Histone MacroH2A1: A Chromatin Point of Intersection between Fasting, Senescence and Cellular Regeneration

Induction of cancer cell stemness by depletion of macrohistone H2A1 in hepatocellular carcinoma

(2018) Oriana Lo Re et al.   HEPATOLOGY

MacroH2A histone variants maintain nuclear organization and heterochromatin architecture

(2017) Julien Douet et al.   JOURNAL OF CELL SCIENCE

Variants of core histones and their roles in cell fate decisions, development and cancer

(2017) Marcus Buschbeck et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

MacroH2A1.1 regulates mitochondrial respiration by limiting nuclear NAD+ consumption

(2017) Melanija Posavec Marjanović et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

MacroH2A1.1 cooperates with EZH2 to promote adipogenesis by regulating Wnt signaling

(2017) Danyang Wan et al.   Journal of Molecular Cell Biology

MacroH2A1.1 regulates mitochondrial respiration by limiting nuclear NAD+ consumption

(2017) Melanija Posavec Marjanović et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DNA Hypomethylation and Histone Variant macroH2A1 Synergistically Attenuate Chemotherapy-Induced Senescence to Promote Hepatocellular Carcinoma Progression

(2016) M. Borghesan et al.   CANCER RESEARCH

Efficacy and epigenetic interactions of novel DNA hypomethylating agent guadecitabine (SGI-110) in preclinical models of hepatocellular carcinoma

(2016) Simone Jueliger et al.   Epigenetics

The characterization of macroH2A beyond vertebrates supports an ancestral origin and conserved role for histone variants in chromatin

(2016) Ciro Rivera-Casas et al.   Epigenetics

The poly(ADP-ribose)-dependent chromatin remodeler Alc1 induces local chromatin relaxation upon DNA damage

(2016) Hafida Sellou et al.   MOLECULAR BIOLOGY OF THE CELL

Histone macroH2A1.2 promotes metabolic health and leanness by inhibiting adipogenesis

(2016) Valerio Pazienza et al.   Epigenetics & Chromatin

Epigenetic clock analyses of cellular senescence and ageing

(2016) Donna Lowe et al.   Oncotarget

The Histone Variant MacroH2A1.2 Is Necessary for the Activation of Muscle Enhancers and Recruitment of the Transcription Factor Pbx1

(2016) Stefania Dell’Orso et al.   Cell Reports

SIRT1-metabolite binding histone macroH2A1.1 protects hepatocytes against lipid accumulation

(2016) Valerio Pazienza et al.   Aging-US

A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan

(2015) Sebastian Brandhorst et al.   Cell Metabolism

MacroH2A1 isoforms are associated with epigenetic markers for activation of lipogenic genes in fat-induced steatosis

(2015) Christine Podrini et al.   FASEB JOURNAL

ATM, MacroH2A.1, and SASP: The Checks and Balances of Cellular Senescence

(2015) Marek Kozlowski et al.   MOLECULAR CELL

MacroH2A1 and ATM Play Opposing Roles in Paracrine Senescence and the Senescence-Associated Secretory Phenotype

(2015) Hongshan Chen et al.   MOLECULAR CELL

MacroH2A1 downregulation enhances the stem-like properties of bladder cancer cells by transactivation of Lin28B

(2015) S-J Park et al.   ONCOGENE

CHD1L Regulated PARP1-Driven Pluripotency and Chromatin Remodeling During the Early-Stage Cell Reprogramming

(2015) Bo-Hua Jiang et al.   STEM CELLS

MacroH2A1 associates with nuclear lamina and maintains chromatin architecture in mouse liver cells

(2015) Yuhua Fu et al.   Scientific Reports

Histone Chaperones: Assisting Histone Traffic and Nucleosome Dynamics

(2014) Zachary A. Gurard-Levin et al.   Annual Review of Biochemistry

Histone H3 Variants and Their Chaperones During Development and Disease: Contributing to Epigenetic Control

(2014) Dan Filipescu et al.   Annual Review of Cell and Developmental Biology

Histone variants and lipid metabolism

(2014) Michela Borghesan et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Prolonged Fasting Reduces IGF-1/PKA to Promote Hematopoietic-Stem-Cell-Based Regeneration and Reverse Immunosuppression

(2014) Chia-Wei Cheng et al.   Cell Stem Cell

Genetic ablation of macrohistone H2A1 leads to increased leanness, glucose tolerance and energy expenditure in mice fed a high-fat diet

(2014) F Sheedfar et al.   INTERNATIONAL JOURNAL OF OBESITY

Mice without MacroH2A Histone Variants

(2014) J. R. Pehrson et al.   MOLECULAR AND CELLULAR BIOLOGY

The Histone Variant MacroH2A1 Regulates Target Gene Expression in Part by Recruiting the Transcriptional Coregulator PELP1

(2014) K. M. Hussey et al.   MOLECULAR AND CELLULAR BIOLOGY

MacroH2A1.1 and PARP-1 cooperate to regulate transcription by promoting CBP-mediated H2B acetylation

(2014) Hongshan Chen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Photoactivation of Endogenous Latent Transforming Growth Factor- 1 Directs Dental Stem Cell Differentiation for Regeneration

(2014) P. R. Arany et al.   Science Translational Medicine

Environmental responses mediated by histone variants

(2014) Paul B. Talbert et al.   TRENDS IN CELL BIOLOGY

MacroH2A – An epigenetic regulator of cancer

(2013) Neus Cantariño et al.   CANCER LETTERS

Inflammation and cancer stem cells

(2013) Sarah Shigdar et al.   CANCER LETTERS

Senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning

(2013) Mekayla Storer et al.   CELL

Macro domains as metabolite sensors on chromatin

(2013) Melanija Posavec et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Histone variants in pluripotency and disease

(2013) P. J. Skene et al.   DEVELOPMENT

Visualization of inactive X chromosome in preimplantation embryos utilizing MacroH2A-EGFP transgenic mouse

(2013) Atsumi Soma et al.   GENESIS

Macro Histone Variants Are Critical for the Differentiation of Human Pluripotent Cells

(2013) María J. Barrero et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Role of NF-κB Signaling in the Maintenance of Pluripotency of Human Induced Pluripotent Stem Cells

(2013) Osamu Takase et al.   PLoS One

Correction: Immunopositivity for Histone MacroH2A1 Isoforms Marks Steatosis-Associated Hepatocellular Carcinoma

(2013) Francesca Rappa et al.   PLoS One

MacroH2A histone variants act as a barrier upon reprogramming towards pluripotency

(2013) Alexandre Gaspar-Maia et al.   Nature Communications

Macrohistone Variants Preserve Cell Identity by Preventing the Gain of H3K4me2 during Reprogramming to Pluripotency

(2013) María J. Barrero et al.   Cell Reports

DNA methylation age of human tissues and cell types

(2013) Steve Horvath   GENOME BIOLOGY

Differential Regulation and Predictive Potential of MacroH2A1 Isoforms in Colon Cancer

(2012) Judith C. Sporn et al.   AMERICAN JOURNAL OF PATHOLOGY

ATRX-mediated chromatin association of histone variant macroH2A1 regulates  -globin expression

(2012) K. Ratnakumar et al.   GENES & DEVELOPMENT

Histone variant macroH2A marks embryonic differentiation in vivo and acts as an epigenetic barrier to induced pluripotency

(2012) V. Pasque et al.   JOURNAL OF CELL SCIENCE

MacroH2A1 Regulates the Balance between Self-Renewal and Differentiation Commitment in Embryonic and Adult Stem Cells

(2012) C. Creppe et al.   MOLECULAR AND CELLULAR BIOLOGY

Splicing switch of an epigenetic regulator by RNA helicases promotes tumor-cell invasiveness

(2012) Etienne Dardenne et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

MacroH2A in stem cells: a story beyond gene repression

(2012) Catherine Creppe et al.   Epigenomics

QKI-Mediated Alternative Splicing of the Histone Variant MacroH2A1 Regulates Cancer Cell Proliferation

(2011) L. Novikov et al.   MOLECULAR AND CELLULAR BIOLOGY

DNA Repair Factor APLF Is a Histone Chaperone

(2011) Pawan Vinod Mehrotra et al.   MOLECULAR CELL

Histone Variants and Their Post-Translational Modifications in Primary Human Fat Cells

(2011) Åsa Jufvas et al.   PLoS One

Epigenetic factors influencing resistance to nuclear reprogramming

(2011) Vincent Pasque et al.   TRENDS IN GENETICS

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Rapid Elimination of the Histone Variant MacroH2A from Somatic Cell Heterochromatin after Nuclear Transfer

(2010) Ching-Chien Chang et al.   Cellular Reprogramming

Genome-Wide Distribution of MacroH2A1 Histone Variants in Mouse Liver Chromatin

(2010) L. N. Changolkar et al.   MOLECULAR AND CELLULAR BIOLOGY

The histone variant macroH2A suppresses melanoma progression through regulation of CDK8

(2010) Avnish Kapoor et al.   NATURE

Histone variants — ancient wrap artists of the epigenome

(2010) Paul B. Talbert et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Histone variant macroH2A1 deletion in mice causes female-specific steatosis

(2010) Mathieu Boulard et al.   Epigenetics & Chromatin

The histone variant macroH2A1 marks repressed autosomal chromatin, but protects a subset of its target genes from silencing

(2009) M. J. Gamble et al.   GENES & DEVELOPMENT

Hepatic epigenetic phenotype predetermines individual susceptibility to hepatic steatosis in mice fed a lipogenic methyl-deficient diet

(2009) Igor P. Pogribny et al.   JOURNAL OF HEPATOLOGY

A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation

(2009) Gyula Timinszky et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The histone variant macroH2A is an epigenetic regulator of key developmental genes

(2009) Marcus Buschbeck et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Histone macroH2A isoforms predict the risk of lung cancer recurrence

(2009) J C Sporn et al.   ONCOGENE

Control of NF- B-dependent Transcriptional Responses by Chromatin Organization

(2009) G. Natoli   Cold Spring Harbor Perspectives in Biology

Weak but Uniform Enrichment of the Histone Variant macroH2A1 along the Inactive X Chromosome

(2008) F. Mietton et al.   MOLECULAR AND CELLULAR BIOLOGY

A phosphorylated subpopulation of the histone variant macroH2A1 is excluded from the inactive X chromosome and enriched during mitosis

(2008) E. Bernstein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA