Selective Activation of a Prodrug by Thioredoxin Reductase Providing a Strategy to Target Cancer Cells

Fluorogenic reaction-based prodrug conjugates as targeted cancer theranostics

(2018) Min Hee Lee et al.   CHEMICAL SOCIETY REVIEWS

The A to Z of modulated cell patterning by mammalian thioredoxin reductases

(2018) Markus Dagnell et al.   FREE RADICAL BIOLOGY AND MEDICINE

Characterization of Hydrophilic Gold(I) N-Heterocyclic Carbene (NHC) Complexes as Potent TrxR Inhibitors Using Biochemical and Mass Spectrometric Approaches

(2017) Özden Karaca et al.   INORGANIC CHEMISTRY

Design, Synthesis, and Biological Evaluation of Coupled Bioactive Scaffolds as Potential Anticancer Agents for Dual Targeting of Dihydrofolate Reductase and Thioredoxin Reductase

(2017) Hui-Li Ng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Tamoxifen-like metallocifens target the thioredoxin system determining mitochondrial impairment leading to apoptosis in Jurkat cells

(2017) Valeria Scalcon et al.   Metallomics

Targeting the Thioredoxin System for Cancer Therapy

(2017) Junmin Zhang et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Targeting the tumour microenvironment with an enzyme-responsive drug delivery system for the efficient therapy of breast and pancreatic cancers

(2017) Brigitte Renoux et al.   Chemical Science

Highly Selective Fluorescent Probe for Imaging H2Se in Living Cells and in Vivo Based on the Disulfide Bond

(2016) Fanpeng Kong et al.   ANALYTICAL CHEMISTRY

Targeting Cancer with PCPA-Drug Conjugates: LSD1 Inhibition-Triggered Release of 4-Hydroxytamoxifen

(2016) Yosuke Ota et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Integrin-Targeting Knottin Peptide-Drug Conjugates Are Potent Inhibitors of Tumor Cell Proliferation

(2016) Nick Cox et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Inhibition of thioredoxin reductase by alantolactone prompts oxidative stress-mediated apoptosis of HeLa cells

(2016) Junmin Zhang et al.   BIOCHEMICAL PHARMACOLOGY

A small molecule probe reveals declined mitochondrial thioredoxin reductase activity in a Parkinson's disease model

(2016) Yaping Liu et al.   CHEMICAL COMMUNICATIONS

A fast response and red emission probe for mammalian thioredoxin reductase

(2016) Huilong Ma et al.   CHEMICAL COMMUNICATIONS

Inhibitory nitrosylation of mammalian thioredoxin reductase 1: Molecular characterization and evidence for its functional role in cellular nitroso-redox imbalance

(2016) Rotem Engelman et al.   FREE RADICAL BIOLOGY AND MEDICINE

Designing piperlongumine-directed anticancer agents by an electrophilicity-based prooxidant strategy: A mechanistic investigation

(2016) Wen-Jing Yan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Targeting Thioredoxin Reductase by Parthenolide Contributes to Inducing Apoptosis of HeLa Cells

(2016) Dongzhu Duan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anticancer and Antiangiogenic Iron(II) Complexes That Target Thioredoxin Reductase to Trigger Cancer Cell Apoptosis

(2016) Lina Xie et al.   JOURNAL OF MEDICINAL CHEMISTRY

Liposomal Texaphyrin Theranostics for Metastatic Liver Cancer

(2016) Min Hee Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody–drug conjugates

(2016) Leanna R. Staben et al.   Nature Chemistry

Disulfide-Based Multifunctional Conjugates for Targeted Theranostic Drug Delivery

(2015) Min Hee Lee et al.   ACCOUNTS OF CHEMICAL RESEARCH

Gold(i) thiotetrazolates as thioredoxin reductase inhibitors and antiproliferative agents

(2015) Tatiyana V. Serebryanskaya et al.   DALTON TRANSACTIONS

Synthesis of Xanthohumol Analogues and Discovery of Potent Thioredoxin Reductase Inhibitor as Potential Anticancer Agent

(2015) Baoxin Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Selective Selenol Fluorescent Probes: Design, Synthesis, Structural Determinants, and Biological Applications

(2015) Baoxin Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dual protection of hydroxytyrosol, an olive oil polyphenol, against oxidative damage in PC12 cells

(2015) Shoujiao Peng et al.   Food & Function

An Activatable Theranostic for Targeted Cancer Therapy and Imaging

(2014) Sankarprasad Bhuniya et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A furanyl acryl conjugated coumarin as an efficient inhibitor and a highly selective off–on fluorescent probe for covalent labelling of thioredoxin reductase

(2014) Lei Huang et al.   CHEMICAL COMMUNICATIONS

Gemcitabine: Metabolism and molecular mechanisms of action, sensitivity and chemoresistance in pancreatic cancer

(2014) Lucas de Sousa Cavalcante et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Interaction of adenanthin with glutathione and thiol enzymes: Selectivity for thioredoxin reductase and inhibition of peroxiredoxin recycling

(2014) Marjolein Soethoudt et al.   FREE RADICAL BIOLOGY AND MEDICINE

Evidence for Targeting Thioredoxin Reductases with Ferrocenyl Quinone Methides. A Possible Molecular Basis for the Antiproliferative Effect of Hydroxyferrocifens on Cancer Cells

(2014) Anna Citta et al.   JOURNAL OF MEDICINAL CHEMISTRY

Dithiaarsanes Induce Oxidative Stress-Mediated Apoptosis in HL-60 Cells by Selectively Targeting Thioredoxin Reductase

(2014) Yaping Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Development and Bioorthogonal Activation of Palladium-Labile Prodrugs of Gemcitabine

(2014) Jason T. Weiss et al.   JOURNAL OF MEDICINAL CHEMISTRY

In Vivo and in Situ Tracking Cancer Chemotherapy by Highly Photostable NIR Fluorescent Theranostic Prodrug

(2014) Xumeng Wu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An Activatable Prodrug for the Treatment of Metastatic Tumors

(2014) Eun-Joong Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Identification of Michael Acceptor-Centric Pharmacophores with Substituents That Yield Strong Thioredoxin Reductase Inhibitory Character Correlated to Antiproliferative Activity

(2013) Fei-Fei Gan et al.   ANTIOXIDANTS & REDOX SIGNALING

Highly Selective Off–On Fluorescent Probe for Imaging Thioredoxin Reductase in Living Cells

(2013) Liangwei Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Folate-Based Near-Infrared Fluorescent Theranostic Gemcitabine Delivery

(2013) Zhigang Yang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Gemcitabine–Coumarin–Biotin Conjugates: A Target Specific Theranostic Anticancer Prodrug

(2013) Sukhendu Maiti et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Thioredoxin System as a Therapeutic Target in Human Health and Disease

(2012) Dler Faieeq Darweesh Mahmood et al.   ANTIOXIDANTS & REDOX SIGNALING

Direct Fluorescence Monitoring of the Delivery and Cellular Uptake of a Cancer-Targeted RGD Peptide-Appended Naphthalimide Theragnostic Prodrug

(2012) Min Hee Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Small molecule inhibitors of mammalian thioredoxin reductase

(2011) Wenqing Cai et al.   FREE RADICAL BIOLOGY AND MEDICINE

Structural and Kinetic Characterization of Human Deoxycytidine Kinase Variants Able To Phosphorylate 5-Substituted Deoxycytidine and Thymidine Analogues,

(2010) Saugata Hazra et al.   BIOCHEMISTRY

Selenoproteins—What unique properties can arise with selenocysteine in place of cysteine?

(2010) Elias S.J. Arnér   EXPERIMENTAL CELL RESEARCH

Selenoproteins

(2008) Jun Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY