Article
Pharmacology & Pharmacy
Xiaozhen Gu, Nan Shen, Chengqing Huang, Hui-Li Wang
Summary: Lead exposure inhibits the differentiation of C2C12 myoblasts by regulating HDAC2.
Article
Biochemistry & Molecular Biology
Maozhi Hu, Yibei Zhang, Dan Gu, Xiang Chen, Matthew K. Waldor, Xiaohui Zhou
Summary: The study revealed that the T3SS effector VgpA in Vibrio parahaemolyticus interacts with the host cell nucleolus protein EBP2, leading to re-localization of c-Myc and increased cell proliferation. This interaction enhances EBP2 affinity for c-Myc, prolonging the oncoprotein's half-life and ultimately contributing to the pathogenesis of V. parahaemolyticus infection.
Article
Biochemistry & Molecular Biology
Zhiyuan Yan, Qiansong He
Summary: LINC01234, miR-513a-5p, and AOX1 play crucial roles in the progression of osteoporosis by regulating osteogenic differentiation and proliferation of human bone marrow mesenchymal stem cells (hMSCs). LINC01234 suppression inhibits osteogenic differentiation, while miR-513a-5p enhances osteogenic differentiation by modulating AOX1. These findings provide a new theoretical basis for the treatment of osteoporosis.
MOLECULAR BIOTECHNOLOGY
(2023)
Article
Oncology
Siyu Gu, Yue Hou, Katarina Dovat, Sinisa Dovat, Chunhua Song, Zheng Ge
Summary: This study investigated the synergistic effect and mechanism of combining Chidamide, a histone deacetylase inhibitor, with Cladribine, a purine nucleoside analog, in Acute myeloid leukemia (AML). The combination showed significant inhibitory effects on cell proliferation, cell cycle arrest, and apoptosis in AML cell lines and primary AML cells. The underlying mechanism involves targeting the HDAC2/c-Myc/RCC1 signaling pathway in AML.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2023)
Article
Cell Biology
Rui Chen, Si Lei, Yanling She, Shanyao Zhou, Huacai Shi, Cheng Li, Ting Jiang
Summary: The study investigated the role of a novel long non-coding RNA, lnc-GD2H, in promoting C2C12 myoblast proliferation, differentiation, and muscle regeneration. Results revealed that lnc-GD2H promoted myoblast proliferation and differentiation through various pathways, providing a potential target for therapeutic interventions in muscle disorders.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Xichen Wan, Songjiao Zhao, Yiqin Dai, Jing Zhang, Yan Shen, Lan Gong, Qihua Le
Summary: Our study demonstrated that WNT16b enhances the proliferation and maintains the stemness of hLESCs through the activation of the non-canonical calcium/calcineurin A/NFATC2 pathway in vitro and in vivo. WNT16b binds with Frizzled7, promotes the release of Ca2+, and activates calcineurin A and NFATC2, leading to the increased expression of H3K4me3, H3K14ac, and H3K27ac in the promoter regions of FoxM1 and c-MYC. This study also showed that WNT16b-co-incubated hLESCs can reconstruct a stable ocular surface and inhibit corneal neovascularization in mice with LSCD.
CELL PROLIFERATION
(2023)
Article
Oncology
Dapeng Li, Changyu Yao, Zhao Ding, Ping Liu, Xue Chen, Weiwei Liu, Fangzheng Yi, Chuanya Jiang, Hongwu Li, Yehai Liu, Jing Wu
Summary: The study reveals that PES1 expression is associated with prognosis and tumour growth in head and neck squamous cell carcinoma. It also plays a role in drug resistance and may serve as a potential cancer marker and therapeutic target for HNSCC.
