Biosynthesis and Heterologous Production of Vioprolides: Rational Biosynthetic Engineering and Unprecedented 4-Methylazetidinecarboxylic Acid Formation

Correlating chemical diversity with taxonomic distance for discovery of natural products in myxobacteria

(2018) Thomas Hoffmann et al.   Nature Communications

Efficient methylation of C2 in l-tryptophan by the cobalamin-dependent radicalS-adenosylmethionine methylase TsrM requires an unmodified N1 amine

(2017) Anthony J. Blaszczyk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biosynthesis of Branched Alkoxy Groups: Iterative Methyl Group Alkylation by a Cobalamin-Dependent Radical SAM Enzyme

(2017) Yuanyou Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Heterologous production of myxobacterial α-pyrone antibiotics in Myxococcus xanthus

(2017) Hilda Sucipto et al.   METABOLIC ENGINEERING

Natural products from myxobacteria: novel metabolites and bioactivities

(2017) J. Herrmann et al.   NATURAL PRODUCT REPORTS

The B12-Radical SAM Enzyme PoyC Catalyzes Valine Cβ-Methylation during Polytheonamide Biosynthesis

(2016) Aubérie Parent et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Seven enzymes create extraordinary molecular complexity in an uncultivated bacterium

(2016) Michael F. Freeman et al.   Nature Chemistry

Genetic engineering and heterologous expression of the disorazol biosynthetic gene cluster via Red/ET recombineering

(2016) Qiang Tu et al.   Scientific Reports

Taichunamides: Prenylated Indole Alkaloids from Aspergillus taichungensis (IBT 19404)

(2015) Ippei Kagiyama et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Consecutive radicalS-adenosylmethionine methylations form the ethyl side chain in thienamycin biosynthesis

(2015) Daniel R. Marous et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heterologous Production of Glidobactins/Luminmycins inEscherichia coliNissle Containing the Glidobactin Biosynthetic Gene Cluster fromBurkholderiaDSM7029

(2014) Xiaoying Bian et al.   CHEMBIOCHEM

A Hybrid Non-Ribosomal Peptide/Polyketide Synthetase Containing Fatty-Acyl Ligase (FAAL) Synthesizes the β-Amino Fatty Acid Lipopeptides Puwainaphycins in the Cyanobacterium Cylindrospermum alatosporum

(2014) Jan Mareš et al.   PLoS One

Initial characterization of Fom3 from Streptomyces wedmorensis: The methyltransferase in fosfomycin biosynthesis

(2013) Kylie D. Allen et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

GenK-Catalyzed C-6′ Methylation in the Biosynthesis of Gentamicin: Isolation and Characterization of a Cobalamin-Dependent Radical SAM Enzyme

(2013) Hak Joong Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Improved seamless mutagenesis by recombineering using ccdB for counterselection

(2013) Hailong Wang et al.   NUCLEIC ACIDS RESEARCH

antiSMASH 2.0—a versatile platform for genome mining of secondary metabolite producers

(2013) Kai Blin et al.   NUCLEIC ACIDS RESEARCH

Heterologous Expression and Genetic Engineering of the Tubulysin Biosynthetic Gene Cluster Using Red/ET Recombineering and Inactivation Mutagenesis

(2012) Yi Chai et al.   CHEMISTRY & BIOLOGY

Type I Interferons Promote Fatal Immunopathology by Regulating Inflammatory Monocytes and Neutrophils during Candida Infections

(2012) Olivia Majer et al.   PLoS Pathogens

Heterologous Expression of the Oxytetracycline Biosynthetic Pathway in Myxococcus xanthus

(2010) D. C. Stevens et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Characterization of the Polyoxin Biosynthetic Gene Cluster fromStreptomyces cacaoiand Engineered Production of Polyoxin H

(2009) Wenqing Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanistic and functional insights into fatty acid activation in Mycobacterium tuberculosis

(2009) Pooja Arora et al.   Nature Chemical Biology

Efficient transfer of two large secondary metabolite pathway gene clusters into heterologous hosts by transposition

(2008) Jun Fu et al.   NUCLEIC ACIDS RESEARCH