Inflammation and tuberculosis: host-directed therapies

Autologous mesenchymal stromal cell infusion as adjunct treatment in patients with multidrug and extensively drug-resistant tuberculosis: an open-label phase 1 safety trial

(2014) Aliaksandr Skrahin et al.   Lancet Respiratory Medicine

Assessment of Clofazimine Activity in a Second-Line Regimen for Tuberculosis in Mice

(2013) Jacques H. Grosset et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Acceleration of Tuberculosis Treatment by Adjunctive Therapy with Verapamil as an Efflux Inhibitor

(2013) Shashank Gupta et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Efflux Inhibition with Verapamil Potentiates Bedaquiline in Mycobacterium tuberculosis

(2013) Shashank Gupta et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Expression of M. tuberculosis-induced suppressor of cytokine signaling (SOCS) 1, SOCS3, FoxP3 and secretion of IL-6 associates with differing clinical severity of tuberculosis

(2013) Kiran I Masood et al.   BMC INFECTIOUS DISEASES

BCL-2 Inhibition: Stemming the Tide of Myeloid Malignancies

(2013) Leah J. Hogdal et al.   Cell Stem Cell

BCL-2 Inhibition Targets Oxidative Phosphorylation and Selectively Eradicates Quiescent Human Leukemia Stem Cells

(2013) Eleni D. Lagadinou et al.   Cell Stem Cell

Inflammasomes and host defenses against bacterial infections

(2013) Gregory I Vladimer et al.   CURRENT OPINION IN MICROBIOLOGY

Autophagy as an immune effector against tuberculosis

(2013) Steven B Bradfute et al.   CURRENT OPINION IN MICROBIOLOGY

TB: the Yin and Yang of lipid mediators

(2013) David M Tobin et al.   CURRENT OPINION IN PHARMACOLOGY

Costs of tuberculosis disease in the European Union: a systematic analysis and cost calculation

(2013) R. Diel et al.   EUROPEAN RESPIRATORY JOURNAL

Systems level immune response analysis and personalized medicine

(2013) Petter Brodin et al.   Expert Review of Clinical Immunology

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

(2013) Raúl Muñoz-Planillo et al.   IMMUNITY

Histone deacetylase inhibitors in the treatment for multiple myeloma

(2013) Teru Hideshima et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Clinical experience of using clofazimine to treat multidrug-resistant tuberculosis [Correspondence]

(2013) Jung-Wan Yoo et al.   INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE

Ibuprofen Therapy Resulted in Significantly Decreased Tissue Bacillary Loads and Increased Survival in a New Murine Experimental Model of Active Tuberculosis

(2013) Cristina Vilaplana et al.   JOURNAL OF INFECTIOUS DISEASES

Progress and challenges in childhood tuberculosis

(2013) Ben J Marais et al.   LANCET INFECTIOUS DISEASES

Tuberculosis comorbidity with communicable and non-communicable diseases: integrating health services and control efforts

(2013) Ben J Marais et al.   LANCET INFECTIOUS DISEASES

Corticosteroids for prevention of mortality in people with tuberculosis: a systematic review and meta-analysis

(2013) Julia A Critchley et al.   LANCET INFECTIOUS DISEASES

Immunotherapy at Large: Balancing tumor immunity and inflammatory pathology

(2013) Glenn Dranoff   NATURE MEDICINE

Safety and Tumor Responses with Lambrolizumab (Anti–PD-1) in Melanoma

(2013) Omid Hamid et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Future of Antibiotics and Resistance

(2013) Brad Spellberg et al.   NEW ENGLAND JOURNAL OF MEDICINE

Autophagy in Human Health and Disease

(2013) Augustine M.K. Choi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Multiplicity of effectors of the cardioprotective agent, diazoxide

(2013) William A. Coetzee   PHARMACOLOGY & THERAPEUTICS

A Broad Profile of Co-Dominant Epitopes Shapes the Peripheral Mycobacterium tuberculosis Specific CD8+ T-Cell Immune Response in South African Patients with Active Tuberculosis

(2013) Rebecca Axelsson-Robertson et al.   PLoS One

Host Targeted Activity of Pyrazinamide in Mycobacterium tuberculosis Infection

(2013) Claudia Manca et al.   PLoS One

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD271+ Bone Marrow Mesenchymal Stem Cells May Provide a Niche for Dormant Mycobacterium tuberculosis

(2013) B. Das et al.   Science Translational Medicine

Reactivation of latent HIV by histone deacetylase inhibitors

(2013) Kotaro Shirakawa et al.   TRENDS IN MICROBIOLOGY

Antitubercular specific activity of ibuprofen and the other 2-arylpropanoic acids using the HT-SPOTi whole-cell phenotypic assay

(2013) Juan D Guzman et al.   BMJ Open

Eliminating the latent HIV reservoir by reactivation strategies: Advancing to clinical trials

(2013) Thomas Rasmussen et al.   Human Vaccines & Immunotherapeutics

Vitamin D Induces Interleukin-1β Expression: Paracrine Macrophage Epithelial Signaling Controls M. tuberculosis Infection

(2013) Mark Verway et al.   PLoS Pathogens

Mycobacterium tuberculosis and the host cell inflammasome: a complex relationship

(2013) Volker Briken et al.   Frontiers in Cellular and Infection Microbiology

Corticosteroid-modulated Immune Activation in the Tuberculosis Immune Reconstitution Inflammatory Syndrome

(2012) Graeme Meintjes et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Host Genotype-Specific Therapies Can Optimize the Inflammatory Response to Mycobacterial Infections

(2012) David M. Tobin et al.   CELL

Stimulation of HIV-1-Specific Cytolytic T Lymphocytes Facilitates Elimination of Latent Viral Reservoir after Virus Reactivation

(2012) Liang Shan et al.   IMMUNITY

Comparison of accessing online databases between physicians and nurses in Taiwan

(2012) Ya-Wen Chiu et al.   Informatics for Health & Social Care

Outcomes of clofazimine for the treatment of drug-resistant tuberculosis: a systematic review and meta-analysis

(2012) Teesta Dey et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Tuberculosis and Tuberculosis/HIV/AIDS-Associated Mortality in Africa: The Urgent Need to Expand and Invest in Routine and Research Autopsies

(2012) V. Mudenda et al.   JOURNAL OF INFECTIOUS DISEASES

Rational Development of Adjunct Immune-Based Therapies for Drug-Resistant Tuberculosis: Hypotheses and Experimental Designs

(2012) A. Zumla et al.   JOURNAL OF INFECTIOUS DISEASES

The Immunological Footprint of Mycobacterium tuberculosis T-cell Epitope Recognition

(2012) Rebecca Axelsson-Robertson et al.   JOURNAL OF INFECTIOUS DISEASES

Adjunct Immunotherapies for Tuberculosis

(2012) M. Uhlin et al.   JOURNAL OF INFECTIOUS DISEASES

Distinct Phases of Blood Gene Expression Pattern Through Tuberculosis Treatment Reflect Modulation of the Humoral Immune Response

(2012) Jacqueline M. Cliff et al.   JOURNAL OF INFECTIOUS DISEASES

Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome–dependent processing of IL-1β

(2012) Bibhuti B Mishra et al.   NATURE IMMUNOLOGY

Increased Levels of BAFF and APRIL Related to Human Active Pulmonary Tuberculosis

(2012) Kai Liu et al.   PLoS One

Safety of Cell Therapy with Mesenchymal Stromal Cells (SafeCell): A Systematic Review and Meta-Analysis of Clinical Trials

(2012) Manoj M. Lalu et al.   PLoS One

Metronidazole prevents reactivation of latent Mycobacterium tuberculosis infection in macaques

(2012) P. L. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy protects against active tuberculosis by suppressing bacterial burden and inflammation

(2012) E. F. Castillo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How host heterogeneity governs tuberculosis reinfection?

(2012) M. G. M. Gomes et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

BCG-specific IgG-secreting peripheral plasmablasts as a potential biomarker of active tuberculosis in HIV negative and HIV positive patients

(2012) Senait Ashenafi et al.   THORAX

Rituximab combination therapy in relapsing multiple sclerosis

(2012) Anne H. Cross et al.   Therapeutic Advances in Neurological Disorders

Apoptosis-Inducing Activity of Clofazimine in Macrophages

(2011) Yasuo Fukutomi et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Imatinib-Sensitive Tyrosine Kinases Regulate Mycobacterial Pathogenesis and Represent Therapeutic Targets against Tuberculosis

(2011) Ruth J. Napier et al.   Cell Host & Microbe

Critical role for NLRP3 in necrotic death triggered by Mycobacterium tuberculosis

(2011) Ka-Wing Wong et al.   CELLULAR MICROBIOLOGY

Activation of the NLRP3 inflammasome byMycobacterium tuberculosisis uncoupled from susceptibility to active tuberculosis

(2011) Anca Dorhoi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Pathogenesis and prevention of immune reconstitution disease during antiretroviral therapy

(2011) Stephen D Lawn et al.   Expert Review of Anti-Infective Therapy

Increased (6 exon) interleukin-7 production after M. tuberculosis infection and soluble interleukin-7 receptor expression in lung tissue

(2011) L Rane et al.   GENES AND IMMUNITY

Cell death and infection: A double-edged sword for host and pathogen survival

(2011) Hiroshi Ashida et al.   JOURNAL OF CELL BIOLOGY

Decreased IL-7 Signaling in T Cells From Patients With PTLD After Allogeneic HSCT

(2011) Hamdy Omar et al.   JOURNAL OF IMMUNOTHERAPY

Outbreaks of Mycobacterium Tuberculosis MDR Strains Induce High IL-17 T-Cell Response in Patients With MDR Tuberculosis That Is Closely Associated With High Antigen Load

(2011) Juan I. Basile et al.   JOURNAL OF INFECTIOUS DISEASES

Apoptosis is an innate defense function of macrophages against Mycobacterium tuberculosis

(2011) S M Behar et al.   Mucosal Immunology

Dominant TNF-α+ Mycobacterium tuberculosis–specific CD4+ T cell responses discriminate between latent infection and active disease

(2011) Alexandre Harari et al.   NATURE MEDICINE

Autophagy induced by valproic acid is associated with oxidative stress in glioma cell lines

(2011) J. Fu et al.   NEURO-ONCOLOGY

Identification of Probable Early-Onset Biomarkers for Tuberculosis Disease Progression

(2011) Jayne S. Sutherland et al.   PLoS One

Increased levels of BAFF in patients with systemic lupus erythematosus are associated with acute-phase reactants, independent of BAFF genetics: a case–control study

(2011) Gro Ø. Eilertsen et al.   RHEUMATOLOGY

The lta4h Locus Modulates Susceptibility to Mycobacterial Infection in Zebrafish and Humans

(2010) David M. Tobin et al.   CELL

Suppressor of cytokine signaling-3 is affected in T-cells from tuberculosisTB patients

(2010) M. Jacobsen et al.   CLINICAL MICROBIOLOGY AND INFECTION

IL-17 and Th17 cells in tuberculosis

(2010) Egídio Torrado et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Increased IgG1, IFN-γ, TNF-α and IL-6 responses to Mycobacterium tuberculosis antigens in patients with Tuberculosis are lower after chemotherapy

(2010) Ana Márcia M. Mattos et al.   INTERNATIONAL IMMUNOLOGY

Immune responses to malignancies

(2010) Theresa L. Whiteside   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The adaptor molecule CARD9 is essential for tuberculosis control

(2010) Anca Dorhoi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pathological role of interleukin 17 in mice subjected to repeated BCG vaccination after infection withMycobacterium tuberculosis

(2010) Andrea Cruz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Understanding Latent Tuberculosis: A Moving Target

(2010) P. L. Lin et al.   JOURNAL OF IMMUNOLOGY

Role of aspirin in tuberculous meningitis: A randomized open label placebo controlled trial

(2010) U.K. Misra et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Cytotoxic therapy for severe swine flu A/H1N1

(2010) Jan-Inge Henter et al.   LANCET

Regulation between survival, persistence, and elimination of intracellular mycobacteria: a nested equilibrium of delicate balances

(2010) Dhiraj Kumar et al.   MICROBES AND INFECTION

An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis

(2010) Matthew P. R. Berry et al.   NATURE

Production of TNF-α, IL-12(p40) and IL-17 Can Discriminate between Active TB Disease and Latent Infection in a West African Cohort

(2010) Jayne S. Sutherland et al.   PLoS One

Humoral ‘reactome’ profiles using peptide microarray chips

(2010) Davide Valentini et al.   TRENDS IN IMMUNOLOGY

Expression of latent human immunodeficiency type 1 is induced by novel and selective histone deacetylase inhibitors

(2009) Nancie M Archin et al.   AIDS

Sensing pathogens and danger signals by the inflammasome

(2009) Joao HF Pedra et al.   CURRENT OPINION IN IMMUNOLOGY

Valproic acid (VPA), a histone deacetylase (HDAC) inhibitor, diminishes lymphoproliferation in the Fas -deficient MRL/lpr−/− murine model of autoimmune lymphoproliferative syndrome (ALPS)

(2009) Kennichi C. Dowdell et al.   EXPERIMENTAL HEMATOLOGY

Histone deacetylase inhibitors: Potential in cancer therapy

(2009) P.A. Marks et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Interleukin 17 acts in synergy with B cell–activating factor to influence B cell biology and the pathophysiology of systemic lupus erythematosus

(2009) Agnès Doreau et al.   NATURE IMMUNOLOGY

Pyroptosis: host cell death and inflammation

(2009) Tessa Bergsbaken et al.   NATURE REVIEWS MICROBIOLOGY

Mycobacterium tuberculosis Prevents Inflammasome Activation

(2008) Sharon S. Master et al.   Cell Host & Microbe

Expression analysis and functional activity of interleukin-7 splice variants

(2008) N K Vudattu et al.   GENES AND IMMUNITY

Immune parameters as markers of tuberculosis extent of disease and early prediction of anti-tuberculosis chemotherapy response

(2008) Joel Fleury Djoba Siawaya et al.   JOURNAL OF INFECTION

Pattern Recognition in Pulmonary Tuberculosis Defined by High Content Peptide Microarray Chip Analysis Representing 61 Proteins from M. tuberculosis

(2008) Simani Gaseitsiwe et al.   PLoS One