Hypertension-induced synapse loss and impairment in synaptic plasticity in the mouse hippocampus mimics the aging phenotype: implications for the pathogenesis of vascular cognitive impairment
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Title
Hypertension-induced synapse loss and impairment in synaptic plasticity in the mouse hippocampus mimics the aging phenotype: implications for the pathogenesis of vascular cognitive impairment
Authors
Keywords
Hypertension, Blood pressure, Vascular aging, Microcirculation, Inflammation, Dementia
Journal
GeroScience
Volume 39, Issue 4, Pages 385-406
Publisher
Springer Nature
Online
2017-06-30
DOI
10.1007/s11357-017-9981-y
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Note: Only part of the references are listed.- Postsynaptic synaptotagmins mediate AMPA receptor exocytosis during LTP
- (2017) Dick Wu et al. NATURE
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- (2017) Nicole M. Ashpole et al. GeroScience
- The role of transplanted visceral fat from the long-lived growth hormone receptor knockout mice on insulin signaling
- (2017) Mohammed T. Bennis et al. GeroScience
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- (2017) Sangkyu Kim et al. GeroScience
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- (2017) Judit Tenk et al. GeroScience
- Influence of Nrf2 activators on subcellular skeletal muscle protein and DNA synthesis rates after 6 weeks of milk protein feeding in older adults
- (2017) Adam R. Konopka et al. GeroScience
- Geroscience and the trans-NIH Geroscience Interest Group, GSIG
- (2017) Felipe Sierra et al. GeroScience
- Cognitive status, fast walking speed and walking speed reserve—the Gait and Alzheimer Interactions Tracking (GAIT) study
- (2017) Michele L. Callisaya et al. GeroScience
- Neuroprotective mechanisms of astaxanthin: a potential therapeutic role in preserving cognitive function in age and neurodegeneration
- (2017) Bethany Grimmig et al. GeroScience
- Retention of the “first-trial effect” in gait-slip among community-living older adults
- (2017) Xuan Liu et al. GeroScience
- The association between frailty, the metabolic syndrome, and mortality over the lifespan
- (2017) Alice E. Kane et al. GeroScience
- The phospholipid composition of the human entorhinal cortex remains relatively stable over 80 years of adult aging
- (2017) Sarah E. Hancock et al. GeroScience
- Apigenin suppresses the senescence-associated secretory phenotype and paracrine effects on breast cancer cells
- (2017) Kevin M. Perrott et al. GeroScience
- The GH/IGF-1 axis in a critical period early in life determines cellular DNA repair capacity by altering transcriptional regulation of DNA repair-related genes: implications for the developmental origins of cancer
- (2017) Andrej Podlutsky et al. GeroScience
- Cerebromicrovascular dysfunction predicts cognitive decline and gait abnormalities in a mouse model of whole brain irradiation-induced accelerated brain senescence
- (2017) Zoltan Ungvari et al. GeroScience
- A new mouse model of frailty: the Cu/Zn superoxide dismutase knockout mouse
- (2017) Sathyaseelan S. Deepa et al. GeroScience
- Microglia activation and phagocytosis: relationship with aging and cognitive impairment in the rhesus monkey
- (2017) Eli Shobin et al. GeroScience
- The impact of aging on cardiac extracellular matrix
- (2017) Cesar A. Meschiari et al. GeroScience
- Asymptomatic heart valve dysfunction in healthy middle-aged companion dogs and its implications for cardiac aging
- (2017) Silvan R. Urfer et al. GeroScience
- IGF-1 deficiency in a critical period early in life influences the vascular aging phenotype in mice by altering miRNA-mediated post-transcriptional gene regulation: implications for the developmental origins of health and disease hypothesis
- (2016) Stefano Tarantini et al. AGE
- Circulating IGF-1 deficiency exacerbates hypertension-induced microvascular rarefaction in the mouse hippocampus and retrosplenial cortex: implications for cerebromicrovascular and brain aging
- (2016) Stefano Tarantini et al. AGE
- Dietary obesity reversibly induces synaptic stripping by microglia and impairs hippocampal plasticity
- (2016) Shuai Hao et al. BRAIN BEHAVIOR AND IMMUNITY
- Dynamin 1- and 3-Mediated Endocytosis Is Essential for the Development of a Large Central Synapse In Vivo
- (2016) Fan Fan et al. JOURNAL OF NEUROSCIENCE
- Metabotropic Glutamate Receptors Induce a Form of LTP Controlled by Translation and Arc Signaling in the Hippocampus
- (2016) Hui Wang et al. JOURNAL OF NEUROSCIENCE
- BDNF-induced LTP is associated with rapid Arc/Arg3.1-dependent enhancement in adult hippocampal neurogenesis
- (2016) Sjoukje D. Kuipers et al. Scientific Reports
- Do Copy Number Changes in CACNA2D2, CACNA2D3, and CACNA1D Constitute a Predisposing Risk Factor for Alzheimer’s Disease?
- (2016) Darine Villela et al. Frontiers in Genetics
- p38 MAPK Inhibition Improves Synaptic Plasticity and Memory in Angiotensin II-dependent Hypertensive Mice
- (2016) Hai-long Dai et al. Scientific Reports
- Aging exacerbates hypertension-induced cerebral microhemorrhages in mice: role of resveratrol treatment in vasoprotection
- (2015) Peter Toth et al. AGING CELL
- IGF-1 deficiency impairs neurovascular coupling in mice: implications for cerebromicrovascular aging
- (2015) Peter Toth et al. AGING CELL
- The change of spatial cognition ability in depression rat model and the possible association with down-regulated protein expression of TRPC6
- (2015) Ye Liu et al. BEHAVIOURAL BRAIN RESEARCH
- Pharmacologically-Induced Neurovascular Uncoupling is Associated with Cognitive Impairment in Mice
- (2015) Stefano Tarantini et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Complement C3-Deficient Mice Fail to Display Age-Related Hippocampal Decline
- (2015) Q. Shi et al. JOURNAL OF NEUROSCIENCE
- Microglia-Dependent Alteration of Glutamatergic Synaptic Transmission and Plasticity in the Hippocampus during Peripheral Inflammation
- (2015) K. Riazi et al. JOURNAL OF NEUROSCIENCE
- Aging Exacerbates Pressure-Induced Mitochondrial Oxidative Stress in Mouse Cerebral Arteries: Figure 1.
- (2015) Zsolt Springo et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Genetically-controlled Vesicle-Associated Membrane Protein 1 expression may contribute to Alzheimer’s pathophysiology and susceptibility
- (2015) Daniel Sevlever et al. Molecular Neurodegeneration
- Aging alters long-term potentiation–related gene networks and impairs synaptic protein synthesis in the rat hippocampus
- (2015) Margaret M. Ryan et al. NEUROBIOLOGY OF AGING
- Lack of synaptic vesicle protein SV2B protects against amyloid-β25–35-induced oxidative stress, cholinergic deficit and cognitive impairment in mice
- (2014) Eric Detrait et al. BEHAVIOURAL BRAIN RESEARCH
- Repetitive transcranial magnetic stimulation (rTMS) influences spatial cognition and modulates hippocampal structural synaptic plasticity in aging mice
- (2014) Jun Ma et al. EXPERIMENTAL GERONTOLOGY
- Differential contributions of microglial and neuronal IKKβ to synaptic plasticity and associative learning in alert behaving mice
- (2014) Vasiliki Kyrargyri et al. GLIA
- Hypertension and Dementia
- (2014) Costantino Iadecola HYPERTENSION
- IGF-1 Deficiency Impairs Cerebral Myogenic Autoregulation in Hypertensive Mice
- (2014) Peter Toth et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Neutralization of Nogo-A Enhances Synaptic Plasticity in the Rodent Motor Cortex and Improves Motor Learning in Vivo
- (2014) A. Zemmar et al. JOURNAL OF NEUROSCIENCE
- Reversal of Age-Related Learning Deficiency by the Vertebrate PACAP and IGF-1 in a Novel Invertebrate Model of Aging: The Pond Snail (Lymnaea stagnalis)
- (2014) Z. Pirger et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- A fine balance: Regulation of hippocampal Arc/Arg3.1 transcription, translation and degradation in a rat model of normal cognitive aging
- (2014) Bonnie R. Fletcher et al. NEUROBIOLOGY OF LEARNING AND MEMORY
- Balance and Stability of Synaptic Structures during Synaptic Plasticity
- (2014) Daniel Meyer et al. NEURON
- Deficiency in LRP6-Mediated Wnt Signaling Contributes to Synaptic Abnormalities and Amyloid Pathology in Alzheimer’s Disease
- (2014) Chia-Chen Liu et al. NEURON
- Clathrin/AP-2 Mediate Synaptic Vesicle Reformation from Endosome-like Vacuoles but Are Not Essential for Membrane Retrieval at Central Synapses
- (2014) Natalia L. Kononenko et al. NEURON
- Syntaxin 1B, but Not Syntaxin 1A, Is Necessary for the Regulation of Synaptic Vesicle Exocytosis and of the Readily Releasable Pool at Central Synapses
- (2014) Tatsuya Mishima et al. PLoS One
- Midlife Hypertension and 20-Year Cognitive Change
- (2014) Rebecca F. Gottesman et al. JAMA Neurology
- Synergistic effects of hypertension and aging on cognitive function and hippocampal expression of genes involved in β-amyloid generation and Alzheimer's disease
- (2013) Anna Csiszar et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Role of 20-HETE, TRPC channels, and BKCa in dysregulation of pressure-induced Ca2+ signaling and myogenic constriction of cerebral arteries in aged hypertensive mice
- (2013) Peter Toth et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- The Honolulu-Asia Aging Study: Epidemiologic and Neuropathologic Research on Cognitive Impairment
- (2013) Rebecca P. Gelber et al. Current Alzheimer Research
- Blockade of BDNF signaling turns chemically-induced long-term potentiation into long-term depression
- (2013) A. Montalbano et al. HIPPOCAMPUS
- Hypertension
- (2013) Giuseppe Faraco et al. HYPERTENSION
- Temporal Evolution of Cognitive Changes in Incident Hypertension
- (2013) Sebastian Köhler et al. HYPERTENSION
- Age-Related Autoregulatory Dysfunction and Cerebromicrovascular Injury in Mice with Angiotensin II-induced Hypertension
- (2013) Peter Toth et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Synapsin II and Rab3a Cooperate in the Regulation of Epileptic and Synaptic Activity in the CA1 Region of the Hippocampus
- (2013) P. Feliciano et al. JOURNAL OF NEUROSCIENCE
- Effects of central and peripheral inflammation on hippocampal synaptic plasticity
- (2013) Massimiliano Di Filippo et al. NEUROBIOLOGY OF DISEASE
- LTP Requires a Unique Postsynaptic SNARE Fusion Machinery
- (2013) Sandra Jurado et al. NEURON
- Insulin-like growth factor-1 in CNS and cerebrovascular aging
- (2013) William E. Sonntag et al. Frontiers in Aging Neuroscience
- Insulin-like growth factor-1 rescues synaptic and motor deficits in a mouse model of autism and developmental delay
- (2013) Ozlem Bozdagi et al. Molecular Autism
- α-Synuclein knockout mice have cognitive impairments
- (2012) V.S. Kokhan et al. BEHAVIOURAL BRAIN RESEARCH
- Hypertension Induces Brain β-Amyloid Accumulation, Cognitive Impairment, and Memory Deterioration Through Activation of Receptor for Advanced Glycation End Products in Brain Vasculature
- (2012) Daniela Carnevale et al. HYPERTENSION
- Central Cardiovascular Circuits Contribute to the Neurovascular Dysfunction in Angiotensin II Hypertension
- (2012) C. Capone et al. JOURNAL OF NEUROSCIENCE
- Altered balance between excitatory and inhibitory inputs onto CA1 pyramidal neurons from SV2A-deficient but not SV2B-deficient mice
- (2012) Kumar Venkatesan et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Aging, Synaptic Dysfunction, and Insulin-Like Growth Factor (IGF)-1
- (2012) F. Deak et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Nonconserved Ca2+/Calmodulin Binding Sites in Munc13s Differentially Control Synaptic Short-Term Plasticity
- (2012) N. Lipstein et al. MOLECULAR AND CELLULAR BIOLOGY
- VAMP4 directs synaptic vesicles to a pool that selectively maintains asynchronous neurotransmission
- (2012) Jesica Raingo et al. NATURE NEUROSCIENCE
- Age-dependent neuroinflammatory responses and deficits in long-term potentiation in the hippocampus during systemic inflammation
- (2012) X. Liu et al. NEUROSCIENCE
- RIM genes differentially contribute to organizing presynaptic release sites
- (2012) P. S. Kaeser et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- ‘Alzheimer-like’ pathology in a murine model of arterial hypertension
- (2011) Daniela Carnevale et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- IRS-2 Deficiency Impairs NMDA Receptor-Dependent Long-term Potentiation
- (2011) Eduardo D. Martín et al. CEREBRAL CORTEX
- SNARE protein expression in synaptic terminals and astrocytes in the adult hippocampus: A comparative analysis
- (2011) Vanessa Schubert et al. GLIA
- Growth cone morphology and spreading are regulated by a dynamin-cortactin complex at point contacts in hippocampal neurons
- (2011) Svetlana Kurklinsky et al. JOURNAL OF NEUROCHEMISTRY
- CaMKII Plays a Nonenzymatic Role in Hippocampal Synaptic Plasticity and Learning by Targeting CaMKII to Synapses
- (2011) N. Z. Borgesius et al. JOURNAL OF NEUROSCIENCE
- Growth Hormone and IGF-1 Deficiency Exacerbate High-Fat Diet-Induced Endothelial Impairment in Obese Lewis Dwarf Rats: Implications for Vascular Aging
- (2011) L. C. Bailey-Downs et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Free Radical Production, Antioxidant Capacity, and Oxidative Stress Response Signatures in Fibroblasts From Lewis Dwarf Rats: Effects of Life Span-Extending Peripubertal GH Treatment
- (2011) Z. Ungvari et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Liver-Specific Knockdown of IGF-1 Decreases Vascular Oxidative Stress Resistance by Impairing the Nrf2-Dependent Antioxidant Response: A Novel Model of Vascular Aging
- (2011) L. C. Bailey-Downs et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Aging and infection reduce expression of specific brain-derived neurotrophic factor mRNAs in hippocampus
- (2011) Timothy R. Chapman et al. NEUROBIOLOGY OF AGING
- Enhancement of LTP in Aged Rats is Dependent on Endogenous BDNF
- (2011) Maria J Diógenes et al. NEUROPSYCHOPHARMACOLOGY
- Long-term deficiency of circulating and hippocampal insulin-like growth factor I induces depressive behavior in adult mice: a potential model of geriatric depression
- (2011) M. Mitschelen et al. NEUROSCIENCE
- NogoA restricts synaptic plasticity in the adult hippocampus on a fast time scale
- (2011) A. Delekate et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Rab3B protein is required for long-term depression of hippocampal inhibitory synapses and for normal reversal learning
- (2011) T. Tsetsenis et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Vascular Contributions to Cognitive Impairment and Dementia
- (2011) Philip B. Gorelick et al. STROKE
- Reversal of aging-associated hippocampal synaptic plasticity deficits by reductants via regulation of thiol redox and NMDA receptor function
- (2010) Yuan-Jian Yang et al. AGING CELL
- The Role of Microglia in Synaptic Stripping and Synaptic Degeneration: A Revised Perspective
