Bolstering Immunity through Pattern Recognition Receptors: A Unique Approach to Control Tuberculosis

Targeted pulmonary delivery of inducers of host macrophage autophagy as a potential host-directed chemotherapy of tuberculosis

(2016) Anuradha Gupta et al.   ADVANCED DRUG DELIVERY REVIEWS

Potential of immunomodulatory agents as adjunct host-directed therapies for multidrug-resistant tuberculosis

(2016) Alimuddin Zumla et al.   BMC Medicine

Reactive oxygen species production by human dendritic cells involves TLR2 and dectin-1 and is essential for efficient immune response against Mycobacteria

(2016) María Mercedes Romero et al.   CELLULAR MICROBIOLOGY

T-cell exhaustion in tuberculosis: pitfalls and prospects

(2016) Nargis Khan et al.   CRITICAL REVIEWS IN MICROBIOLOGY

Host-directed therapies for infectious diseases: current status, recent progress, and future prospects

(2016) Alimuddin Zumla et al.   LANCET INFECTIOUS DISEASES

A novel therapeutic strategy of lipidated promiscuous peptide against Mycobacterium tuberculosis by eliciting Th1 and Th17 immunity of host

(2016) Pradeep K Rai et al.   Scientific Reports

Oral Tolerance to Environmental Mycobacteria Interferes with Intradermal, but Not Pulmonary, Immunization against Tuberculosis

(2016) Dominique N. Price et al.   PLoS Pathogens

Stimulation through CD40 and TLR-4 Is an Effective Host Directed Therapy against Mycobacterium tuberculosis

(2016) Nargis Khan et al.   Frontiers in Immunology

Signaling through NOD-2 and TLR-4 Bolsters the T cell Priming Capability of Dendritic cells by Inducing Autophagy

(2016) Nargis Khan et al.   Scientific Reports

Triggering through NOD-2 Differentiates Bone Marrow Precursors to Dendritic Cells with Potent Bactericidal activity

(2016) Nargis Khan et al.   Scientific Reports

Infergen Stimulated Macrophages Restrict Mycobacterium tuberculosis Growth by Autophagy and Release of Nitric Oxide

(2016) Susanta Pahari et al.   Scientific Reports

High-dose vitamin D3 in adults with pulmonary tuberculosis: a double-blind randomized controlled trial

(2015) Nestan Tukvadze et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

LAG3 Expression in Active Mycobacterium tuberculosis Infections

(2015) Bonnie L. Phillips et al.   AMERICAN JOURNAL OF PATHOLOGY

Enrichment of regulatory T-cells in blood of patients with multidrug-resistant tuberculosis

(2015) N. Li et al.   INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE

NOD-2 and TLR-4 Signaling Reinforces the Efficacy of Dendritic Cells and Reduces the Dose of TB Drugs against Mycobacterium tuberculosis

(2015) Nargis Khan et al.   Journal of Innate Immunity

Adjunctive vitamin D for treatment of active tuberculosis in India: a randomised, double-blind, placebo-controlled trial

(2015) Peter Daley et al.   LANCET INFECTIOUS DISEASES

Exploring the potential of adjunct therapy in tuberculosis

(2015) Geetha Vani Rayasam et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Tim-3 blocking rescue macrophage and T cell function against Mycobacterium tuberculosis infection in HIV+ patients

(2015) Isabel Sada-Ovalle et al.   Journal of the International AIDS Society

Modulation of host responses by oral commensal bacteria

(2015) Deirdre A Devine et al.   Journal of Oral Microbiology

Role of the Microbiota in Immunity and Inflammation

(2014) Yasmine Belkaid et al.   CELL

Analysis of Th1, Th17 and regulatory T cells in tuberculosis case contacts

(2014) R.E. García Jacobo et al.   CELLULAR IMMUNOLOGY

Challenges and solutions for a rational vaccine design for TB-endemic regions

(2014) Uthaman Gowthaman et al.   CRITICAL REVIEWS IN MICROBIOLOGY

Antibiotic resistance and the environment--there and back again: Science & Society series on Science and Drugs

