The integrin–collagen connection – a glue for tissue repair?

Fibrin activates GPVI in human and mouse platelets

(2015) O. M. Alshehri et al.   BLOOD

Integrin α1-null Mice Exhibit Improved Fatty Liver When Fed a High Fat Diet Despite Severe Hepatic Insulin Resistance

(2015) Ashley S. Williams et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An epigenetically distinct breast cancer cell subpopulation promotes collective invasion

(2015) Jill M. Westcott et al.   JOURNAL OF CLINICAL INVESTIGATION

Cooperation between IL-7 Receptor and Integrin α2β1 (CD49b) Drives Th17-Mediated Bone Loss

(2015) Mohammed-Amine El Azreq et al.   JOURNAL OF IMMUNOLOGY

Collagen Induces Maturation of Human Monocyte-Derived Dendritic Cells by Signaling through Osteoclast-Associated Receptor

(2015) Heidi S. Schultz et al.   JOURNAL OF IMMUNOLOGY

OSCAR Is a Receptor for Surfactant Protein D That Activates TNF-α Release from Human CCR2+Inflammatory Monocytes

(2015) Alexander D. Barrow et al.   JOURNAL OF IMMUNOLOGY

Reduced Granulation Tissue and Wound Strength in the Absence of α11β1 Integrin

(2015) Jan-Niklas Schulz et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Lack of Collagen VI Promotes Wound-Induced Hair Growth

(2015) Peiwen Chen et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Integrin α3β1 regulates kidney collecting duct development via TRAF6-dependent K63-linked polyubiquitination of Akt

(2015) Eugenia M. Yazlovitskaya et al.   MOLECULAR BIOLOGY OF THE CELL

Identification of a large set of rare complete human knockouts

(2015) Patrick Sulem et al.   NATURE GENETICS

Integrin α11β1 regulates cancer stromal stiffness and promotes tumorigenicity and metastasis in non-small cell lung cancer

(2015) R Navab et al.   ONCOGENE

Integrin α1β1 expression is controlled by c-MYC in colorectal cancer cells

(2015) S Boudjadi et al.   ONCOGENE

Identification and isolation of a dermal lineage with intrinsic fibrogenic potential

(2015) Y. Rinkevich et al.   SCIENCE

The α v β 1 integrin plays a critical in vivo role in tissue fibrosis

(2015) Nilgun I. Reed et al.   Science Translational Medicine

The adhesion G protein-coupled receptor GPR56 is a cell-autonomous regulator of oligodendrocyte development

(2015) Stefanie Giera et al.   Nature Communications

Type I Collagen Receptor (α2β1) Signaling Promotes Prostate Cancer Invasion through RhoC GTPase

(2015) Christopher L. Hall et al.   NEOPLASIA

Integrin α1β1 participates in chondrocyte transduction of osmotic stress

(2014) Christina L. Jablonski et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Epigenetic and in vivo comparison of diverse MSC sources reveals an endochondral signature for human hematopoietic niche formation

(2014) A. Reinisch et al.   BLOOD

Prolyl-4-hydroxylase α subunit 2 promotes breast cancer progression and metastasis by regulating collagen deposition

(2014) Gaofeng Xiong et al.   BMC CANCER

Citrullination of collagen II affects integrin-mediated cell adhesion in a receptor-specific manner

(2014) Kalle Sipilä et al.   FASEB JOURNAL

Glycated Collagen Induces α11 Integrin Expression Through TGF-β2 and Smad3

(2014) Ilana Talior-Volodarsky et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Integrin-mediated type II TGF-β receptor tyrosine dephosphorylation controls SMAD-dependent profibrotic signaling

(2014) Xiwu Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Leukocyte-associated Ig-like receptor-1 is a novel inhibitory receptor for surfactant protein D

(2014) Marloes J. M. Olde Nordkamp et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Post-translational modifications of integrin ligands as pathogenic mechanisms in disease

(2014) Cédric Zeltz et al.   MATRIX BIOLOGY

Collagen receptors integrin alpha2beta1 and discoidin domain receptor 1 regulate maturation of the glomerular basement membrane and loss of integrin alpha2beta1 delays kidney fibrosis in COL4A3 knockout mice

(2014) Diana Rubel et al.   MATRIX BIOLOGY

Integrin α1β1 differentially regulates cytokine-mediated responses in chondrocytes

(2014) R. Parekh et al.   OSTEOARTHRITIS AND CARTILAGE

The wound healing, chronic fibrosis, and cancer progression triad

(2014) Brad Rybinski et al.   PHYSIOLOGICAL GENOMICS

Fibroblast α11β1 Integrin Regulates Tensional Homeostasis in Fibroblast/A549 Carcinoma Heterospheroids

(2014) Ning Lu et al.   PLoS One

α2β1 Integrin, GPVI Receptor, and Common FcRγ Chain on Mouse Platelets Mediate Distinct Responses to Collagen in Models of Thrombosis

(2014) Robin J. Marjoram et al.   PLoS One

Molecular composition and function of integrin-based collagen glues—Introducing COLINBRIs

(2013) Cédric Zeltz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Age-related bone deterioration is diminished by disrupted collagen sensing in integrin α2β1 deficient mice

(2013) Richard Stange et al.   BONE

GPR56 Inhibits Melanoma Growth by Internalizing and Degrading Its Ligand TG2

(2013) L. Yang et al.   CANCER RESEARCH

Discoidin Domain Receptor 1 Protein Is a Novel Modulator of Megakaryocyte-Collagen Interactions

(2013) Vittorio Abbonante et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct fibroblast lineages determine dermal architecture in skin development and repair

(2013) Ryan R. Driskell et al.   NATURE

Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs

(2013) Neil C Henderson et al.   NATURE MEDICINE

Cadherin-17 interacts with α2β1 integrin to regulate cell proliferation and adhesion in colorectal cancer cells causing liver metastasis

(2013) R A Bartolomé et al.   ONCOGENE

Conditional Knockout of Integrin α2β1 in Murine Megakaryocytes Leads to Reduced Mean Platelet Volume

(2013) David Habart et al.   PLoS One

Canine Chondrodysplasia Caused by a Truncating Mutation in Collagen-Binding Integrin Alpha Subunit 10

(2013) Kaisa Kyöstilä et al.   PLoS One

GPR56 Functions Together with α3β1 Integrin in Regulating Cerebral Cortical Development

(2013) Sung-Jin Jeong et al.   PLoS One

Distinct biophysical mechanisms of focal adhesion kinase mechanoactivation by different extracellular matrix proteins

(2013) J. Seong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression of integrin alpha 10 is transcriptionally activated by pRb in mouse osteoblasts and is downregulated in multiple solid tumors

(2013) B E Engel et al.   Cell Death & Disease

Interactions between the discoidin domain receptor 1 and  1 integrin regulate attachment to collagen

(2013) L. A. Staudinger et al.   Biology Open

Effective treatment of mouse experimental colitis by alpha 2 integrin antibody: comparison with alpha 4 antibody and conventional therapy

(2012) L. Gillberg et al.   Acta Physiologica

α11 integrin stimulates myofibroblast differentiation in diabetic cardiomyopathy

(2012) Ilana Talior-Volodarsky et al.   CARDIOVASCULAR RESEARCH

GPR56 in cancer progression: current status and future perspective

(2012) Liquan Yang et al.   Future Oncology

Novel α2β1 Integrin Inhibitors Reveal That Integrin Binding to Collagen under Shear Stress Conditions Does Not Require Receptor Preactivation

(2012) Liisa Nissinen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mapping of Potent and Specific Binding Motifs, GLOGEN and GVOGEA, for Integrin α1β1 Using Collagen Toolkits II and III

(2012) Samir W. Hamaia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

α11β1 integrin-mediated MMP-13-dependent collagen lattice contraction by fibroblasts: Evidence for integrin-coordinated collagen proteolysis

(2012) Malgorzata M. Barczyk et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Inhibition of Integrin  2 1 Ameliorates Glomerular Injury

(2012) C. M. Borza et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The future of glycoprotein VI as an antithrombotic target

(2012) M. ZAHID et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Disease-Associated Mutations Prevent GPR56-Collagen III Interaction

(2012) Rong Luo et al.   PLoS One

Discoidin Domain Receptors Promote α1β1- and α2β1-Integrin Mediated Cell Adhesion to Collagen by Enhancing Integrin Activation

(2012) Huifang Xu et al.   PLoS One

Transmembrane Collagen Receptors

(2011) Birgit Leitinger   Annual Review of Cell and Developmental Biology

The loss of α2β1 integrin suppresses joint inflammation and cartilage destruction in mouse models of rheumatoid arthritis

(2011) Marvin A. Peters et al.   ARTHRITIS AND RHEUMATISM

Non-Smad signaling pathways

(2011) Yabing Mu et al.   CELL AND TISSUE RESEARCH

Phase I Study of E7820, an Oral Inhibitor of Integrin  -2 Expression with Antiangiogenic Properties, in Patients with Advanced Malignancies

(2011) M. Mita et al.   CLINICAL CANCER RESEARCH

Diet-Induced Muscle Insulin Resistance Is Associated With Extracellular Matrix Remodeling and Interaction With Integrin  2 1 in Mice

(2011) L. Kang et al.   DIABETES

Disease-associated GPR56 Mutations Cause Bilateral Frontoparietal Polymicrogyria via Multiple Mechanisms

(2011) Nien-Yi Chiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dwarfism in Mice Lacking Collagen-binding Integrins α2β1 and α11β1 Is Caused by Severely Diminished IGF-1 Levels

(2011) Katrin Blumbach et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice

(2011) Alexander David Barrow et al.   JOURNAL OF CLINICAL INVESTIGATION

Specific expression of GPR56 by human cytotoxic lymphocytes

(2011) Yen-Ming Peng et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Integrin genes and susceptibility to human melanoma

