Evidence that miR-146a attenuates aging- and trauma-induced osteoarthritis by inhibiting Notch1, IL-6, and IL-1 mediated catabolism

Long-term effects of a lifestyle intervention and oral glucosamine sulphate in primary care on incident knee OA in overweight women

(2017) Bastiaan C. de Vos et al.   RHEUMATOLOGY

miR-146a facilitates osteoarthritis by regulating cartilage homeostasis via targeting Camk2d and Ppp3r2

(2017) Xudong Zhang et al.   Cell Death & Disease

Ageing and the pathogenesis of osteoarthritis

(2016) Richard F. Loeser et al.   Nature Reviews Rheumatology

Strong association of the polymorphisms in PBEF1 and knee OA risk: a two-stage population-based study in China

(2016) Minjie Chu et al.   Scientific Reports

Deficient Mechanical Activation of Anabolic Transcripts and Post-Traumatic Cartilage Degeneration in Matrilin-1 Knockout Mice

(2016) Yupeng Chen et al.   PLoS One

MicroRNA-146a reduces IL-1 dependent inflammatory responses in the intervertebral disc

(2015) Su-Xi Gu et al.   GENE

Early postnatal ablation of the microRNA-processing enzyme, Drosha, causes chondrocyte death and impairs the structural integrity of the articular cartilage

(2015) T. Kobayashi et al.   OSTEOARTHRITIS AND CARTILAGE

A dual role for NOTCH signaling in joint cartilage maintenance and osteoarthritis

(2015) Zhaoyang Liu et al.   Science Signaling

A dual role for NOTCH signaling in joint cartilage maintenance and osteoarthritis

(2015) Zhaoyang Liu et al.   Science Signaling

Mechanical activation of mammalian target of rapamycin pathway is required for cartilage development

(2014) Yingjie Guan et al.   FASEB JOURNAL

Is OA a mechanical or systemic disease?

(2014) Flavia M. Cicuttini et al.   Nature Reviews Rheumatology

The individual and socioeconomic impact of osteoarthritis

(2014) David J. Hunter et al.   Nature Reviews Rheumatology

Epigenetics in osteoarthritis and its implication for future therapeutics

(2013) Gun-Il Im et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Impact of Notch Signaling on Inflammatory Responses in Cardiovascular Disorders

(2013) Thibaut Quillard et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Notch signaling is involved in human articular chondrocytes de-differentiation during osteoarthritis

(2013) Nadia Sassi et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Insights from human genetic studies into the pathways involved in osteoarthritis

(2013) Louise N. Reynard et al.   Nature Reviews Rheumatology

Post-traumatic osteoarthritis: from mouse models to clinical trials

(2013) Christopher B. Little et al.   Nature Reviews Rheumatology

Notch signaling in chondrocytes modulates endochondral ossification and osteoarthritis development

(2013) Y. Hosaka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Osteoarthritis: A disease of the joint as an organ

(2012) Richard F. Loeser et al.   ARTHRITIS AND RHEUMATISM

miR-146a regulates mechanotransduction and pressure-induced inflammation in small airway epithelium

(2012) Yan Huang et al.   FASEB JOURNAL

miR-146a, an IL-1β responsive miRNA, induces vascular endothelial growth factor and chondrocyte apoptosis by targeting Smad4

(2012) Jing Li et al.   ARTHRITIS RESEARCH & THERAPY

MiR-365: a mechanosensitive microRNA stimulates chondrocyte differentiation through targeting histone deacetylase 4

(2011) Ying-Jie Guan et al.   FASEB JOURNAL

MicroRNA-146a is linked to pain-related pathophysiology of osteoarthritis

(2011) Xin Li et al.   GENE

miR-146ais a significant brake on autoimmunity, myeloproliferation, and cancer in mice

(2011) Mark P. Boldin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

MicroRNAs in NF- B signaling

(2011) X. Ma et al.   Journal of Molecular Cell Biology

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

NF-κB Signaling: Multiple Angles to Target OA

(2010) Kenneth B. Marcu et al.   CURRENT DRUG TARGETS

MicroRNA-140 and the silencing of osteoarthritis

(2010) E. Araldi et al.   GENES & DEVELOPMENT

Role of proinflammatory cytokines in the pathophysiology of osteoarthritis

(2010) Mohit Kapoor et al.   Nature Reviews Rheumatology

The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in the mouse

(2010) S.S. Glasson et al.   OSTEOARTHRITIS AND CARTILAGE

New developments in osteoarthritis. Posttraumatic osteoarthritis: pathogenesis and pharmacological treatment options

(2010) Martin K Lotz   ARTHRITIS RESEARCH & THERAPY

Plasma and synovial fluid microRNAs as potential biomarkers of rheumatoid arthritis and osteoarthritis

(2010) Koichi Murata et al.   ARTHRITIS RESEARCH & THERAPY

Expression of MicroRNA-146a in osteoarthritis cartilage

(2009) Keiichiro Yamasaki et al.   ARTHRITIS AND RHEUMATISM

Adding fuel to fire: microRNAs as a new class of mediators of inflammation

(2008) F J Sheedy et al.   ANNALS OF THE RHEUMATIC DISEASES

Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis

(2008) Joanna Stanczyk et al.   ARTHRITIS AND RHEUMATISM

Notch1, Jagged1, and HES5 Are Abundantly Expressed in Osteoarthritis

(2008) C. Karlsson et al.   CELLS TISSUES ORGANS

Widespread changes in protein synthesis induced by microRNAs

(2008) Matthias Selbach et al.   NATURE

ADAMTS5−/− mice have less subchondral bone changes after induction of osteoarthritis through surgical instability: implications for a link between cartilage and subchondral bone changes

(2008) S.M. Botter et al.   OSTEOARTHRITIS AND CARTILAGE

MicroRNAs and immunity: Novel players in the regulation of normal immune function and inflammation

(2008) Enikö Sonkoly et al.   SEMINARS IN CANCER BIOLOGY