The Role of Histone Protein Modifications and Mutations in Histone Modifiers in Pediatric B-Cell Progenitor Acute Lymphoblastic Leukemia

Polycomb-dependent epigenetic landscape in adult T-cell leukemia

(2016) D. Fujikawa et al.   BLOOD

Illegitimate RAG-mediated recombination events are involved inIKZF1Δ3-6 deletion inBCR-ABL1lymphoblastic leukaemia

(2016) Y. Dong et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

UTX inhibition as selective epigenetic therapy against TAL1-driven T-cell acute lymphoblastic leukemia

(2016) Aissa Benyoucef et al.   GENES & DEVELOPMENT

Epigenetic regulators and their impact on therapy in acute myeloid leukemia

(2016) F. Pastore et al.   HAEMATOLOGICA

EZH2 mutations and promoter hypermethylation in childhood acute lymphoblastic leukemia

(2016) Vivien Schäfer et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Combined copy number and mutation analysis identifies oncogenic pathways associated with transformation of follicular lymphoma

(2016) A Bouska et al.   LEUKEMIA

Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas

(2016) Joshua D Campbell et al.   NATURE GENETICS

Epigenetic modulators, modifiers and mediators in cancer aetiology and progression

(2016) Andrew P. Feinberg et al.   NATURE REVIEWS GENETICS

WDR5 high expression and its effect on tumorigenesis in leukemia

(2016) Zheng Ge et al.   Oncotarget

Transcription-coupled genetic instability marks acute lymphoblastic leukemia structural variation hotspots

(2016) Merja Heinäniemi et al.   eLife

Epigenetic regulators and their impact on therapy in acute myeloid leukemia

(2016) F. Pastore et al.   HAEMATOLOGICA

Tumor-specific HSP90 inhibition as a therapeutic approach in JAK-mutant acute lymphoblastic leukemias

(2015) N. Kucine et al.   BLOOD

Targeting casein kinase II restores Ikaros tumor suppressor activity and demonstrates therapeutic efficacy in high-risk leukemia

(2015) C. Song et al.   BLOOD

Epigenetics and approaches to targeted epigenetic therapy in acute myeloid leukemia

(2015) B. J. Wouters et al.   BLOOD

Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy

(2015) S. Picaud et al.   CANCER RESEARCH

Targeting DOT1L and HOX gene expression in MLL-rearranged leukemia and beyond

(2015) Chun-Wei Chen et al.   EXPERIMENTAL HEMATOLOGY

Transcriptional Regulation ofJARID1B/KDM5BHistone Demethylase by Ikaros, Histone Deacetylase 1 (HDAC1), and Casein Kinase 2 (CK2) in B-cell Acute Lymphoblastic Leukemia

(2015) Haijun Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A novel recurrent EP300–ZNF384 gene fusion in B-cell precursor acute lymphoblastic leukemia

(2015) Y Gocho et al.   LEUKEMIA

KRAS and CREBBP mutations: a relapse-linked malicious liaison in childhood high hyperdiploid acute lymphoblastic leukemia

(2015) K Malinowska-Ozdowy et al.   LEUKEMIA

Preserved global histone H4 acetylation linked to ETV6-RUNX1 fusion and PAX5 deletions is associated with favorable outcome in pediatric B-cell progenitor acute lymphoblastic leukemia

(2015) K. Janczar et al.   LEUKEMIA RESEARCH

Next-generation-sequencing of recurrent childhood high hyperdiploid acute lymphoblastic leukemia reveals mutations typically associated with high risk patients

(2015) Cai Chen et al.   LEUKEMIA RESEARCH

The mutational landscape of cutaneous T cell lymphoma and Sézary syndrome

(2015) Ana Carolina da Silva Almeida et al.   NATURE GENETICS

Mutation of chromatin modifiers; an emerging hallmark of germinal center B-cell lymphomas

(2015) M A Lunning et al.   Blood Cancer Journal

DNA methylation-based subtype prediction for pediatric acute lymphoblastic leukemia

(2015) Jessica Nordlund et al.   Clinical Epigenetics

Targetable Kinase-Activating Lesions in Ph-like Acute Lymphoblastic Leukemia

(2015) Kathryn G. Roberts et al.   NEW ENGLAND JOURNAL OF MEDICINE

A novel integrated cytogenetic and genomic classification refines risk stratification in pediatric acute lymphoblastic leukemia

