Seven enzymes create extraordinary molecular complexity in an uncultivated bacterium

Leader Peptide Establishes Dehydration Order, Promotes Efficiency, and Ensures Fidelity During Lacticin 481 Biosynthesis

(2016) Christopher J. Thibodeaux et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Selection-based discovery of macrocyclic peptides for the next generation therapeutics

(2015) Tomomi Morioka et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Post-translational modifications as key regulators of bacterial metabolic fluxes

(2015) Tippapha Pisithkul et al.   CURRENT OPINION IN MICROBIOLOGY

Structural analysis of leader peptide binding enables leader-free cyanobactin processing

(2015) Jesko Koehnke et al.   Nature Chemical Biology

A prevalent peptide-binding domain guides ribosomal natural product biosynthesis

(2015) Brandon J Burkhart et al.   Nature Chemical Biology

Consecutive radicalS-adenosylmethionine methylations form the ethyl side chain in thienamycin biosynthesis

(2015) Daniel R. Marous et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Operon structure and cotranslational subunit association direct protein assembly in bacteria

(2015) Y.-W. Shieh et al.   SCIENCE

Applications of the class II lanthipeptide protease LicP for sequence-specific, traceless peptide bond cleavage

(2015) Weixin Tang et al.   Chemical Science

The thiostrepton A tryptophan methyltransferase TsrM catalyses a cob(II)alamin-dependent methyl transfer reaction

(2015) Alhosna Benjdia et al.   Nature Communications

Substrate Specificity of the Lanthipeptide Peptidase ElxP and the Oxidoreductase ElxO

(2014) Manuel A. Ortega et al.   ACS Chemical Biology

RadicalS-Adenosyl Methionine Epimerases: Regioselective Introduction of DiverseD-Amino Acid Patterns into Peptide Natural Products

(2014) Brandon I. Morinaka et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Systematic Analysis of Biosynthetic Gene Clusters in the Human Microbiome Reveals a Common Family of Antibiotics

(2014) Mohamed S. Donia et al.   CELL

An environmental bacterial taxon with a large and distinct metabolic repertoire

(2014) Micheal C. Wilson et al.   NATURE

Structure and mechanism of the tRNA-dependent lantibiotic dehydratase NisB

(2014) Manuel A. Ortega et al.   NATURE

Deciphering post-translational modification codes

(2013) Adam P. Lothrop et al.   FEBS LETTERS

Effect of posttranslational modifications on enzyme function and assembly

(2013) Helena Ryšlavá et al.   Journal of Proteomics

Involvement and Unusual Substrate Specificity of a Prolyl Oligopeptidase in Class III Lanthipeptide Maturation

(2013) Ginka H. Völler et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Platforms for antibiotic discovery

(2013) Kim Lewis   NATURE REVIEWS DRUG DISCOVERY

Different Biosynthetic Pathways to Fosfomycin in Pseudomonas syringae and Streptomyces Species

(2012) Seung Young Kim et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Regulatable Vectors for Environmental Gene Expression in Alphaproteobacteria

(2012) Adrian J. Tett et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Determination of the Absolute Configuration of Peptide Natural Products by Using Stable Isotope Labeling and Mass Spectrometry

(2012) Helge B. Bode et al.   CHEMISTRY-A EUROPEAN JOURNAL

Selective Modification of the N-Terminal Structure of Polytheonamide B Significantly Changes its Cytotoxicity and Activity as an Ion Channel

(2012) Naoki Shinohara et al.   ChemMedChem

Deuterium Labeled Peptides Give Insights into the Directionality of Class III Lantibiotic Synthetase LabKC

(2012) Bartlomiej Krawczyk et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Selectivity, Directionality, and Promiscuity in Peptide Processing from a Bacillus sp. Al Hakam Cyclodehydratase

(2012) Joel O. Melby et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature

(2012) Paul G. Arnison et al.   NATURAL PRODUCT REPORTS

Metagenome Mining Reveals Polytheonamides as Posttranslationally Modified Ribosomal Peptides

(2012) M. F. Freeman et al.   SCIENCE

Radical-Mediated Enzymatic Methylation: A Tale of Two SAMS

(2011) Qi Zhang et al.   ACCOUNTS OF CHEMICAL RESEARCH

In Vitro Phosphinate Methylation by PhpK fromKitasatospora phosalacinea

(2011) Williard J. Werner et al.   BIOCHEMISTRY

Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains

(2011) Ming Yang et al.   FEBS Journal

Solution Structure of Polytheonamide B, a Highly Cytotoxic Nonribosomal Polypeptide from Marine Sponge

(2010) Toshiyuki Hamada et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Subtilases: The superfamily of subtilisin-like serine proteases

(2010) Roland J. Siezen et al.   PROTEIN SCIENCE

Antibiotics: Natural products essential to human health

(2009) Arnold L. Demain   MEDICINAL RESEARCH REVIEWS

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY