Aging, Synaptic Dysfunction, and Insulin-Like Growth Factor (IGF)-1

Postsynaptic Complexin Controls AMPA Receptor Exocytosis during LTP

(2012) Mohiuddin Ahmad et al.   NEURON

Alzheimer’s disease is not “brain aging”: neuropathological, genetic, and epidemiological human studies

(2011) Peter T. Nelson et al.   ACTA NEUROPATHOLOGICA

Activity-Dependent IGF-1 Exocytosis Is Controlled by the Ca2+-Sensor Synaptotagmin-10

(2011) Peng Cao et al.   CELL

Long-term plasticity at inhibitory synapses

(2011) Pablo E Castillo et al.   CURRENT OPINION IN NEUROBIOLOGY

Circulating IGF1 regulates hippocampal IGF1 levels and brain gene expression during adolescence

(2011) Han Yan et al.   JOURNAL OF ENDOCRINOLOGY

Reduced brain insulin-like growth factor I function during aging

(2011) Alexandre Pastoris Muller et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Hippocampal dysregulation of synaptic plasticity-associated proteins with age-related cognitive decline

(2011) Heather D. VanGuilder et al.   NEUROBIOLOGY OF DISEASE

Serum insulin like growth factor-1 is associated with working memory, executive function and selective attention in a sample of healthy, fit older adults

(2011) D. Bellar et al.   NEUROSCIENCE

Long-term deficiency of circulating and hippocampal insulin-like growth factor I induces depressive behavior in adult mice: a potential model of geriatric depression

(2011) M. Mitschelen et al.   NEUROSCIENCE

Age-related changes in gene expression are accelerated in Alzheimer's disease

(2011) P. Saetre et al.   SYNAPSE

The Hippocampal Neuroproteome with Aging and Cognitive Decline: Past Progress and Future Directions

(2011) Heather D. VanGuilder et al.   Frontiers in Aging Neuroscience

Rosiglitazone reversal of Tg2576 cognitive deficits is independent of peripheral gluco-regulatory status

(2010) Jennifer Rodriguez-Rivera et al.   BEHAVIOURAL BRAIN RESEARCH

Synaptic NMDAR activity suppresses FOXO1 expression via a cis-acting FOXO binding site: FOXO1 is a FOXO target gene

(2010) Bashayer Mubarak et al.   Channels

IGF-I and the aging mammalian brain

(2010) J. Piriz et al.   EXPERIMENTAL GERONTOLOGY

Pharmacological and Genetic Accumulation of Hypoxia-Inducible Factor-1  Enhances Excitatory Synaptic Transmission in Hippocampal Neurons through the Production of Vascular Endothelial Growth Factor

(2010) Y. F. Huang et al.   JOURNAL OF NEUROSCIENCE

Stable Mossy Fiber Long-Term Potentiation Requires Calcium Influx at the Granule Cell Soma, Protein Synthesis, and Microtubule-Dependent Axonal Transport

(2010) S. J. Barnes et al.   JOURNAL OF NEUROSCIENCE

Nogo-A Stabilizes the Architecture of Hippocampal Neurons

(2010) M. Zagrebelsky et al.   JOURNAL OF NEUROSCIENCE

Intracellular Redox State Alters NMDA Receptor Response during Aging through Ca2+/Calmodulin-Dependent Protein Kinase II

(2010) K. Bodhinathan et al.   JOURNAL OF NEUROSCIENCE

Genetic Deletion and Pharmacological Inhibition of Nogo-66 Receptor Impairs Cognitive Outcome after Traumatic Brain Injury in Mice

(2010) Anders Hånell et al.   JOURNAL OF NEUROTRAUMA

Neural mechanisms of ageing and cognitive decline

(2010) Nicholas A. Bishop et al.   NATURE

Rod photoreceptor cell death is induced by okadaic acid through activation of PKC and L-type voltage-dependent Ca2+ channels and prevented by IGF-1

(2010) Juliana Adão-Novaes et al.   NEUROCHEMISTRY INTERNATIONAL

Age-related changes in grey and white matter structure throughout adulthood

(2010) Antonio Giorgio et al.   NEUROIMAGE

Effects of age on axon terminals forming axosomatic and axodendritic inhibitory synapses in prefrontal cortex

(2010) J.J. Soghomonian et al.   NEUROSCIENCE

Ageing and protein aggregation-mediated disorders: from invertebrates to mammals

(2010) A. Dillin et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Epilepsy in the elderly

(2009) Ilo E. Leppik et al.   Annals of the New York Academy of Sciences

Reduced IGF-1 Signaling Delays Age-Associated Proteotoxicity in Mice

(2009) Ehud Cohen et al.   CELL

Massive gliosis induced by interleukin-6 suppresses Aβ deposition in vivo: evidence against inflammation as a driving force for amyloid deposition

(2009) Paramita Chakrabarty et al.   FASEB JOURNAL

Insulin Receptor Dysfunction Impairs Cellular Clearance of Neurotoxic Oligomeric Aβ

(2009) Wei-Qin Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Munc18-1 binding to the neuronal SNARE complex controls synaptic vesicle priming

(2009) Ferenc Deák et al.   JOURNAL OF CELL BIOLOGY

Early-onset GH deficiency results in spatial memory impairment in mid-life and is prevented by GH supplementation

(2009) E Nieves-Martinez et al.   JOURNAL OF ENDOCRINOLOGY

Protection of synapses against Alzheimer's-linked toxins: Insulin signaling prevents the pathogenic binding of Aβ oligomers

(2009) Fernanda G. De Felice et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane Fusion: Grappling with SNARE and SM Proteins

(2009) T. C. Sudhof et al.   SCIENCE

Nuclear Calcium Signaling Controls Expression of a Large Gene Pool: Identification of a Gene Program for Acquired Neuroprotection Induced by Synaptic Activity

(2009) Sheng-Jia Zhang et al.   PLoS Genetics

Spike Timing–Dependent Plasticity: A Hebbian Learning Rule

(2008) Natalia Caporale et al.   Annual Review of Neuroscience

Cognition in the adult with childhood-onset GH deficiency

(2008) I Caroline van Nieuwpoort et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Caloric restriction and age affect synaptic proteins in hippocampal CA3 and spatial learning ability

(2008) Michelle M. Adams et al.   EXPERIMENTAL NEUROLOGY

Synapsin IIa Controls the Reserve Pool of Glutamatergic Synaptic Vesicles

(2008) D. Gitler et al.   JOURNAL OF NEUROSCIENCE

Role of IGF Signaling in Olfactory Sensory Map Formation and Axon Guidance

(2008) Jonathan A. Scolnick et al.   NEURON

Endocytosis Is Required for Synaptic Activity-Dependent Release of Amyloid-β In Vivo

(2008) John R. Cirrito et al.   NEURON

RIM1  phosphorylation at serine-413 by protein kinase A is not required for presynaptic long-term plasticity or learning

(2008) P. S. Kaeser et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutamate receptor subunits expression in memory-associated brain structures: Regional variations and effects of aging

(2008) Ping Liu et al.   SYNAPSE

Brain IGF-1 Receptors Control Mammalian Growth and Lifespan through a Neuroendocrine Mechanism

(2008) Laurent Kappeler et al.   PLOS BIOLOGY

The effects of exercise on spatial learning and anxiety-like behavior are mediated by an IGF-I-dependent mechanism related to hippocampal neurogenesis

(2007) J.L. Trejo et al.   MOLECULAR AND CELLULAR NEUROSCIENCE