficacy In vivo

(2010) R. Razavi et al.   CLINICAL CANCER RESEARCH

Inhibition of the PI3K Pathway: Hope We Can Believe in?

(2010) M. S. van der Heijden et al.   CLINICAL CANCER RESEARCH

Targeting RET Receptor Tyrosine Kinase Activation in Cancer

(2010) J. E. Phay et al.   CLINICAL CANCER RESEARCH

The Telomerase Antagonist, Imetelstat, Efficiently Targets Glioblastoma Tumor-Initiating Cells Leading to Decreased Proliferation and Tumor Growth

(2010) C. O. Marian et al.   CLINICAL CANCER RESEARCH

Targeting Hedgehog -- a Cancer Stem Cell Pathway

(2010) A. A. Merchant et al.   CLINICAL CANCER RESEARCH

Targeting Wnt Signaling: Can We Safely Eradicate Cancer Stem Cells?

(2010) F. Takahashi-Yanaga et al.   CLINICAL CANCER RESEARCH

The Difficulty of Targeting Cancer Stem Cell Niches

(2010) M. A. LaBarge   CLINICAL CANCER RESEARCH

Targeting Notch to Target Cancer Stem Cells

(2010) A. Pannuti et al.   CLINICAL CANCER RESEARCH

Phase I evaluation of cediranib, a selective VEGFR signalling inhibitor, in combination with gefitinib in patients with advanced tumours

(2010) Hester van Cruijsen et al.   EUROPEAN JOURNAL OF CANCER

Novel investigational drugs for basal cell carcinoma

(2010) Po-Lin So et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

The hedgehog pathway inhibitor GDC-0449 shows potential in skin and other cancers

(2010) Sheila A Doggrell   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Phase II Study of Cediranib, an Oral Pan–Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor, in Patients With Recurrent Glioblastoma

(2010) Tracy T. Batchelor et al.   JOURNAL OF CLINICAL ONCOLOGY

Phase II Study of Cediranib (AZD 2171), an Inhibitor of the Vascular Endothelial Growth Factor Receptor, for Second-Line Therapy of Small Cell Lung Cancer (National Cancer Institute #7097)

(2010) Suresh S. Ramalingam et al.   Journal of Thoracic Oncology

HER2 as a cancer stem-cell target

(2010) Rafael Roesler et al.   LANCET ONCOLOGY

Antibodies targeting cancer stem cells: A new paradigm in immunotherapy?

(2010) Mahendra P. Deonarain et al.   mAbs

Cytotoxic Effects Induced by Docetaxel, Gefitinib, and Cyclopamine on Side Population and Nonside Population Cell Fractions from Human Invasive Prostate Cancer Cells

(2010) M. Mimeault et al.   MOLECULAR CANCER THERAPEUTICS

Evaluation of Selective  -Secretase Inhibitor PF-03084014 for Its Antitumor Efficacy and Gastrointestinal Safety to Guide Optimal Clinical Trial Design

(2010) P. Wei et al.   MOLECULAR CANCER THERAPEUTICS

Therapeutic antibody targeting of individual Notch receptors

(2010) Yan Wu et al.   NATURE

Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells

(2010) Lucia Ricci-Vitiani et al.   NATURE

Glioblastoma stem-like cells give rise to tumour endothelium

(2010) Rong Wang et al.   NATURE

Activation of the hedgehog pathway confers a poor prognosis in embryonal and fusion gene-negative alveolar rhabdomyosarcoma

(2010) A Zibat et al.   ONCOGENE

Telomerase Inhibition Targets Clonogenic Multiple Myeloma Cells through Telomere Length-Dependent and Independent Mechanisms

(2010) Sarah K. Brennan et al.   PLoS One

Ectopic Expression of Germline Genes Drives Malignant Brain Tumor Growth in Drosophila

(2010) A. Janic et al.   SCIENCE

Tyrosine Kinase Inhibitors: The First Decade

(2010) Meetu Agrawal et al.   Current Hematologic Malignancy Reports

Assessing the risk to health care staff from long-term exposure to anticancer drugs - the case of monoclonal antibodies

(2010) Gabriele Halsen et al.   JOURNAL OF ONCOLOGY PHARMACY PRACTICE

Cancer Stem Cells: The Other Face of Janus

(2009) Sahil Mittal et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Differentiation therapy of leukemia: 3 decades of development

(2009) D. Nowak et al.   BLOOD

Targeting breast cancer stem cells

(2009) Max S. Wicha   BREAST

CD44 targeting reduces tumour growth and prevents post-chemotherapy relapse of human breast cancers xenografts

(2009) E Marangoni et al.   BRITISH JOURNAL OF CANCER

Vandetanib (ZD6474), an inhibitor of VEGFR and EGFR signalling, as a novel molecular-targeted therapy against cholangiocarcinoma

(2009) D Yoshikawa et al.   BRITISH JOURNAL OF CANCER

Metastatic colorectal cancer cells from patients previously treated with chemotherapy are sensitive to T-cell killing mediated by CEA/CD3-bispecific T-cell-engaging BiTE antibody

(2009) T Osada et al.   BRITISH JOURNAL OF CANCER

Cediranib (recentin, AZD2171) reverses ABCB1- and ABCC1-mediated multidrug resistance by inhibition of their transport function

(2009) Li-yang Tao et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Preclinical Profile of a Potent  -Secretase Inhibitor Targeting Notch Signaling with In vivo Efficacy and Pharmacodynamic Properties

(2009) L. Luistro et al.   CANCER RESEARCH

The Emerging Role of EpCAM in Cancer and Stem Cell Signaling

(2009) M. Munz et al.   CANCER RESEARCH

Dofequidar fumarate sensitizes cancer stem-like side population cells to chemotherapeutic drugs by inhibiting ABCG2/BCRP-mediated drug export

(2009) Ryohei Katayama et al.   CANCER SCIENCE

Identification of Selective Inhibitors of Cancer Stem Cells by High-Throughput Screening

(2009) Piyush B. Gupta et al.   CELL

Heterogeneity in Cancer: Cancer Stem Cells versus Clonal Evolution

(2009) Mark Shackleton et al.   CELL

Aspirin induces apoptosis in mesenchymal stem cells requiring Wnt/β-catenin pathway

(2009) L. Deng et al.   CELL PROLIFERATION

Monoclonal Antibody-Mediated Targeting of CD123, IL-3 Receptor α Chain, Eliminates Human Acute Myeloid Leukemic Stem Cells

(2009) Liqing Jin et al.   Cell Stem Cell

DLL4 Blockade Inhibits Tumor Growth and Reduces Tumor-Initiating Cell Frequency

(2009) Timothy Hoey et al.   Cell Stem Cell

Different Response of Human Glioma Tumor-initiating Cells to Epidermal Growth Factor Receptor Kinase Inhibitors

(2009) Fabrizio Griffero et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antitumor Activity of an EpCAM/CD3-bispecific BiTE Antibody During Long-term Treatment of Mice in the Absence of T-cell Anergy and Sustained Cytokine Release

(2009) Maria Amann et al.   JOURNAL OF IMMUNOTHERAPY

Low or undetectable numbers of Philadelphia chromosome-positive leukemic stem cells (Ph+CD34+CD38neg) in chronic myeloid leukemia patients in complete cytogenetic remission after tyrosine kinase inhibitor therapy

(2009) S Mustjoki et al.   LEUKEMIA

Cancer stem cells: mirage or reality?

(2009) Piyush B Gupta et al.   NATURE MEDICINE

Tumour-initiating cells: challenges and opportunities for anticancer drug discovery

(2009) Bin-Bing S. Zhou et al.   NATURE REVIEWS DRUG DISCOVERY

The Hedgehog Pathway and Pancreatic Cancer

(2009) Manuel Hidalgo et al.   NEW ENGLAND JOURNAL OF MEDICINE

Treatment of Medulloblastoma with Hedgehog Pathway Inhibitor GDC-0449

(2009) Charles M. Rudin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inhibition of the Hedgehog Pathway in Advanced Basal-Cell Carcinoma

(2009) Daniel D. Von Hoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

Vandetanib (Zactima, ZD6474) Antagonizes ABCC1- and ABCG2-Mediated Multidrug Resistance by Inhibition of Their Transport Function

(2009) Li-sheng Zheng et al.   PLoS One

Combined Bezafibrate and Medroxyprogesterone Acetate: Potential Novel Therapy for Acute Myeloid Leukaemia

(2009) Farhat L. Khanim et al.   PLoS One

Smoothened Mutation Confers Resistance to a Hedgehog Pathway Inhibitor in Medulloblastoma

(2009) R. L. Yauch et al.   SCIENCE

Stem cell concepts renew cancer research

(2008) J. E. Dick   BLOOD

Histone deacetylase inhibitors: mechanism of action and therapeutic use in cancer

(2008) Olaia Martínez-Iglesias et al.   Clinical & Translational Oncology

Resveratrol Exerts Antiproliferative Activity and Induces Apoptosis in Waldenstrom's Macroglobulinemia

(2008) A. M. Roccaro et al.   CLINICAL CANCER RESEARCH

Hedgehog signalling in endocrine development and disease

(2008) Peter J King et al.   JOURNAL OF ENDOCRINOLOGY

Simulations of a specific inhibitor of the dishevelled PDZ domain

(2008) Xin Chen et al.   JOURNAL OF MOLECULAR MODELING

Modulation of cancer cell line differentiation: A neglected proteomic analysis with potential implications in pathophysiology, diagnosis, prognosis, and therapy of cancer

(2008) Roberto Scatena et al.   Proteomics Clinical Applications

Mitochondria, PPARs, and Cancer: Is Receptor-Independent Action of PPAR Agonists a Key?

(2008) Roberto Scatena et al.   PPAR Research