Article
Obstetrics & Gynecology
Ferran Barrachina, Alberto de la Iglesia, Meritxell Jodar, Ada Soler-Ventura, Carme Mallofre, Leonardo Rodriguez-Carunchio, Afsaneh Goudarzi, Juan Manuel Corral, Josep Lluis Ballesca, Judit Castillo, Rafael Oliva
Summary: In this study, the researchers investigated the alteration of histone H4 acetylation (H4ac) in the seminiferous tubules of testicular tumour patients. They found a considerable dysregulation of H4ac in the unaffected cells of the seminiferous tubules adjacent to the tumours, suggesting a potential paracrine effect of the neoplasia. This epigenetic alteration could have implications for the molecular changes in male germ cells in testicular tumour patients.
HUMAN REPRODUCTION
(2022)
Article
Biochemistry & Molecular Biology
Anagh Ray, Preeti Khan, Ronita Nag Chaudhuri
Summary: The study highlights the importance of lysine acetylation in maintaining chromatin structure and function, specifically focusing on the role of H4K16 acetylation in regulating the expression of constitutive genes. Deacetylation of H4K16 is associated with hypoacetylation of H4K12 and H3K9, along with hyperacetylation of H3K56, creating a chromatin landscape conducive for transcription of constitutive genes.
Article
Biochemistry & Molecular Biology
Juan Hormazabal, Francisco Saavedra, Claudia Espinoza-Arratia, Nicolas W. Martinez, Tatiana Cruces, Ivan E. Alfaro, Alejandra Loyola
Summary: In this study, the researchers identified chaperone-mediated autophagy (CMA) as the main pathway for the degradation of histones H3 and H4. The protein tNASP stabilizes histone H3 levels by preventing its entry into lysosomes. The study also revealed that CMA degrades unfolded histone H3.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Nando D. Das, Jen-Chien Chang, Chung-Chau Hon, S. Thomas Kelly, Shinsuke Ito, Marina Lizio, Bogumil Kaczkowski, Hisami Watanabe, Keisuke Katsushima, Atsushi Natsume, Haruhiko Koseki, Yutaka Kondo, Aki Minoda, Takashi Umehara
Summary: This study found that H4K5acK8ac and H3K27ac signals have some overlap in binding to the super-enhancer transcription factor BRD4 at higher levels, but they also have distinct specificities, especially in glioblastoma stem-like cell lines. Deletion of H4K5acK8ac-preferred super-enhancers associated with MYCN and NFIC resulted in a reduction in stem-like properties.
Article
Hematology
Daniela R. Anderson, Wendy Stock, Theodore G. Karrison, Avi Leader
Summary: The level of D-dimer is associated with the risk of venous or arterial thrombosis in patients with ALL within 100 days after diagnosis.
Article
Oncology
Roxana Carmona, Hande Kizilocak, Elizabeth Marquez-Casas, Siobhan Vasquez, Lingyun Ji, Richard H. Ko, Guy Young, Julie Jaffray
Summary: Older children with ALL and those with elevated TAT, PTF 1.2, or D-dimer levels exhibited an increased risk of VTE, which may be potentially useful in predicting VTE in future studies.
PEDIATRIC BLOOD & CANCER
(2022)
Review
Hematology
Stephanie J. Si Lim, James B. Ford, Michelle L. Hermiston
Summary: T-cell lymphoblastic lymphoma (T-LLy) and T-cell acute lymphoblastic leukemia (T-ALL) were historically considered as variations of the same disease. However, recent evidence suggests that they may be distinct clinical and biological entities due to differential responses to chemotherapy. This article examines the differences between T-LLy and T-ALL, provides recommendations on the treatment of newly diagnosed and relapsed/refractory T-LLy patients, and discusses ongoing investigations into novel therapies and the role of stem cell transplantation.
Article
Biology
Calvin Jon A. Leonen, Miho Shimada, Caroline E. Weller, Tomoyoshi Nakadai, Peter L. Hsu, Elizabeth L. Tyson, Arpit Mishra, Patrick M. M. Shelton, Martin Sadilek, R. David Hawkins, Ning Zheng, Robert G. Roeder, Champak Chatterjee
Summary: Post-translational modification of histones by the small ubiquitin-like modifier protein SUMO plays a key role in gene silencing, centromeric localization, and DNA repair in eukaryotes. The study demonstrated that H4K12su inhibits acetylation of H4 tail and methylation of H3K4 associated with transcription activation, as well as transcription mediated by RNA polymerase II. Cell-based assays confirmed the negative crosstalk between histone sumoylation and acetylation/methylation in human cells.
Article
Medical Laboratory Technology
Rania M. Gawdat, Sahar A. Khalil, Naglaa M. Hassan, Reem Nabil, Nevin M. Alazhary
Summary: The study found that SMYD2 gene expression levels are higher in childhood B-ALL patients and associated with unfavorable cytogenetics. High expression levels of SMYD2 may serve as an independent prognostic factor for childhood B-ALL.