(2014) S. Berkner et al.   EMBO REPORTS

Dectin-2 Is a Direct Receptor for Mannose-Capped Lipoarabinomannan of Mycobacteria

(2014) Akiko Yonekawa et al.   IMMUNITY

Gut Microbiota: A Natural Adjuvant for Vaccination

(2014) Oliver Pabst et al.   IMMUNITY

Interaction of Pattern Recognition Receptors with Mycobacterium Tuberculosis

(2014) Esmaeil Mortaz et al.   JOURNAL OF CLINICAL IMMUNOLOGY

NOD2-Deficient Mice Have Impaired Resistance to Mycobacterium tuberculosis Infection through Defective Innate and Adaptive Immunity

(2014) M. Divangahi et al.   JOURNAL OF IMMUNOLOGY

Programmed Death (PD)-1:PD-Ligand 1/PD-Ligand 2 Pathway Inhibits T Cell Effector Functions during Human Tuberculosis

(2014) J. O. Jurado et al.   JOURNAL OF IMMUNOLOGY

Triggering Through Toll-like Receptor 2 Limits Chronically Stimulated T-helper Type 1 Cells From Undergoing Exhaustion

(2014) Sathi Babu Chodisetti et al.   JOURNAL OF INFECTIOUS DISEASES

Inflammation and tuberculosis: host-directed therapies

(2014) A. Zumla et al.   JOURNAL OF INTERNAL MEDICINE

Human Lung Epithelial Cells Contain Mycobacterium tuberculosis in a Late Endosomal Vacuole and Are Efficiently Recognized by CD8+ T Cells

(2014) Melanie J. Harriff et al.   PLoS One

IL-32 is a molecular marker of a host defense network in human tuberculosis

(2014) D. Montoya et al.   Science Translational Medicine

Programmed death-1 receptor suppresses γ-IFN producing NKT cells in human tuberculosis

(2014) Amar Singh et al.   TUBERCULOSIS

Multivalent glycoconjugates as vaccines and potential drug candidates

(2014) Sumati Bhatia et al.   MedChemComm

Progress in tuberculosis vaccine development and host-directed therapies—a state of the art review

(2014) Stefan H E Kaufmann et al.   Lancet Respiratory Medicine

Challenges in the development of drugs for the treatment of tuberculosis

(2013) Adeeb Shehzad et al.   Brazilian Journal of Infectious Diseases

CD40 ligand and interferon-γ induce an antimicrobial response againstMycobacterium tuberculosisin human monocytes

(2013) Georgiana M. Klug-Micu et al.   IMMUNOLOGY

Early clearance ofMycobacterium tuberculosis: a new frontier in prevention

(2013) Ayesha J. Verrall et al.   IMMUNOLOGY

The Dectin-2 family of C-type lectin-like receptors: an update

(2013) Bernhard Kerscher et al.   INTERNATIONAL IMMUNOLOGY

Innate sensors of pathogen and stress: Linking inflammation to obesity

(2013) Chengcheng Jin et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Inhibiting the Programmed Death 1 Pathway Rescues Mycobacterium tuberculosis–Specific Interferon γ–Producing T Cells From Apoptosis in Patients With Pulmonary Tuberculosis

(2013) Amar Singh et al.   JOURNAL OF INFECTIOUS DISEASES

Tuberculosis vaccines: Time to think about the next generation

(2013) Stefan H.E. Kaufmann   SEMINARS IN IMMUNOLOGY

The Immunobiology of Toll-Like Receptor 4 Agonists

(2013) Julia K. Bohannon et al.   SHOCK

Beyond pattern recognition: NOD-like receptors in dendritic cells

(2013) Jayendra Kumar Krishnaswamy et al.   TRENDS IN IMMUNOLOGY

Signaling by Myeloid C-Type Lectin Receptors in Immunity and Homeostasis

(2012) David Sancho et al.   Annual Review of Immunology

Multivalent glycoconjugates as anti-pathogenic agents

(2012) Anna Bernardi et al.   CHEMICAL SOCIETY REVIEWS

Vaccines against mucosal infections

(2012) Jan Holmgren et al.   CURRENT OPINION IN IMMUNOLOGY

Actin' as a Death Signal

(2012) Teunis B.H. Geijtenbeek   IMMUNITY

F-Actin Is an Evolutionarily Conserved Damage-Associated Molecular Pattern Recognized by DNGR-1, a Receptor for Dead Cells

