Honokiol targets mitochondria to halt cancer progression and metastasis

LXR ligands sensitize EGFR-TKI-resistant human lung cancer cells in vitro by inhibiting Akt activation

(2015) Ying Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Lung Cancer Brain Metastases

(2015) Sarah B. Goldberg et al.   CANCER JOURNAL

Antiproliferative effects of mitochondria-targeted cationic antioxidants and analogs: Role of mitochondrial bioenergetics and energy-sensing mechanism

(2015) Gang Cheng et al.   CANCER LETTERS

STAT3 Inhibition Enhances the Therapeutic Efficacy of Immunogenic Chemotherapy by Stimulating Type 1 Interferon Production by Cancer Cells

(2015) Heng Yang et al.   CANCER RESEARCH

The Pharmacokinetics and Tissue Distribution of Honokiol and its Metabolites in Rats

(2015) Wang Jun-jun et al.   EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS

A Synthetic Lethal Interaction between Glutathione Synthesis and Mitochondrial Reactive Oxygen Species Provides a Tumor-Specific Vulnerability Dependent on STAT3

(2015) Daniel J. Garama et al.   MOLECULAR AND CELLULAR BIOLOGY

Honokiol confers immunogenicity by dictating calreticulin exposure, activating ER stress and inhibiting epithelial-to-mesenchymal transition

(2015) Shing-Hwa Liu et al.   Molecular Oncology

Targeting mitochondria metabolism for cancer therapy

(2015) Samuel E Weinberg et al.   Nature Chemical Biology

Epithelial–mesenchymal transition in human cancer: Comprehensive reprogramming of metabolism, epigenetics, and differentiation

(2015) Linna Li et al.   PHARMACOLOGY & THERAPEUTICS

Acute and sub-chronic toxicity studies of honokiol microemulsion

(2015) Qianqian Zhang et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Honokiol Downregulates Kruppel-Like Factor 4 Expression, Attenuates Inflammation, and Reduces Histopathology After Spinal Cord Injury in Rats

(2015) Jia Liu et al.   SPINE

Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3

(2015) Vinodkumar B. Pillai et al.   Nature Communications

Honokiol inhibits the growth of head and neck squamous cell carcinoma by targeting epidermal growth factor receptor

(2015) Tripti Singh et al.   Oncotarget

SIRT3 inhibits prostate cancer by destabilizing oncoprotein c-MYC through regulation of the PI3K/Akt pathway

(2015) Yizhou Quan et al.   Oncotarget

Honokiol abrogates leptin-induced tumor progression by inhibiting Wnt1-MTA1-β-catenin signaling axis in a microRNA-34a dependent manner

(2015) Dimiter B. Avtanski et al.   Oncotarget

Antibiotics that target mitochondria effectively eradicate cancer stem cells, across multiple tumor types: Treating cancer like an infectious disease

(2015) Rebecca Lamb et al.   Oncotarget

Simultaneous DNA and RNA Mapping of Somatic Mitochondrial Mutations across Diverse Human Cancers

(2015) James B. Stewart et al.   PLoS Genetics

Elimination of Cancer Stem-Like Cells and Potentiation of Temozolomide Sensitivity by Honokiol in Glioblastoma Multiforme Cells

(2015) I-Chun Lai et al.   PLoS One

Profiling and targeting of cellular bioenergetics: inhibition of pancreatic cancer cell proliferation

(2014) G Cheng et al.   BRITISH JOURNAL OF CANCER

Honokiol Inhibits Lung Tumorigenesis through Inhibition of Mitochondrial Function

(2014) J. Pan et al.   Cancer Prevention Research

Honokiol nanosuspensions: Preparation, increased oral bioavailability and dramatically enhanced biodistribution in the cardio-cerebro-vascular system

(2014) Meihua Han et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Characterization of metabolic profile of honokiol in rat feces using liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry and 13C stable isotope labeling

(2014) Yinfeng Dong et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

UPLC-MS/MS-ESI assay for simultaneous determination of magnolol and honokiol in rat plasma: Application to pharmacokinetic study after administration emulsion of the isomer

(2014) Yi-Ling Sheng et al.   JOURNAL OF ETHNOPHARMACOLOGY

Toxicity Profile of Temozolomide in the Treatment of 300 Malignant Glioma Patients in Korea

(2014) So Hyun Bae et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

Honokiol inhibits melanoma stem cells by targeting notch signaling

(2014) Gaurav Kaushik et al.   MOLECULAR CARCINOGENESIS

Honokiol inhibits epithelial-mesenchymal transition in breast cancer cells by targeting signal transducer and activator of transcription 3/Zeb1/E-cadherin axis

