Article
Cell & Tissue Engineering
Ju-Fang Liu, Po-Chun Chen, Thai-Yen Ling, Chun-Han Hou
Summary: This study demonstrates that heat shock induces the expression of HSPs in hPDMCs through the activation of ROS, p38 MAPK, Akt signaling, and HSF1, which plays a protective role.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Parasitology
Nancy A. Aguoru, Ruth S. Kirk, Anthony J. Walker
Summary: This study provides a detailed molecular bioinformatic analysis of heat shock proteins (HSPs) in the human parasitic blood fluke Schistosoma mansoni. The results reveal the classification, expression patterns, protein interactions, and phosphorylation sites of HSPs in different stages of the parasite's life cycle. The findings suggest that HSPs play important roles in parasite survival and development, and offer insights for future investigations and therapeutics development against schistosomiasis.
PARASITES & VECTORS
(2022)
Article
Biochemistry & Molecular Biology
Michael W. Dorrity, Lauren M. Saunders, Madeleine Duran, Sanjay R. Srivatsan, Eliza Barkan, Dana L. Jackson, Sydney M. Sattler, Brent Ewing, Christine Queitsch, Jay Shendure, David W. Raible, David Kimelman, Cole Trapnell
Summary: Temperature stress can disrupt the proportions and gene expression programs of different cell types during embryonic development, leading to asynchrony in developmental timing. Sheath cells, a specialized cell type, are particularly sensitive to temperature and their accumulation of misfolded proteins can result in structural failure of the notochord and anatomical defects.
Article
Multidisciplinary Sciences
Netta Shemesh, Juman Jubran, Shiran Dror, Eyal Simonovsky, Omer Basha, Chanan Argov, Idan Hekselman, Mehtap Abu-Qarn, Ekaterina Vinogradov, Omry Mauer, Tatiana Tiago, Serena Carra, Anat Ben-Zvi, Esti Yeger-Lotem
Summary: The authors demonstrate that the human chaperone system consists of ubiquitous core chaperones and tissue-specific variable chaperones, and perturbation of which leads to tissue-specific phenotypes. The core chaperones are significantly more abundant across tissues and important for cell survival, forming tissue-specific functional networks. This functional organization is established in development and declines with age, highlighting the importance of understanding tissue-specific differences in protein folding capacities.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Christoph Neumayr, Vanja Haberle, Leonid Serebreni, Katharina Karner, Oliver Hendy, Ann Boija, Jonathan E. Henninger, Charles H. Li, Karel Stejskal, Gen Lin, Katharina Bergauer, Michaela Pagani, Martina Rath, Karl Mechtler, Cosmas D. Arnold, Alexander Stark
Summary: This paper investigates different types of enhancers and their reliance on cofactors. The authors find that some enhancers can function without commonly used cofactors, regulating distinct gene regulatory programs.
Article
Biochemistry & Molecular Biology
Lydia K. Muranova, Vladislav M. Shatov, Andrey Slushchev, Nikolai B. Gusev
Summary: In this study, a reliable and simple method to prepare untagged recombinant human HspB7 was developed. It was found that HspB7 can form different oligomeric structures under different conditions, and the factors influencing the formation of these oligomers were investigated.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Valeria Calvaresi, Line T. Truelsen, Sidsel B. Larsen, Nikolaj H. T. Petersen, Thomas Kirkegaard, Kasper D. Rand
Summary: Calvaresi et al. utilized hydrogen-deuterium exchange coupled to mass spectrometry to investigate the conformational dynamics of human heat shock protein Hsp70 in relation to lysosomal membranes and pH transitions. Their study revealed new insights into how Hsp70 stabilizes lysosomal membranes and inhibits the release of degradative enzymes, providing potential guidance for future drug development in lysosomal storage disorders.
COMMUNICATIONS BIOLOGY
(2021)
Article
Plant Sciences
Anthony Guihur, Bruno Fauvet, Andrija Finka, Manfredo Quadroni, Pierre Goloubinoff
Summary: In the scorching summer dawn, land plants establish molecular defenses to prepare for extreme midday temperatures, inducing heat-shock proteins for acquired thermotolerance. Despite high protein crowding, heat priming did not accumulate HSP chaperones in chloroplasts, while HSP20s accumulated in the cytosol, suggesting their role in preventing heat-labile protein aggregation.