(2014) A. V. Moorman et al.   BLOOD

The H3K27me3 demethylase UTX is a gender-specific tumor suppressor in T-cell acute lymphoblastic leukemia

(2014) Joni Van der Meulen et al.   BLOOD

Akt-Dependent Metabolic Reprogramming Regulates Tumor Cell Histone Acetylation

(2014) Joyce V. Lee et al.   Cell Metabolism

Epigenetic deregulation in pediatric acute lymphoblastic leukemia

(2014) Zac Chatterton et al.   Epigenetics

Epigenetics in T-cell acute lymphoblastic leukemia

(2014) Sofie Peirs et al.   IMMUNOLOGICAL REVIEWS

Histone methylation and V(D)J recombination

(2014) Noriko Shimazaki et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Targeting MLL1 H3K4 Methyltransferase Activity in Mixed-Lineage Leukemia

(2014) Fang Cao et al.   MOLECULAR CELL

Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia

(2014) Panagiotis Ntziachristos et al.   NATURE

Dual kinase-bromodomain inhibitors for rationally designed polypharmacology

(2014) Pietro Ciceri et al.   Nature Chemical Biology

Genetic landscape of esophageal squamous cell carcinoma

(2014) Yi-Bo Gao et al.   NATURE GENETICS

Identification of functional cooperative mutations of SETD2 in human acute leukemia

(2014) Xiaofan Zhu et al.   NATURE GENETICS

RAG-mediated recombination is the predominant driver of oncogenic rearrangement in ETV6-RUNX1 acute lymphoblastic leukemia

(2014) Elli Papaemmanuil et al.   NATURE GENETICS

An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia

(2014) Birgit Knoechel et al.   NATURE GENETICS

Histone core modifications regulating nucleosome structure and dynamics

(2014) Peter Tessarz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Evidences for mutations in the histone modifying gene SETD2 as critical drivers in leukemia development

(2014) QianFei Wang et al.   Science China-Life Sciences

Mutations in epigenetic regulators including SETD2 are gained during relapse in paediatric acute lymphoblastic leukaemia

(2014) Brenton G. Mar et al.   Nature Communications

The landscape of somatic mutations in epigenetic regulators across 1,000 paediatric cancer genomes

(2014) Robert Huether et al.   Nature Communications

The genomic landscape of acute lymphoblastic leukemia in children and young adults

(2014) C. G. Mullighan   Hematology-American Society of Hematology Education Program

Epigenetic Modifications in Pediatric Acute Lymphoblastic Leukemia

(2014) Michael J. Burke et al.   Frontiers in Pediatrics

Potent inhibition of DOT1L as treatment of MLL-fusion leukemia

(2013) S. R. Daigle et al.   BLOOD

Leukemic transformation by the MLL-AF6 fusion oncogene requires the H3K79 methyltransferase Dot1l

(2013) A. J. Deshpande et al.   BLOOD

Integration of High-Resolution Methylome and Transcriptome Analyses to Dissect Epigenomic Changes in Childhood Acute Lymphoblastic Leukemia

(2013) S. Busche et al.   CANCER RESEARCH

Histone-modifying enzymes: their role in the pathogenesis of acute leukemia and their therapeutic potential

(2013) Ly P. Vu et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Integrated genetic and epigenetic analysis of childhood acute lymphoblastic leukemia

(2013) Maria E. Figueroa et al.   JOURNAL OF CLINICAL INVESTIGATION

Point mutation E1099K in MMSET/NSD2 enhances its methyltranferase activity and leads to altered global chromatin methylation in lymphoid malignancies

(2013) J A Oyer et al.   LEUKEMIA

The expression of histone deacetylase 4 is associated with prednisone poor-response in childhood acute lymphoblastic leukemia

(2013) Bernd Gruhn et al.   LEUKEMIA RESEARCH

Sites of Acetylation on Newly Synthesized Histone H4 Are Required for Chromatin Assembly and DNA Damage Response Signaling

(2013) Zhongqi Ge et al.   MOLECULAR AND CELLULAR BIOLOGY

The genomic landscape of hypodiploid acute lymphoblastic leukemia

(2013) Linda Holmfeldt et al.   NATURE GENETICS

Integrated genomic analysis identifies recurrent mutations and evolution patterns driving the initiation and progression of follicular lymphoma

