MYC—Master Regulator of the Cancer Epigenome and Transcriptome

Highly effective combination of LSD1 (KDM1A) antagonist and pan-histone deacetylase inhibitor against human AML cells

(2017) W Fiskus et al.   LEUKEMIA

N-Myc Induces an EZH2-Mediated Transcriptional Program Driving Neuroendocrine Prostate Cancer

(2016) Etienne Dardenne et al.   CANCER CELL

Targeting Aberrant Epigenetic Networks Mediated by PRMT1 and KDM4C in Acute Myeloid Leukemia

(2016) Ngai Cheung et al.   CANCER CELL

MYC interaction with the tumor suppressive SWI/SNF complex member INI1 regulates transcription and cellular transformation

(2016) Angelina Stojanova et al.   CELL CYCLE

Pharmacological inhibition of LSD1 for the treatment of MLL-rearranged leukemia

(2016) Zizhen Feng et al.   Journal of Hematology & Oncology

Loss of p300 accelerates MDS-associated leukemogenesis

(2016) G Cheng et al.   LEUKEMIA

Preclinical activity of CPI-0610, a novel small-molecule bromodomain and extra-terminal protein inhibitor in the therapy of multiple myeloma

(2016) K T Siu et al.   LEUKEMIA

A Novel LSD1 Inhibitor T-3775440 Disrupts GFI1B-Containing Complex Leading to Transdifferentiation and Impaired Growth of AML Cells

(2016) Yoshinori Ishikawa et al.   MOLECULAR CANCER THERAPEUTICS

PIM1 kinase inhibition as a targeted therapy against triple-negative breast tumors with elevated MYC expression

(2016) Dai Horiuchi et al.   NATURE MEDICINE

A Myc-driven self-reinforcing regulatory network maintains mouse embryonic stem cell identity

(2016) Luca Fagnocchi et al.   Nature Communications

In Vivo Functional Platform Targeting Patient-Derived Xenografts Identifies WDR5-Myc Association as a Critical Determinant of Pancreatic Cancer

(2016) Alessandro Carugo et al.   Cell Reports

Decitabine improves outcomes in older patients with acute myeloid leukemia and higher blast counts

(2015) Tapan M. Kadia et al.   AMERICAN JOURNAL OF HEMATOLOGY

Decitabine improves progression-free survival in older high-risk MDS patients with multiple autosomal monosomies: results of a subgroup analysis of the randomized phase III study 06011 of the EORTC Leukemia Cooperative Group and German MDS Study Group

(2015) Michael Lübbert et al.   ANNALS OF HEMATOLOGY

Myc and its interactors take shape

(2015) William B. Tu et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Preparation of a mixed-matrix hydrogel of vorinostat for topical administration on the rats as experimental model

(2015) Wenwen Dai et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

BioID identifies novel c-MYC interacting partners in cultured cells and xenograft tumors

(2015) Dharmendra Dingar et al.   Journal of Proteomics

The Role of Histone Demethylase KDM4B in Myc Signaling in Neuroblastoma

(2015) Jun Yang et al.   JNCI-Journal of the National Cancer Institute

Interaction with WDR5 Promotes Target Gene Recognition and Tumorigenesis by MYC

(2015) Lance R. Thomas et al.   MOLECULAR CELL

Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia

(2015) Florian Grebien et al.   Nature Chemical Biology

Pre-Anchoring of Pin1 to Unphosphorylated c-Myc in a Fuzzy Complex Regulates c-Myc Activity

(2015) Sara Helander et al.   STRUCTURE

Tricyclic analogues of epidithiodioxopiperazine alkaloids with promising in vitro and in vivo antitumor activity

(2015) Marcus Baumann et al.   Chemical Science

Targeting p300 Addiction in CBP-Deficient Cancers Causes Synthetic Lethality by Apoptotic Cell Death due to Abrogation of MYC Expression

(2015) H. Ogiwara et al.   Cancer Discovery

Lysine-specific demethylase (LSD1/KDM1A) and MYCN cooperatively repress tumor suppressor genes in neuroblastoma

(2015) Stefano Amente et al.   Oncotarget

BRD4-targeted therapy induces Myc-independent cytotoxicity in Gnaq/11-mutatant uveal melanoma cells

(2015) Grazia Ambrosini et al.   Oncotarget

The Role of Histone Demethylase KDM4B in Myc Signaling in Neuroblastoma

(2015) Jun Yang et al.   JNCI-Journal of the National Cancer Institute

Histone acetyltransferase inhibitors block neuroblastoma cell growth in vivo

(2015) J M Gajer et al.   Oncogenesis

The interplay between histone deacetylases and c-Myc in the transcriptional suppression of HPP1 in colon cancer