PLANT CELL AND ENVIRONMENT
(2021)
Article
Entomology
Fu-Jing He, Feng Zhu, Ming-Xing Lu, Yu-Zhou Du
Summary: Small heat shock proteins (sHSPs) and heat shock factors (HSFs) play crucial roles in temperature stress response. In this study, two genes from Cotesia chilonis were cloned and characterized: the heat-induced HSP11.0 and the master regulator HSF. Both genes were found to be sensitive to high and low temperature stress, with their expression patterns positively correlated during temperature stress.
Review
Cell Biology
Ariadni Androvitsanea, Kostas Stylianou, Eleni Drosataki, Ioannis Petrakis
Summary: Research has shown that heat-shock proteins can have varying effects on the immune system, either triggering immune responses or alleviating them, which is important for studying and treating autoimmune diseases.
Article
Plant Sciences
Tung-Yi Lin, Wei-Jyun Hua, Hsin Yeh, Ai-Jung Tseng
Summary: The study demonstrates that FIPs LZ-8 and GMI induce changes in the proteomic profile of tumor lesions in LLC1 cell-bearing mouse, potentially regulating heat shock proteins (HSPs)-related cell viability and inhibiting cell migration and inducing apoptosis. Inhibition of HSPs may contribute to the anti-lung cancer activity of FIPs.
Review
Biochemistry & Molecular Biology
Ayush Ranawade, Rati Sharma, Erel Levine
Summary: The Heat Shock Response (HSR) is a conserved genetic system that protects the proteome in organisms. Mathematical modeling has been crucial in understanding its regulation, but there are still many unanswered questions that can benefit from quantitative modeling.
Article
Biochemistry & Molecular Biology
Marzieh Davoudi, Jinfeng Chen, Qunfeng Lou
Summary: This study comprehensively analyzed the HSP70s gene family in pumpkin, including phylogenetic relationship, gene structure, gene duplication, collinearity, and promoter analysis. The study found 21 HSP70s genes in pumpkin, classified into five groups, and identified their cellular localization. Promoter analysis indicated the potential role of this gene family in stress tolerance. The study also analyzed the expression patterns of HSP70s genes in pumpkin under progressive drought stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Hager Mohamed, Eric Gebski, Rufranshell Reyes, Samuel Beane, Brian Wigdahl, Fred C. Krebs, Katharina Stapelmann, Vandana Miller
Summary: The study examined the responses of two human leukemic cell lines to NTP-generated reactive oxygen and nitrogen species, demonstrating that cells can modulate the RONS-mediated changes in liquid chemistry, and the immunomodulatory effects of NTP may be independent of its cytotoxicity.
Article
Biochemistry & Molecular Biology
Yongchao Ke, Mingyue Xu, Delight Hwarari, Jinhui Chen, Liming Yang
Summary: Heat shock proteins (HSPs) are important molecular chaperones involved in regulating plant growth and stress responses. In this study, 60 HSP genes were identified in the L. chinense genome, with phylogenetic analysis showing close relation to Cinnamomum kanehirae HSP gene family. Duplication events analysis revealed segmental and tandem duplications, indicating a role in gene expansion and evolution. Our findings provide new insights into the function and regulatory mechanisms of the LchiHSP gene family in response to abiotic stresses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Obstetrics & Gynecology
So Ling Lau, Zara Lin Zau Lok, Shuk Yi Annie Hui, Genevieve Po Gee Fung, Hugh Simon Lam, Tak Yeung Leung
Summary: This study investigated the predictors of adverse long-term outcomes in infants with umbilical artery pH <7. It found that a cord arterial pH of <6.9 and an Apgar score at 5 min <7 were independent prognostic factors for neonatal/infant death or adverse long-term neurological outcomes.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Article
Oncology
Jinglin Zhang, Bonan Chen, Hui Li, Yifei Wang, Xiaoli Liu, Kit Yee Wong, Wai Nok Chan, Aden K. Y. Chan, Alvin H. k Cheung, Kam Tong Leung, Yujuan Dong, Yi Pan, Huixing Ke, Li Liang, Zhaocai Zhou, Jianyong Xiao, Chi Chun Wong, William K. K. Wu, Alfred S. L. Cheng, Brigette B. Y. Ma, Jun Yu, Kwok Wai Lo, Wei Kang, Ka Fai To
Summary: Colorectal cancer (CRC) is a common cancer worldwide, and the tumor microenvironment, specifically cancer-associated fibroblasts (CAFs), plays a crucial role in promoting CRC progression.
JOURNAL OF PATHOLOGY
(2023)
Article
Pediatrics
Xue-Lian Wang, Eman Leung, Genevieve Po Gee Fung, Hugh Simon Lam
Summary: This study provides a detailed analysis of neonatal deaths in Hong Kong, showing that overall neonatal mortality remains stable but varies among different gestational weeks. The proportion of extremely preterm infants who died significantly increased, with hemorrhagic conditions being the leading cause of death. Congenital anomalies were the leading cause of death in neonates born after 27 weeks' gestation, but their cause-specific mortality has decreased, mainly attributed to trisomy 13/18 and multiple anomalies.
WORLD JOURNAL OF PEDIATRICS
(2023)
Article
Immunology
Shaojun Liu, Joseph G. S. Tsun, Genevieve P. G. Fung, Grace C. Y. Lui, Kathy Y. Y. Chan, Paul K. S. Chan, Renee W. Y. Chan
Summary: This study compared the effect of a booster vaccine in inducing mucosal and serological antibody between Covid-19 recovered patients and vaccine-only subjects. The results showed that the booster expanded the nasal antibody levels in recovered patients and improved the inhibition against the BA.1 variant and ancestral SARS-CoV-2. The nasal antibodies induced by natural infection lasted longer than those induced by vaccines, while both groups maintained high levels of plasma antibodies for at least 21 weeks after booster.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Huan Yan, Jing-Ling Zhang, Kam-Tong Leung, Kwok-Wai Lo, Jun Yu, Ka-Fai To, Wei Kang
Summary: Gastric cancer is a highly life-threatening malignancy, particularly in Asian countries. Aberrant activation of G-protein-coupled receptors (GPCRs) and G proteins promotes the progression of gastric cancer. These activated GPCRs/G proteins can potentially serve as valuable biomarkers for early diagnosis and prognostic prediction, as well as therapeutic targets. This review summarizes the recent research progress of GPCRs and highlights their mechanisms in tumorigenesis, specifically in gastric cancer initiation and progression.
Article
Pediatrics
Lai Ling Hui, Frederick K. Ho, Charlotte Margaret Wright, Tim J. Cole, Hugh Simon Lam, Han-Bing Deng, Hung-Kwan So, Patrick Ip, E. Anthony S. Nelson
Summary: Using the WHO head circumference standards would lead to the overdiagnosis of macrocephaly and the underdiagnosis of microcephaly, except for Indians and some Asian neonates. Population-specific cut-offs or references are more appropriate for many populations. Healthcare professionals need to be educated about the limitations of the WHO head circumference standards.
ARCHIVES OF DISEASE IN CHILDHOOD
(2023)
Article
Pediatrics
Xuelian Wang, Lai Ling Hui, Tim J. Cole, E. Anthony S. Nelson, Hugh Simon Lam
Summary: This study compared the fitness of the INTERGROWTH-21st birth weight standards (INTERGROWTH21) with a local reference (FOK2003) for ethnic Chinese babies. The results showed that INTERGROWTH21 performed less well, especially in infants born <33 weeks' gestation, compared to FOK2003 in predicting complications related to small-for-gestational-age (SGA) infants. A more robust chart based on a larger sample of appropriately selected infants is needed.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2023)
Article
Clinical Neurology
Qiu-Ye Lan, Kate Ching-Ching Chan, Chun-Ting Au, Peggy Hiu-Ying Chan, Ngan Yin Chan, Yun Kwok Wing, Albert Martin Li, Hugh Simon Lam
Summary: This study aimed to evaluate the secular trends of sleep-wake patterns of preschool children in Hong Kong. It found a significant downward trend in sleep duration and a positive correlation between parental and children's sleep duration.
