Adenosine signaling during acute and chronic disease states

A Novel Molecular Signature for Elevated Tricuspid Regurgitation Velocity in Sickle Cell Disease

(2012) Ankit A. Desai et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The A2B adenosine receptor modulates pulmonary hypertension associated with interstitial lung disease

(2012) Harry Karmouty-Quintana et al.   FASEB JOURNAL

Equilibrative nucleoside transporter 1 (ENT1) regulates postischemic blood flow during acute kidney injury in mice

(2012) Almut Grenz et al.   JOURNAL OF CLINICAL INVESTIGATION

Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch crucial for myocardial adaptation to ischemia

(2012) Tobias Eckle et al.   NATURE MEDICINE

Adenosine receptor expression in rheumatoid synovium: a basis for methotrexate action

(2012) Lisa K Stamp et al.   ARTHRITIS RESEARCH & THERAPY

Hyaluronan Fragments Promote Inflammation by Down-Regulating the Anti-inflammatory A2a Receptor

(2011) Samuel L. Collins et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Elevated Airway Purines in COPD

(2011) Charles R. Esther et al.   CHEST

Links Between Insulin Resistance, Adenosine A2B Receptors, and Inflammatory Markers in Mice and Humans

(2011) R. A. Figler et al.   DIABETES

Pharmacological and therapeutic effects of A3 adenosine receptor agonists

(2011) Pnina Fishman et al.   DRUG DISCOVERY TODAY

Adenosine promotes alternative macrophage activation via A2A and A2B receptors

(2011) Balázs Csóka et al.   FASEB JOURNAL

Adenosinergic Regulation of the Expansion and Immunosuppressive Activity of CD11b+Gr1+ Cells

(2011) S. Ryzhov et al.   JOURNAL OF IMMUNOLOGY

Hypoxia-Inducible Factor-1α–Dependent Protection from Intestinal Ischemia/Reperfusion Injury Involves Ecto-5′-Nucleotidase (CD73) and the A2B Adenosine Receptor

(2011) Melanie L. Hart et al.   JOURNAL OF IMMUNOLOGY

Adenosine A2A receptor activation stimulates collagen production in sclerodermic dermal fibroblasts either directly and through a cross-talk with the cannabinoid system

(2011) Pietro Enea Lazzerini et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

A2B Adenosine Receptor-Mediated Induction of IL-6 Promotes CKD

(2011) Y. Dai et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Hypoxia and Inflammation

(2011) Holger K. Eltzschig et al.   NEW ENGLAND JOURNAL OF MEDICINE

International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and Classification of Adenosine Receptors--An Update

(2011) B. B. Fredholm et al.   PHARMACOLOGICAL REVIEWS

Past, present and future of A2A adenosine receptor antagonists in the therapy of Parkinson's disease

(2011) Marie Therese Armentero et al.   PHARMACOLOGY & THERAPEUTICS

Interleukin-6 Contributes to Inflammation and Remodeling in a Model of Adenosine Mediated Lung Injury

(2011) Mesias Pedroza et al.   PLoS One

A2A and A3 adenosine receptor expression in rheumatoid arthritis: upregulation, inverse correlation with disease activity score and suppression of inflammatory cytokine and metalloproteinase release

(2011) Katia Varani et al.   ARTHRITIS RESEARCH & THERAPY

Pulmonary Hypertension and Idiopathic Pulmonary Fibrosis

(2010) Laszlo Farkas et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Adenosine A2A receptors induced on iNKT and NK cells reduce pulmonary inflammation and injury in mice with sickle cell disease

(2010) K. L. Wallace et al.   BLOOD

Adenosine signaling via the adenosine 2B receptor is involved in bronchiolitis obliterans development

(2010) Yunge Zhao et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Distinct Roles for the A2B Adenosine Receptor in Acute and Chronic Stages of Bleomycin-Induced Lung Injury

(2010) Y. Zhou et al.   JOURNAL OF IMMUNOLOGY

SP1-Dependent Induction of CD39 Facilitates Hepatic Ischemic Preconditioning

(2010) M. L. Hart et al.   JOURNAL OF IMMUNOLOGY

Signaling through the A2B Adenosine Receptor Dampens Endotoxin-Induced Acute Lung Injury

(2010) U. Schingnitz et al.   JOURNAL OF IMMUNOLOGY

Detrimental effects of adenosine signaling in sickle cell disease

(2010) Yujin Zhang et al.   NATURE MEDICINE

Alterations in Adenosine Metabolism and Signaling in Patients with Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis

(2010) Yang Zhou et al.   PLoS One

Attenuation of Chronic Pulmonary Inflammation in A2BAdenosine Receptor Knockout Mice

(2009) Rinat Zaynagetdinov et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The Role of Adenosine A2A Receptor Signaling in Bronchiolitis Obliterans

(2009) Christine L. Lau et al.   ANNALS OF THORACIC SURGERY

Targeting the A2B adenosine receptor during gastrointestinal ischemia and inflammation

(2009) Holger K Eltzschig et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Adenosine and osteopontin contribute to the development of chronic obstructive pulmonary disease

(2009) Daniel J. Schneider et al.   FASEB JOURNAL

Increased adenosine contributes to penile fibrosis, a dangerous feature of priapism, via A2B adenosine receptor signaling

(2009) Jiaming Wen et al.   FASEB JOURNAL

Extracellular 2′,3′-cAMP Is a Source of Adenosine

(2009) Edwin K. Jackson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adenosine signaling contributes to ethanol-induced fatty liver in mice

(2009) Zhongsheng Peng et al.   JOURNAL OF CLINICAL INVESTIGATION

A2A Adenosine Receptor Deficiency Leads to Impaired Tracheal Relaxation via NADPH Oxidase Pathway in Allergic Mice

(2009) A. Nadeem et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Adenosine signaling and the regulation of chronic lung disease

(2009) Yang Zhou et al.   PHARMACOLOGY & THERAPEUTICS

CD39 deletion exacerbates experimental murine colitis and human polymorphisms increase susceptibility to inflammatory bowel disease

(2009) D. J. Friedman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacological Blockade of A2A Receptors Prevents Dermal Fibrosis in a Model of Elevated Tissue Adenosine

(2008) Patricia Fernández et al.   AMERICAN JOURNAL OF PATHOLOGY

Adenosine A2A Receptor Blockade or Deletion Diminishes Fibrocyte Accumulation in the Skin in a Murine Model of Scleroderma, Bleomycin-induced Fibrosis

(2008) Majid Katebi et al.   INFLAMMATION

Excess adenosine in murine penile erectile tissues contributes to priapism via A2B adenosine receptor signaling

(2008) Tiejuan Mi et al.   JOURNAL OF CLINICAL INVESTIGATION

Dopamine D2 and Adenosine A2A Receptors Regulate NMDA-Mediated Excitation in Accumbens Neurons Through A2A–D2 Receptor Heteromerization

(2008) Karima Azdad et al.   NEUROPSYCHOPHARMACOLOGY

Progress in the discovery of selective, high affinity A2B adenosine receptor antagonists as clinical candidates

(2008) Rao V. Kalla et al.   Purinergic Signalling

The Reno-Vascular A2B Adenosine Receptor Protects the Kidney from Ischemia

(2008) Almut Grenz et al.   PLOS MEDICINE