(2014) Dimiter B. Avtanski et al.   Molecular Oncology

Honokiol Suppresses Renal Cancer Cells’ Metastasis via Dual-Blocking Epithelial-Mesenchymal Transition and Cancer Stem Cell Properties through Modulating miR-141/ZEB2 Signaling

(2014) Weidong Li et al.   MOLECULES AND CELLS

SIRT3 regulates cellular iron metabolism and cancer growth by repressing iron regulatory protein 1

(2014) S M Jeong et al.   ONCOGENE

Honokiol Enhances Paclitaxel Efficacy in Multi-Drug Resistant Human Cancer Model through the Induction of Apoptosis

(2014) Xu Wang et al.   PLoS One

Honokiol Protected against Heatstroke-Induced Oxidative Stress and Inflammation in Diabetic Rats

(2014) Chuan-Chih Hsu et al.   International Journal of Endocrinology

Honokiol augments the anti-cancer effects of oxaliplatin in colon cancer cells

(2013) H. Hua et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Mitochondria-targeted vitamin E analogs inhibit breast cancer cell energy metabolism and promote cell death

(2013) Gang Cheng et al.   BMC CANCER

Chemoprevention of Lung Squamous Cell Carcinoma by Ginseng

(2013) J. Pan et al.   Cancer Prevention Research

Honokiol thwarts gastric tumor growth and peritoneal dissemination by inhibiting Tpl2 in an orthotopic model

(2013) Hung-Chuan Pan et al.   CARCINOGENESIS

Identification of metabolites of honokiol in rat urine using 13C stable isotope labeling and liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry

(2013) Juan Liu et al.   JOURNAL OF CHROMATOGRAPHY A

Identification of honokiol metabolites in rats by the method of stable isotope cluster technique and ultra-high performance liquid chromatography/quadrupole-time-of-flight mass spectrometry

(2013) Huijun Lai et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

O6-methylguanine-DNA methyltransferase (MGMT) immunohistochemistry as a predictor of resistance to temozolomide in primary CNS lymphoma

(2013) Xiaoyin Jiang et al.   JOURNAL OF NEURO-ONCOLOGY

Long-term supplementation of honokiol and magnolol ameliorates body fat accumulation, insulin resistance, and adipose inflammation in high-fat fed mice

(2013) Young-Je Kim et al.   MOLECULAR NUTRITION & FOOD RESEARCH

EGFR–STAT3 signaling promotes formation of malignant peripheral nerve sheath tumors

(2013) J Wu et al.   ONCOGENE

Honokiol Inhibits Non-Small Cell Lung Cancer Cell Migration by Targeting PGE2-Mediated Activation of β-Catenin Signaling

(2013) Tripti Singh et al.   PLoS One

Honokiol and magnolol stimulate glucose uptake by activating PI3K-dependent Akt in L6 myotubes

(2012) Sun-Sil Choi et al.   BIOFACTORS

Mitochondria-Targeted Drugs Synergize with 2-Deoxyglucose to Trigger Breast Cancer Cell Death

(2012) G. Cheng et al.   CANCER RESEARCH

Targeting Stat3 Abrogates EGFR Inhibitor Resistance in Cancer

(2012) M. Sen et al.   CLINICAL CANCER RESEARCH

Honokiol: A Novel Natural Agent for Cancer Prevention and Therapy

(2012) S. Arora et al.   CURRENT MOLECULAR MEDICINE

Inhibition of class I histone deacetylases in non-small cell lung cancer by honokiol leads to suppression of cancer cell growth and induction of cell death in vitro and in vivo

(2012) Tripti Singh et al.   Epigenetics

The Import of the Transcription Factor STAT3 into Mitochondria Depends on GRIM-19, a Component of the Electron Transport Chain

(2012) Prasad Tammineni et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adipokine leptin in obesity-related pathology of breast cancer

(2012) Amitabha Ray   JOURNAL OF BIOSCIENCES

Mitochondrial Respiration - An Important Therapeutic Target in Melanoma

(2012) Michelle Barbi de Moura et al.   PLoS One

Honokiol radiosensitizes colorectal cancer cells: enhanced activity in cells with mismatch repair defects

(2011) Zhiyun He et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

O6-Methylguanine DNA methyltransferase expression in tumor cells predicts outcome of radiotherapy plus concomitant and adjuvant temozolomide therapy in patients with primary glioblastoma

(2011) Reiko Watanabe et al.   Brain Tumor Pathology

Antimetastatic activity of honokiol in osteosarcoma

(2011) Patrick Steinmann et al.   CANCER

Targeting NFĸB mediated breast cancer chemoresistance through selective inhibition of sphingosine kinase-2

(2011) James W. Antoon et al.   CANCER BIOLOGY & THERAPY

STAT3 Is Necessary for Proliferation and Survival in Colon Cancer-Initiating Cells

(2011) L. Lin et al.   CANCER RESEARCH

Differences underlying EGFR and HER2 oncogene addiction

(2011) Anthony C. Faber et al.   CELL CYCLE

Curcumin

(2011) Mark G. Alexandrow et al.   EUROPEAN JOURNAL OF CANCER PREVENTION

Honokiol inhibits signal transducer and activator of transcription-3 signaling, proliferation, and survival of hepatocellular carcinoma cells via the protein tyrosine phosphatase SHP-1

(2011) Peramaiyan Rajendran et al.   JOURNAL OF CELLULAR PHYSIOLOGY

In vitro metabolism and disposition of honokiol in rat and human livers

(2011) Michaela Böhmdorfer et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Overcoming Erlotinib Resistance in EGFR Mutation-Positive Non-Small Cell Lung Cancer Cells by Targeting Survivin

(2011) K. Okamoto et al.   MOLECULAR CANCER THERAPEUTICS

Mitochondrial Localized STAT3 Is Involved in NGF Induced Neurite Outgrowth

(2011) Lihan Zhou et al.   PLoS One

Honokiol Arrests Cell Cycle, Induces Apoptosis, and Potentiates the Cytotoxic Effect of Gemcitabine in Human Pancreatic Cancer Cells

(2011) Sumit Arora et al.   PLoS One

Honokiol Crosses BBB and BCSFB, and Inhibits Brain Tumor Growth in Rat 9L Intracerebral Gliosarcoma Model and Human U251 Xenograft Glioma Model

(2011) Xianhuo Wang et al.   PLoS One

Honokiol Inhibits Epidermal Growth Factor Receptor Signaling and Enhances the Antitumor Effects of Epidermal Growth Factor Receptor Inhibitors

(2010) R. J. Leeman-Neill et al.   CLINICAL CANCER RESEARCH

PI3K/Akt Signalling Pathway Specific Inhibitors: A Novel Strategy to Sensitize Cancer Cells to Anti-Cancer Drugs

(2010) Marco Falasca   CURRENT PHARMACEUTICAL DESIGN

Akt associates with nuclear factor κB and plays an important role in chemoresistance of gastric cancer cells

(2010) Yu   ONCOLOGY REPORTS

Neuroprotective effect of honokiol and magnolol, compounds from Magnolia officinalis, on beta-amyloid-induced toxicity in PC12 cells

(2010) Chu Peng Hoi et al.   PHYTOTHERAPY RESEARCH

Role of STAT3 in In Vitro Transformation Triggered by TRK Oncogenes

(2010) Claudia Miranda et al.   PLoS One

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

(2010) F. Weinberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anti-inflammatory effect of honokiol is mediated by PI3K/Akt pathway suppression

(2009) Byung Hun Kim et al.   ACTA PHARMACOLOGICA SINICA

Honokiol, a Multifunctional Antiangiogenic and Antitumor Agent

(2009) Levi E. Fried et al.   ANTIOXIDANTS & REDOX SIGNALING

Down-regulation of c-Src/EGFR-mediated signaling activation is involved in the honokiol-induced cell cycle arrest and apoptosis in MDA-MB-231 human breast cancer cells

(2009) Eun-Jung Park et al.   CANCER LETTERS

Liposomal honokiol, a potent anti-angiogenesis agent, in combination with radiotherapy produces a synergistic antitumor efficacy without increasing toxicity

(2009) Jia Hu et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Improved therapeutic effectiveness by combining liposomal honokiol with cisplatin in lung cancer model

(2008) Qi-qi Jiang et al.   BMC CANCER

The EGFR-STAT3 Oncogenic Pathway Up-regulates the Eme1 Endonuclease to Reduce DNA Damage after Topoisomerase I Inhibition

(2008) A. Vigneron et al.   CANCER RESEARCH

Anti-tumor effect of honokiol alone and in combination with other anti-cancer agents in breast cancer

(2008) Hongyu Liu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Liposomal honokiol inhibits VEGF-D-induced lymphangiogenesis and metastasis in xenograft tumor model

(2008) Jing Wen et al.   INTERNATIONAL JOURNAL OF CANCER

Synergistic antitumor effects of liposomal honokiol combined with adriamycin in breast cancer models

(2008) Wenli Hou et al.   PHYTOTHERAPY RESEARCH