Article
Multidisciplinary Sciences
Jeff Yat-Fai Chung, Philip Chiu-Tsun Tang, Max Kam-Kwan Chan, Vivian Weiwen Xue, Xiao-Ru Huang, Calvin Sze-Hang Ng, Dongmei Zhang, Kam-Tong Leung, Chun-Kwok Wong, Tin-Lap Lee, Eric W-F Lam, David J. Nikolic-Paterson, Ka-Fai To, Hui-Yao Lan, Patrick Ming-Kuen Tang
Summary: In this study, the researchers found that phenotype and function of tumor-associated neutrophils (TANs) are influenced by the microenvironment, resulting in different impact on tumor development as N1 or N2 state. They discovered that Smad3 activation is negatively correlated with N2 state and patient survival in NSCLC patients. In preclinical lung cancer models, targeting Smad3 reprogrammed TANs to an antitumor state (N1), suppressing tumor growth. Mechanistically, Smad3 regulated the maturity of TANs and maintained the N2 state through controlling genes related to cell fate determination. Thus, the findings suggest that Smad3 signaling could be a therapeutic target for cancer immunotherapy.
NATURE COMMUNICATIONS
(2023)
Article
Biology
Chi-Keung Cheng, Yuk-Lin Yung, Hoi-Yun Chan, Kam-Tong Leung, Kathy Y. Y. Chan, Alex W. K. Leung, Frankie W. T. Cheng, Chi-Kong Li, Thomas S. K. Wan, Xi Luo, Herbert-Augustus Pitts, Joyce S. S. Cheung, Natalie P. H. Chan, Margaret H. L. Ng
Summary: A genomic analysis of pediatric acute myeloid leukemia patients reveals extensive gene fusion events and mutations, providing new insights into the genetic complexities of this cancer. The study highlights the importance of understanding the genetic basis of pediatric AML for improving prognostic classification and treatment options.
COMMUNICATIONS BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Yang Lyu, Fuda Xie, Bonan Chen, Wing Sum Shin, Wei Chen, Yulong He, Kam Tong Leung, Gary M. K. Tse, Jun Yu, Ka Fai To, Wei Kang
Summary: This review focuses on the complex interaction between the nervous system and gastrointestinal (GI) cancer, exploring the mechanisms of GI cancer development. It discusses the intricate relationship between the nervous system and GI tract development and tumor progression, as well as the feedback regulation of tumor cells on the nervous system. The review also highlights the influence of various components within the tumor microenvironment on GI cancer occurrence and progression. Furthermore, it emphasizes the transformation relationship between non-neuronal cells and neuronal cells, inspiring the development of nervous system-guided anti-tumor drugs.
Article
Oncology
Kam Tong Leung, Jiaoyang Cai, Yu Liu, Kathy Yuen Yee Chan, Jingbo Shao, Hui Yang, Qun Hu, Yao Xue, Xuedong Wu, Xia Guo, Xiaowen Zhai, Ningling Wang, Xue Li, Xin Tian, Zheng Li, Ning Xue, Yuxia Guo, Lingzhen Wang, Yao Zou, Peifang Xiao, Yingyi He, Runming Jin, Jingyan Tang, Jun J. Yang, Shuhong Shen, Ching-Hon Pui, Chi Kong Li
Summary: CD9 has prognostic significance in childhood acute lymphoblastic leukemia (ALL), especially in the intermediate/high-risk arms and patients with minimal residual disease, providing insights into necessary interventions and informing timely therapeutic interventions.
Meeting Abstract
Oncology
John Tak Kit Cheung, Chi Zhang, Wing Hei Ng, Kathy Yuen Yee Chan, Han Wang, Chi Kong Li, Kam Tong Leung
PEDIATRIC BLOOD & CANCER
(2022)
Article
Medicine, General & Internal
Sl Lau, Sani Tk Wong, Wt Tse, Genevieve Pg Fung, Hugh Simon Lam, Daljit Singh Sahota, Ty Leung
Summary: This study investigated the perinatal mortality rate and causes of multiple pregnancies in Hong Kong, and found that although the prevalence of multiple pregnancies increased during the study period, the corresponding total perinatal mortality rate improved. This improvement was associated with improvements in antenatal care, treatment, and a decrease in preterm birth rate.
HONG KONG MEDICAL JOURNAL
(2022)