Porcine to Human Heart Transplantation: Is Clinical Application Now Appropriate?

Anti-Gal and Anti-Neu5Gc Responses in Nonimmunosuppressed Patients After Treatment With Rabbit Antithymocyte Polyclonal IgGs

(2017) Apolline Salama et al.   TRANSPLANTATION

Humoral Reactivity of Renal Transplant-Waitlisted Patients to Cells From GGTA1/CMAH/B4GalNT2, and SLA Class I Knockout Pigs

(2017) Gregory R. Martens et al.   TRANSPLANTATION

Hemodynamic and perioperative management in two different preclinical pig-to-baboon cardiac xenotransplantation models

(2017) Tanja Mayr et al.   XENOTRANSPLANTATION

Immunological and physiological observations in baboons with life-supporting genetically engineered pig kidney grafts

(2017) Hayato Iwase et al.   XENOTRANSPLANTATION

From the bench to clinical practice: understanding the challenges and uncertainties in immunogenicity testing for biopharmaceuticals

(2016) G. R. Gunn et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Silencing porcine genes significantly reduces human-anti-pig cytotoxicity profiles: an alternative to direct complement regulation

(2016) James R. Butler et al.   TRANSGENIC RESEARCH

Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft

(2016) Muhammad M. Mohiuddin et al.   Nature Communications

Heart Disease and Stroke Statistics—2016 Update

(2015) Dariush Mozaffarian et al.   CIRCULATION

The role of genetically engineered pigs in xenotransplantation research

(2015) David KC Cooper et al.   JOURNAL OF PATHOLOGY

First clinical use of a bioprosthetic total artificial heart: report of two cases

(2015) Alain Carpentier et al.   LANCET

Genome-wide inactivation of porcine endogenous retroviruses (PERVs)

(2015) L. Yang et al.   SCIENCE

Pig-to-baboon heterotopic heart transplantation - exploratory preliminary experience with pigs transgenic for human thrombomodulin and comparison of three costimulation blockade-based regimens

(2015) Hayato Iwase et al.   XENOTRANSPLANTATION

Pre-clinical heterotopic intrathoracic heart xenotransplantation: a possibly useful clinical technique

(2015) Jan-Michael Abicht et al.   XENOTRANSPLANTATION

Early graft failure of GalTKO pig organs in baboons is reduced by expression of a human complement pathway-regulatory protein

(2015) Agnes M. Azimzadeh et al.   XENOTRANSPLANTATION

Pre-transplant antibody screening and anti-CD154 costimulation blockade promote long-term xenograft survival in a pig-to-primate kidney transplant model

(2015) Laura Higginbotham et al.   XENOTRANSPLANTATION

Evaluation of human and non-human primate antibody binding to pig cells lacking GGTA1/CMAH/β4GalNT2 genes

(2015) Jose L. Estrada et al.   XENOTRANSPLANTATION

Systemic inflammation in xenograft recipients (SIXR): A new paradigm in pig-to-primate xenotransplantation?

(2015) Mohamed B. Ezzelarab et al.   International Journal of Surgery

Recent investigations into pig antigen and anti-pig antibody expression

(2015) Guerard W. Byrne et al.   International Journal of Surgery

Preventing transfer of infectious agents

(2015) Joachim Denner et al.   International Journal of Surgery

Progress towards overcoming coagulopathy and hemostatic dysfunction associated with xenotransplantation

(2015) Peter J. Cowan et al.   International Journal of Surgery

Current status of pig heart xenotransplantation

(2015) Muhammad M. Mohiuddin et al.   International Journal of Surgery

Transplantation in the Highly Sensitized Pediatric Patient

(2014) Chesney Castleberry et al.   CIRCULATION

Genetically engineered pigs and target-specific immunomodulation provide significant graft survival and hope for clinical cardiac xenotransplantation

(2014) Muhammad M. Mohiuddin et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

Effects of ASKP1240 Combined With Tacrolimus or Mycophenolate Mofetil on Renal Allograft Survival in Cynomolgus Monkeys

(2014) Lijun Song et al.   TRANSPLANTATION

Porcine Cytomegalovirus Infection Is Associated With Early Rejection of Kidney Grafts in a Pig to Baboon Xenotransplantation Model

(2014) Kazuhiko Yamada et al.   TRANSPLANTATION

Joint Plenary Session: How Can We Overcome Immune Responses Associated with Presensitization? - Optimal Regimen, Accommodation and B-Cell Tolerance

(2014)   XENOTRANSPLANTATION

Histopathologic insights into the mechanism of anti-non-Gal antibody-mediated pig cardiac xenograft rejection

(2014) Guerard W. Byrne et al.   XENOTRANSPLANTATION

Efficient generation of genetically distinct pigs in a single pregnancy using multiplexed single-guide RNA and carbohydrate selection

(2014) Ping Li et al.   XENOTRANSPLANTATION

Progress in pig-to-non-human primate transplantation models (1998-2013): a comprehensive review of the literature

(2014) David K. C. Cooper et al.   XENOTRANSPLANTATION

Are there advantages in the use of specific pathogen-free baboons in pig organ xenotransplantation models?

