Relaxin Family Peptides and Their Receptors

Design of the RELAXin in Acute Heart Failure Study

(2012) Piotr Ponikowski et al.   AMERICAN HEART JOURNAL

Minimization of Human Relaxin-3 Leading to High-Affinity Analogues with Increased Selectivity for Relaxin-Family Peptide 3 Receptor (RXFP3) over RXFP1

(2012) Fazel Shabanpoor et al.   JOURNAL OF MEDICINAL CHEMISTRY

Relaxin induces matrix-metalloproteinases-9 and -13 via RXFP1: Induction of MMP-9 involves the PI3K, ERK, Akt and PKC-ζ pathways

(2012) Nisar Ahmad et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

In Vitro Pharmacological Characterization of RXFP3 Allosterism: An Example of Probe Dependency

(2012) Lily Alvarez-Jaimes et al.   PLoS One

Maternal vasodilation in pregnancy: the emerging role of relaxin

(2011) Kirk P. Conrad   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Constitutive formation of an RXFP1-signalosome: a novel paradigm in GPCR function and regulation

(2011) Michelle L Halls   BRITISH JOURNAL OF PHARMACOLOGY

Effects of Relaxin on Arterial Dilation, Remodeling, and Mechanical Properties

(2011) Kirk P. Conrad et al.   CURRENT HYPERTENSION REPORTS

Relaxin Induces Rapid Dilation of Rodent Small Renal and Human Subcutaneous Arteries via PI3 Kinase and Nitric Oxide

(2011) Jonathan T. McGuane et al.   ENDOCRINOLOGY

The rise and fall of endothelin receptor antagonists in congestive heart failure

(2011) M. L. Handoko et al.   EUROPEAN RESPIRATORY JOURNAL

Endometrial LGR7 expression during menstrual cycle

(2011) Maria Rosaria Campitiello et al.   FERTILITY AND STERILITY

Angiogenic Growth Factors Are New and Essential Players in the Sustained Relaxin Vasodilatory Pathway in Rodents and Humans

(2011) Jonathan T. McGuane et al.   HYPERTENSION

The Minimal Active Structure of Human Relaxin-2

(2011) Mohammed Akhter Hossain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Relaxin-3 systems in the brain—The first 10 years

(2011) Craig M. Smith et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Relaxin polymorphisms associated with metabolic disturbance in patients treated with antipsychotics

(2011) Janet Munro et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Design, Synthesis, and Characterization of a Single-Chain Peptide Antagonist for the Relaxin-3 Receptor RXFP3

(2011) Linda M. Haugaard-Kedström et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

In search of new therapeutic targets and strategies for heart failure: recent advances in basic science

(2011) Ajay M Shah et al.   LANCET

Medical therapy for chronic heart failure

(2011) Henry Krum et al.   LANCET

R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/ -catenin signaling

(2011) K. S. Carmon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Decreased Expression of the Rat Myometrial Relaxin Receptor (RXFP1) in Late Pregnancy Is Partially Mediated by the Presence of the Conceptus1

(2010) Lenka A. Vodstrcil et al.   BIOLOGY OF REPRODUCTION

Progesterone Withdrawal, and Not Increased Circulating Relaxin, Mediates the Decrease in Myometrial Relaxin Receptor (RXFP1) Expression in Late Gestation in Rats1

(2010) Lenka A. Vodstrcil et al.   BIOLOGY OF REPRODUCTION

Insulin-Like 3 Exposure of the Fetal Rat Gubernaculum Modulates Expression of Genes Involved in Neural Pathways1

(2010) Kamin J. Johnson et al.   BIOLOGY OF REPRODUCTION

Ligand-directed signalling at β-adrenoceptors

(2010) Bronwyn A. Evans et al.   BRITISH JOURNAL OF PHARMACOLOGY

Relaxin family peptide systems and the central nervous system

(2010) G. E. Callander et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Beta-arrestins as regulators of signal termination and transduction: How do they determine what to scaffold?