CLINICAL LABORATORY
(2023)
Editorial Material
Hematology
Gary Schiller
Summary: The study introduces a convenient clinical prognostic tool based on cytogenetic and molecular profiling to identify which group of older and fit AML patients may benefit from intensive induction and consolidation chemotherapy.
Article
Oncology
Wenting Hu, Yin Ting Cheung, Yanjing Tang, Li Hong, Yuan Zhu, Jing Chen, Zhuo Wang, Min Zhou, Yijin Gao, Jing Chen, Benshang Li, Huiliang Xue, Longjun Gu, Shuhong Shen, Jingyan Tang, Ching-Hon Pui, Hiroto Inaba, Jiaoyang Cai
Summary: Studies on the association between BMI at diagnosis and treatment outcomes in Chinese children with ALL have shown inconsistent results. While weight status was not associated with event-free survival or overall survival, overweight patients were at a higher risk of treatment-related mortality.
Article
Biochemistry & Molecular Biology
Deimante Zukauskaite, Aida Vitkeviciene, Akvile Zlibinaite, Raminta Bausyte, Diana Ramasauskaite, Ruta Navakauskiene
Summary: The aim of this study was to analyze the changes in epigenetic modulators, histone modifications, and DNA methylation during induced human endometrial stromal cells (ESC) in vitro decidualization. The results revealed that HDAC2 and subunits of PRC2 were down-regulated while the global level of H4hyperAc and H3K27me3 increased during ESC decidualization. Specific gene promoters' histone acetylation level also increased during the induced ESC decidualization, indicating the importance of epigenetic regulation in endometrial decidualization.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2023)
Article
Plant Sciences
Xiaoyun Xin, Tongbing Su, Peirong Li, Weihong Wang, Xiuyun Zhao, Yangjun Yu, Deshuang Zhang, Shuancang Yu, Fenglan Zhang
Summary: The study demonstrated that BrHIS4.A04 interacts with BrVIN3.1 to prevent premature bolting by attenuating the expression of photoperiodic flowering genes through the ABA signaling pathway under drought conditions. The findings suggest the potential for fine-tuning flowering time in crops through genetic engineering without growth penalty.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Article
Hematology
Kangkang Liu, Jingbo Shao, Jiaoyang Cai, Jingyan Tang, Shuhong Shen, Fengling Xu, Yuanyuan Ren, Aijun Zhang, Xin Tian, Xiaoqian Lu, Shaoyan Hu, Qun Hu, Hua Jiang, Fen Zhou, Changda Liang, Alex Wing Kwan Leung, Xiaowen Zhai, Chunfu Li, Yongjun Fang, Zhenling Wang, Lu Wen, Hui Yang, Ningling Wang, Hui Jiang
Summary: A retrospective analysis was conducted to investigate possible risk factors for death in children with acute lymphoblastic leukemia (ALL) after treatment with CCCG-ALL-2015 in China. Independent risk factors were identified, including age at diagnosis ≥10 years, high-risk final risk level, certain genetic abnormalities, presence of CNS3, and certain levels of minimal residual disease (MRD). Treatment-related mortality (TRM) accounted for a significant proportion of deaths, with a majority caused by severe infections. The CCCG-ALL-2015 regimen has shown a safety profile comparable to that of developed countries.
ANNALS OF HEMATOLOGY
(2023)
Article
Oncology
Hui Zeng, Hai-Bo Dong, Qi-Guo Zhang, Min Zhou, Qian Zhang, Lan-Xin Chen, Cui-Ying Yuan, Ru-Ru Jiang, Jin-Wen Liu, Jian Ou-Yang, Jie He, Bing Chen
Summary: In this retrospective study, the disease characteristics and prognostic power of additional cytogenetic abnormalities (ACA) in acute promyelocytic leukemia (APL) patients treated with ATRA-ATO-containing regimens were investigated. The study showed that patients with ACA had decreased hemoglobin levels and worse risk stratification. Patients harboring ACA had inferior event-free survival (EFS), especially in CD34 and CD56 negative APL. ACA should be considered as an independent prognostic factor for EFS and risk-adapted therapeutic strategies should be developed.
Article
Chemistry, Analytical
Guifen Chang, Ying Zhao, Bin Zhao, Xiumin Yang, Shuaihua Zhang, Chun Wang, Zhi Wang
Summary: This study successfully constructed a new triazine-based hypercrosslinked polymer CC-Py and applied it to the sensitive determination of NBs in environmental water samples. The method showed low detection limits, good reproducibility, and high enrichment factors, providing a facile and sensitive approach for the trace-level determination of NBs in real water samples.