(2014) Jian Wang et al.   CANCER BIOLOGY & THERAPY

MYC through miR-17-92 Suppresses Specific Target Genes to Maintain Survival, Autonomous Proliferation, and a Neoplastic State

(2014) Yulin Li et al.   CANCER CELL

BET Protein Inhibitor JQ1 Attenuates Myc-Amplified MCC Tumor Growth In Vivo

(2014) Q. Shao et al.   CANCER RESEARCH

Targeting MLL1 H3K4 Methyltransferase Activity in Mixed-Lineage Leukemia

(2014) Fang Cao et al.   MOLECULAR CELL

Selective transcriptional regulation by Myc in cellular growth control and lymphomagenesis

(2014) Arianna Sabò et al.   NATURE

Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles

(2014) Susanne Walz et al.   NATURE

The interaction of MYC with the trithorax protein ASH2L promotes gene transcription by regulating H3K27 modification

(2014) A. Ullius et al.   NUCLEIC ACIDS RESEARCH

Dynamic Rearrangement of F-Actin Is Required to Maintain the Antitumor Effect of Trichostatin A

(2014) Dong-Hee Yang et al.   PLoS One

BET and HDAC inhibitors induce similar genes and biological effects and synergize to kill in Myc-induced murine lymphoma

(2014) Joydeep Bhadury et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rational design and validation of a Tip60 histone acetyltransferase inhibitor

(2014) Chunxia Gao et al.   Scientific Reports

MYC and Transcription Elongation

(2014) P. B. Rahl et al.   Cold Spring Harbor Perspectives in Medicine

Polycomb repressive complex 2 (PRC2) suppresses E -myc lymphoma

(2013) S. C. W. Lee et al.   BLOOD

Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers

(2013) Jakob Lovén et al.   CELL

BET Bromodomain Inhibition of MYC-Amplified Medulloblastoma

(2013) P. Bandopadhayay et al.   CLINICAL CANCER RESEARCH

Histone methyltransferaseSuv39h1deficiency preventsMyc-induced chromosomal instability in murine myeloid leukemias

(2013) Beate Vajen et al.   GENES CHROMOSOMES & CANCER

Physical Interaction between MYCN Oncogene and Polycomb Repressive Complex 2 (PRC2) in Neuroblastoma

(2013) Daisy Corvetta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Decitabine represses translocatedMYConcogene in Burkitt lymphoma

(2013) Hanfeng Guan et al.   JOURNAL OF PATHOLOGY

Quantitative Dissection and Stoichiometry Determination of the Human SET1/MLL Histone Methyltransferase Complexes

(2013) R. van Nuland et al.   MOLECULAR AND CELLULAR BIOLOGY

Distinct and Combinatorial Functions of Jmjd2b/Kdm4b and Jmjd2c/Kdm4c in Mouse Embryonic Stem Cell Identity

(2013) Partha Pratim Das et al.   MOLECULAR CELL

Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy

(2013) Cigall Kadoch et al.   NATURE GENETICS

Coordinated Silencing of MYC-Mediated miR-29 by HDAC3 and EZH2 as a Therapeutic Target of Histone Modification in Aggressive B-Cell Lymphomas

(2012) Xinwei Zhang et al.   CANCER CELL

Transcriptional Amplification in Tumor Cells with Elevated c-Myc

(2012) Charles Y. Lin et al.   CELL

MYC on the Path to Cancer

(2012) Chi V. Dang   CELL

EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations

(2012) Michael T. McCabe et al.   NATURE

The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

(2012) Jinghui Zhang et al.   NATURE

Characterisation of a Tip60 Specific Inhibitor, NU9056, in Prostate Cancer

(2012) Kelly Coffey et al.   PLoS One

The Origin and Nature of Tightly Clustered BTG1 Deletions in Precursor B-Cell Acute Lymphoblastic Leukemia Support a Model of Multiclonal Evolution

(2012) Esmé Waanders et al.   PLoS Genetics

Intrathecal 5-azacytidine inhibits global DNA methylation and methyl- CpG-binding protein 2 expression and alleviates neuropathic pain in rats following chronic constriction injury

(2011) Ying Wang et al.   BRAIN RESEARCH

BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc

(2011) Jake E. Delmore et al.   CELL

High frequency of BTG1 deletions in acute lymphoblastic leukemia in children with down syndrome

(2011) Catarina Lundin et al.   GENES CHROMOSOMES & CANCER

Loss of Dnmt3b function upregulates the tumor modifier Ment and accelerates mouse lymphomagenesis