(2010) Kathryn A. DeFea   CELLULAR SIGNALLING

Sub-picomolar relaxin signalling by a pre-assembled RXFP1, AKAP79, AC2, β-arrestin 2, PDE4D3 complex

(2010) Michelle L Halls et al.   EMBO JOURNAL

Endometrial expression of relaxin and relaxin receptor in endometriosis

(2010) Sara S. Morelli et al.   FERTILITY AND STERILITY

Relaxin Therapy Reverses Large Artery Remodeling and Improves Arterial Compliance in Senescent Spontaneously Hypertensive Rats

(2010) Qi Xu et al.   HYPERTENSION

Unveiling the Vasodilatory Actions and Mechanisms of Relaxin

(2010) Kirk P. Conrad   HYPERTENSION

AKAP79 Interacts with Multiple Adenylyl Cyclase (AC) Isoforms and Scaffolds AC5 and -6 to α-Amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA) Receptors

(2010) Riad Efendiev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insulin-like 6 Is Induced by Muscle Injury and Functions as a Regenerative Factor

(2010) Ling Zeng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Positive Inotropic Effect of Relaxin-2 in Human Atrial Myocardium is Preserved in End-Stage Heart Failure: Role of Gi-Phosphoinositide-3 Kinase Signaling

(2010) Thomas Dschietzig et al.   JOURNAL OF CARDIAC FAILURE

Distribution of relaxin-3 and RXFP3 within arousal, stress, affective, and cognitive circuits of mouse brain

(2010) Craig M. Smith et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Prevention of Bleomycin-Induced Pulmonary Fibrosis by a Novel Antifibrotic Peptide with Relaxin-Like Activity

(2010) A. Pini et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

A missense mutation in LRR8 of RXFP2 is associated with cryptorchidism

(2010) Rebecca M. Harris et al.   MAMMALIAN GENOME

Membrane receptors: Structure and function of the relaxin family peptide receptors

(2010) Roy C.K. Kong et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Relaxin Enhances S100A4 and Promotes Growth of Human Thyroid Carcinoma Cell Xenografts

(2010) Y. Radestock et al.   MOLECULAR CANCER RESEARCH

Suppression of Insulin-Like3 Receptor Reveals the Role of β-Catenin and Notch Signaling in Gubernaculum Development

(2010) Elena M. Kaftanovskaya et al.   MOLECULAR ENDOCRINOLOGY

Relaxin family peptides in the male reproductive system--a critical appraisal

(2010) R. Ivell et al.   MOLECULAR HUMAN REPRODUCTION

H2 Relaxin Is a Biased Ligand Relative to H3 Relaxin at the Relaxin Family Peptide Receptor 3 (RXFP3)

(2010) E. T. van der Westhuizen et al.   MOLECULAR PHARMACOLOGY

Centrally administered relaxin-3 induces Fos expression in the osmosensitive areas in rat brain and facilitates water intake

(2010) Hiroki Otsubo et al.   PEPTIDES

Role of the intra-A-chain disulfide bond of insulin-like peptide 3 in binding and activation of its receptor, RXFP2

(2010) Suode Zhang et al.   PEPTIDES

Seven Transmembrane Receptors as Shapeshifting Proteins: The Impact of Allosteric Modulation and Functional Selectivity on New Drug Discovery

(2010) T. Kenakin et al.   PHARMACOLOGICAL REVIEWS

Beyond Desensitization: Physiological Relevance of Arrestin-Dependent Signaling

(2010) L. M. Luttrell et al.   PHARMACOLOGICAL REVIEWS

The role of RXFP2 in mediating androgen-induced inguinoscrotal testis descent in LH receptor knockout mice

(2010) F P Yuan et al.   REPRODUCTION

Regulation by Ca2+-Signaling Pathways of Adenylyl Cyclases

(2010) M. L. Halls et al.   Cold Spring Harbor Perspectives in Biology

Prolonged RXFP1 and RXFP2 signaling can be explained by poor internalization and a lack of β-arrestin recruitment