(2012) Susan Ahrens et al.   IMMUNITY

The Tim3-Galectin 9 Pathway Induces Antibacterial Activity in Human Macrophages Infected with Mycobacterium tuberculosis

(2012) I. Sada-Ovalle et al.   JOURNAL OF IMMUNOLOGY

Foxp3+ Regulatory T Cells among Tuberculosis Patients: Impact on Prognosis and Restoration of Antigen Specific IFN-γ Producing T Cells

(2012) Amar Singh et al.   PLoS One

Lipidated promiscuous peptides vaccine for tuberculosis-endemic regions

(2012) Uthaman Gowthaman et al.   TRENDS IN MOLECULAR MEDICINE

Manipulation of Costimulatory Molecules by Intracellular Pathogens: Veni, Vidi, Vici!!

(2012) Nargis Khan et al.   PLoS Pathogens

Vaccines against Tuberculosis: Where Are We and Where Do We Need to Go?

(2012) Tom H. M. Ottenhoff et al.   PLoS Pathogens

Prospects for TIM3-Targeted Antitumor Immunotherapy

(2011) S. F. Ngiow et al.   CANCER RESEARCH

γδT Cells Cross-Link Innate and Adaptive Immunity inMycobacterium tuberculosisInfection

(2011) Serena Meraviglia et al.   Clinical & Developmental Immunology

Innate Immune Effectors in Mycobacterial Infection

(2011) Hiroyuki Saiga et al.   Clinical & Developmental Immunology

Innate Immune Recognition ofMycobacterium tuberculosis

(2011) Johanneke Kleinnijenhuis et al.   Clinical & Developmental Immunology

DEC-205 mediates antigen uptake and presentation by both resting and activated human plasmacytoid dendritic cells

(2011) Jurjen Tel et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Programmed death ligand 1 is over-expressed by neutrophils in the blood of patients with active tuberculosis

(2011) Finlay W. McNab et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Eritoran tetrasodium (E5564) treatment for sepsis: review of preclinical and clinical studies

(2011) Amisha Barochia et al.   Expert Opinion on Drug Metabolism & Toxicology

Pathogen Recognition by the Innate Immune System

(2011) Himanshu Kumar et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Molecular basis and mechanisms of drug resistance in Mycobacterium tuberculosis: classical and new drugs

(2011) P. E. Almeida Da Silva et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

A Novel Human IgA Monoclonal Antibody Protects against Tuberculosis

(2011) S. Balu et al.   JOURNAL OF IMMUNOLOGY

Promiscuous Peptide of 16 kDa Antigen Linked to Pam2Cys Protects Against Mycobacterium tuberculosis by Evoking Enduring Memory T-Cell Response

(2011) Uthaman Gowthaman et al.   JOURNAL OF INFECTIOUS DISEASES

Combining cytokine-induced killer cells with vaccination in cancer immunotherapy: More than one plus one?

(2011) Sharmilan Thanendrarajan et al.   LEUKEMIA RESEARCH

Co-Administration of IL-1+IL-6+TNF-α with Mycobacterium tuberculosis Infected Macrophages Vaccine Induces Better Protective T Cell Memory than BCG

(2011) Vijender Singh et al.   PLoS One

Syk-coupled C-type lectins in immunity

(2011) Ann M. Kerrigan et al.   TRENDS IN IMMUNOLOGY

Cytokines in Cancer Immunotherapy

(2011) Sylvia Lee et al.   Cancers

Enemy at the gates: dendritic cells and immunity to mucosal pathogens

(2010) Adam C Soloff et al.   CELL RESEARCH

A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis*

(2010) Todd W. Rice et al.   CRITICAL CARE MEDICINE

The CD4-like molecule LAG-3, biology and therapeutic applications

(2010) Sophie Sierro et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Vaccine Adjuvants: Putting Innate Immunity to Work

