The neuroimmune transcriptome and alcohol dependence: potential for targeted therapies

Pharmacological targeting of ion channels for cancer therapy: In vivo evidences

(2016) Luigi Leanza et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Leveraging big data to transform target selection and drug discovery

(2016) B Chen et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Alcohol resistance inDrosophilais modulated by the Toll innate immune pathway

(2016) B. R. Troutwine et al.   GENES BRAIN AND BEHAVIOR

Differential Response of Glial Fibrillary Acidic Protein-Positive Astrocytes in the Rat Prefrontal Cortex Following Ethanol Self-Administration

(2015) Cecilia Bull et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Chronic Intracerebroventricular Infusion of Monocyte Chemoattractant Protein-1 Leads to a Persistent Increase in Sweetened Ethanol Consumption During Operant Self-Administration But Does Not Influence Sucrose Consumption in Long-Evans Rats

(2015) John P. Valenta et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Astrocyte Dysfunction Induced by Alcohol in Females but Not Males

(2015) Clare J. Wilhelm et al.   BRAIN PATHOLOGY

Treatment of Obesity with Celastrol

(2015) Junli Liu et al.   CELL

Pharmacological targeting of dopamine D3 receptors: Possible clinical applications of selective drugs

(2015) Emilio Merlo Pich et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Therapies in early development for the treatment of opiate addiction

(2015) Marta Rodríguez-Arias et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

The sequenced rat brain transcriptome - its use in identifying networks predisposing alcohol consumption

(2015) Laura M. Saba et al.   FEBS Journal

Pioneering government-sponsored drug repositioning collaborations: progress and learning

(2015) Donald E. Frail et al.   NATURE REVIEWS DRUG DISCOVERY

GLAST But Not Least—Distribution, Function, Genetics and Epigenetics of l-Glutamate Transport in Brain—Focus on GLAST/EAAT1

(2015) Omar Šerý et al.   NEUROCHEMICAL RESEARCH

Ceftriaxone attenuates ethanol drinking and restores extracellular glutamate concentration through normalization of GLT-1 in nucleus accumbens of male alcohol-preferring rats

(2015) Sujan C. Das et al.   NEUROPHARMACOLOGY

Cytokines and chemokines as biomarkers of ethanol-induced neuroinflammation and anxiety-related behavior: Role of TLR4 and TLR2

(2015) María Pascual et al.   NEUROPHARMACOLOGY

CRF-Amplified Neuronal TLR4/MCP-1 Signaling Regulates Alcohol Self-Administration

(2015) Harry L June et al.   NEUROPSYCHOPHARMACOLOGY

Identification of Glial Activation Markers by Comparison of Transcriptome Changes between Astrocytes and Microglia following Innate Immune Stimulation

(2015) Silvia Madeddu et al.   PLoS One

Elusive roles for reactive astrocytes in neurodegenerative diseases

(2015) Lucile Ben Haim et al.   Frontiers in Cellular Neuroscience

Epigenetic modulation of brain gene networks for cocaine and alcohol abuse

(2015) Sean P. Farris et al.   Frontiers in Neuroscience

Chronic Ethanol Exposure Produces Time- and Brain Region-Dependent Changes in Gene Coexpression Networks

(2015) Elizabeth A. Osterndorff-Kahanek et al.   PLoS One

Exploring the Role of Central Astrocytic Glutamate Uptake in Ethanol Reward in Mice

(2014) Karen L. Smith et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Drug repositioning by integrating target information through a heterogeneous network model

(2014) Wenhui Wang et al.   BIOINFORMATICS

Role of Inflammatory Pathways, Blood Mononuclear Cells, and Gut-Derived Bacterial Products in Alcohol Dependence

(2014) Sophie Leclercq et al.   BIOLOGICAL PSYCHIATRY

Sublime Microglia: Expanding Roles for the Guardians of the CNS

(2014) Michael W. Salter et al.   CELL

From the era of genome analysis to the era of genomic drug discovery: a pioneering example of rheumatoid arthritis

(2014) Y. Okada   CLINICAL GENETICS

Acute and chronic administration of a low-dose combination of topiramate and ondansetron reduces ethanol’s reinforcing effects in male alcohol preferring (P) rats.

(2014) Catherine F. Moore et al.   EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY

Drug–Disease Association and Drug-Repositioning Predictions in Complex Diseases Using Causal Inference–Probabilistic Matrix Factorization

(2014) Jihong Yang et al.   Journal of Chemical Information and Modeling

The PDE4 Inhibitor Rolipram Prevents NF- B Binding Activity and Proinflammatory Cytokine Release in Human Chorionic Cells

(2014) R. Herve et al.   JOURNAL OF IMMUNOLOGY

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Transcriptome organization for chronic alcohol abuse in human brain

(2014) S P Farris et al.   MOLECULAR PSYCHIATRY

Rat Nucleus Accumbens Core Astrocytes Modulate Reward and the Motivation to Self-Administer Ethanol after Abstinence

