Enhancing Drug Efficacy and Therapeutic Index through Cheminformatics-Based Selection of Small Molecule Binary Weapons That Improve Transporter-Mediated Targeting: A Cytotoxicity System Based on Gemcitabine
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Title
Enhancing Drug Efficacy and Therapeutic Index through Cheminformatics-Based Selection of Small Molecule Binary Weapons That Improve Transporter-Mediated Targeting: A Cytotoxicity System Based on Gemcitabine
Authors
Keywords
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Journal
Frontiers in Pharmacology
Volume 8, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2017-03-27
DOI
10.3389/fphar.2017.00155
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- (2016) Paul D. Leeson ADVANCED DRUG DELIVERY REVIEWS
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- Whole genomes redefine the mutational landscape of pancreatic cancer
- (2015) Nicola Waddell et al. NATURE
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- (2015) M. Uhlen et al. SCIENCE
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- Three-dimensional structure of the human breast cancer resistance protein (BCRP/ABCG2) in an inward-facing conformation
- (2015) Mark F. Rosenberg et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
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- (2014) Przemyslaw M. Mrozikiewicz et al. ACTA PHARMACEUTICA
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- (2014) Ke Li et al. Cell Stem Cell
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- (2014) Eugene J. Koay et al. JOURNAL OF CLINICAL INVESTIGATION
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- (2013) James D. Young et al. MOLECULAR ASPECTS OF MEDICINE
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- Human Concentrative Nucleoside Transporter 3 Transfection with Ultrasound and Microbubbles in Nucleoside Transport Deficient HEK293 Cells Greatly Increases Gemcitabine Uptake
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- (2012) Karin Lanthaler et al. BMC BIOLOGY
- Advancing Pharmacometrics and Systems Pharmacology
- (2012) S A Waldman et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Physiologically Based Pharmacokinetics Joined With In Vitro–In Vivo Extrapolation of ADME: A Marriage Under the Arch of Systems Pharmacology
- (2012) A Rostami-Hodjegan CLINICAL PHARMACOLOGY & THERAPEUTICS
- Gemcitabine: A Critical Nucleoside for Cancer Therapy
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- (2012) Wendy A. Warr JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN
- The MUC4 mucin mediates gemcitabine resistance of human pancreatic cancer cells via the Concentrative Nucleoside Transporter family
- (2012) N Skrypek et al. ONCOGENE
- Combined analysis of intratumoral human equilibrative nucleoside transporter 1 (hENT1) and ribonucleotide reductase regulatory subunit M1 (RRM1) expression is a powerful predictor of survival in patients with pancreatic carcinoma treated with adjuvant gemcitabine-based chemotherapy after operative resection
- (2012) Naoya Nakagawa et al. SURGERY
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- (2011) Soichiro Morinaga et al. ANNALS OF SURGICAL ONCOLOGY
- Systems Pharmacology: Network Analysis to Identify Multiscale Mechanisms of Drug Action
- (2011) Shan Zhao et al. Annual Review of Pharmacology and Toxicology
- Effect of its deaminated metabolite, 2′,2′-difluorodeoxyuridine, on the transport and toxicity of gemcitabine in HeLa cells
- (2011) L.S. Hodge et al. BIOCHEMICAL PHARMACOLOGY
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- (2011) Yeeman K. Ramtohul et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
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- (2011) Y. D. Bhutia et al. CANCER RESEARCH
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- Molecular complexity and fragment-based drug discovery: ten years on
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- (2011) I. Borbath et al. EUROPEAN JOURNAL OF CANCER
- Nucleobase Transport by Human Equilibrative Nucleoside Transporter 1 (hENT1)
- (2011) Sylvia Y. M. Yao et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Human equilibrative nucleoside transporter 1 expression is a strong independent prognostic factor in UICC T3-T4 pancreatic cancer patients treated with preoperative gemcitabine-based chemoradiotherapy
- (2011) Yasuhiro Murata et al. Journal of Hepato-Biliary-Pancreatic Sciences
- Development of a Liver-Targeted Stearoyl-CoA Desaturase (SCD) Inhibitor (MK-8245) to Establish a Therapeutic Window for the Treatment of Diabetes and Dyslipidemia
- (2011) Renata M. Oballa et al. JOURNAL OF MEDICINAL CHEMISTRY
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- (2011) Tommaso M. De Pas et al. Journal of Thoracic Oncology
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- (2011) Pedro Cano-Soldado et al. MEDICINAL RESEARCH REVIEWS
- Induced pluripotent stem cells — opportunities for disease modelling and drug discovery
- (2011) Marica Grskovic et al. NATURE REVIEWS DRUG DISCOVERY
- How were new medicines discovered?