(2013) Jessica Okosun et al.   NATURE GENETICS

The mutational landscape of adenoid cystic carcinoma

(2013) Allen S Ho et al.   NATURE GENETICS

Global chromatin profiling reveals NSD2 mutations in pediatric acute lymphoblastic leukemia

(2013) Jacob D Jaffe et al.   NATURE GENETICS

Genomic Characterization of Childhood Acute Lymphoblastic Leukemia

(2013) Charles G. Mullighan   SEMINARS IN HEMATOLOGY

BET inhibition as a single or combined therapeutic approach in primary paediatric B-precursor acute lymphoblastic leukaemia

(2013) D Da Costa et al.   Blood Cancer Journal

Genome-wide signatures of differential DNA methylation in pediatric acute lymphoblastic leukemia

(2013) Jessica Nordlund et al.   GENOME BIOLOGY

Tyrosine kinome sequencing of pediatric acute lymphoblastic leukemia: a report from the Children's Oncology Group TARGET Project

(2012) M. L. Loh et al.   BLOOD

BET bromodomain inhibition targets both c-Myc and IL7R in high-risk acute lymphoblastic leukemia

(2012) C. J. Ott et al.   BLOOD

Pediatric acute lymphoblastic leukemia: where are we going and how do we get there?

(2012) C.-H. Pui et al.   BLOOD

Epigenetic reprogramming reverses the relapse-specific gene expression signature and restores chemosensitivity in childhood B-lymphoblastic leukemia

(2012) T. Bhatla et al.   BLOOD

Targeting JAK1/2 and mTOR in murine xenograft models of Ph-like acute lymphoblastic leukemia

(2012) S. L. Maude et al.   BLOOD

Increased activity of histone deacetylases in childhood acute lymphoblastic leukaemia and acute myeloid leukaemia: support for histone deacetylase inhibitors as antileukaemic agents

(2012) Jürgen Sonnemann et al.   BRITISH JOURNAL OF HAEMATOLOGY

Genome-wide DNA methylation profiling predicts relapse in childhood B-cell acute lymphoblastic leukaemia

(2012) Juan Sandoval et al.   BRITISH JOURNAL OF HAEMATOLOGY

Cancer Epigenetics: From Mechanism to Therapy

(2012) Mark A. Dawson et al.   CELL

Molecular genetics of B-precursor acute lymphoblastic leukemia

(2012) Charles G. Mullighan   JOURNAL OF CLINICAL INVESTIGATION

CREBBP HAT domain mutations prevail in relapse cases of high hyperdiploid childhood acute lymphoblastic leukemia

(2012) A Inthal et al.   LEUKEMIA

Preclinical activity of LBH589 alone or in combination with chemotherapy in a xenogeneic mouse model of human acute lymphoblastic leukemia

(2012) A Vilas-Zornoza et al.   LEUKEMIA

Novel mutations target distinct subgroups of medulloblastoma

(2012) Giles Robinson et al.   NATURE

Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer

(2012) Martin Peifer et al.   NATURE GENETICS

Targeting Epigenetic Readers in Cancer

(2012) Mark A. Dawson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing

(2012) J. G. Lohr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fingerprinting Acute Leukemia: DNA Methylation Profiling of B-Acute Lymphoblastic Leukemia

(2012) Luisa Cimmino et al.   Cancer Discovery

The Role of Bromodomain Proteins in Regulating Gene Expression

(2012) Gabrielle A. Josling et al.   Genes

Genomic profiling of B-progenitor acute lymphoblastic leukemia

(2011) Charles G. Mullighan   BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY

Key pathways are frequently mutated in high-risk childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group

(2011) J. Zhang et al.   BLOOD

Crebbp haploinsufficiency in mice alters the bone marrow microenvironment, leading to loss of stem cells and excessive myelopoiesis

(2011) S. N. Zimmer et al.   BLOOD

Histone H4 acetylation by immunohistochemistry and prognosis in relapsed acute lymphocytic leukaemia (ALL)

(2011) Anjali S. Advani et al.   BRITISH JOURNAL OF HAEMATOLOGY

Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor

(2011) Scott R. Daigle et al.   CANCER CELL

MLL-Rearranged Leukemia Is Dependent on Aberrant H3K79 Methylation by DOT1L

(2011) Kathrin M. Bernt et al.   CANCER CELL

Decoding the chromatin modification landscape

(2011) Till Bartke et al.   CELL CYCLE

Regulation of chromatin by histone modifications

(2011) Andrew J Bannister et al.   CELL RESEARCH

Targeting Epigenetics through Histone Deacetylase Inhibitors in Acute Lymphoblastic Leukemia

(2011) A. Mummery et al.   CURRENT CANCER DRUG TARGETS

Genomic profiling in Down syndrome acute lymphoblastic leukemia identifies histone gene deletions associated with altered methylation profiles

(2011) M G Loudin et al.   LEUKEMIA

CREBBP mutations in relapsed acute lymphoblastic leukaemia

(2011) Charles G. Mullighan et al.   NATURE

Inactivating mutations of acetyltransferase genes in B-cell lymphoma

(2011) Laura Pasqualucci et al.   NATURE

Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma

(2011) Ryan D. Morin et al.   NATURE

Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder

(2011) Yaoting Gui et al.   NATURE GENETICS

Improving outcomes for high-risk ALL: Translating new discoveries into clinical care

(2011) Stephen P. Hunger et al.   PEDIATRIC BLOOD & CANCER

A role for DOT1L inMLL-rearranged leukemias

(2011) Kathrin M Bernt et al.   Epigenomics

Targeting Epigenetic Programs in MLL-Rearranged Leukemias

(2011) K. M. Bernt et al.   Hematology-American Society of Hematology Education Program

Epigenetic silencing of BIM in glucocorticoid poor-responsive pediatric acute lymphoblastic leukemia, and its reversal by histone deacetylase inhibition

(2010) P. S. Bachmann et al.   BLOOD

Rearrangement of CRLF2 is associated with mutation of JAK kinases, alteration of IKZF1, Hispanic/Latino ethnicity, and a poor outcome in pediatric B-progenitor acute lymphoblastic leukemia

(2010) R. C. Harvey et al.   BLOOD

Histone H4 acetylation by immunohistochemistry and prognosis in newly diagnosed adult acute lymphoblastic leukemia (ALL) patients

(2010) Anjali S Advani et al.   BMC CANCER

research paper: Differential expression of HDAC3, HDAC7 and HDAC9 is associated with prognosis and survival in childhood acute lymphoblastic leukaemia

(2010) Daniel Antunes Moreno et al.   BRITISH JOURNAL OF HAEMATOLOGY

New Strategies in Acute Lymphoblastic Leukemia: Translating Advances in Genomics into Clinical Practice

(2010) C. G. Mullighan   CLINICAL CANCER RESEARCH

DNA methylation and miRNA expression profiling in childhood B-cell acute lymphoblastic leukemia

(2010) Zac Chatterton et al.   Epigenomics

DNA methylation for subtype classification and prediction of treatment outcome in patients with childhood acute lymphoblastic leukemia

(2009) L. Milani et al.   BLOOD

The DNA methylome of pediatric acute lymphoblastic leukemia

(2009) Josef Davidsson et al.   HUMAN MOLECULAR GENETICS

Genomic analysis of acute leukemia

(2009) C. G. MULLIGHAN   International Journal of Laboratory Hematology

H3K4me3 Stimulates the V(D)J RAG Complex for Both Nicking and Hairpinning in trans in Addition to Tethering in cis: Implications for Translocations

(2009) Noriko Shimazaki et al.   MOLECULAR CELL

JAK2 phosphorylates histone H3Y41 and excludes HP1α from chromatin

(2009) Mark A. Dawson et al.   NATURE

Histone H4 lysine 16 acetylation regulates cellular lifespan

(2009) Weiwei Dang et al.   NATURE

Deletion ofIKZF1and Prognosis in Acute Lymphoblastic Leukemia

(2009) Charles G. Mullighan et al.   NEW ENGLAND JOURNAL OF MEDICINE

JAK mutations in high-risk childhood acute lymphoblastic leukemia

(2009) C. G. Mullighan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Global Genomic Characterization of Acute Lymphoblastic Leukemia

(2008) Charles G. Mullighan et al.   SEMINARS IN HEMATOLOGY

Epigenetics in Acute Myeloid Leukemia

(2008) Christoph Plass et al.   SEMINARS IN ONCOLOGY