(2009) Gabrielle E. Callander et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Expression of LGR7 in the Primate Corpus Luteum Implicates the Corpus Luteum as a Relaxin Target Organ

(2009) Priya B. Maseelall et al.   Annals of the New York Academy of Sciences

Relaxin Activates Multiple cAMP Signaling Pathway Profiles in Different Target Cells

(2009) Michelle L. Halls et al.   Annals of the New York Academy of Sciences

Behavioral Phenotyping of Mixed Background (129S5:B6) Relaxin-3 Knockout Mice

(2009) Craig M. Smith et al.   Annals of the New York Academy of Sciences

Role of Relaxin in Regulation of Fibrosis in the Lung

(2009) Mimi L. K. Tang et al.   Annals of the New York Academy of Sciences

Verification of a Relaxin-3 Knockout/LacZ Reporter Mouse as a Model of Relaxin-3 Deficiency

(2009) Craig M. Smith et al.   Annals of the New York Academy of Sciences

Relaxin Family Genes in Humans and Teleosts

(2009) Sergey Yegorov et al.   Annals of the New York Academy of Sciences

Regulation of Rxfp2 (Lgr8) Expression in the Mouse Fetal Kidney by the Transcription Factor Pod1 (Tcf 21)

(2009) Mary Familari et al.   Annals of the New York Academy of Sciences

Activation of Relaxin-Related Receptors by Short, Linear Peptides Derived from a Collagen-Containing Precursor

(2009) Ronen Shemesh et al.   Annals of the New York Academy of Sciences

Metabolic and Neuroendocrine Responses to RXFP3 Modulation in the Central Nervous System

(2009) Steven W. Sutton et al.   Annals of the New York Academy of Sciences

Modeling the Primary Hormone-Binding Site of RXFP1 and RXFP2

(2009) Daniel J. Scott et al.   Annals of the New York Academy of Sciences

First Clinical Experience with Intravenous Recombinant Human Relaxin in Compensated Heart Failure

(2009) Thomas Dschietzig et al.   Annals of the New York Academy of Sciences

New Roles for INSL3 in Adults

(2009) Alberto Ferlin et al.   Annals of the New York Academy of Sciences

Scientific Rationale and Design of a Phase I Safety Study of Relaxin in Women with Severe Preeclampsia

(2009) Elaine Unemori et al.   Annals of the New York Academy of Sciences

Resolving the Unconventional Mechanisms Underlying RXFP1 and RXFP2 Receptor Function

(2009) Brigham J. Hartley et al.   Annals of the New York Academy of Sciences

INSL3 Plays a Role in the Balance between Bone Formation and Resorption

(2009) Anastasia Pepe et al.   Annals of the New York Academy of Sciences

Relaxin Family Peptides and Receptors in Mammalian Brain

(2009) Andrew L. Gundlach et al.   Annals of the New York Academy of Sciences

Structural Insights into the Function of Relaxins

(2009) K. Johan Rosengren et al.   Annals of the New York Academy of Sciences

Distribution of Relaxin-3 mRNA and Immunoreactivity and RXFP3-Binding Sites in the Brain of the Macaque, Macaca fascicularis

(2009) Sherie Ma et al.   Annals of the New York Academy of Sciences

Structure of human insulin-like peptide 5 and characterization of conserved hydrogen bonds and electrostatic interactions within the relaxin framework

(2009) Linda M. Haugaard-Jönsson et al.   BIOCHEMICAL JOURNAL

Dynamics of INSL3 Peptide Expression in the Rodent Testis1

(2009) Ravinder Anand-Ivell et al.   BIOLOGY OF REPRODUCTION

Relaxin Reverses Airway Remodeling and Airway Dysfunction in Allergic Airways Disease