(2011) Ryan A. Hlady et al.   JOURNAL OF CLINICAL INVESTIGATION

Myc Regulates the Transcription of the PRC2 Gene To Control the Expression of Developmental Genes in Embryonic Stem Cells

(2011) F. Neri et al.   MOLECULAR AND CELLULAR BIOLOGY

Pim1 promotes human prostate cancer cell tumorigenicity and c-MYC transcriptional activity

(2010) Jongchan Kim et al.   BMC CANCER

Tumor Stroma-Derived TGF-β Limits Myc-Driven Lymphomagenesis via Suv39h1-Dependent Senescence

(2010) Maurice Reimann et al.   CANCER CELL

c-Myc Regulates Transcriptional Pause Release

(2010) Peter B. Rahl et al.   CELL

TGFβ-dependent gene expression shows that senescence correlates with abortive differentiation along several lineages in Myc-induced lymphomas

(2010) Judith Müller et al.   CELL CYCLE

The interaction between Myc and Miz1 is required to antagonize TGF -dependent autocrine signaling during lymphoma formation and maintenance

(2010) J. van Riggelen et al.   GENES & DEVELOPMENT

The regulatory role of c-MYC on HDAC2 and PcG expression in human multipotent stem cells

(2010) Dilli Ram Bhandari et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Lysine Methylation Regulates E2F1-Induced Cell Death

(2010) Haroula Kontaki et al.   MOLECULAR CELL

Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders

(2010) Thomas Ernst et al.   NATURE GENETICS

Transcriptional upregulation of histone deacetylase 2 promotes Myc-induced oncogenic effects

(2010) G M Marshall et al.   ONCOGENE

LSD1-mediated demethylation of histone H3 lysine 4 triggers Myc-induced transcription

(2010) S Amente et al.   ONCOGENE

Pim1 kinase synergizes with c-MYC to induce advanced prostate carcinoma

(2010) J Wang et al.   ONCOGENE

Sin3B Expression Is Required for Cellular Senescence and Is Up-regulated upon Oncogenic Stress

(2009) K. B. Grandinetti et al.   CANCER RESEARCH

DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation

(2009) T. B. Miranda et al.   MOLECULAR CANCER THERAPEUTICS

Epigenetic Silencing of the RASSF1A Tumor Suppressor Gene through HOXB3-Mediated Induction of DNMT3B Expression

(2009) Rajendra Kumar Palakurthy et al.   MOLECULAR CELL

Mechanisms of Polycomb gene silencing: knowns and unknowns

(2009) Jeffrey A. Simon et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors

(2008) Nagma Khan et al.   BIOCHEMICAL JOURNAL

Aberrant DNA methylation is a dominant mechanism in MDS progression to AML

(2008) Y. Jiang et al.   BLOOD

N-Myc Regulates a Widespread Euchromatic Program in the Human Genome Partially Independent of Its Role as a Classical Transcription Factor

(2008) R. Cotterman et al.   CANCER RESEARCH

Myc-Mediated Transcriptional Repression by Recruitment of Histone Deacetylase

(2008) J. F. Kurland et al.   CANCER RESEARCH

Induction of a novel histone deacetylase 1/c-Myc/Mnt/Max complex formation is implicated in parity-induced refractoriness to mammary carcinogenesis

(2008) Yoichiro Matsuoka et al.   CANCER SCIENCE

A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse

(2008) G. Schotta et al.   GENES & DEVELOPMENT

MYCtranslocation and an increased copy number predict poor prognosis in adult diffuse large B-cell lymphoma (DLBCL), especially in germinal centre-like B cell (GCB) type

(2008) S O Yoon et al.   HISTOPATHOLOGY

Ezh2 Requires PHF1 To Efficiently Catalyze H3 Lysine 27 Trimethylation In Vivo

(2008) K. Sarma et al.   MOLECULAR AND CELLULAR BIOLOGY

Ezh1 and Ezh2 Maintain Repressive Chromatin through Different Mechanisms

(2008) Raphael Margueron et al.   MOLECULAR CELL

Pim kinase-dependent inhibition of c-Myc degradation

(2008) Y Zhang et al.   ONCOGENE

Analysis of Myc-Induced Histone Modifications on Target Chromatin

(2008) Francesca Martinato et al.   PLoS One

Specific requirement of the chromatin modifier mSin3B in cell cycle exit and cellular differentiation

(2008) G. David et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Combined Analysis of Murine and Human Microarrays and ChIP Analysis Reveals Genes Associated with the Ability of MYC To Maintain Tumorigenesis

(2008) Chi-Hwa Wu et al.   PLoS Genetics