(2011) R. E. Lenci et al.   MUTAGENESIS

Loss of the α2β1 Integrin Alters Human Papilloma Virus-Induced Squamous Carcinoma Progression In Vivo and In Vitro

(2011) Thuy Tran et al.   PLoS One

Prognostic gene-expression signature of carcinoma-associated fibroblasts in non-small cell lung cancer

(2011) R. Navab et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic reciprocity in the wound microenvironment

(2011) Gregory S. Schultz et al.   WOUND REPAIR AND REGENERATION

Cross Talk among TGF-  Signaling Pathways, Integrins, and the Extracellular Matrix

(2011) J. S. Munger et al.   Cold Spring Harbor Perspectives in Biology

Integrins α2β1 and α11β1 regulate the survival of mesenchymal stem cells on collagen I

(2011) C Popov et al.   Cell Death & Disease

Collagen XIII Induced in Vascular Endothelium Mediates α1β1 Integrin-Dependent Transmigration of Monocytes in Renal Fibrosis

(2010) Jameel Dennis et al.   AMERICAN JOURNAL OF PATHOLOGY

The genetics of normal platelet reactivity

(2010) T. J. Kunicki et al.   BLOOD

Novel markers of mesenchymal stem cells defined by genome-wide gene expression analysis of stromal cells from different sources

(2010) Nikolas Kaltz et al.   EXPERIMENTAL CELL RESEARCH

Lumican inhibits cell migration through α2β1 integrin

(2010) Cédric Zeltz et al.   EXPERIMENTAL CELL RESEARCH

Integrin α1β1 Promotes Caveolin-1 Dephosphorylation by Activating T Cell Protein-tyrosine Phosphatase

(2010) Corina M. Borza et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Fibroblast Integrin α11β1 Is Induced in a Mechanosensitive Manner Involving Activin A and Regulates Myofibroblast Differentiation

(2010) Sergio Carracedo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The T-box transcription factor Brachyury promotes epithelial-mesenchymal transition in human tumor cells

(2010) Romaine I. Fernando et al.   JOURNAL OF CLINICAL INVESTIGATION

The α2β1 integrin is a metastasis suppressor in mouse models and human cancer

(2010) Norma E. Ramirez et al.   JOURNAL OF CLINICAL INVESTIGATION

Integrin  1 1 Regulates Epidermal Growth Factor Receptor Activation by Controlling Peroxisome Proliferator-Activated Receptor  -Dependent Caveolin-1 Expression

(2010) X. Chen et al.   MOLECULAR AND CELLULAR BIOLOGY

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Integrins

(2009) Malgorzata Barczyk et al.   CELL AND TISSUE RESEARCH

LAIR and collagens in immune regulation

(2009) Linde Meyaard   IMMUNOLOGY LETTERS

Integrin signalling at a glance

(2009) D. S. Harburger et al.   JOURNAL OF CELL SCIENCE

Integrin α1β1 is involved in the differentiation into myofibroblasts in adult reactive tissues in vivo

(2009) Alejandro Rodriguez et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The human α11 integrin promoter drives fibroblast-restricted expression in vivo and is regulated by TGF-β1 in a Smad- and Sp1-dependent manner

(2009) Ning Lu et al.   MATRIX BIOLOGY

The Extracellular Matrix: Not Just Pretty Fibrils

(2009) R. O. Hynes   SCIENCE

Shining new light on 3D cell motility and the metastatic process

(2009) Paolo P. Provenzano et al.   TRENDS IN CELL BIOLOGY

Integrin α1β1 Regulates Matrix Metalloproteinases via P38 Mitogen-Activated Protein Kinase in Mesangial Cells

(2008) Dominic Cosgrove et al.   AMERICAN JOURNAL OF PATHOLOGY

Collagen density promotes mammary tumor initiation and progression

(2008) Paolo P Provenzano et al.   BMC Medicine

Loss of Integrin  1 1 Ameliorates Kras-Induced Lung Cancer

(2008) I. Macias-Perez et al.   CANCER RESEARCH

Decorin Regulates Endothelial Cell Motility on Collagen I through Activation of Insulin-like Growth Factor I Receptor and Modulation of α2β1 Integrin Activity

(2008) Lorna R. Fiedler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The protein tyrosine phosphatase TCPTP controls VEGFR2 signalling

(2008) E. Mattila et al.   JOURNAL OF CELL SCIENCE

Cancer as an overhealing wound: an old hypothesis revisited

(2008) Matthias Schäfer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Epithelial to Mesenchymal Transition of a Primary Prostate Cell Line with Switches of Cell Adhesion Modules but without Malignant Transformation

(2008) Xi-Song Ke et al.   PLoS One

The inhibitory collagen receptor LAIR-1 (CD305)

(2007) L. Meyaard   JOURNAL OF LEUKOCYTE BIOLOGY