Structural and Dynamical Insights on HLA-DR2 Complexes That Confer Susceptibility to Multiple Sclerosis in Sardinia: A Molecular Dynamics Simulation Study
Published 2013 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Structural and Dynamical Insights on HLA-DR2 Complexes That Confer Susceptibility to Multiple Sclerosis in Sardinia: A Molecular Dynamics Simulation Study
Authors
Keywords
-
Journal
PLoS One
Volume 8, Issue 3, Pages e59711
Publisher
Public Library of Science (PLoS)
Online
2013-03-27
DOI
10.1371/journal.pone.0059711
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Viruses and Multiple Sclerosis
- (2012) Jussi Oskari Virtanen et al. CNS & Neurological Disorders-Drug Targets
- HLA-DRB1-DQB1 Haplotypes Confer Susceptibility and Resistance to Multiple Sclerosis in Sardinia
- (2012) Eleonora Cocco et al. PLoS One
- Epitope Flexibility and Dynamic Footprint Revealed by Molecular Dynamics of a pMHC-TCR Complex
- (2012) Cyril F. Reboul et al. PLoS Computational Biology
- Multiple Sclerosis: New Insights in Pathogenesis and Novel Therapeutics
- (2011) Daniel Ontaneda et al. Annual Review of Medicine
- Understanding biomolecular motion, recognition, and allostery by use of conformational ensembles
- (2011) R. Bryn Fenwick et al. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
- Environmental triggers of multiple sclerosis
- (2011) Kristina Kakalacheva et al. FEBS LETTERS
- Electrostatic modifications of the human leukocyte antigen-DR P9 peptide-binding pocket and susceptibility to primary sclerosing cholangitis
- (2011) Johannes R. Hov et al. HEPATOLOGY
- Molecular mimicry as an inducing trigger for CNS autoimmune demyelinating disease
- (2011) Emily M. L. Chastain et al. IMMUNOLOGICAL REVIEWS
- Loss of T Cell Antigen Recognition Arising from Changes in Peptide and Major Histocompatibility Complex Protein Flexibility
- (2011) Francis K. Insaidoo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Disparate Degrees of Hypervariable Loop Flexibility Control T-Cell Receptor Cross-Reactivity, Specificity, and Binding Mechanism
- (2011) Daniel R. Scott et al. JOURNAL OF MOLECULAR BIOLOGY
- Small molecule modulators of MHC class II antigen presentation: Mechanistic insights and implications for therapeutic application
- (2011) Melissa J. Call MOLECULAR IMMUNOLOGY
- Epstein–Barr virus nuclear antigen-1 B-cell epitopes in multiple sclerosis twins
- (2011) R Mechelli et al. Multiple Sclerosis Journal
- Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis
- (2011) Stephen Sawcer et al. NATURE
- Characterization of Structural Features Controlling the Receptiveness of Empty Class II MHC Molecules
- (2011) Bernd Rupp et al. PLoS One
- Conformational lability in the class II MHC 310 helix and adjacent extended strand dictate HLA-DM susceptibility and peptide exchange
- (2011) C. A. Painter et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Pathway and mechanism of drug binding to G-protein-coupled receptors
- (2011) Ron O. Dror et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- T cell receptor recognition of self and foreign antigens in the induction of autoimmunity
- (2011) Kai W. Wucherpfennig et al. SEMINARS IN IMMUNOLOGY
- The role of antigen presenting cells in multiple sclerosis
- (2010) Emily M.L. Chastain et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Eucb: A C++ program for molecular dynamics trajectory analysis
- (2010) Ioannis G. Tsoulos et al. COMPUTER PHYSICS COMMUNICATIONS
- Conformational heterogeneity of MHC class II induced upon binding to different peptides is a key regulator in antigen presentation and epitope selection
- (2010) Scheherazade Sadegh-Nasseri et al. IMMUNOLOGIC RESEARCH
- Molecular Simulations Reveal the Mechanism and the Determinants for Ampicillin Translocation through OmpF
- (2010) Amit Kumar et al. JOURNAL OF PHYSICAL CHEMISTRY B
- A Comparative Approach Linking Molecular Dynamics of Altered Peptide Ligands and MHC with In Vivo Immune Responses
- (2010) Bernhard Knapp et al. PLoS One
- Bidirectional binding of invariant chain peptides to an MHC class II molecule
- (2010) S. Gunther et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Induced fit, conformational selection and independent dynamic segments: an extended view of binding events
- (2010) Peter Csermely et al. TRENDS IN BIOCHEMICAL SCIENCES
- T Cell Receptor Cross-reactivity Directed by Antigen-Dependent Tuning of Peptide-MHC Molecular Flexibility
- (2009) Oleg Y. Borbulevych et al. IMMUNITY
- T Cell-Mediated Autoimmune Disease Due to Low-Affinity Crossreactivity to Common Microbial Peptides
- (2009) Maria Harkiolaki et al. IMMUNITY
- Altered peptide ligands of myelin basic protein (MBP87���99) conjugated to reduced mannan modulate immune responses in mice
- (2009) Maria Katsara et al. IMMUNOLOGY
- AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility
- (2009) Garrett M. Morris et al. JOURNAL OF COMPUTATIONAL CHEMISTRY
- The Binding of Antigenic Peptides to HLA-DR Is Influenced by Interactions between Pocket 6 and Pocket 9
- (2009) E. A. James et al. JOURNAL OF IMMUNOLOGY
- Peptide binding to MHC class I and II proteins: New avenues from new methods
- (2009) Rakina Yaneva et al. MOLECULAR IMMUNOLOGY
- Variations in the Electrostatic Landscape of Class II Human Leukocyte Antigen Molecule Induced by Modifications in the Myelin Basic Protein Peptide: A Theoretical Approach
- (2009) William A. Agudelo et al. PLoS One
- Conformational changes and flexibility in T-cell receptor recognition of peptide–MHC complexes
- (2008) Kathryn M. Armstrong et al. BIOCHEMICAL JOURNAL
- Flexibility of the MHC class II peptide binding cleft in the bound, partially filled, and empty states: A molecular dynamics simulation study
- (2008) Rakina Yaneva et al. BIOPOLYMERS
- Molecular Dynamics—Solvated Interaction Energy Studies of Protein–Protein Interactions: The MP1–p14 Scaffolding Complex
- (2008) Qizhi Cui et al. JOURNAL OF MOLECULAR BIOLOGY
- Analysis of key parameters for molecular dynamics of pMHC molecules
- (2008) Ulrich Omasits et al. MOLECULAR SIMULATION
- The genetics of multiple sclerosis: SNPs to pathways to pathogenesis
- (2008) Jorge R. Oksenberg et al. NATURE REVIEWS GENETICS
- Anchor Side Chains of Short Peptide Fragments Trigger Ligand-Exchange of Class II MHC Molecules
- (2008) Shashank Gupta et al. PLoS One
- Model for the Peptide-Free Conformation of Class II MHC Proteins
- (2008) Corrie A. Painter et al. PLoS One
- A Systematic Assessment of MHC Class II Peptide Binding Predictions and Evaluation of a Consensus Approach
- (2008) Peng Wang et al. PLoS Computational Biology
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreDiscover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversation