Relaxin Prevents Cardiac Fibroblast-Myofibroblast Transition via Notch-1-Mediated Inhibition of TGF-β/Smad3 Signaling

TGF-β signaling in tissue fibrosis: Redox controls, target genes and therapeutic opportunities

(2012) Rohan Samarakoon et al.   CELLULAR SIGNALLING

The Notch pathway controls fibrotic and regenerative repair in the adult heart

(2012) Mohamed Nemir et al.   EUROPEAN HEART JOURNAL

Relaxin induces matrix-metalloproteinases-9 and -13 via RXFP1: Induction of MMP-9 involves the PI3K, ERK, Akt and PKC-ζ pathways

(2012) Nisar Ahmad et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The regulation of fibrosis in airway remodeling in asthma

(2012) Simon G. Royce et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Bone Marrow Mesenchymal Stromal Cells Stimulate Skeletal Myoblast Proliferation through the Paracrine Release of VEGF

(2012) Chiara Sassoli et al.   PLoS One

Notch receptor–ligand binding and activation: Insights from molecular studies

(2012) Chandramouli R. Chillakuri et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Relaxin Regulates Myofibroblast Contractility and Protects against Lung Fibrosis

(2011) Xiangwei Huang et al.   AMERICAN JOURNAL OF PATHOLOGY

The role of ADAM-mediated shedding in vascular biology

(2011) Daniela Dreymueller et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Relaxin promotes growth and maturation of mouse neonatal cardiomyocytes in vitro: clues for cardiac regeneration

(2011) Silvia Nistri et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Relaxin remodels fibrotic healing following myocardial infarction

(2011) Chrishan S Samuel et al.   LABORATORY INVESTIGATION

Alternative origins of stroma in normal organs and disease

(2011) Mikhail G. Kolonin et al.   Stem Cell Research

Relaxin Regulates MMP Expression and Promotes Satellite Cell Mobilization During Muscle Healing in Both Young and Aged Mice

(2010) Xiaodong Mu et al.   AMERICAN JOURNAL OF PATHOLOGY

The Role of SnoN in Transforming Growth Factor β1-induced Expression of Metalloprotease-Disintegrin ADAM12

(2010) Emilia Solomon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prevention of Bleomycin-Induced Pulmonary Fibrosis by a Novel Antifibrotic Peptide with Relaxin-Like Activity

(2010) A. Pini et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

HDAC-mediated control of ERK- and PI3K-dependent TGF-β-induced extracellular matrix-regulating genes

(2010) Matt J. Barter et al.   MATRIX BIOLOGY

Notch1 Signaling in FIZZ1 Induction of Myofibroblast Differentiation

(2009) Tianju Liu et al.   AMERICAN JOURNAL OF PATHOLOGY

Alterations in mRNA and protein levels of metalloproteinases-2, -9, and -14 and tissue inhibitor of metalloproteinase-2 responses to traumatic skeletal muscle injury

(2009) Brian R. Barnes et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Investigations into the Inhibitory Effects of Relaxin on Renal Myofibroblast Differentiation

(2009) Chrishan S. Samuel et al.   Annals of the New York Academy of Sciences

Skeletal myoblasts overexpressing relaxin improve differentiation and communication of primary murine cardiomyocyte cell cultures

(2009) Lucia Formigli et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Relaxin for the treatment of patients with acute heart failure (Pre-RELAX-AHF): a multicentre, randomised, placebo-controlled, parallel-group, dose-finding phase IIb study

(2009) John R Teerlink et al.   LANCET

Cardiovascular effects of relaxin: from basic science to clinical therapy

(2009) Xiao-Jun Du et al.   Nature Reviews Cardiology

Relaxin and Nitric Oxide Signalling

(2008) M. Baccari et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Relaxin inhibits renal myofibroblast differentiation via RXFP1, the nitric oxide pathway, and Smad2

(2008) Ishanee Mookerjee et al.   FASEB JOURNAL