Efficacy and epigenetic interactions of novel DNA hypomethylating agent guadecitabine (SGI-110) in preclinical models of hepatocellular carcinoma

DNA Hypomethylation and Histone Variant macroH2A1 Synergistically Attenuate Chemotherapy-Induced Senescence to Promote Hepatocellular Carcinoma Progression

(2016) M. Borghesan et al.   CANCER RESEARCH

SIRT1-metabolite binding histone macroH2A1.1 protects hepatocytes against lipid accumulation

(2016) Valerio Pazienza et al.   Aging-US

Interventions to Slow Aging in Humans: Are We Ready?

(2015) Valter D. Longo et al.   AGING CELL

An international consortium proposal of uniform response criteria for myelodysplastic/myeloproliferative neoplasms (MDS/MPN) in adults

(2015) M. R. Savona et al.   BLOOD

Molecular Pathways: At the Crossroads of Cancer Epigenetics and Immunotherapy

(2015) M. Maio et al.   CLINICAL CANCER RESEARCH

Immunomodulatory action of the DNA methyltransferase inhibitor SGI-110 in epithelial ovarian cancer cells and xenografts

(2015) Pragya Srivastava et al.   Epigenetics

MacroH2A1 isoforms are associated with epigenetic markers for activation of lipogenic genes in fat-induced steatosis

(2015) Christine Podrini et al.   FASEB JOURNAL

DNA methylation-based prognosis and epidrivers in hepatocellular carcinoma

(2015) Augusto Villanueva et al.   HEPATOLOGY

Safety and tolerability of guadecitabine (SGI-110) in patients with myelodysplastic syndrome and acute myeloid leukaemia: a multicentre, randomised, dose-escalation phase 1 study

(2015) Jean-Pierre J Issa et al.   LANCET ONCOLOGY

Guadecitabine (SGI-110) priming sensitizes hepatocellular carcinoma cells to oxaliplatin

(2015) Yuting Kuang et al.   Molecular Oncology

Histone Variants and Epigenetics

(2015) Steven Henikoff et al.   Cold Spring Harbor Perspectives in Biology

Fasting cycles potentiate the efficacy of gemcitabine treatment in in vitro and in vivo pancreatic cancer models

(2015) Martina D’Aronzo et al.   Oncotarget

Amphiregulin activates human hepatic stellate cells and is upregulated in non alcoholic steatohepatitis

(2015) Chad McKee et al.   Scientific Reports

Characterization of hepatic lipid profiles in a mouse model with nonalcoholic steatohepatitis and subsequent fibrosis

(2015) Kosuke Saito et al.   Scientific Reports

High cytidine deaminase expression in the liver provides sanctuary for cancer cells from decitabine treatment effects

(2015) Quteba Ebrahem et al.   Oncotarget

Histone variants and lipid metabolism

(2014) Michela Borghesan et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The Novel, Small-Molecule DNA Methylation Inhibitor SGI-110 as an Ovarian Cancer Chemosensitizer

(2014) F. Fang et al.   CLINICAL CANCER RESEARCH

Epigenetics in liver disease

(2014) Derek A. Mann   HEPATOLOGY

Normalization of a NAFLD gene expression signature

(2014) Manlio Vinciguerra   HEPATOLOGY

SGI-110 and entinostat therapy reduces lung tumor burden and reprograms the epigenome

(2014) Carmen S. Tellez et al.   INTERNATIONAL JOURNAL OF CANCER

Immunomodulatory action of SGI-110, a hypomethylating agent, in acute myeloid leukemia cells and xenografts

(2014) Pragya Srivastava et al.   LEUKEMIA RESEARCH

HCC—subtypes, stratification and sorafenib

(2014) Gregory J. Gores   Nature Reviews Gastroenterology & Hepatology

Liver diseases and aging: friends or foes?

(2013) Fareeba Sheedfar et al.   AGING CELL

MacroH2A – An epigenetic regulator of cancer

(2013) Neus Cantariño et al.   CANCER LETTERS

Relationship Between Methylome and Transcriptome in Patients With Nonalcoholic Fatty Liver Disease

(2013) Susan K. Murphy et al.   GASTROENTEROLOGY

Genome-Wide Methylation Analysis and Epigenetic Unmasking Identify Tumor Suppressor Genes in Hepatocellular Carcinoma

(2013) Kate Revill et al.   GASTROENTEROLOGY

Hepatic gene expression profiles differentiate presymptomatic patients with mild versus severe nonalcoholic fatty liver disease

(2013) Cynthia A. Moylan et al.   HEPATOLOGY

Differential Induction of Apoptosis and Senescence by the DNA Methyltransferase Inhibitors 5-Azacytidine and 5-Aza-2'-Deoxycytidine in Solid Tumor Cells

(2013) S. Venturelli et al.   MOLECULAR CANCER THERAPEUTICS

Immunopositivity for Histone MacroH2A1 Isoforms Marks Steatosis-Associated Hepatocellular Carcinoma

(2013) Francesca Rappa et al.   PLoS One

Immunomodulatory activity of SGI-110, a 5-aza-2′-deoxycytidine-containing demethylating dinucleotide

(2012) Sandra Coral et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Molecular mechanisms of sorafenib action in liver cancer cells

(2012) Melchiorre Cervello et al.   CELL CYCLE

DNA Methyltransferases 1 and 3b Expression in Huh-7 Cells Expressing HCV Core Protein of Different Genotypes

(2012) Giorgia Benegiamo et al.   DIGESTIVE DISEASES AND SCIENCES

Dilated cardiomyopathy and mitochondrial dysfunction in Sirt1-deficient mice: A role for Sirt1-Mef2 in adult heart

(2012) A. Planavila et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

DNMT1-mediated PTEN hypermethylation confers hepatic stellate cell activation and liver fibrogenesis in rats

(2012) Er-Bao Bian et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Effects of tetrahydrouridine on pharmacokinetics and pharmacodynamics of oral decitabine

(2011) D. Lavelle et al.   BLOOD

QKI-Mediated Alternative Splicing of the Histone Variant MacroH2A1 Regulates Cancer Cell Proliferation

(2011) L. Novikov et al.   MOLECULAR AND CELLULAR BIOLOGY

Hypermethylated levels of E-cadherin promoter in Huh-7 cells expressing the HCV core protein

(2011) Maria Ripoli et al.   VIRUS RESEARCH

Dual antitumour effect of 5-azacytidine by inducing a breakdown of resistance-mediating factors and epigenetic modulation

(2010) S. Venturelli et al.   GUT

Synergism between DNA methylation and macroH2A1 occupancy in epigenetic silencing of the tumor suppressor gene p16(CDKN2A)

(2010) Michal Barzily-Rokni et al.   NUCLEIC ACIDS RESEARCH