- (2011) David C. Swinney et al. NATURE REVIEWS DRUG DISCOVERY
- Expression and promoter methylation analysis of ATP-binding cassette genes in pancreatic cancer
- (2011) Yi Miao ONCOLOGY REPORTS
- Systems Pharmacology: Bridging Systems Biology and Pharmacokinetics-Pharmacodynamics (PKPD) in Drug Discovery and Development
- (2011) Piet H. van der Graaf et al. PHARMACEUTICAL RESEARCH
- Concise Review: A Chemical Approach to Control Cell Fate and Function
- (2011) Wenlin Li et al. STEM CELLS
- Molecular obesity, potency and other addictions in drug discovery
- (2011) Michael M. Hann MedChemComm
- Similarity searching
- (2011) Dagmar Stumpfe et al. Wiley Interdisciplinary Reviews-Computational Molecular Science
- Discovery of novel hepatoselective HMG-CoA reductase inhibitors for treating hypercholesterolemia: A bench-to-bedside case study on tissue selective drug distribution
- (2010) Jeffrey A. Pfefferkorn et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- The prognostic significance of human equilibrative nucleoside transporter 1 expression in patients with metastatic bladder cancer treated with gemcitabine-cisplatin-based combination chemotherapy
- (2010) Nagahide Matsumura et al. BJU INTERNATIONAL
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- (2010) Milena Gusella et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
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- (2010) Motofumi Tanaka et al. CANCER
- MicroRNA-21 in Pancreatic Cancer: Correlation with Clinical Outcome and Pharmacologic Aspects Underlying Its Role in the Modulation of Gemcitabine Activity
- (2010) Elisa Giovannetti et al. CANCER RESEARCH
- Human Equilibrative Nucleoside Transporter 1 (hENT1) Levels Predict Response to Gemcitabine in Patients With Biliary Tract Cancer (BTC)
- (2010) D. Santini et al. CURRENT CANCER DRUG TARGETS
- Link between high-affinity adenosine concentrative nucleoside transporter-2 (CNT2) and energy metabolism in intestinal and liver parenchymal cells
- (2010) Isabel Huber-Ruano et al. JOURNAL OF CELLULAR PHYSIOLOGY
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- (2010) Daniele Santini et al. JOURNAL OF CELLULAR PHYSIOLOGY
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- (2010) NATURE REVIEWS DRUG DISCOVERY
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- (2010) M. Molina-Arcas et al. NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
- Identification of MicroRNA-21 as a Biomarker for Chemoresistance and Clinical Outcome Following Adjuvant Therapy in Resectable Pancreatic Cancer
- (2010) Jin-Hyeok Hwang et al. PLoS One
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- Alteration of microRNA expression in vinyl carbamate-induced mouse lung tumors and modulation by the chemopreventive agent indole-3-carbinol
- (2009) T. Melkamu et al. CARCINOGENESIS
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- (2009) Bo Feng et al. Cell Stem Cell
- Single Nucleotide Polymorphisms of Gemcitabine Metabolic Genes and Pancreatic Cancer Survival and Drug Toxicity
- (2009) T. Okazaki et al. CLINICAL CANCER RESEARCH
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- (2009) R. Marechal et al. CLINICAL CANCER RESEARCH
- Recent progress in fragment-based lead discovery
- (2009) Michèle N Schulz et al. CURRENT OPINION IN PHARMACOLOGY
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- (2009) Paul Dobson et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
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- (2009) Miriam Molina-Arcas et al. Current Vascular Pharmacology
- Clinical pharmacology and pharmacogenetics of gemcitabine
- (2009) Andrea Wong et al. DRUG METABOLISM REVIEWS
- Structural motifs modulating the carcinogenic risk of aromatic amines
- (2009) Romualdo Benigni et al. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
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- (2009) Meryem Köse et al. Future Medicinal Chemistry
- Fragment-based ligand discovery
- (2009) M. Fischer et al. MOLECULAR INTERVENTIONS
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