ANALYTICA CHIMICA ACTA
(2023)
Article
Engineering, Environmental
Qing Lin, Shaocheng Zhang, Li-Juan Yu, Baoxiu Hou, Shuaihua Zhang, Zheng Wang, Jianjun Song, Xiaoxian Zhao
Summary: In this study, a freestanding anode material for rechargeable sodium-ion batteries was designed by encapsulating Fe3O4/FeS2 heterojunction in a carbon membrane. The material exhibited high specific capacity, low cost, and was suitable for large-scale energy storage. It provided a fast electron transfer pathway and alleviated volume expansion during charging/discharging process. The direct contact between the heterojunction and electrolyte shortened the diffusion path of Na+, resulting in improved performance.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Engineering, Environmental
Qianqian Wang, Shuaihua Zhang, Zhi Li, Zhi Wang, Chun Wang, Saad M. Alshehri, Yoshio Bando, Yusuke Yamauchi, Qiuhua Wu
Summary: In this study, a series of novel hypercrosslinked polymers with adjustable polarity were designed and synthesized for the preconcentration of aflatoxins. By integrating magnetism into the polymers, a magnetic sorbent was prepared and displayed excellent adsorption ability. The method achieved good linearity, low detection limits, and high enrichment factors.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Analytical
Yahuan Li, Yang Li, Qingyun Chang, Xiaohuan Zang, Shuaihua Zhang, Chun Wang, Zhi Wang
Summary: MXene-polyvinylpyrrolidone (MXene-PVP) was prepared by physically doping and spray drying to overcome the aggregation issue of MXene. The resulting MXene-PVP was carbonized to create a carbonized MXene-PVP (MXene-PVP-C), which was then immobilized on a stainless steel wire using the sol-gel approach to produce a solid-phase microextraction (SPME) fiber. This fiber was used to extract polycyclic aromatic hydrocarbons (PAHs) from tea beverages, and the extracted PAHs were detected using gas chromatography. Central composite design methodology was employed to investigate the main SPME parameters. Under optimized conditions, the method achieved low detection limits (0.03-0.15 μg/L) and quantification limits (0.10-0.50 μg/L) for the PAHs. The method exhibited good recoveries (78.6% to 122%) for the spiked PAHs in tea beverages, with low relative standard deviations (less than 8.2% for single-fiber and 9.6% for fiber-to-fiber).
MICROCHEMICAL JOURNAL
(2023)
Article
Engineering, Chemical
Xiaohuan Zang, Qingyun Chang, Hongda Li, Xiaoxian Zhao, Shuaihua Zhang, Chun Wang, Zhi Wang
Summary: In this study, a ringent multi-shelled hollow MIL-88B was prepared as the fiber coating material for the microextraction of organochlorine pesticides from fish samples. The optimized experimental conditions allowed for a wide linear range and low limits of detection. The method demonstrated good repeatability and reproducibility, and successfully analyzed four different fish samples.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Engineering, Environmental
Zixuan Cai, Xin Zhou, Yushi Yang, Jie Li, Weihua Liu, Qianqian Wang, Lin Hao, Zhi Wang, Yusuke Yamauchi, Jungmok You, Shuaihua Zhang, Qiuhua Wu, Chun Wang
Summary: A series of cyano-functionalized ionic porous organic polymers (CN-iPOPs) were prepared and used for the sensitive analysis of estrogens in environmental and food samples. The optimized CN-iPOP3 showed exceptional sorption capacity for estrogens, making it an advanced adsorbent for solid phase extraction (SPE) of estrogens.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Xiaohong Liu, Xingtao Xu, Xiaoxu Xuan, Wei Xia, Guilin Feng, Shuaihua Zhang, Zhen-Guo Wu, Benhe Zhong, Xiaodong Guo, Keyu Xie, Yusuke Yamauchi
Summary: In this study, a yolk-shell nanoarchitecture of NASICON-structured NTP/C materials (ys-NTP@C) was developed using a metal-organic framework@ covalent organic polymer (MOF@COP) as a sacrificial template and space-confined nanoreactor. ys-NTP@C exhibited good CDI performance with high salt adsorption capacities (SACs) and good cycling stability. This study provides a new synthetic paradigm for preparing yolk-shell structured materials and highlights the potential use of yolk-shell nanoarchitectures for electrochemical desalination.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Engineering, Environmental
Jingyu Wu, Xiaoxu Xuan, Shuaihua Zhang, Zhi Li, Haolin Li, Bin Zhao, Haolin Ye, Zhichang Xiao, Xiaoxian Zhao, Xingtao Xu, Xinjuan Liu, Jungmok You, Yusuke Yamauchi
Summary: A simultaneous MOF-on-MOF growth combined with the MOF-etching strategy was developed to tailor MOF/MOF nanorings, which were then transformed into N, P co-doped carbon rings (NPC-Rings) through thermal transformation and phosphidation activation. The hierarchically porous structure of NPC-Rings exhibited high adsorption capacity, fast salt adsorption rate, and superior capacity retention stability. Finite element simulations demonstrated that the unique structure of NPC-Rings significantly promoted current density and charge migration, leading to stronger salt adsorption capacity.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Biochemical Research Methods
Xinyue Zhang, Zhi Li, Yang Wang, Shuaihua Zhang, Xiaohuan Zang, Chun Wang, Zhi Wang
Summary: This study developed a simple strategy to integrate black phosphorus nanosheets with metal-organic framework to form a nanocomposite, which was used as a solid-phase microextraction fiber coating for efficient extraction of organophosphorus pesticides. The method exhibited good linearity, low limits of detection, and good repeatability, and was successfully applied for the analysis of trace organophosphorus pesticides in environmental water samples.
