Article
Biochemistry & Molecular Biology
Haocheng Qin, Cuicui Wang, Yonghua He, Aiwu Lu, Tiandao Li, Bo Zhang, Jie Shen
Summary: Osteoarthritis (OA) is a prevalent joint disease and a leading cause of disability, but its underlying pathogenesis is poorly understood. Inflammation is known to disturb joint homeostasis in OA, and microRNA-146a-5p (miR-146a-5p) has been identified as a key regulator of inflammation in this study. Increased expression of miR-146a-5p was found in human OA cartilage, and experimental results showed that miR-146a-5p can regulate inflammatory responses and catabolism in chondrocytes. Silencing miR-146a-5p alleviated cartilage destruction and reduced OA-induced pain in a mouse model.
Article
Cell Biology
Dongyun Li, Xiaoying Wang, Tengda Yi, Lin Zhang, Lirui Feng, Mingxing Zhang, Yongsheng He, Shunkui Gang
Summary: The study aims to explore the function and regulatory mechanism of a novel lncRNA, MINCR, in osteoarthritis (OA). The findings demonstrate that MINCR prevents OA progression by targeting miR-146a-5p to promote BMPR2 expression.
Article
Cell Biology
Yusuke Fujiwara, Chenyang Ding, Yohei Sanada, Dilimulati Yimiti, Masakazu Ishikawa, Tomoyuki Nakasa, Naosuke Kamei, Kazunori Imaizumi, Martin K. Lotz, Takayuki Akimoto, Shigeru Miyaki, Nobuo Adachi
Summary: This study investigated the role of miR-23a/b clusters in osteoarthritis (OA). Through experiments on genetically modified mice, it was found that miR-23a/b clusters do not significantly contribute to the pathogenesis of OA.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Xin-Xin Zhang, Shi-Hao He, Xu Liang, Wei Li, Tian-Fang Li, Dai-Feng Li
Summary: Osteoarthritis is a chronic joint disease characterized by cartilage destruction, with aging playing a key role. Current treatments are palliative, and there is a need for disease-modifying drugs. Cellular senescence, synovial inflammation, and epigenetic changes may contribute to its pathogenesis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Chenteng Lai, Boyi Liao, Song Peng, Peng Fang, Bao Nirong, Lei Zhang
Summary: The study demonstrates that SFB-miR-214-3p exosomes can alleviate inflammation and degeneration of cartilage tissues, suggesting their potential therapeutic value in treating osteoarthritis.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Orthopedics
K. M. Scott, D. J. Cohen, M. Hays, D. W. Nielson, M. W. Grinstaff, T. B. Lawson, B. D. Snyder, B. D. Boyan, Z. Schwartz
Summary: Both miR-122 and miR-451 were upregulated in OA in a rat bilateral anterior cruciate ligament transection (ACLT) model. miR-122 prevented the effects of IL-1 beta on rArCs, while miR-451 exacerbated them.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Review
Immunology
James Orman Early, Lauren E. Fagan, Annie M. Curtis, Oran D. Kennedy
Summary: Inflammation is an important biological response to tissue damage, but dysregulation of the process can lead to tissue damage. Mitochondria play a key role in orchestrating the inflammatory response, beyond their traditional function in energy production. Osteoarthritis, previously thought of as non-inflammatory, now appears to involve chronic inflammation as well.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Lindsey H. Burton, Maryam F. Afzali, Lauren B. Radakovich, Margaret A. Campbell, Lauren A. Culver, Christine S. Olver, Kelly S. Santangelo
Summary: The study demonstrated that pharmacologic iron chelation with deferoxamine reduced iron levels and delayed the progression of primary osteoarthritis in an animal model. Reduction of iron content alleviated cartilage lesions, decreased chondrocyte hypocellularity, enhanced expression of anti-apoptotic genes, and decreased expression of matrix-degrading enzymes.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Orthopedics
Shannon K. Walsh, Rikin Soni, Lisa M. Arendt, Melissa C. Skala, Corinne R. Henak
Summary: The study revealed age-dependent metabolic activity in cartilage, with metabolic dysfunction impacting gene expression related to tissue maintenance. Glycolysis, oxidative phosphorylation activity, and optical redox ratio were positively correlated with severity of cartilage damage.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2022)
Article
Integrative & Complementary Medicine
Yiming Xu, Song Xue, Tian Zhang, Xinmeng Jin, Cong Wang, Haiming Lu, Yiming Zhong, Hongjie Chen, Libo Zhu, Jinzhong Ma, Weilin Sang
Summary: This study found that Toddalolactone (TOD) can inhibit inflammation and the expression of catabolic mediators in inflammatory chondrocytes in vitro, as well as inhibit RANKL-induced osteoclast differentiation. The study also confirmed that TOD can suppress articular cartilage destruction and bone resorption by inhibiting the activation of NF-kappa B and MAPK signaling pathways. In an ACLT mouse model, TOD was found to reduce cartilage erosion and bone resorption.
Review
Orthopedics
M. H. J. van den Bosch
Summary: This review summarizes important articles and research focuses on osteoarthritis biology published between 2019 and 2020, covering topics such as inflammatory changes, stem cell therapy, drug treatment, and microbiome. Overall, significant breakthroughs have been made in understanding the biology of osteoarthritis development over the past year, exploring new therapeutic possibilities.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Review
Geriatrics & Gerontology
Shital Wakale, Xiaoxin Wu, Yogita Sonar, Antonia Sun, Xiwei Fan, Ross Crawford, Indira Prasadam
Summary: Osteoarthritis (OA) is a common degenerative joint disease that significantly impairs the physical function of the elderly population. This review focuses on the age-related changes in chondrocytes and their impact on OA development, including senescence, mitochondrial dysfunction, epigenetic modifications, and decreased growth factor response. These changes also extend to the matrix, subchondral bone, and synovium. Understanding these alterations provides potential therapeutic approaches for OA treatment.
Article
Pharmacology & Pharmacy
Jiaqin Wu, Yuna Qian, Cheng Chen, Fan Feng, Lianhong Pan, Li Yang, Chunli Wang
Summary: This study demonstrated that Hesperetin (HPT) has chondroprotective and anti-inflammatory effects on chondrocytes through the AMPK signaling pathway, inhibiting TNF-alpha-induced cartilage degradation and promoting chondrocyte proliferation. RNA sequencing identified potential molecular targets, with 549 differentially expressed genes, and highlighted the importance of the AMPK pathway in mediating HPT's protective effects. Overall, HPT shows promise as a natural drug for osteoarthritis treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Medicine, General & Internal
Cecile Lambert, Jeremie Zappia, Christelle Sanchez, Antoine Florin, Jean-Emile Dubuc, Yves Henrotin
Summary: Activation of immune systems during osteoarthritis is associated with low-grade systemic inflammation, driven by synovium cells activated by DAMPs released during cartilage degradation. Understanding DAMPs, their receptors, and associated pathological mechanisms is crucial for controlling the effects of degenerative joint diseases like OA.
FRONTIERS IN MEDICINE
(2021)
Article
Medicine, Research & Experimental
Shengyuan Zheng, Senbo An, Yan Luo, Djandan Tadum Arthur Vithran, Shaoqu Yang, Bangbao Lu, Zhenhan Deng, Yusheng Li
Summary: HYBID is a new enzyme that degrades hyaluronan and is present in various cells of the human body. Recent research has found that HYBID is over-expressed in chondrocytes and synoviocytes associated with osteoarthritis. High levels of HYBID are significantly correlated with cartilage degeneration and hyaluronic acid degradation in the joints. Additionally, HYBID can contribute to inflammatory responses and tissue fibrosis in the joints, exacerbating osteoarthritis. Understanding the role of HYBID in osteoarthritis could provide new insights for treatment strategies.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Cell Biology
Kun Yang, Yun Gao, Mingfu Yang, Zuoshang Xu, Qian Chen
CONNECTIVE TISSUE RESEARCH
(2017)
Article
Immunology
S. M. Shahjahan Miah, Chathuraka T. Jayasuriya, Alexander I. Salter, Emma C. Reilly, Celine Fugere, Wentian Yang, Qian Chen, Laurent Brossay
FRONTIERS IN IMMUNOLOGY
(2017)
Article
Engineering, Biomedical
Qihai Liu, Jun Wang, Yupeng Chen, Zhanpeng Zhang, Laura Saunders, Ernestina Schipani, Qian Chen, Peter X. Ma
ACTA BIOMATERIALIA
(2018)
Article
Cell Biology
Huixia Li, Danhui Li, Zhengmin Ma, Zhuang Qian, Xiaomin Kang, Xinxin Jin, Fang Li, Xinluan Wang, Qian Chen, Hongzhi Sun, Shufang Wu
Article
Multidisciplinary Sciences
Chathuraka T. Jayasuriya, Nan Hu, Jing Li, Nicholas Lemme, Richard Terek, Michael G. Ehrlich, Qian Chen
SCIENTIFIC REPORTS
(2018)
Article
Orthopedics
Shilei Wang, Yan Bao, Yinjie Guan, Chunqiu Zhang, Haiying Liu, Xu Yang, Lilan Gao, Tongtong Guo, Qian Chen
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2018)
Article
Anatomy & Morphology
Qi-ling Yuan, Yin-gang Zhang, Qian Chen
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
John Twomey-Kozak, Salomi Desai, Wenguang Liu, Neill Y. Li, Nicholas Lemme, Qian Chen, Brett D. Owens, Chathuraka T. Jayasuriya
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Cell Biology
Yajun Liu, Jonah Schwam, Qian Chen
Summary: Aging is a process of functional decline and tissue degeneration that occurs as organisms age. Cellular senescence, caused by replicative stress, telomere erosion, and stem cell exhaustion, plays a key role in tissue degradation and cell death in aging-related diseases. The interaction between senescent and non-senescent cells may lead to the death of non-senescent cells and tissue degeneration in aging organs.
Review
Chemistry, Medicinal
Brandon Vorrius, Zhen Qiao, Jonathan Ge, Qian Chen
Summary: The musculoskeletal system is composed of specialized connective tissues that provide protection, structure, and mobility to the body. However, diseases of the musculoskeletal system are increasing in burden, resulting in pain, disability, and a decrease in quality of life. Regenerative drug therapies for musculoskeletal disorders are in demand, but effective drug delivery poses challenges.
Article
Mathematics, Interdisciplinary Applications
Zhen Qiao, Hongtao Zhang, Hai-Feng Ji, Qian Chen
Article
Rheumatology
Nan Hu, Yun Gao, Chathuraka T. Jayasuriya, Wenguang Liu, Heng Du, Jing Ding, Meng Feng, Qian Chen
ARTHRITIS RESEARCH & THERAPY
(2019)
Article
Cell Biology
Longhuo Wu, Haiqing Liu, Linfu Li, Daohua Xu, Yun Gao, Yingjie Guan, Qian Chen
CONNECTIVE TISSUE RESEARCH
(2018)