Serelaxin induces Notch1 signaling and alleviates hepatocellular damage in orthotopic liver transplantation

Myeloid Notch1 deficiency activates the RhoA/ROCK pathway and aggravates hepatocellular damage in mouse ischemic livers

(2018) Ling Lu et al.   HEPATOLOGY

Macrophage heme oxygenase-1-SIRT1-p53 axis regulates sterile inflammation in liver ischemia-reperfusion injury

(2017) Kojiro Nakamura et al.   JOURNAL OF HEPATOLOGY

Relaxin protects cardiac muscle cells from hypoxia/reoxygenation injury: involvement of the Notch-1 pathway

(2015) Giulia Boccalini et al.   FASEB JOURNAL

Relaxin inhibits cardiac fibrosis and endothelial–mesenchymal transition via the Notch pathway

(2015) Xi Zhou et al.   Drug Design Development and Therapy

Relaxin has anti-apoptotic effects on human trophoblast-derived HTR-8/SV neo cells

(2013) Romana S.Z. Lodhi et al.   GYNECOLOGICAL ENDOCRINOLOGY

Relaxin modulates human and rat hepatic myofibroblast function and ameliorates portal hypertensionin vivo

(2013) Jonathan A. Fallowfield et al.   HEPATOLOGY

Acute treatment with relaxin protects the kidney against ischaemia/reperfusion injury

(2013) Massimo Collino et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Relaxin Family Peptides and Their Receptors

(2013) R. A. D. Bathgate et al.   PHYSIOLOGICAL REVIEWS

Relaxin Prevents Cardiac Fibroblast-Myofibroblast Transition via Notch-1-Mediated Inhibition of TGF-β/Smad3 Signaling

(2013) Chiara Sassoli et al.   PLoS One

Serelaxin, recombinant human relaxin-2, for treatment of acute heart failure (RELAX-AHF): a randomised, placebo-controlled trial

(2012) John R Teerlink et al.   LANCET

Ischaemia–reperfusion injury in liver transplantation—from bench to bedside

(2012) Yuan Zhai et al.   Nature Reviews Gastroenterology & Hepatology

Relaxin Modulates Proinflammatory Cytokine Secretion from Human Decidual Macrophages1

(2011) J.S. Horton et al.   BIOLOGY OF REPRODUCTION

Canonical notch pathway protects hepatocytes from ischemia/reperfusion injury in mice by repressing reactive oxygen species production through JAK2/STAT3 signaling

(2011) Heng-Chao Yu et al.   HEPATOLOGY

Relaxin is a candidate drug for lung preservation: Relaxin-induced protection of rat lungs from ischemia-reperfusion injury

(2009) Konstantin Alexiou et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Cardiovascular effects of relaxin: from basic science to clinical therapy

(2009) Xiao-Jun Du et al.   Nature Reviews Cardiology

Translocation of iron from lysosomes into mitochondria is a key event during oxidative stress-induced hepatocellular injury

(2008) Akira Uchiyama et al.   HEPATOLOGY

Inhibition of Kupffer cell-mediated early proinflammatory response with carbon monoxide in transplant-induced hepatic ischemia/reperfusion injury in rats

(2008) Koji Tomiyama et al.   HEPATOLOGY

RXFP1-inactive relaxin activates human glucocorticoid receptor: Further investigations into the relaxin–GR pathway

(2008) Thomas Dschietzig et al.   REGULATORY PEPTIDES

The multifaceted role of Notch in cardiac development and disease

(2007) Frances A. High et al.   NATURE REVIEWS GENETICS