Can Integrin Agonists Have Cards to Play against Cancer? A Literature Survey of Small Molecules Integrin Activators

Emergence of Small-Molecule Non-RGD-Mimetic Inhibitors for RGD Integrins

(2017) Lisa M. Miller et al.   JOURNAL OF MEDICINAL CHEMISTRY

The opposing roles of laminin-binding integrins in cancer

(2017) Veronika Ramovs et al.   MATRIX BIOLOGY

High Affinity vs. Native Fibronectin in the Modulation of αvβ3 Integrin Conformational Dynamics: Insights from Computational Analyses and Implications for Molecular Design

(2017) Antonella Paladino et al.   PLoS Computational Biology

Integrin β1 activation induces an anti-melanoma host response

(2017) Laila Ritsma et al.   PLoS One

Pyrintegrin Induces Soft Tissue Formation by Transplanted or Endogenous Cells

(2017) Bhranti S. Shah et al.   Scientific Reports

Aggretin Venom Polypeptide as a Novel Anti-angiogenesis Agent by Targeting Integrin alpha2beta1

(2017) Ching Hu Chung et al.   Scientific Reports

Downstream effect profiles discern different mechanisms of integrin αLβ2 inhibition

(2016) Riccardo V. Mancuso et al.   BIOCHEMICAL PHARMACOLOGY

Importance of membrane-proximal N-glycosylation on integrin β1 in its activation and complex formation

(2016) Sicong Hou et al.   FASEB JOURNAL

The integrin–collagen connection – a glue for tissue repair?

(2016) Cédric Zeltz et al.   JOURNAL OF CELL SCIENCE

New β-Lactam Derivatives Modulate Cell Adhesion and Signaling Mediated by RGD-Binding and Leukocyte Integrins

(2016) Monica Baiula et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of Novel c(AmpRGD)–Sunitinib Dual Conjugates as Molecular Tools Targeting the αvβ3 Integrin/VEGFR2 Couple and Impairing Tumor-Associated Angiogenesis

(2016) Andrea Sartori et al.   JOURNAL OF MEDICINAL CHEMISTRY

Integrin Ligands with α/β-Hybrid Peptide Structure: Design, Bioactivity, and Conformational Aspects

(2016) Rossella De Marco et al.   MEDICINAL RESEARCH REVIEWS

Integrin-based therapeutics: biological basis, clinical use and new drugs

(2016) Klaus Ley et al.   NATURE REVIEWS DRUG DISCOVERY

Efficacy of Leukadherin-1 in the Prevention of Hyperoxia-Induced Lung Injury in Neonatal Rats

(2015) Jawahar Jagarapu et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Mimicking bone extracellular matrix: Integrin-binding peptidomimetics enhance osteoblast-like cells adhesion, proliferation, and differentiation on titanium

(2015) Roberta Fraioli et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

α5β1 integrin recycling promotes Arp2/3-independent cancer cell invasion via the formin FHOD3

(2015) Nikki R. Paul et al.   JOURNAL OF CELL BIOLOGY

A Podocyte-Based Automated Screening Assay Identifies Protective Small Molecules

(2015) H. W. Lee et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Local 3D matrix microenvironment regulates cell migration through spatiotemporal dynamics of contractility-dependent adhesions

(2015) Andrew D. Doyle et al.   Nature Communications

Identification and X-ray Co-crystal Structure of a Small-Molecule Activator of LFA-1-ICAM-1 Binding

(2014) Martin Hintersteiner et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Targeting integrins αvβ3 and α5β1 with new β-lactam derivatives

(2014) Paola Galletti et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Cilengitide combined with standard treatment for patients with newly diagnosed glioblastoma with methylated MGMT promoter (CENTRIC EORTC 26071-22072 study): a multicentre, randomised, open-label, phase 3 trial

(2014) Roger Stupp et al.   LANCET ONCOLOGY

The integrin adhesome: from genes and proteins to human disease

(2014) Sabina E. Winograd-Katz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Small molecule agonists of integrin CD11b/CD18 do not induce global conformational changes and are significantly better than activating antibodies in reducing vascular injury

(2013) Mohd Hafeez Faridi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Enhanced cell adhesion and mature intracellular structure promoted by squaramide-based RGD mimics on bioinert surfaces

(2013) Sri Kamesh Narasimhan et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Agonist Leukadherin-1 Increases CD11b/CD18-Dependent Adhesion Via Membrane Tethers

(2013) Emrah Celik et al.   BIOPHYSICAL JOURNAL

Small Molecule Agonist of Very Late Antigen-4 (VLA-4) Integrin Induces Progenitor Cell Adhesion

(2013) Peter Vanderslice et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Complete integrin headpiece opening in eight steps

(2013) Jieqing Zhu et al.   JOURNAL OF CELL BIOLOGY

The B-cell receptor orchestrates environment-mediated lymphoma survival and drug resistance in B-cell malignancies

(2013) K H Shain et al.   ONCOGENE

Effects of Intracoronary CD34 + Stem Cell Transplantation in Nonischemic Dilated Cardiomyopathy Patients

(2012) Bojan Vrtovec et al.   CIRCULATION RESEARCH

Early Stem Cell Engraftment Predicts Late Cardiac Functional Recovery

(2012) Junwei Liu et al.   Circulation-Cardiovascular Imaging

Structural specializations of α4β7, an integrin that mediates rolling adhesion

(2012) Yamei Yu et al.   JOURNAL OF CELL BIOLOGY

Integrins as therapeutic targets

(2012) Simon L. Goodman et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Integrin Targeted Therapeutics

(2012) Melissa Millard et al.   Theranostics

Regulation of Integrin Activation

(2011) Chungho Kim et al.   Annual Review of Cell and Developmental Biology

Cilengitide: The First Anti-Angiogenic Small Molecule Drug Candidate. Design, Synthesis and Clinical Evaluation

(2011) Carlos Mas-Moruno et al.   Anti-Cancer Agents in Medicinal Chemistry

Cyclic RGD β-Lactam Peptidomimetics Induce Differential Gene Expression in Human Endothelial Cells

(2011) Jesus M. Aizpurua et al.   CHEMBIOCHEM

Development of Isoxazoline-Containing Peptidomimetics as Dual αvβ3 and α5β1 Integrin Ligands

(2011) Alessandra Tolomelli et al.   ChemMedChem

Opening the Field of Integrin Biology to “Biased Agonism”

(2011) Daniel I. Simon   CIRCULATION RESEARCH

Integrin inside-out signaling and the immunological synapse

(2011) Timothy A Springer et al.   CURRENT OPINION IN CELL BIOLOGY

Rab25 and CLIC3 Collaborate to Promote Integrin Recycling from Late Endosomes/Lysosomes and Drive Cancer Progression

(2011) Marta A. Dozynkiewicz et al.   DEVELOPMENTAL CELL

Integrin α3β1 as a breast cancer target

(2011) Sita Subbaram et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

αLβ2 Integrin is indispensable for CD8+ T-cell recruitment in experimental pancreatic and hepatocellular cancer

(2011) Takayuki Takeichi et al.   INTERNATIONAL JOURNAL OF CANCER

Small Molecule-Mediated Activation of the Integrin CD11b/CD18 Reduces Inflammatory Disease

(2011) D. Maiguel et al.   Science Signaling

Integrin Structure, Activation, and Interactions

(2011) I. D. Campbell et al.   Cold Spring Harbor Perspectives in Biology

Closed headpiece of integrin  IIb 3 and its complex with an  IIb 3-specific antagonist that does not induce opening

(2010) J. Zhu et al.   BLOOD

The final steps of integrin activation: the end game

(2010) Sanford J. Shattil et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules

(2010) Y. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of novel agonists of the integrin CD11b/CD18

(2009) Mohd. Hafeez Faridi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The integrin α2β1 agonist, aggretin, promotes proliferation and migration of VSMC through NF-kB translocation and PDGF production

(2009) Ching-Hu Chung et al.   BRITISH JOURNAL OF PHARMACOLOGY

The C-terminal Region of Laminin β Chains Modulates the Integrin Binding Affinities of Laminins

(2009) Yukimasa Taniguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors

(2009) Andrew R Reynolds et al.   NATURE MEDICINE

Integrin Agonists as Adjuvants in Chemotherapy for Melanoma

(2008) M. A. Schwartz et al.   CLINICAL CANCER RESEARCH