Non-canonical functions of cell cycle cyclins and cyclin-dependent kinases

Two-way communication between the metabolic and cell cycle machineries: the molecular basis

(2015) Joanna Kaplon et al.   CELL CYCLE

Cell cycle, cytoskeleton dynamics and beyond: the many functions of cyclins and CDK inhibitors

(2015) Nawal Bendris et al.   CELL CYCLE

Cell cycle regulation of mitochondrial function

(2015) Isabel C Lopez-Mejia et al.   CURRENT OPINION IN CELL BIOLOGY

The history and future of targeting cyclin-dependent kinases in cancer therapy

(2015) Uzma Asghar et al.   NATURE REVIEWS DRUG DISCOVERY

Palbociclib in Hormone-Receptor–Positive Advanced Breast Cancer

(2015) Nicholas C. Turner et al.   NEW ENGLAND JOURNAL OF MEDICINE

RB1 dual role in proliferation and apoptosis: cell fate control and implications for cancer therapy

(2015) Paola Indovina et al.   Oncotarget

Cyclin E/Cdk2-dependent phosphorylation of Mcl-1 determines its stability and cellular sensitivity to BH3 mimetics

(2015) Gaurav S. Choudhary et al.   Oncotarget

CDK6 as a key regulator of hematopoietic and leukemic stem cell activation

(2014) Ruth Scheicher et al.   BLOOD

Coordination of proliferation and neuronal differentiation by the retinoblastoma protein family

(2014) Itsuki Ajioka   DEVELOPMENT GROWTH & DIFFERENTIATION

D-Cyclins Repress Apoptosis in Hematopoietic Cells by Controlling Death Receptor Fas and Its Ligand FasL

(2014) Yoon Jong Choi et al.   DEVELOPMENTAL CELL

Cyclin B1/Cdk1 Coordinates Mitochondrial Respiration for Cell-Cycle G2/M Progression

(2014) Zhaoqing Wang et al.   DEVELOPMENTAL CELL

Cyclin D1 and C/EBPβ LAP1 Operate in a Common Pathway To Promote Mammary Epithelial Cell Differentiation

(2014) Qiang Liu et al.   MOLECULAR AND CELLULAR BIOLOGY

Cyclin D1–Cdk4 controls glucose metabolism independently of cell cycle progression

(2014) Yoonjin Lee et al.   NATURE

Cyclin D3 promotes pancreatic  -cell fitness and viability in a cell cycle-independent manner and is targeted in autoimmune diabetes

(2014) N. A. Saavedra-Avila et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cyclin-dependent kinases

(2014) Marcos Malumbres   GENOME BIOLOGY

A Kinase-Independent Function of CDK6 Links the Cell Cycle to Tumor Angiogenesis

(2013) Karoline Kollmann et al.   CANCER CELL

Cyclin D1 localizes in the cytoplasm of keratinocytes during skin differentiation and regulates cell–matrix adhesion

(2013) Rita Fernández-Hernández et al.   CELL CYCLE

Foxp3 Protein Stability Is Regulated by Cyclin-dependent Kinase 2

(2013) Peter A. Morawski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular mechanisms underlying RB protein function

(2013) Frederick A. Dick et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Control of cell cycle transcription during G1 and S phases

(2013) Cosetta Bertoli et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Signaling through cyclin D-dependent kinases

(2013) Y J Choi et al.   ONCOGENE

Fbw7-dependent cyclin E regulation ensures terminal maturation of bone marrow erythroid cells by restraining oxidative metabolism

(2013) Y Xu et al.   ONCOGENE

Chromatin Relaxation-Mediated Induction of p19INK4d Increases the Ability of Cells to Repair Damaged DNA

(2013) María F. Ogara et al.   PLoS One

Site-Specific Phosphorylation of the DNA Damage Response Mediator Rad9 by Cyclin-Dependent Kinases Regulates Activation of Checkpoint Kinase 1

(2013) Carla Manuela Abreu et al.   PLoS Genetics

Controlling DNA-end resection: a new task for CDKs

(2013) Lorenza P. Ferretti et al.   Frontiers in Genetics

The Requirement for Cyclin D Function in Tumor Maintenance

(2012) Yoon Jong Choi et al.   CANCER CELL

Cyclin D1 Activity Regulates Autophagy and Senescence in the Mammary Epithelium

(2012) N. E. Brown et al.   CANCER RESEARCH

Cyclin D1 inhibits hepatic lipogenesis via repression of carbohydrate response element binding protein and hepatocyte nuclear factor 4α

(2012) Eric A. Hanse et al.   CELL CYCLE

Multiple phosphorylation of Rad9 by CDK is required for DNA damage checkpoint activation

(2012) Guoliang Wang et al.   CELL CYCLE

Post-translational modification of Ngn2 differentially affects transcription of distinct targets to regulate the balance between progenitor maintenance and differentiation

(2012) C. Hindley et al.   DEVELOPMENT

ChIP sequencing of cyclin D1 reveals a transcriptional role in chromosomal instability in mice

(2012) Mathew C. Casimiro et al.   JOURNAL OF CLINICAL INVESTIGATION

Cyclin-Dependent Kinase 2 Controls Peripheral Immune Tolerance

(2012) N. Chunder et al.   JOURNAL OF IMMUNOLOGY

Loss of Cdk2 and Cdk4 Induces a Switch from Proliferation to Differentiation in Neural Stem Cells

(2012) Shuhui Lim et al.   STEM CELLS

Cyclin-Dependent Kinases in Brain Development and Disease

(2011) Susan C. Su et al.   Annual Review of Cell and Developmental Biology

A Systematic Screen for CDK4/6 Substrates Links FOXM1 Phosphorylation to Senescence Suppression in Cancer Cells

(2011) Lars Anders et al.   CANCER CELL

Cyclin D1 Inhibits Mitochondrial Activity in B Cells

(2011) G. Tchakarska et al.   CANCER RESEARCH

Cycling or not cycling: cell cycle regulatory molecules and adult neurogenesis

(2011) Pierre Beukelaers et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Coordinated regulation of differentiation and proliferation of embryonic cardiomyocytes by a jumonji (Jarid2)-cyclin D1 pathway

(2011) K. Nakajima et al.   DEVELOPMENT

Cell cycle-regulated multi-site phosphorylation of Neurogenin 2 coordinates cell cycling with differentiation during neurogenesis

(2011) F. Ali et al.   DEVELOPMENT

Cyclin E Constrains Cdk5 Activity to Regulate Synaptic Plasticity and Memory Formation

(2011) Junko Odajima et al.   DEVELOPMENTAL CELL

A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers

(2011) Siwanon Jirawatnotai et al.   NATURE

Cell cycle regulation of DNA double-strand break end resection by Cdk1-dependent Dna2 phosphorylation

(2011) Xuefeng Chen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Physiological Relevance of Cell Cycle Kinases

(2011) Marcos Malumbres   PHYSIOLOGICAL REVIEWS

A cyclin-D1 interaction with BAX underlies its oncogenic role and potential as a therapeutic target in mantle cell lymphoma

(2011) E. Beltran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cyclin D1 promotes neurogenesis in the developing spinal cord in a cell cycle-independent manner

(2011) A. I. Lukaszewicz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cyclin D1 blocks the anti-proliferative function of RUNX3 by interfering with RUNX3–p300 interaction

(2010) Kazunori Iwatani et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Nuclear Cyclin D1/CDK4 Kinase Regulates CUL4 Expression and Triggers Neoplastic Growth via Activation of the PRMT5 Methyltransferase

(2010) Priya Aggarwal et al.   CANCER CELL

The RB-E2F1 Pathway Regulates Autophagy

(2010) H. Jiang et al.   CANCER RESEARCH

Alternative Cyclin D1 Splice Forms Differentially Regulate the DNA Damage Response

(2010) Z. Li et al.   CANCER RESEARCH

Cyclin D1/Cyclin-Dependent Kinase 4 Interacts with Filamin A and Affects the Migration and Invasion Potential of Breast Cancer Cells

(2010) Z. Zhong et al.   CANCER RESEARCH

Cell cycle proteins in epithelial cell differentiation: Implications for breast cancer

(2010) C. Elizabeth Caldon et al.   CELL CYCLE

Cycling through metabolism

(2010) Victor Aguilar et al.   EMBO Molecular Medicine

Phosphorylation of the PRC2 component Ezh2 is cell cycle-regulated and up-regulates its binding to ncRNA

(2010) S. Kaneko et al.   GENES & DEVELOPMENT

Transcriptional role of cyclin D1 in development revealed by a genetic–proteomic screen

(2010) Frédéric Bienvenu et al.   NATURE

The landscape of somatic copy-number alteration across human cancers

(2010) Rameen Beroukhim et al.   NATURE

Cyclin-dependent kinases regulate epigenetic gene silencing through phosphorylation of EZH2

(2010) Shuai Chen et al.   NATURE CELL BIOLOGY

Dynamics of Rad9 Chromatin Binding and Checkpoint Function Are Mediated by Its Dimerization and Are Cell Cycle–Regulated by CDK1 Activity

(2010) Magda Granata et al.   PLoS Genetics

Cdk1 Targets Srs2 to Complete Synthesis-Dependent Strand Annealing and to Promote Recombinational Repair

(2010) Marco Saponaro et al.   PLoS Genetics

Cyclin D1 promotes anchorage-independent cell survival by inhibiting FOXO-mediated anoikis

(2009) L Gan et al.   CELL DEATH AND DIFFERENTIATION

Cdk4/CyclinD1 Overexpression in Neural Stem Cells Shortens G1, Delays Neurogenesis, and Promotes the Generation and Expansion of Basal Progenitors

(2009) Christian Lange et al.   Cell Stem Cell

The Carboxyl Terminus of Brca2 Links the Disassembly of Rad51 Complexes to Mitotic Entry

(2009) Nabieh Ayoub et al.   CURRENT BIOLOGY

Cell cycle independent role of Cyclin E during neural cell fate specification in Drosophila is mediated by its regulation of Prospero function

(2009) Christian Berger et al.   DEVELOPMENTAL BIOLOGY

The CDK4–pRB–E2F1 pathway controls insulin secretion

(2009) Jean-Sébastien Annicotte et al.   NATURE CELL BIOLOGY

Cdk2 suppresses cellular senescence induced by the c-myc oncogene

(2009) Stefano Campaner et al.   NATURE CELL BIOLOGY

Phosphorylation by Cdk2 is required for Myc to repress Ras-induced senescence in cotransformation

(2009) P. Hydbring et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CDK Inhibitors: Cell Cycle Regulators and Beyond

(2008) Arnaud Besson et al.   DEVELOPMENTAL CELL

Alternate Cyclin D1 mRNA Splicing Modulates p27KIP1Binding and Cell Migration

(2008) Zhiping Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CDK targets Sae2 to control DNA-end resection and homologous recombination

(2008) Pablo Huertas et al.   NATURE

Cyclin D1 mediates resistance to apoptosis through upregulation of molecular chaperones and consequent redistribution of cell death regulators

(2008) G Roué et al.   ONCOGENE