Honokiol analogs: a novel class of anticancer agents targeting cell signaling pathways and other bioactivities

Targeting the intrinsic inflammatory pathway: honokiol exerts proapoptotic effects through STAT3 inhibition in transformed Barrett's cells

(2012) Chunhua Yu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Design and synthesis of 4-O-methylhonokiol analogs as inhibitors of cyclooxygenase-2 (COX-2) and PGF1 production

(2012) Bit Lee et al.   BIOORGANIC & MEDICINAL CHEMISTRY

In vitro growth inhibition of human cancer cells by novel honokiol analogs

(2012) Jyh Ming Lin et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Honokiol: A Novel Natural Agent for Cancer Prevention and Therapy

(2012) S. Arora et al.   CURRENT MOLECULAR MEDICINE

The natural products magnolol and honokiol are positive allosteric modulators of both synaptic and extra-synaptic GABAA receptors

(2012) Mikhail Alexeev et al.   NEUROPHARMACOLOGY

Calpain/SHP-1 Interaction by Honokiol Dampening Peritoneal Dissemination of Gastric Cancer in nu/nu Mice

(2012) Shing Hwa Liu et al.   PLoS One

Synthesis and neurite growth evaluation of new analogues of honokiol, a neolignan with potent neurotrophic activity

(2011) Vemula Praveen Kumar et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

An expedient synthesis of honokiol and its analogues as potential neuropreventive agents

(2011) Subhankar Tripathi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Mechanisms of Osteoclastogenesis Inhibition by a Novel Class of Biphenyl-Type Cannabinoid CB2 Receptor Inverse Agonists

(2011) Wolfgang Schuehly et al.   CHEMISTRY & BIOLOGY

Apoptosis induced by Magnolia Grandiflora extract in chlorambucil-resistant B-chronic lymphocytic leukemia cells

(2011) GustavoHoracio Marin et al.   Journal of Cancer Research and Therapeutics

Honokiol inhibits signal transducer and activator of transcription-3 signaling, proliferation, and survival of hepatocellular carcinoma cells via the protein tyrosine phosphatase SHP-1

(2011) Peramaiyan Rajendran et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Modulation of GABAA-Receptors by Honokiol and Derivatives: Subtype Selectivity and Structure–Activity Relationship

(2011) Barbara Taferner et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural Modification of Honokiol, a Biphenyl Occurring in Magnolia officinalis: the Evaluation of Honokiol Analogues as Inhibitors of Angiogenesis and for Their Cytotoxicity and Structure–Activity Relationship

(2011) Liang Ma et al.   JOURNAL OF MEDICINAL CHEMISTRY

Honokiol produces anti-neoplastic effects on melanoma cells in vitro

(2011) Patrick W. Mannal et al.   JOURNAL OF SURGICAL ONCOLOGY

Honokiol Arrests Cell Cycle, Induces Apoptosis, and Potentiates the Cytotoxic Effect of Gemcitabine in Human Pancreatic Cancer Cells

(2011) Sumit Arora et al.   PLoS One

Honokiol Crosses BBB and BCSFB, and Inhibits Brain Tumor Growth in Rat 9L Intracerebral Gliosarcoma Model and Human U251 Xenograft Glioma Model

(2011) Xianhuo Wang et al.   PLoS One

Honokiol: a promising small molecular weight natural agent for the growth inhibition of oral squamous cell carcinoma cells

(2011) Xi‐rui Chen et al.   International Journal of Oral Science

Synthesis and microbiological evaluation of honokiol derivatives as new antimicrobial agents

(2010) Young-Soo Kim et al.   ARCHIVES OF PHARMACAL RESEARCH

Honokiol inhibits gastric tumourigenesis by activation of 15-lipoxygenase-1 and consequent inhibition of peroxisome proliferator-activated receptor-γ and COX-2-dependent signals

(2010) Shing Hwa Liu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Honokiol Inhibits Epidermal Growth Factor Receptor Signaling and Enhances the Antitumor Effects of Epidermal Growth Factor Receptor Inhibitors

(2010) R. J. Leeman-Neill et al.   CLINICAL CANCER RESEARCH

Discovery of novel anticancer therapeutics targeting the PI3K/Akt/mTOR pathway

(2010) Sauveur-Michel Maira et al.   Future Medicinal Chemistry

Distinct Photoacidity of Honokiol from Magnolol

(2010) Hongmei Li et al.   JOURNAL OF FLUORESCENCE

Involvement of p38 mitogen-activated protein kinase pathway in honokiol-induced apoptosis in a human hepatoma cell line (hepG2)

(2010) Junfang Deng et al.   LIVER INTERNATIONAL

Signal Transducer and Activator of Transcription-3, Inflammation, and Cancer

(2009) Bharat B. Aggarwal et al.   Annals of the New York Academy of Sciences

Honokiol, a Multifunctional Antiangiogenic and Antitumor Agent

(2009) Levi E. Fried et al.   ANTIOXIDANTS & REDOX SIGNALING

Design and synthesis of ten biphenyl-neolignan derivatives and their in vitro inhibitory potency against cyclooxygenase-1/2 activity and 5-lipoxygenase-mediated LTB4-formation

(2009) Wolfgang Schühly et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Semi-synthesis and anti-proliferative activity evaluation of novel analogues of Honokiol

(2009) Youfu Luo et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Down-regulation of c-Src/EGFR-mediated signaling activation is involved in the honokiol-induced cell cycle arrest and apoptosis in MDA-MB-231 human breast cancer cells

(2009) Eun-Jung Park et al.   CANCER LETTERS

Honokiol induces cell apoptosis in human chondrosarcoma cells through mitochondrial dysfunction and endoplasmic reticulum stress

(2009) Ying-Ju Chen et al.   CANCER LETTERS

Liposomal honokiol, a potent anti-angiogenesis agent, in combination with radiotherapy produces a synergistic antitumor efficacy without increasing toxicity

(2009) Jia Hu et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Honokiol-mediated Inhibition of PI3K/mTOR Pathway

(2009) Courtney Crane et al.   JOURNAL OF IMMUNOTHERAPY

Gender differences in expression of the human caspase-12 long variant determines susceptibility to Listeria monocytogenes infection

(2009) G. Yeretssian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Improved therapeutic effectiveness by combining liposomal honokiol with cisplatin in lung cancer model

(2008) Qi-qi Jiang et al.   BMC CANCER

Honokiol, a Constituent of Oriental Medicinal Herb Magnolia officinalis, Inhibits Growth of PC-3 Xenografts In vivo in Association with Apoptosis Induction

(2008) E.-R. Hahm et al.   CLINICAL CANCER RESEARCH

Honokiol Suppresses Survival Signals Mediated by Ras-Dependent Phospholipase D Activity in Human Cancer Cells

(2008) A. Garcia et al.   CLINICAL CANCER RESEARCH

Honokiol, a natural therapeutic candidate, induces apoptosis and inhibits angiogenesis of ovarian tumor cells

(2008) Zhengyu Li et al.   European Journal of Obstetrics & Gynecology and Reproductive Biology

Liposomal honokiol, a promising agent for treatment of cisplatin-resistant human ovarian cancer

(2008) Hong Luo et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

The natural product honokiol preferentially inhibits cellular FLICE-inhibitory protein and augments death receptor-induced apoptosis

(2008) S. M. Raja et al.   MOLECULAR CANCER THERAPEUTICS

Synergistic antitumor effects of liposomal honokiol combined with adriamycin in breast cancer models

(2008) Wenli Hou et al.   PHYTOTHERAPY RESEARCH

Enhancement of therapeutic effectiveness by combining liposomal honokiol with cisplatin in ovarian carcinoma

(2007) Y. LIU et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER