Integrin-Targeting Knottin Peptide-Drug Conjugates Are Potent Inhibitors of Tumor Cell Proliferation

Chlorotoxin: A Helpful Natural Scorpion Peptide to Diagnose Glioma and Fight Tumor Invasion

(2015) Lucie Dardevet et al.   Toxins

A Chemically Cross-Linked Knottin Dimer Binds Integrins with Picomolar Affinity and Inhibits Tumor Cell Migration and Proliferation

(2014) Jun W. Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Potent Anti-CD70 Antibody–Drug Conjugate Combining a Dimeric Pyrrolobenzodiazepine Drug with Site-Specific Conjugation Technology

(2013) Scott C. Jeffrey et al.   BIOCONJUGATE CHEMISTRY

Antibody–drug conjugates: current status and future directions

(2013) Heidi L. Perez et al.   DRUG DISCOVERY TODAY

Engineered knottin peptide enables noninvasive optical imaging of intracranial medulloblastoma

(2013) Sarah J. Moore et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antibody-Drug Conjugates in Cancer Therapy

(2012) Eric L. Sievers et al.   Annual Review of Medicine

Platinum(IV)-chlorotoxin (CTX) conjugates for targeting cancer cells

(2012) Nora Graf et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Integrins as therapeutic targets

(2012) Simon L. Goodman et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Nucleobase Transport by Human Equilibrative Nucleoside Transporter 1 (hENT1)

(2011) Sylvia Y. M. Yao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Dual-Labeled Knottin Peptide for PET and Near-Infrared Fluorescence Imaging of Integrin Expression in Living Subjects

(2010) Richard H. Kimura et al.   BIOCONJUGATE CHEMISTRY

PET Imaging of Tumor Neovascularization in a Transgenic Mouse Model with a Novel 64Cu-DOTA-Knottin Peptide

(2010) C. H. Nielsen et al.   CANCER RESEARCH

Targeted Contrast-Enhanced Ultrasound Imaging of Tumor Angiogenesis with Contrast Microbubbles Conjugated to Integrin-Binding Knottin Peptides

(2010) J. K. Willmann et al.   JOURNAL OF NUCLEAR MEDICINE

Integrins as therapeutic targets: lessons and opportunities

(2010) Dermot Cox et al.   NATURE REVIEWS DRUG DISCOVERY

Novel immunoconjugates comprised of streptonigrin and 17-amino-geldanamycin attached via a dipeptide-p-aminobenzyl-amine linker system

(2009) Patrick J. Burke et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Engineered Knottin Peptides: A New Class of Agents for Imaging Integrin Expression in Living Subjects

(2009) R. H. Kimura et al.   CANCER RESEARCH

Biological diversity and therapeutic potential of natural and engineered cystine knot miniproteins

(2009) Harald Kolmar   CURRENT OPINION IN PHARMACOLOGY

Engineered cystine knot peptides that bind αvβ3, αvβ5, and α5β1 integrins with low-nanomolar affinity

(2009) Richard H. Kimura et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Cu-Catalyzed Azide−Alkyne Cycloaddition

(2008) Morten Meldal et al.   CHEMICAL REVIEWS

Ziconotide: an update and review

(2008) Jason A Williams et al.   EXPERT OPINION ON PHARMACOTHERAPY

Alternative binding proteins: Biological activity and therapeutic potential of cystine-knot miniproteins

(2008) Harald Kolmar   FEBS Journal

Engineered Cystine-Knot Peptides that Bind αvβ3 Integrin with Antibody-Like Affinities

(2008) Adam P. Silverman et al.   JOURNAL OF MOLECULAR BIOLOGY