(2014) Huidong Zhou et al.   XENOTRANSPLANTATION

Cloning and expression of porcine β1,4 N-acetylgalactosaminyl transferase encoding a new xenoreactive antigen

(2014) Guerard W. Byrne et al.   XENOTRANSPLANTATION

One-Year Heterotopic Cardiac Xenograft Survival in a Pig to Baboon Model

(2013) M. M. Mohiuddin et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Fifth INTERMACS annual report: Risk factor analysis from more than 6,000 mechanical circulatory support patients

(2013) James K. Kirklin et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Long-Term IgG Response to Porcine Neu5Gc Antigens without Transmission of PERV in Burn Patients Treated with Porcine Skin Xenografts

(2013) L. Scobie et al.   JOURNAL OF IMMUNOLOGY

Regulatory Sequences of the Porcine THBD Gene Facilitate Endothelial-Specific Expression of Bioactive Human Thrombomodulin in Single- and Multitransgenic Pigs

(2013) Annegret Wuensch et al.   TRANSPLANTATION

Role of anti-CD40 antibody-mediated costimulation blockade on non-Gal antibody production and heterotopic cardiac xenograft survival in a GTKO.hCD46Tg pig-to-baboon model

(2013) Muhammad M. Mohiuddin et al.   XENOTRANSPLANTATION

Double knockout pigs deficient in N-glycolylneuraminic acid and Galactose α-1,3-Galactose reduce the humoral barrier to xenotransplantation

(2013) Andrew J. Lutz et al.   XENOTRANSPLANTATION

Alternative Immunomodulatory Strategies for Xenotransplantation: CD40/154 Pathway-Sparing Regimens Promote Xenograft Survival

(2012) P. Thompson et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Cardiac xenotransplantation

(2012) Guerard W. Byrne et al.   Current Opinion in Organ Transplantation

Transgenic swine: Expression of human CD39 protects against myocardial injury

(2012) Debra G. Wheeler et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Biallelic knockout of the α-1,3 galactosyltransferase gene in porcine liver-derived cells using zinc finger nucleases

(2012) Ping Li et al.   JOURNAL OF SURGICAL RESEARCH

Analyses of pig genomes provide insight into porcine demography and evolution

(2012) Martien A. M. Groenen et al.   NATURE

Human CD55 Expression Blocks Hyperacute Rejection and Restricts Complement Activation in Gal Knockout Cardiac Xenografts

(2012) Christopher G.A. McGregor et al.   TRANSPLANTATION

Production of cloned pigs expressing human thrombomodulin in endothelial cells

(2012) Satoko Yazaki et al.   XENOTRANSPLANTATION

B-Cell Depletion Extends the Survival of GTKO.hCD46Tg Pig Heart Xenografts in Baboons for up to 8 Months

(2011) M. M. Mohiuddin et al.   AMERICAN JOURNAL OF TRANSPLANTATION

CD40-Specific Costimulation Blockade Enhances Neonatal Porcine Islet Survival in Nonhuman Primates

(2011) P. Thompson et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Clinical xenotransplantation: the next medical revolution?

(2011) Burcin Ekser et al.   LANCET

Changes in cardiac gene expression after pig-to-primate orthotopic xenotransplantation

(2011) Guerard W. Byrne et al.   XENOTRANSPLANTATION

Potential impact of the non-human sialic acid N-glycolylneuraminic acid on transplant rejection risk

(2011) Vered Padler-Karavani et al.   XENOTRANSPLANTATION

Identification of New Carbohydrate and Membrane Protein Antigens in Cardiac Xenotransplantation

(2010) Guerard W. Byrne et al.   TRANSPLANTATION

Surgical and Nonsurgical Complications of a Pig to Baboon Heterotopic Heart Transplantation Model

(2010) P.C. Corcoran et al.   TRANSPLANTATION PROCEEDINGS

Characterization of a CD46 transgenic pig and protection of transgenic kidneys against hyperacute rejection in non-immunosuppressed baboons

(2010) Bruce E. Loveland et al.   XENOTRANSPLANTATION

Potential value of human thrombomodulin and DAF expression for coagulation control in pig-to-human xenotransplantation

(2010) Yuko Miwa et al.   XENOTRANSPLANTATION

Combining Cariporide with Glyceryl Trinitrate Optimizes Cardiac Preservation During Porcine Heart Transplantation

(2009) A. J. Hing et al.   AMERICAN JOURNAL OF TRANSPLANTATION

The Innate Immune Response and Activation of Coagulation in α1,3-Galactosyltransferase Gene-Knockout Xenograft Recipients

(2009) Mohamed Ezzelarab et al.   TRANSPLANTATION

Pigs transgenic for human thrombomodulin have elevated production of activated protein C

(2009) Björn Petersen et al.   XENOTRANSPLANTATION

Thrombotic Microangiopathy Associated with Humoral Rejection of Cardiac Xenografts from α1,3-Galactosyltransferase Gene-Knockout Pigs in Baboons

(2008) Akira Shimizu et al.   AMERICAN JOURNAL OF PATHOLOGY

Rejection of Cardiac Xenografts Transplanted from α1,3-Galactosyltransferase Gene-Knockout (GalT-KO) Pigs to Baboons

(2008) Y. Hisashi et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Coagulation dysregulation as a barrier to xenotransplantation in the primate

(2008) Chih Che Lin et al.   TRANSPLANT IMMUNOLOGY

Xenotransplantation of solid organs in the pig-to-primate model

(2008) Burcin Ekser et al.   TRANSPLANT IMMUNOLOGY

Expression of Tissue Factor and Initiation of Clotting by Human Platelets and Monocytes After Incubation With Porcine Endothelial Cells

(2008) Chih Che Lin et al.   TRANSPLANTATION