Osteoarthritis year in review 2020: biology

Metformin attenuates cartilage degeneration in an experimental osteoarthritis model by regulating AMPK/mTOR

(2020) Xiaofeng Feng et al.   Aging-US

Secreted Factors and EV-miRNAs Orchestrate the Healing Capacity of Adipose Mesenchymal Stem Cells for the Treatment of Knee Osteoarthritis

(2020) Enrico Ragni et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Intra-articular depletion of macrophages increases acute synovitis and alters macrophage polarity in the injured mouse knee

(2020) K.N. Bailey et al.   OSTEOARTHRITIS AND CARTILAGE

Metformin limits osteoarthritis development and progression through activation of AMPK signalling

(2020) Jun Li et al.   ANNALS OF THE RHEUMATIC DISEASES

Faecal microbiota transplantation from metabolically compromised human donors accelerates osteoarthritis in mice

(2020) ZeYu Huang et al.   ANNALS OF THE RHEUMATIC DISEASES

Lorecivivint, a Novel Intra‐articular CLK/DYRK1A Inhibitor and Wnt Pathway Modulator for Treatment of Knee Osteoarthritis: A Phase 2 Randomized Trial

(2020) Yusuf Yazici et al.   Arthritis & Rheumatology

Single-cell mass cytometry reveals cross-talk between inflammation-dampening and inflammation-amplifying cells in osteoarthritic cartilage

(2020) Fiorella Carla Grandi et al.   Science Advances

Kinsenoside attenuates osteoarthritis by repolarizing macrophages through inactivating NF-κB/MAPK signaling and protecting chondrocytes

(2019) Feng Zhou et al.   Acta Pharmaceutica Sinica B

Metformin Augments Anti-Inflammatory and Chondroprotective Properties of Mesenchymal Stem Cells in Experimental Osteoarthritis

(2019) Min-Jung Park et al.   JOURNAL OF IMMUNOLOGY

The New Role of Sirtuin1 in Human Osteoarthritis Chondrocytes by Regulating Autophagy

(2019) Fa-Xue Liao et al.   Cartilage

Conditioned medium of mesenchymal stem cells delays osteoarthritis progression in a rat model by protecting subchondral bone, maintaining matrix homeostasis, and enhancing autophagy

(2019) Wenbo Chen et al.   Journal of Tissue Engineering and Regenerative Medicine

Toll-like receptor 4 promotes high glucose-induced catabolic and inflammatory responses in chondrocytes in an NF-κB-dependent manner

(2019) Hongzhi Liang et al.   LIFE SCIENCES

Modulation of the Wnt pathway through inhibition of CLK2 and DYRK1A by lorecivivint as a novel, potentially disease-modifying approach for knee osteoarthritis treatment

(2019) V. Deshmukh et al.   OSTEOARTHRITIS AND CARTILAGE

Adipose-derived stromal cell secretome reduces TNFα-induced hypertrophy and catabolic markers in primary human articular chondrocytes

(2019) Stefania Niada et al.   Stem Cell Research

IL-1β-Mediated Activation of Adipose-Derived Mesenchymal Stromal Cells Results in PMN Reallocation and Enhanced Phagocytosis: A Possible Mechanism for the Reduction of Osteoarthritis Pathology

(2019) Stephanie C. M. van Dalen et al.   Frontiers in Immunology

Discovery of an autoantibody signature for the early diagnosis of knee osteoarthritis: data from the Osteoarthritis Initiative

(2019) María Camacho-Encina et al.   ANNALS OF THE RHEUMATIC DISEASES

Osteoarthritic Milieu Affects Adipose‐Derived Mesenchymal Stromal Cells

(2019) Cristina Manferdini et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Locally renewing resident synovial macrophages provide a protective barrier for the joint

(2019) Stephan Culemann et al.   NATURE

Osteoarthritis-associated basic calcium phosphate crystals alter immune cell metabolism and promote M1 macrophage polarization

(2019) O.R. Mahon et al.   OSTEOARTHRITIS AND CARTILAGE

Intestinal microbiome composition and its relation to joint pain and inflammation

(2019) Cindy G. Boer et al.   Nature Communications

Modified ZIF-8 Nanoparticles Attenuate Osteoarthritis by Reprogramming the Metabolic Pathway of Synovial Macrophages

(2019) Feng Zhou et al.   ACS Applied Materials & Interfaces

Active Vitamin D activates chondrocyte autophagy to reduce osteoarthritis via mediating the AMPK/mTOR signaling pathway

(2019) Chunyu Kong et al.   Biochemistry and Cell Biology

Quercetin alleviates rat osteoarthritis by inhibiting inflammation and apoptosis of chondrocytes, modulating synovial macrophages polarization to M2 macrophages