- (2010) V Hugh Perry et al. ASN Neuro
- Oligodendrocyte-Myelin Glycoprotein and Nogo Negatively Regulate Activity-Dependent Synaptic Plasticity
- (2010) S. J. Raiker et al. JOURNAL OF NEUROSCIENCE
- Impaired development of hippocampal mossy fibre synapses in mouse mutants for the presynaptic scaffold protein Bassoon
- (2010) Frederic Lanore et al. JOURNAL OF PHYSIOLOGY-LONDON
- Vasoprotective Effects of Life Span-Extending Peripubertal GH Replacement in Lewis Dwarf Rats
- (2010) Z. Ungvari et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Age-related changes in Arc transcription and DNA methylation within the hippocampus
- (2010) M.R. Penner et al. NEUROBIOLOGY OF AGING
- Rosiglitazone attenuates the age-related changes in astrocytosis and the deficit in LTP
- (2010) Thelma R. Cowley et al. NEUROBIOLOGY OF AGING
- Role of neuroinflammation in hypertension-induced brain amyloid pathology
- (2010) Daniela Carnevale et al. NEUROBIOLOGY OF AGING
- Age-related neuroinflammatory changes negatively impact on neuronal function
- (2010) Marina A. Lynch Frontiers in Aging Neuroscience
- Munc13-2 Differentially Affects Hippocampal Synaptic Transmission and Plasticity
- (2009) J. Breustedt et al. CEREBRAL CORTEX
- Munc18-1 binding to the neuronal SNARE complex controls synaptic vesicle priming
- (2009) Ferenc Deák et al. JOURNAL OF CELL BIOLOGY
- Spontaneous Intracerebral Hemorrhage during Acute and Chronic Hypertension in Mice
- (2009) Yoshinobu Wakisaka et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Age-Dependent Impairment of Spine Morphology and Synaptic Plasticity in Hippocampal CA1 Neurons of a Presenilin 1 Transgenic Mouse Model of Alzheimer's Disease
- (2009) A. Auffret et al. JOURNAL OF NEUROSCIENCE
- Piccolo knockdown-induced impairments of spatial learning and long-term potentiation in the hippocampal CA1 region
- (2009) Daisuke Ibi et al. NEUROCHEMISTRY INTERNATIONAL
- Hypertension Increases the Probability of Alzheimer’s Disease and of Mild Cognitive Impairment in an Arab Community in Northern Israel
- (2009) S.D. Israeli-Korn et al. NEUROEPIDEMIOLOGY
- Transmembrane agrin regulates dendritic filopodia and synapse formation in mature hippocampal neuron cultures
- (2009) S. McCroskery et al. NEUROSCIENCE
- Detection of behavioral alterations and learning deficits in mice lacking synaptophysin
- (2009) U. Schmitt et al. NEUROSCIENCE
- Chronic brain inflammation impairs two forms of long-term potentiation in the rat hippocampal CA1 area
- (2009) Sun Seek Min et al. NEUROSCIENCE LETTERS
- Behavioural phenotyping reveals anxiety-like features of SV2A deficient mice
- (2008) Yves Lamberty et al. BEHAVIOURAL BRAIN RESEARCH
- Deficits in LTP and recognition memory in the genetically hypertensive rat are associated with decreased expression of neurotrophic factors and their receptors in the dentate gyrus
- (2008) Amy Hennigan et al. BEHAVIOURAL BRAIN RESEARCH
- Opposing effects of PSD-93 and PSD-95 on long-term potentiation and spike timing-dependent plasticity
- (2008) Holly J. Carlisle et al. JOURNAL OF PHYSIOLOGY-LONDON
- Threats to the Mind: Aging, Amyloid, and Hypertension
- (2008) C. Iadecola et al. STROKE
- Synaptic plasticity, memory and the hippocampus: a neural network approach to causality
- (2007) Guilherme Neves et al. NATURE REVIEWS NEUROSCIENCE
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