(2009) Simon G. Royce et al.   ENDOCRINOLOGY

Inactivation of Insulin-Like Factor 6 Disrupts the Progression of Spermatogenesis at Late Meiotic Prophase

(2009) Ozanna Burnicka-Turek et al.   ENDOCRINOLOGY

INSL3 has tumor-promoting activity in thyroid cancer

(2009) Sabine Hombach-Klonisch et al.   INTERNATIONAL JOURNAL OF CANCER

Intravenous Recombinant Human Relaxin in Compensated Heart Failure: A Safety, Tolerability, and Pharmacodynamic Trial

(2009) Thomas Dschietzig et al.   JOURNAL OF CARDIAC FAILURE

Localization of relaxin-3 in brain ofMacaca fascicularis: Identification of a nucleus incertus in primate

(2009) Sherie Ma et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Relaxin for the treatment of patients with acute heart failure (Pre-RELAX-AHF): a multicentre, randomised, placebo-controlled, parallel-group, dose-finding phase IIb study

(2009) John R Teerlink et al.   LANCET

Modulation of hippocampal theta oscillations and spatial memory by relaxin-3 neurons of the nucleus incertus

(2009) S. Ma et al.   LEARNING & MEMORY

Relaxin signaling activates peroxisome proliferator-activated receptor gamma

(2009) Sudhir Singh et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Adenylyl Cyclase-A-kinase Anchoring Protein Complexes: The Next Dimension in cAMP Signaling

(2009) C. W. Dessauer   MOLECULAR PHARMACOLOGY

Cardiovascular effects of relaxin: from basic science to clinical therapy

(2009) Xiao-Jun Du et al.   Nature Reviews Cardiology

Swim stress excitation of nucleus incertus and rapid induction of relaxin-3 expression via CRF1 activation

(2009) Avantika Banerjee et al.   NEUROPHARMACOLOGY

Autoregulation of human relaxin-2 gene expression critically involves relaxin and glucocorticoid receptor binding to glucocorticoid response half-sites in the relaxin-2 promoter

(2009) Thomas Dschietzig et al.   REGULATORY PEPTIDES

Locally produced relaxin may affect testis and vas deferens function in rats

(2009) Lais Cavalca Cardoso et al.   REPRODUCTION

Normal prostate morphology in relaxin-mutant mice

(2009) Avinash Ganesan et al.   REPRODUCTION FERTILITY AND DEVELOPMENT

Relaxin and its role in the development and treatment of fibrosis

(2009) Robert G. Bennett   Translational Research

Underpinning compartmentalised cAMP signalling through targeted cAMP breakdown

(2009) Miles D. Houslay   TRENDS IN BIOCHEMICAL SCIENCES

The apparent cooperativity of some GPCRs does not necessarily imply dimerization

(2009) Marc Chabre et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Identification of the N-Linked Glycosylation Sites of the Human Relaxin Receptor and Effect of Glycosylation on Receptor Function†

(2008) Y. Yan et al.   BIOCHEMISTRY

Multiple Signals Regulate Phospholipase CBeta3 in Human Myometrial Cells1

(2008) Miao Zhong et al.   BIOLOGY OF REPRODUCTION

Two neuron clusters in the stem of postembryonic zebrafish brain specifically expressrelaxin-3 gene: First evidence of nucleus incertus in fish

(2008) Aldo Donizetti et al.   DEVELOPMENTAL DYNAMICS

Relaxin Ameliorates Fibrosis in Experimental Diabetic Cardiomyopathy

(2008) Chrishan S. Samuel et al.   ENDOCRINOLOGY

Characterization of Relaxin Receptor (RXFP1) Desensitization and Internalization in Primary Human Decidual Cells and RXFP1-Transfected HEK293 Cells

(2008) András Kern et al.   ENDOCRINOLOGY

Relaxin Family Peptide Receptor-1 Protects against Airway Fibrosis during Homeostasis But Not against Fibrosis Associated with Chronic Allergic Airways Disease

(2008) Chrishan S. Samuel et al.   ENDOCRINOLOGY

Identification of the domains in RXFP4 (GPCR142) responsible for the high affinity binding and agonistic activity of INSL5 at RXFP4 compared to RXFP3 (GPCR135)

(2008) Jessica Zhu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Relaxin inhibits renal myofibroblast differentiation via RXFP1, the nitric oxide pathway, and Smad2

(2008) Ishanee Mookerjee et al.   FASEB JOURNAL

Relaxin, a pleiotropic vasodilator for the treatment of heart failure

(2008) Sam L. Teichman et al.   HEART FAILURE REVIEWS

Insulin-like factor 3 levels in amniotic fluid of human male fetuses

(2008) R. Anand-Ivell et al.   HUMAN REPRODUCTION

Regulation of Receptor Signaling by Relaxin A Chain Motifs

(2008) Jae-Il Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery and Validation of Novel Peptide Agonists for G-protein-coupled Receptors

(2008) Ronen Shemesh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The A-chain of Human Relaxin Family Peptides Has Distinct Roles in the Binding and Activation of the Different Relaxin Family Peptide Receptors

(2008) Mohammed Akhter Hossain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of the R3/I5 Chimeric Relaxin Peptide, a Selective GPCR135 and GPCR142 Agonist

(2008) Linda M. Haugaard-Jönsson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutations in the Insulin-Like Factor 3 Receptor Are Associated With Osteoporosis

(2008) Alberto Ferlin et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Negative cooperativity in H2 relaxin binding to a dimeric relaxin family peptide receptor 1

(2008) Angela Manegold Svendsen et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Relaxin signalling in primary cultures of human myometrial cells

(2008) K. Heng et al.   MOLECULAR HUMAN REPRODUCTION

Relaxin Family Peptide Receptor (RXFP1) Coupling to G i3 Involves the C-Terminal Arg752 and Localization within Membrane Raft Microdomains

(2008) M. L. Halls et al.   MOLECULAR PHARMACOLOGY

Leucine-rich repeat-containing G-protein-coupled receptor 8 in the rat brain: Enrichment in thalamic neurons and their efferent projections

(2008) K. Sedaghat et al.   NEUROSCIENCE

Physiological Roles for G Protein-Regulated Adenylyl Cyclase Isoforms: Insights from Knockout and Overexpression Studies

(2008) Rachna Sadana et al.   NEUROSIGNALS

RXFP1-inactive relaxin activates human glucocorticoid receptor: Further investigations into the relaxin–GR pathway

(2008) Thomas Dschietzig et al.   REGULATORY PEPTIDES

The hormonal induction of cervical remodeling in the common marmoset monkey (Callithrix jacchus)

(2008) Christina Simon et al.   REPRODUCTION

Cloning, Expression, and Functional Characterization of Relaxin Receptor (Leucine-Rich Repeat-Containing G Protein-Coupled Receptor 7) Splice Variants from Human Fetal Membranes

(2007) András Kern et al.   ENDOCRINOLOGY

Cooperative Binding of Insulin-Like Peptide 3 to a Dimeric Relaxin Family Peptide Receptor 2

(2007) Angela Manegold Svendsen et al.   ENDOCRINOLOGY

Endogenous Relaxin Does Not Affect Chronic Pressure Overload-Induced Cardiac Hypertrophy and Fibrosis

(2007) Qi Xu et al.   ENDOCRINOLOGY

Adenovirus-mediated delivery of relaxin reverses cardiac fibrosis

(2007) R.A.D. Bathgate et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Developmental expression and serotonergic regulation of relaxin 3/INSL7 in the nucleus incertus of rat brain

(2007) Yasumasa Miyamoto et al.   REGULATORY PEPTIDES

Serotoninergic regulation of emotional and behavioural control processes

(2007) Roshan Cools et al.   TRENDS IN COGNITIVE SCIENCES