The Immunobiology of Toll-Like Receptor 4 Agonists

TRIF Is Required for TLR4 Mediated Adjuvant Effects on T Cell Clonal Expansion

(2013) Siva K. Gandhapudi et al.   PLoS One

Inefficient TLR4/MD-2 Heterotetramerization by Monophosphoryl Lipid A

(2013) Carolyn R. Casella et al.   PLoS One

Intracellular Delivery of Lipopolysaccharide Induces Effective Th1-Immune Responses Independent of IL-12

(2013) Sachiko Watanabe et al.   PLoS One

Modulating the innate immune response by combinatorial engineering of endotoxin

(2013) Brittany D. Needham et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct TLR adjuvants differentially stimulate systemic and local innate immune responses in nonhuman primates

(2012) M. Kwissa et al.   BLOOD

Adjuvants for immunotherapy

(2012) Oliver Pfaar et al.   Current Opinion in Allergy and Clinical Immunology

Adjuvants for human vaccines

(2012) Carl R Alving et al.   CURRENT OPINION IN IMMUNOLOGY

Understanding efflux in Gram-negative bacteria: opportunities for drug discovery

(2012) Herbert P Schweizer   Expert Opinion on Drug Discovery

Molecular Mechanism Responsible for the Priming of Macrophage Activation

(2012) Hui Deng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective TRIF-Dependent Signaling by a Synthetic Toll-Like Receptor 4 Agonist

(2012) W. S. Bowen et al.   Science Signaling

Systems biology approaches to toll-like receptor signaling

(2012) Alexis Vandenbon et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Development of an AS04-Adjuvanted HPV Vaccine with the Adjuvant System Approach

(2011) Nathalie Garçon et al.   BIODRUGS

TLR7 enables cross-presentation by multiple dendritic cell subsets through a type I IFN-dependent pathway

(2011) J. Z. Oh et al.   BLOOD

Monophosphoryl lipid A induced innate immune responses via TLR4 to enhance clearance of nontypeableHaemophilus influenzaeandMoraxella catarrhalisfrom the nasopharynx in mice

(2011) Takashi Hirano et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

The Toll-Like Receptor 4 Agonist Monophosphoryl Lipid A Augments Innate Host Resistance to Systemic Bacterial Infection

(2011) Christopher D. Romero et al.   INFECTION AND IMMUNITY

Induction of endotoxin tolerance in vivo inhibits activation of IRAK4 and increases negative regulators IRAK-M, SHIP-1, and A20

(2011) Yanbao Xiong et al.   JOURNAL OF LEUKOCYTE BIOLOGY

MicroRNAs Distinguish Translational from Transcriptional Silencing during Endotoxin Tolerance

(2010) Mohamed El Gazzar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recent insights into the structure of Toll-like receptors and post-translational modifications of their associated signalling proteins

(2009) Susan Carpenter et al.   BIOCHEMICAL JOURNAL

The resolution of inflammation: Anti-inflammatory roles for NF-κB

(2009) Toby Lawrence et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Selective Activation of the p38 MAPK Pathway by Synthetic Monophosphoryl Lipid A

(2009) Caglar Cekic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The NF-κB Factor RelB and Histone H3 Lysine Methyltransferase G9a Directly Interact to Generate Epigenetic Silencing in Endotoxin Tolerance

(2009) Xiaoping Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chromatin-Specific Remodeling by HMGB1 and Linker Histone H1 Silences Proinflammatory Genes during Endotoxin Tolerance

(2009) M. E. Gazzar et al.   MOLECULAR AND CELLULAR BIOLOGY

The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

(2009) Beom Seok Park et al.   NATURE

Endotoxin tolerance: new mechanisms, molecules and clinical significance

(2009) Subhra K. Biswas et al.   TRENDS IN IMMUNOLOGY

The Nuclear Factor NF- B Pathway in Inflammation

(2009) T. Lawrence   Cold Spring Harbor Perspectives in Biology

Putting endotoxin to work for us: Monophosphoryl lipid A as a safe and effective vaccine adjuvant

(2008) C. R. Casella et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

G9a and HP1 Couple Histone and DNA Methylation to TNFα Transcription Silencing during Endotoxin Tolerance

(2008) Mohamed El Gazzar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β

(2008) Jonathan C Kagan et al.   NATURE IMMUNOLOGY