JOURNAL OF CHROMATOGRAPHY A
(2023)
Article
Chemistry, Analytical
Mingxin Xu, Jie Li, Qingyun Chang, Xiaohuan Zang, Shuaihua Zhang, Chun Wang, Zhi Wang
Summary: A molecularly imprinted triazine-based conjugated microporous polymer composite was developed for the solid-phase extraction (SPE) of three phenolic endocrine disrupting chemicals in beverages. The method involved derivatization and detection by gas chromatography-electron capture detector. Under optimized conditions, the limits of detection of the analytes ranged from 0.12 to 1.20 μg L-1 and the linear response range was 0.40-50.0 μg L-1. The method showed good recoveries and potential for the monitoring of trace phenolic endocrine disrupting chemicals in real beverage samples.
MICROCHEMICAL JOURNAL
(2023)
Article
Chemistry, Analytical
Yang Li, Xiaohuan Zang, Yahuan Li, Shuaihua Zhang, Chun Wang, Zhi Wang
Summary: A defective UiO-66 with rich defect sites was synthesized and used as the SPME fiber coating material. The defective UiO-66 coating showed high adsorption capability for selectively extracting fungicides. A SPME method with the defective UiO-66 as the fiber coating combined with GC-MS detection was established for sensitive and selective determination of five fungicides in fruit samples. The method exhibited satisfactory recoveries and good precisions.
MICROCHEMICAL JOURNAL
(2023)
Article
Chemistry, Physical
Ying Zhang, Haolin Li, Qian Yang, Shuaihua Zhang, Bin Zhao, Jingyu Wu, Ningzhao Shang, Xiaoxian Zhao, Zhichang Xiao, Xiaohuan Zang, Jeonghun Kim, Xingtao Xu, Yusuke Yamauchi
Summary: In this study, MXene nanosheets were successfully integrated with metal-organic framework-derived carbons to form N, P-doped graphitic carbon/Ti3C2Tx MXene heterostructures. The resulting N, P-GC/MXene electrodes exhibited high salt adsorption capacity, rapid removal rate, and excellent cycling stability, showcasing the potential of MXene-based heterostructures for CDI materials and advancing the development of the CDI technique.
JOURNAL OF MATERIALS CHEMISTRY A
(2023)
Article
Chemistry, Applied
Linlin Ma, Xiaomei Zhou, Jun Sun, Pan Zhang, Baoxiu Hou, Shuaihua Zhang, Ningzhao Shang, Jianjun Song, Hongjun Ye, Hui Shao, Yongfu Tang, Xiaoxian Zhao
Summary: A unique MoS2/FeS2/C heterojunction with abundant defects and a hollow structure was constructed as a promising anode material for sodium-ion battery technologies. The heterojunction enhances Na+ diffusion kinetics and electronic conductivity, resulting in high capacity, excellent rate capability, and cycling stability.
JOURNAL OF ENERGY CHEMISTRY
(2023)
Article
Materials Science, Multidisciplinary
Shuai Li, Jingchong Liu, Linlin Ma, Li-Juan Yu, Lanlan Hou, Dianming Li, Songwei Gao, Guichu Yue, Zhimin Cui, Nu Wang, Xiaoxian Zhao, Yong Zhao
Summary: In this study, a self-supporting multichannel nitrogen-doped carbon fibers membrane embedded with TiO nanoparticles was constructed as the electrode for lithium-sulfur batteries. The electrode exhibited high initial specific capacity, high-rate capability, and good cycling stability at high current densities, providing a promising design strategy for high-performance electrodes in LSBs.
ADVANCED FIBER MATERIALS
(2023)
Meeting Abstract
Pathology
Christopher Humphries, Robert Ohgami, Ken Young, Bangchen Wang, Francisco Vega-Vazquez, Mario Marques-Piubelli, Xiaoxian Zhao, James Rubenstein, Eric Hsi