Article
Cardiac & Cardiovascular Systems
Aleksandra Boikova, Megan J. Bywater, Gregory A. Quaife-Ryan, Jasmin Straube, Lucy Thompson, Camilla Ascanelli, Trevor D. Littlewood, Gerard I. Evan, James E. Hudson, Catherine H. Wilson
Summary: The study reveals that Myc and HRas can cooperate to induce proliferation in adult mammalian cardiomyocytes, but the activity of HRas also leads to cell death, limiting its potential as a regenerative therapeutic target.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cell Biology
Pengxiang Min, Lin Zhang, Yueyuan Wang, Chenxiang Qi, Yixuan Song, Maria Bibi, Yujie Zhang, Yadong Ma, Xuyang Zhao, Minjie Yu, Jun Du
Summary: The study showed that MICAL-L2 is highly expressed in human NSCLC and plays a role in promoting cancer cell proliferation by interacting with and stabilizing c-Myc protein. Depletion of MICAL-L2 led to reduced c-Myc stability and decreased cancer cell proliferation. This suggests that MICAL-L2 may be a potential therapeutic target for NSCLC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Jiang Jiang, Jianfang Li, Weiwu Yao, Wenfang Wang, Bowen Shi, Fei Yuan, Jingyan Dong, Huan Zhang
Summary: FOXC1 is highly expressed in patients with gastric cancer and is associated with poor prognosis by promoting the activation of the Wnt signaling pathway and regulating DKK1 expression, ultimately leading to the proliferation of GC cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Wei Fan, Xiaoling Li
Summary: SIRT1 is a crucial NAD(+)-dependent protein deacetylase in mammals, involved in the metabolic and epigenetic regulation of stem cells through deacetylation of transcriptional factors and co-factors. It forms a positive feedback loop with c-Myc, which is important in tumorigenesis. Recent research has uncovered the significance of the SIRT1-c-Myc axis in the regulation of maintenance and differentiation of various stem cells. This review highlights the recent advances in understanding the role of the SIRT1-c-Myc axis in stem cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Liyuan Wang, Chan Chen, Zemin Song, Honghong Wang, Minghui Ye, Donghai Wang, Wenqian Kang, Hudan Liu, Guoliang Qing
Summary: This study demonstrates that EZH2 directly interacts with MYC and MYCN, promoting their stabilization in a methyltransferase-independent manner. By competing against SCFFBW7 ubiquitin ligase, EZH2 counteracts the degradation of MYC and MYCN, highlighting their role as global oncogenic effectors of EZH2. This research suggests that pharmacologic degradation of EZH2 may be a potential therapeutic approach for MYC-driven cancers.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Mai Nagasaka, Yasumichi Inoue, Manaka Yoshida, Chiharu Miyajima, Daisuke Morishita, Muneshige Tokugawa, Haruna Nakamoto, Mayumi Sugano, Nobumichi Ohoka, Hidetoshi Hayashi
Summary: This study identifies a novel role for the deubiquitinating enzyme USP17 in regulating the stability of c-Myc, suggesting its potential as a therapeutic target for cancer treatment.
Article
Biochemistry & Molecular Biology
Junhong Li, Fangning Wan, Junyu Zhang, Shengfeng Zheng, Yunjie Yang, Zhe Hong, Bo Dai
Summary: SMYD2 is involved in various cancers by methylating histone H3K4 and H3K36. Higher SMYD2 expression is associated with an increased risk of prostate cancer progression and relapse. Inhibition of SMYD2 restrains prostate cancer cell proliferation.
MOLECULAR CARCINOGENESIS
(2023)
Article
Medicine, Research & Experimental
Lingxiao Huang, Zhenni Xu, Xudan Lei, Yujun Huang, Siyu Tu, Lu Xu, Jieying Xia, Dengqun Liu
Summary: This study reveals the important role of inducible nitric oxide synthase (iNOS) in the intestinal crypts and its effects on intestinal stem cell (ISC) proliferation and differentiation. iNOS deficiency leads to morphological changes in the intestine and alters gluconeogenesis and the adaptive immune response. These findings highlight the potential of iNOS as a therapeutic target for intestinal disorders.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Veterinary Sciences
Duree Shin, Aryung Nam, Kun Ho Song, Kyoung Won Seo
JOURNAL OF FELINE MEDICINE AND SURGERY
(2019)
Article
Cell & Tissue Engineering
Yeonsil Yu, Sae Mi Yo, Hwan Hee Park, Song Yi Baek, Yoon-Jin Kim, Seunghee Lee, Yu Lee Kim, Kwang-Won Seo, Kyung-Sun Kang
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2019)
Article
Veterinary Sciences
Hyebin Wang, Aryung Nam, Kunho Song, Hwa Young Youn, Kyoung Won Seo
JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE
(2020)
Article
Veterinary Sciences
Hye Young Kim, Aryung Nam, Kun Ho Song, Hwa Young Youn, Kyoung Won Seo
JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE
(2020)
Article
Veterinary Sciences
Duri Song, Ye-In Oh, Jeong-Mi Kim, Doo-Sung Cheon, Dae-Yong Kim, Kyoung-Won Seo
VETERINARY MEDICINE AND SCIENCE
(2020)
Article
Veterinary Sciences
Yi-Kyeong Jeong, Ye-In Oh, Kun-Ho Song, Kyoung Won Seo
BMC VETERINARY RESEARCH
(2020)
Article
Veterinary Sciences
Jae-Geum Cho, Ye-In Oh, Kun-Ho Song, Kyoung-Won Seo
Summary: This study found that in the infection group, median levels of procalcitonin and absolute neutrophil count were significantly higher than in the normal group, while heparin-binding protein levels showed no significant difference. A procalcitonin level >366 pg/ml was a better biomarker of bacterial infection, compared to heparin-binding protein and absolute neutrophil count.
JOURNAL OF FELINE MEDICINE AND SURGERY
(2021)
Article
Veterinary Sciences
Sookin Nam, Tae-won Kim, Kun-ho Song, Edward C. Feldman, Kyoung-won Seo
Summary: This study analyzed the accuracy of trilostane strength in medication packets filled by hand and using a semi-automatic packing device in veterinary clinics in Korea. The results showed that only 40.9% of trilostane-containing packets had acceptable strength, potentially impacting the treatment response for hyperadrenocorticism in dogs.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2021)
Article
Veterinary Sciences
Da Sol Park, Jongbok Lee, Kun-Ho Song, Kyoung Won Seo
Summary: This is a case report of a cat with acute feline erythroleukaemia and FeLV infection, treated with high-dose cytarabine chemotherapy. While the clinical signs and anaemia improved after treatment, the overall survival time was short, indicating the treatment was not effective. Further studies on erythroleukaemia chemotherapy protocols are necessary.
VETERINARY MEDICINE AND SCIENCE
(2022)
Article
Veterinary Sciences
Aryung Nam, Woo-Jin Song, Ju-Hyun An, Robert B. Rebhun, Hwa-Young Youn, Kyoung-Won Seo
Summary: This study reveals that the Hh/SMO signaling pathway is activated in canine OSA cell lines and that cyclopamine suppresses the survival of OSA cells by inhibiting SMO. This suggests that the Hh/SMO signaling pathway could be a potential therapeutic target for canine OSA.
VETERINARY AND COMPARATIVE ONCOLOGY
(2022)
Article
Veterinary Sciences
Hyung-Kyu Chae, Ye-In Oh, Sumin Park, Ju-Hyun An, Kyoungwon Seo, Kyuyong Kang, Seung-nam Chu, Hwa-Young Youn
Summary: This study retrospectively evaluated the efficacy and safety of oral paclitaxel in dogs with various cancers. The results showed good response rates in certain cancer types and minimal adverse events. Therefore, oral paclitaxel could be a viable option for managing cancer in dogs.
VETERINARY MEDICINE AND SCIENCE
(2022)
Article
Veterinary Sciences
Jae-Hyeon Im, Su-Min Park, Ju-Hyun An, Tea-Hee Kim, Hyung-Kyu Chae, Ye-In Oh, Kyoung-Won Seo, Hwa-Young Youn
Summary: This study aimed to assess the correlation between serum IL-2R and B2M concentrations and the diagnosis and prognosis of canine lymphoma. Results showed that IL-2R concentrations were significantly elevated at the time of lymphoma diagnosis, but B2M concentrations were not. In relapsed dogs, both IL-2R and B2M concentrations were significantly higher than in the control and chemotherapy response groups. Monitoring serum B2M concentration seems to be useful for predicting relapse.
VETERINARY AND COMPARATIVE ONCOLOGY
(2023)
Article
Veterinary Sciences
Jongbok Lee, Jung Keun Lee, Jawon Kim, Ul Soo Choi, Kyoung Won Seo
VETERINARY MEDICINE AND SCIENCE
(2020)
Article
Veterinary Sciences
Jun-Seok Park, Jae-Hong Park, Kyoung-Won Seo, Kun-Ho Song
JOURNAL OF VETERINARY SCIENCE
(2019)
Article
Veterinary Sciences
Hwa-Ran Hong, Ye-In Oh, Young Jun Kim, Kyoung-Won Seo
JOURNAL OF VETERINARY SCIENCE
(2019)