Efficient methylation of C2 in l-tryptophan by the cobalamin-dependent radicalS-adenosylmethionine methylase TsrM requires an unmodified N1 amine

Biosynthesis of Branched Alkoxy Groups: Iterative Methyl Group Alkylation by a Cobalamin-Dependent Radical SAM Enzyme

(2017) Yuanyou Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A B12-dependent radical SAM enzyme involved in oxetanocin A biosynthesis

(2017) Jennifer Bridwell-Rabb et al.   NATURE

The B12-Radical SAM Enzyme PoyC Catalyzes Valine Cβ-Methylation during Polytheonamide Biosynthesis

(2016) Aubérie Parent et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Spectroscopic and Electrochemical Characterization of the Iron–Sulfur and Cobalamin Cofactors of TsrM, an Unusual Radical S-Adenosylmethionine Methylase

(2016) Anthony J. Blaszczyk et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Intrinsic relative nucleophilicity of indoles

(2016) Eduardo Chamorro et al.   THEORETICAL CHEMISTRY ACCOUNTS

Thiostrepton Variants Containing a Contracted Quinaldic Acid Macrocycle Result from Mutagenesis of the Second Residue

(2015) Feifei Zhang et al.   ACS Chemical Biology

Substrate-Tuned Catalysis of the RadicalS-Adenosyl-L-Methionine Enzyme NosL Involved in Nosiheptide Biosynthesis

(2015) Xinjian Ji et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Tryptophan Lyase (NosL): Mechanistic Insights from Substrate Analogues and Mutagenesis

(2015) Dhananjay M. Bhandari et al.   BIOCHEMISTRY

Consecutive radicalS-adenosylmethionine methylations form the ethyl side chain in thienamycin biosynthesis

(2015) Daniel R. Marous et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The thiostrepton A tryptophan methyltransferase TsrM catalyses a cob(II)alamin-dependent methyl transfer reaction

(2015) Alhosna Benjdia et al.   Nature Communications

Biological Matching of Chemical Reactivity: Pairing Indole Nucleophilicity with Electrophilic Isoprenoids

(2014) Christopher T. Walsh   ACS Chemical Biology

Thiopeptide Engineering: A Multidisciplinary Effort towards Future Drugs

(2014) Xavier Just-Baringo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mechanistic Diversity of RadicalS-Adenosylmethionine (SAM)-dependent Methylation

(2014) Matthew R. Bauerle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Initial characterization of Fom3 from Streptomyces wedmorensis: The methyltransferase in fosfomycin biosynthesis

(2013) Kylie D. Allen et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

GenK-Catalyzed C-6′ Methylation in the Biosynthesis of Gentamicin: Isolation and Characterization of a Cobalamin-Dependent Radical SAM Enzyme

(2013) Hak Joong Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A substrate radical intermediate in catalysis by the antibiotic resistance protein Cfr

(2013) Tyler L Grove et al.   Nature Chemical Biology

Thiostrepton tryptophan methyltransferase expands the chemistry of radical SAM enzymes

(2012) Stéphane Pierre et al.   Nature Chemical Biology

Cytochrome P450–catalyzed L-tryptophan nitration in thaxtomin phytotoxin biosynthesis

(2012) Sarah M Barry et al.   Nature Chemical Biology

Radical-Mediated Enzymatic Methylation: A Tale of Two SAMS

(2011) Qi Zhang et al.   ACCOUNTS OF CHEMICAL RESEARCH

In Vitro Phosphinate Methylation by PhpK fromKitasatospora phosalacinea

(2011) Williard J. Werner et al.   BIOCHEMISTRY

Hydrogen Bonding of Tryptophan Radicals Revealed by EPR at 700 GHz

(2011) Stefan Stoll et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stereocontrolled and Efficient Total Synthesis of (−)-Stephanotic Acid Methyl Ester and (−)-Celogentin C

(2010) Weimin Hu et al.   ORGANIC LETTERS

Thiopeptide Biosynthesis Featuring Ribosomally Synthesized Precursor Peptides and Conserved Posttranslational Modifications

(2009) Rijing Liao et al.   CHEMISTRY & BIOLOGY

Thiostrepton Biosynthesis: Prototype for a New Family of Bacteriocins

(2009) Wendy L. Kelly et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Recent advances in thiopeptideantibiotic biosynthesis

(2009) Chaoxuan Li et al.   NATURAL PRODUCT REPORTS

Thiostrepton selectively targets breast cancer cells through inhibition of forkhead box M1 expression

(2008) J. M-M. Kwok et al.   MOLECULAR CANCER THERAPEUTICS

Chemoenzymatic preparation of enantiopure l-benzofuranyl- and l-benzo[b]thiophenyl alanines

(2008) Paula Veronica Podea et al.   TETRAHEDRON-ASYMMETRY

Tryptophan synthase: the workings of a channeling nanomachine

(2008) Michael F. Dunn et al.   TRENDS IN BIOCHEMICAL SCIENCES