Genetic engineering and heterologous expression of the disorazol biosynthetic gene cluster via Red/ET recombineering

Direct cloning and heterologous expression of the salinomycin biosynthetic gene cluster from Streptomyces albus DSM41398 in Streptomyces coelicolor A3(2)

(2015) Jia Yin et al.   Scientific Reports

Comparative Analysis of the Substrate Specificity of trans- versus cis-Acyltransferases of Assembly Line Polyketide Synthases

(2014) Briana J. Dunn et al.   BIOCHEMISTRY

Progress challenges and opportunities for the re-engineering of trans-AT polyketide synthases

(2014) M. Till et al.   BIOTECHNOLOGY LETTERS

Triple negative breast cancers express receptors for LHRH and are potential therapeutic targets for cytotoxic LHRH-analogs, AEZS 108 and AEZS 125

(2014) Stephan Seitz et al.   BMC CANCER

Biotechnology of polyketides: new breath of life for the novel antibiotic genetic pathways discovery through metagenomics

(2014) Elisângela Soares Gomes et al.   BRAZILIAN JOURNAL OF MICROBIOLOGY

Heterologous Production of Glidobactins/Luminmycins inEscherichia coliNissle Containing the Glidobactin Biosynthetic Gene Cluster fromBurkholderiaDSM7029

(2014) Xiaoying Bian et al.   CHEMBIOCHEM

Recent advances in natural product discovery

(2014) Yunzi Luo et al.   CURRENT OPINION IN BIOTECHNOLOGY

Secondary metabolomics: the impact of mass spectrometry-based approaches on the discovery and characterization of microbial natural products

(2014) Daniel Krug et al.   NATURAL PRODUCT REPORTS

Antibiotics from myxobacteria

(2014) Till F. Schäberle et al.   NATURAL PRODUCT REPORTS

High-Titer Heterologous Production in E. coli of Lyngbyatoxin, a Protein Kinase C Activator from an Uncultured Marine Cyanobacterium

(2013) Sarah E. Ongley et al.   ACS Chemical Biology

Correlation Between Sorangium cellulosum Subgroups and Their Potential for Secondary Metabolite Production

(2013) Chayul Lee   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

The role of transcription in heterologous expression of polyketides in bacterial hosts

(2013) D. Cole Stevens et al.   NATURAL PRODUCT REPORTS

Recent advances in the heterologous expression of microbial natural product biosynthetic pathways

(2013) Sarah E. Ongley et al.   NATURAL PRODUCT REPORTS

Direct Cloning, Genetic Engineering, and Heterologous Expression of the Syringolin Biosynthetic Gene Cluster inE. colithrough Red/ET Recombineering

(2012) Xiaoying Bian et al.   CHEMBIOCHEM

Heterologous Expression and Genetic Engineering of the Tubulysin Biosynthetic Gene Cluster Using Red/ET Recombineering and Inactivation Mutagenesis

(2012) Yi Chai et al.   CHEMISTRY & BIOLOGY

Polyketide Proofreading by an Acyltransferase-like Enzyme

(2012) Katja Jensen et al.   CHEMISTRY & BIOLOGY

Luminmycins A–C, Cryptic Natural Products from Photorhabdus luminescens Identified by Heterologous Expression in Escherichia coli

(2012) Xiaoying Bian et al.   JOURNAL OF NATURAL PRODUCTS

Full-length RecE enhances linear-linear homologous recombination and facilitates direct cloning for bioprospecting

(2012) Jun Fu et al.   NATURE BIOTECHNOLOGY

Structure and Mechanism of thetrans-Acting Acyltransferase from the Disorazole Synthase

(2011) Fong T. Wong et al.   BIOCHEMISTRY

Knockout and pullout recombineering for naturally transformable Burkholderia thailandensis and Burkholderia pseudomallei

(2011) Yun Kang et al.   Nature Protocols

The Synthesis of Novel Disorazoles

(2010) Romy Schäckel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Biosynthesis of Thuggacins in Myxobacteria: Comparative Cluster Analysis Reveals Basis for Natural Product Structural Diversity

(2010) Kathrin Buntin et al.   CHEMISTRY & BIOLOGY

Nonribosomal peptide synthetases: structures and dynamics

(2010) Matthias Strieker et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Cloning, reassembling and integration of the entire nikkomycin biosynthetic gene cluster into Streptomyces ansochromogenes lead to an improved nikkomycin production

(2010) Guojian Liao et al.   Microbial Cell Factories

Myxobacterial secondary metabolites: bioactivities and modes-of-action

(2010) Kira J. Weissman et al.   NATURAL PRODUCT REPORTS

Biosynthesis of polyketides by trans-AT polyketide synthases

(2010) Jörn Piel   NATURAL PRODUCT REPORTS

High level expression and purification of bioactive human α-defensin 5 mature peptide in Pichia pastoris

(2009) Aiping Wang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Identifying a Resistance Determinant for the Antimitotic Natural Products Disorazole C1 and A1

(2009) J. S. Lazo et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Isolation, biology and chemistry of the disorazoles: new anti-cancer macrodiolides

(2009) Chad D. Hopkins et al.   NATURAL PRODUCT REPORTS

The impact of genomics on the exploitation of the myxobacterial secondary metabolome

(2009) Silke C. Wenzel et al.   NATURAL PRODUCT REPORTS

Two Functionally Redundant Sfp‐Type 4′‐Phosphopantetheinyl Transferases Differentially Activate Biosynthetic Pathways inMyxococcus xanthus

(2008) Peter Meiser et al.   CHEMBIOCHEM

In Vivo and In Vitro Trans-Acylation by BryP, the Putative Bryostatin Pathway Acyltransferase Derived from an Uncultured Marine Symbiont

(2008) Nicole B. Lopanik et al.   CHEMISTRY & BIOLOGY

Metabolites from symbiotic bacteria

(2008) Jörn Piel   NATURAL PRODUCT REPORTS

Efficient transfer of two large secondary metabolite pathway gene clusters into heterologous hosts by transposition

(2008) Jun Fu et al.   NUCLEIC ACIDS RESEARCH