Journal
GERIATRICS & GERONTOLOGY INTERNATIONAL
Volume 10, Issue -, Pages S1-S9Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1447-0594.2010.00597.x
Keywords
adaptive response; ataxia telangiectasia mutated; DNA repair; oxidative stress; radiation
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Funding
- Japan Society for the Promotion of Science [20590082]
- Cosmetology Research Foundation
- Grants-in-Aid for Scientific Research [20590082] Funding Source: KAKEN
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Oxidative stress is recognized as an important environmental factor in aging; however, because reactive oxygen species (ROS) and related free radicals are normally produced both intra- and extracellularly, air-living organisms cannot avoid the risk of oxidative stress. Consequently, these organisms have evolved various anti-oxidant systems to prevent ROS, scavenge free radicals, repair damaged components and adaptive responses. This review will focus on the repair and adaptive response to oxidative stress, and summarize the changes of these systems as a result aging and their relationship to premature aging. Geriatr Gerontol Int 2010; 10 (Suppl. 1): S1-S9.
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