(2014) Cecilia Bull et al.   NEUROPSYCHOPHARMACOLOGY

Attenuation of Ethanol Withdrawal by Ceftriaxone-Induced Upregulation of Glutamate Transporter EAAT2

(2014) Osama A Abulseoud et al.   NEUROPSYCHOPHARMACOLOGY

The synaptoneurosome transcriptome: a model for profiling the emolecular effects of alcohol

(2014) D Most et al.   PHARMACOGENOMICS JOURNAL

Construction of Drug Network Based on Side Effects and Its Application for Drug Repositioning

(2014) Hao Ye et al.   PLoS One

Human TLR10 is an anti-inflammatory pattern-recognition receptor

(2014) Marije Oosting et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of mitochondria ROS generation in ethanol-induced NLRP3 inflammasome activation and cell death in astroglial cells

(2014) Silvia Alfonso-Loeches et al.   Frontiers in Cellular Neuroscience

Toll-Like Receptors 2, -3 and -4 Prime Microglia but not Astrocytes Across Central Nervous System Regions for ATP-Dependent Interleukin-1β Release

(2014) Laura Facci et al.   Scientific Reports

Inhibition of phosphodiesterase 4 reduces ethanol intake and preference in C57BL/6J mice

(2014) Yuri A. Blednov et al.   Frontiers in Neuroscience

Ibudilast reduces alcohol drinking in multiple animal models of alcohol dependence

(2013) Richard L. Bell et al.   ADDICTION BIOLOGY

Effects of Ethanol on Immune Response in the Brain: Region-Specific Changes in Adolescent Versus Adult Mice

(2013) Cynthia J. M. Kane et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Bioinformatics Analyses Reveal Age-Specific Neuroimmune Modulation as a Target for Treatment of High Ethanol Drinking

(2013) Rajiv G. Agrawal et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Computational Drug Repositioning: From Data to Therapeutics

(2013) M R Hurle et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Cooperation of TLR12 and TLR11 in the IRF8-Dependent IL-12 Response to Toxoplasma gondii Profilin

(2013) M. Raetz et al.   JOURNAL OF IMMUNOLOGY

Alcohol-induced IL-1β in the brain is mediated by NLRP3/ASC inflammasome activation that amplifies neuroinflammation

(2013) Dora Lippai et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Ethanol induces TLR4/TLR2 association, triggering an inflammatory response in microglial cells

(2013) Sara Fernandez-Lizarbe et al.   JOURNAL OF NEUROCHEMISTRY

Immune Players in the CNS: The Astrocyte

(2013) Cathy J. Jensen et al.   Journal of Neuroimmune Pharmacology

Gene Expression in Brain and Liver Produced by Three Different Regimens of Alcohol Consumption in Mice: Comparison with Immune Activation

(2013) Elizabeth Osterndorff-Kahanek et al.   PLoS One

Human genome-guided identification of memory-modulating drugs

(2013) A. Papassotiropoulos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nucleic acids and endosomal pattern recognition: how to tell friend from foe?

(2013) Eva Brencicova et al.   Frontiers in Cellular and Infection Microbiology

Gabapentin Treatment for Alcohol Dependence

(2013) Barbara J. Mason et al.   JAMA Internal Medicine

Brief alcohol exposure alters transcription in astrocytes via the heat shock pathway

(2013) Leonardo Pignataro et al.   Brain and Behavior

The Phosphodiesterase-4 (PDE4) Inhibitor Rolipram Decreases Ethanol Seeking and Consumption in Alcohol-Preferring Fawn-Hooded Rats

(2012) Rui-Ting Wen et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Medication discovery for addiction: Translating the dopamine D3 receptor hypothesis

(2012) Amy Hauck Newman et al.   BIOCHEMICAL PHARMACOLOGY

High Mobility Group Box 1/Toll-like Receptor Danger Signaling Increases Brain Neuroimmune Activation in Alcohol Dependence

(2012) Fulton T. Crews et al.   BIOLOGICAL PSYCHIATRY

Role of intestinal permeability and inflammation in the biological and behavioral control of alcohol-dependent subjects

(2012) Sophie Leclercq et al.   BRAIN BEHAVIOR AND IMMUNITY

Aripiprazole: A Drug with a Novel Mechanism of Action and Possible Efficacy for Alcohol Dependence

(2012) Derick Vergne et al.   CNS & Neurological Disorders-Drug Targets

Naltrexone for the Treatment of Alcoholism: Clinical Findings, Mechanisms of Action, and Pharmacogenetics

(2012) Lara Ray et al.   CNS & Neurological Disorders-Drug Targets

Applications of Connectivity Map in drug discovery and development

(2012) Xiaoyan A. Qu et al.   DRUG DISCOVERY TODAY

Activation of toll-like receptor 3 attenuates alcoholic liver injury by stimulating Kupffer cells and stellate cells to produce interleukin-10 in mice

(2012) Jin-Seok Byun et al.   JOURNAL OF HEPATOLOGY

Chemocentric Informatics Approach to Drug Discovery: Identification and Experimental Validation of Selective Estrogen Receptor Modulators as Ligands of 5-Hydroxytryptamine-6 Receptors and as Potential Cognition Enhancers

(2012) Rima Hajjo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inflammatory Mediators Alter the Astrocyte Transcriptome and Calcium Signaling Elicited by Multiple G-Protein-Coupled Receptors

(2012) M. E. Hamby et al.   JOURNAL OF NEUROSCIENCE

Gene Coexpression Networks in Human Brain Identify Epigenetic Modifications in Alcohol Dependence

(2012) I. Ponomarev et al.   JOURNAL OF NEUROSCIENCE

Genomic Analysis of Reactive Astrogliosis

(2012) J. L. Zamanian et al.   JOURNAL OF NEUROSCIENCE

Synaptic plasticity in the hippocampus shows resistance to acute ethanol exposure in transgenic mice with astrocyte-targeted enhanced CCL2 expression

(2012) Jennifer G. Bray et al.   NEUROPHARMACOLOGY

Striatal Adenosine Signaling Regulates EAAT2 and Astrocytic AQP4 Expression and Alcohol Drinking in Mice

(2012) Moonnoh R Lee et al.   NEUROPSYCHOPHARMACOLOGY

Hepatic expression of toll-like receptors 3, 4, and 9 in primary biliary cirrhosis and chronic hepatitis C

(2012) Petros C. Benias et al.   Clinics and Research in Hepatology and Gastroenterology

Neuroimmune regulation of alcohol consumption: behavioral validation of genes obtained from genomic studies

(2011) Yuri A. Blednov et al.   ADDICTION BIOLOGY

Minocycline reduces ethanol drinking

(2011) R.G. Agrawal et al.   BRAIN BEHAVIOR AND IMMUNITY

Impact of TLR4 on behavioral and cognitive dysfunctions associated with alcohol-induced neuroinflammatory damage

(2011) María Pascual et al.   BRAIN BEHAVIOR AND IMMUNITY

Activation of inflammatory signaling by lipopolysaccharide produces a prolonged increase of voluntary alcohol intake in mice

(2011) Y.A. Blednov et al.   BRAIN BEHAVIOR AND IMMUNITY

Inhibiting the TLR4-MyD88 signalling cascade by genetic or pharmacological strategies reduces acute alcohol-induced sedation and motor impairment in mice

(2011) Yue Wu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Toll-like receptors in inflammation of the central nervous system

(2011) Yan Kong et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Upregulated vimentin suggests new areas of neurodegeneration in a model of an alcohol use disorder

(2011) M.L. Kelso et al.   NEUROSCIENCE

Binge alcohol drinking is associated with GABAA  2-regulated Toll-like receptor 4 (TLR4) expression in the central amygdala

(2011) J. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of phosphodiesterase-4 decreases ethanol intake in mice

(2011) Wei Hu et al.   PSYCHOPHARMACOLOGY

Chlorpromazine for Psychosis-Induced Aggression or Agitation

(2011) U. Ahmed et al.   SCHIZOPHRENIA BULLETIN

Computational Repositioning of the Anticonvulsant Topiramate for Inflammatory Bowel Disease

(2011) J. T. Dudley et al.   Science Translational Medicine

Induction of Innate Immune Gene Expression Cascades in Brain Slice Cultures by Ethanol: Key Role of NF-κB and Proinflammatory Cytokines

(2010) Jian Zou et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Topiramate in the New Generation of Drugs: Efficacy in the Treatment of Alcoholic Patients

(2010) Bankole A. Johnson et al.   CURRENT PHARMACEUTICAL DESIGN

Glial and glutamatergic markers in depression, alcoholism, and their comorbidity

(2010) José Javier Miguel-Hidalgo et al.   JOURNAL OF AFFECTIVE DISORDERS

Endogenous toll-like receptor ligands and their biological significance

(2010) Li Yu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The Microtubule Regulator Stathmin Is an Endogenous Protein Agonist for TLR3

(2010) M. Bsibsi et al.   JOURNAL OF IMMUNOLOGY

Pivotal Role of TLR4 Receptors in Alcohol-Induced Neuroinflammation and Brain Damage

(2010) S. Alfonso-Loeches et al.   JOURNAL OF NEUROSCIENCE

Chronic alcohol neuroadaptation and stress contribute to susceptibility for alcohol craving and relapse

(2010) George R. Breese et al.   PHARMACOLOGY & THERAPEUTICS

Critical Role of TLR4 Response in the Activation of Microglia Induced by Ethanol

(2009) S. Fernandez-Lizarbe et al.   JOURNAL OF IMMUNOLOGY

Minocycline attenuates lipopolysaccharide (LPS)-induced neuroinflammation, sickness behavior, and anhedonia

(2008) Christopher J Henry et al.   Journal of Neuroinflammation

The genomic determinants of alcohol preference in mice

(2008) Boris Tabakoff et al.   MAMMALIAN GENOME

Increased MCP-1 and microglia in various regions of the human alcoholic brain

(2007) Jun He et al.   EXPERIMENTAL NEUROLOGY