Journal
CRITICAL REVIEWS IN MICROBIOLOGY
Volume 41, Issue 3, Pages 389-398Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/1040841X.2013.859125
Keywords
TB; T cell memory; Endemic areas; Vaccine; BCG
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Funding
- CSIR
- DBT, India
- DBT
- National Health and Medical Research Council of Australia
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Vaccines have been successful for global eradication or control of dreaded diseases such as smallpox, diphtheria, tetanus, yellow fever, whooping cough, polio, and measles. Unfortunately, this success has not been achieved for controlling tuberculosis (TB) worldwide. Bacillus Calmette Guerin (BCG) is the only available vaccine against TB. Paradoxically, BCG has deciphered success in the Western world but has failed in TB-endemic areas. In this article, we highlight and discuss the aspects of immunity responsible for controlling Mycobacterium tuberculosis infection and factors responsible for the failure of BCG in TB-endemic countries. In addition, we also suggest strategies that contribute toward the development of successful vaccine in protecting populations where BCG has failed.
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