(2019) Yue Hu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Lumican is upregulated in osteoarthritis and contributes to TLR4-induced pro-inflammatory activation of cartilage degradation and macrophage polarization

(2019) G. Barreto et al.   OSTEOARTHRITIS AND CARTILAGE

Combination COX-2 inhibitor and metformin attenuate rate of joint replacement in osteoarthritis with diabetes: A nationwide, retrospective, matched-cohort study in Taiwan

(2018) Chieh-Hua Lu et al.   PLoS One

The Western Diet–Microbiome-Host Interaction and Its Role in Metabolic Disease

(2018) Marit Zinöcker et al.   Nutrients

SOX-6, 9-Transfected Adipose Stem Cells to Treat Surgically-induced Osteoarthritis in Goats

(2018) Ji-Yun Ko et al.   TISSUE ENGINEERING PART A

Macrophage Immunometabolism: Where Are We (Going)?

(2017) Jan Van den Bossche et al.   TRENDS IN IMMUNOLOGY

Geography, Ethnicity or Subsistence-Specific Variations in Human Microbiome Composition and Diversity

(2017) Vinod K. Gupta et al.   Frontiers in Microbiology

Conditional Macrophage Depletion Increases Inflammation and Does Not Inhibit the Development of Osteoarthritis in Obese Macrophage Fas-Induced Apoptosis-Transgenic Mice

(2017) Chia-Lung Wu et al.   Arthritis & Rheumatology

AMPK deficiency in chondrocytes accelerated the progression of instability-induced and ageing-associated osteoarthritis in adult mice

(2017) Sheng Zhou et al.   Scientific Reports

Diabetes Medications as Monotherapy or Metformin-Based Combination Therapy for Type 2 Diabetes

(2016) Nisa M. Maruthur et al.   ANNALS OF INTERNAL MEDICINE

Inflammatory Cells in Patients with Endstage Knee Osteoarthritis: A Comparison between the Synovium and the Infrapatellar Fat Pad

(2016) I. R. Klein-Wieringa et al.   JOURNAL OF RHEUMATOLOGY

Both systemic and local lipopolysaccharide (LPS) burden are associated with knee OA severity and inflammation

(2016) Z.Y. Huang et al.   OSTEOARTHRITIS AND CARTILAGE

Type II diabetes mellitus and incident osteoarthritis of the hand: a population-based case–control analysis

(2016) N. Frey et al.   OSTEOARTHRITIS AND CARTILAGE

Adipose Mesenchymal Stromal Cell-Based Therapy for Severe Osteoarthritis of the Knee: A Phase I Dose-Escalation Trial

(2016) Yves-Marie Pers et al.   Stem Cells Translational Medicine

Treatment efficacy of adipose-derived stem cells in experimental osteoarthritis is driven by high synovial activation and reflected by S100A8/A9 serum levels

(2014) R.F. Schelbergen et al.   OSTEOARTHRITIS AND CARTILAGE

Adipose-Derived Mesenchymal Stem Cells Exert Antiinflammatory Effects on Chondrocytes and Synoviocytes From Osteoarthritis Patients Through Prostaglandin E2

(2013) Cristina Manferdini et al.   ARTHRITIS AND RHEUMATISM

Intra-articular delivery of adipose derived stromal cells attenuates osteoarthritis progression in an experimental rabbit model

(2013) Giovanna Desando et al.   ARTHRITIS RESEARCH & THERAPY

Linked decreases in liver kinase B1 and AMP-activated protein kinase activity modulate matrix catabolic responses to biomechanical injury in chondrocytes

(2013) Freyr Petursson et al.   ARTHRITIS RESEARCH & THERAPY

Antiinflammatory and chondroprotective effects of intraarticular injection of adipose-derived stem cells in experimental osteoarthritis

(2012) Menno ter Huurne et al.   ARTHRITIS AND RHEUMATISM

Diabetes-induced osteoarthritis: from a new paradigm to a new phenotype

(2011) F. Berenbaum   ANNALS OF THE RHEUMATIC DISEASES

Chondrocyte AMP-activated protein kinase activity suppresses matrix degradation responses to proinflammatory cytokines interleukin-1β and tumor necrosis factor α

(2011) Robert Terkeltaub et al.   ARTHRITIS AND RHEUMATISM

Impaired glucose transporter-1 degradation and increased glucose transport and oxidative stress in response to high glucose in chondrocytes from osteoarthritic versus normal human cartilage

(2009) Susana C Rosa et al.   ARTHRITIS RESEARCH & THERAPY