(2010) Robert L. Coffman et al.   IMMUNITY

Drogas antituberculose: interações medicamentosas, efeitos adversos e utilização em situações especiais - parte 1: fármacos de primeira linha

(2010) Marcos Abdo Arbex et al.   Jornal Brasileiro de Pneumologia

Intranasal Poly-IC treatment exacerbates tuberculosis in mice through the pulmonary recruitment of a pathogen-permissive monocyte/macrophage population

(2010) Lis R.V. Antonelli et al.   JOURNAL OF CLINICAL INVESTIGATION

The adaptor molecule CARD9 is essential for tuberculosis control

(2010) Anca Dorhoi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Coadministration of Interleukins 7 and 15 with Bacille Calmette‐Guérin Mounts Enduring T Cell Memory Response againstMycobacterium tuberculosis

(2010) Vijender Singh et al.   JOURNAL OF INFECTIOUS DISEASES

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Targeting Toll-like receptors: emerging therapeutics?

(2010) Elizabeth J. Hennessy et al.   NATURE REVIEWS DRUG DISCOVERY

Toll-like receptors: linking inflammation to metabolism

(2010) A. Christine Könner et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses

(2009) T. H. Mogensen   CLINICAL MICROBIOLOGY REVIEWS

Phase 2 trial of eritoran tetrasodium (E5564), a Toll-like receptor 4 antagonist, in patients with severe sepsis*

(2009) Mark Tidswell et al.   CRITICAL CARE MEDICINE

Pattern recognition: recent insights from Dectin-1

(2009) Delyth M Reid et al.   CURRENT OPINION IN IMMUNOLOGY

Pathogen recognition by DC-SIGN shapes adaptive immunity

(2009) Teunis BH Geijtenbeek et al.   Future Microbiology

Innate immunity

(2009) Stuart E. Turvey et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Dectin-1 is Inducible and Plays an Essential Role for Mycobacteria-Induced Innate Immune Responses in Airway Epithelial Cells

(2009) Hye-Mi Lee et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle

(2009) Eri Ishikawa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Induction of Th1/Th17 immune response by Mycobacterium tuberculosis : role of dectin-1, mannose receptor, and DC-SIGN

(2009) Elena Zenaro et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Identification of a dendritic cell receptor that couples sensing of necrosis to immunity

(2009) David Sancho et al.   NATURE

Activation of innate immune antiviral responses by Nod2

(2009) Ahmed Sabbah et al.   NATURE IMMUNOLOGY

The spectrum of latent tuberculosis: rethinking the biology and intervention strategies

(2009) Clifton E. Barry et al.   NATURE REVIEWS MICROBIOLOGY

C-type lectin Mincle is an activating receptor for pathogenic fungus,Malassezia

(2009) Sho Yamasaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New Drugs against Tuberculosis: Problems, Progress, and Evaluation of Agents in Clinical Development

(2008) J. van den Boogaard et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mycobacterium abscessusactivates the macrophage innate immune response via a physical and functional interaction between TLR2 and dectin-1

(2008) Dong-Min Shin et al.   CELLULAR MICROBIOLOGY

Oral Immunization with Recombinant Lactobacillus plantarum Induces a Protective Immune Response in Mice with Lyme Disease

(2008) B. del Rio et al.   Clinical and Vaccine Immunology

Novel anti-infectives: is host defence the answer?

(2008) Pamela Hamill et al.   CURRENT OPINION IN BIOTECHNOLOGY

Vaccine adjuvants: Current challenges and future approaches

(2008) Jennifer H. Wilson-Welder et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Tuberculosis and latent tuberculosis infection in close contacts of people with pulmonary tuberculosis in low-income and middle-income countries: a systematic review and meta-analysis

(2008) Janina Morrison et al.   LANCET INFECTIOUS DISEASES