Apremilast Alters Behavioral Responses to Ethanol in Mice: I. Reduced Consumption and Preference

Apremilast Alters Behavioral Responses to Ethanol in Mice: II. Increased Sedation, Intoxication, and Reduced Acute Functional Tolerance

(2018) Yuri A. Blednov et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Microglial-specific transcriptome changes following chronic alcohol consumption

(2018) Gizelle M. McCarthy et al.   NEUROPHARMACOLOGY

Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N=112 117)

(2017) T-K Clarke et al.   MOLECULAR PSYCHIATRY

Phosphodiesterase 4b expression plays a major role in alcohol-induced neuro-inflammation

(2017) Diana V. Avila et al.   NEUROPHARMACOLOGY

Effects of Ibudilast on the Subjective, Reinforcing, and Analgesic Effects of Oxycodone in Recently Detoxified Adults with Opioid Dependence

(2017) Verena E Metz et al.   NEUROPSYCHOPHARMACOLOGY

Development of the Neuroimmune Modulator Ibudilast for the Treatment of Alcoholism: A Randomized, Placebo-Controlled, Human Laboratory Trial

(2017) Lara A Ray et al.   NEUROPSYCHOPHARMACOLOGY

Attenuation of ethanol abstinence-induced anxiety- and depressive-like behavior by the phosphodiesterase-4 inhibitor rolipram in rodents

(2017) Mei-Fang Gong et al.   PSYCHOPHARMACOLOGY

Impact of the Innate Immune Response in the Actions of Ethanol on the Central Nervous System

(2016) Jorge Montesinos et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Ibudilast attenuates subjective effects of methamphetamine in a placebo-controlled inpatient study

(2016) Matthew J. Worley et al.   DRUG AND ALCOHOL DEPENDENCE

The Neuroimmune Basis of Excessive Alcohol Consumption

(2016) Jody Mayfield et al.   NEUROPSYCHOPHARMACOLOGY

The neuroimmune transcriptome and alcohol dependence: potential for targeted therapies

(2016) Anna Warden et al.   PHARMACOGENOMICS

Mechanisms of neuroimmune gene induction in alcoholism

(2015) Fulton T. Crews et al.   PSYCHOPHARMACOLOGY

Apremilast is a selective PDE4 inhibitor with regulatory effects on innate immunity

(2014) P.H. Schafer et al.   CELLULAR SIGNALLING

Inhibition of phosphodiesterase 4 reduces ethanol intake and preference in C57BL/6J mice

(2014) Yuri A. Blednov et al.   Frontiers in Neuroscience

Ibudilast reduces alcohol drinking in multiple animal models of alcohol dependence

(2013) Richard L. Bell et al.   ADDICTION BIOLOGY

Neuroimmune signaling: a key component of alcohol abuse

(2013) Jody Mayfield et al.   CURRENT OPINION IN NEUROBIOLOGY

Gene Expression in Brain and Liver Produced by Three Different Regimens of Alcohol Consumption in Mice: Comparison with Immune Activation

(2013) Elizabeth Osterndorff-Kahanek et al.   PLoS One

Escalation of intake under intermittent ethanol access in diverse mouse genotypes

(2012) Alan M. Rosenwasser et al.   ADDICTION BIOLOGY

The Phosphodiesterase-4 (PDE4) Inhibitor Rolipram Decreases Ethanol Seeking and Consumption in Alcohol-Preferring Fawn-Hooded Rats

(2012) Rui-Ting Wen et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Proinflammatory cytokine regulation of cyclic AMP-phosphodiesterase 4 signaling in microgliain vitroand following CNS injury

(2012) Mousumi Ghosh et al.   GLIA

The determination and interpretation of the therapeutic index in drug development

(2012) Patrick Y. Muller et al.   NATURE REVIEWS DRUG DISCOVERY

Intermittent (Every-Other-Day) Drinking Induces Rapid Escalation of Ethanol Intake and Preference in Adolescent and Adult C57BL/6J Mice

(2011) Roberto I. Melendez   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Cyclic nucleotide phosphodiesterase (PDE) isozymes as targets of the intracellular signalling network: benefits of PDE inhibitors in various diseases and perspectives for future therapeutic developments

(2011) Thérèse Keravis et al.   BRITISH JOURNAL OF PHARMACOLOGY

Inhibition of phosphodiesterase-4 decreases ethanol intake in mice

(2011) Wei Hu et al.   PSYCHOPHARMACOLOGY

Apremilast: a novel PDE4 inhibitor in the treatment of autoimmune and inflammatory diseases

(2010) Georg Schett et al.   Therapeutic Advances in Musculoskeletal Disease

Apremilast, a cAMP phosphodiesterase-4 inhibitor, demonstrates anti-inflammatory activity in vitro and in a model of psoriasis

(2009) PH Schafer et al.   BRITISH JOURNAL OF PHARMACOLOGY

Discovery of (S)-N-{2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide (Apremilast), a Potent and Orally Active Phosphodiesterase 4 and Tumor Necrosis Factor-α Inhibitor

(2009) Hon-Wah Man et al.   JOURNAL OF MEDICINAL CHEMISTRY

Reversal of long-term dendritic spine alterations in Alzheimer disease models

(2009) D. L. Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Voluntary ethanol consumption in 22 inbred mouse strains

(2008) Naomi Yoneyama et al.   ALCOHOL

Intermittent Access to 20% Ethanol Induces High Ethanol Consumption in Long-Evans and Wistar Rats

(2008) Jeffrey A. Simms et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Can the anti-inflammatory potential of PDE4 inhibitors be realized: guarded optimism or wishful thinking?

(2008) M A Giembycz   BRITISH JOURNAL OF PHARMACOLOGY