The apparent permeabilities of Caco-2 cells to marketed drugs: magnitude, and independence from both biophysical properties and endogenite similarities

Application of Caco-2 Cell Line in Herb-Drug Interaction Studies: Current Approaches and Challenges

(2016) Charles Awortwe et al.   JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES

A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells

(2015) Micah J. Niphakis et al.   CELL

A Call for Systematic Research on Solute Carriers

(2015) Adrián César-Razquin et al.   CELL

Software review: the KNIME workflow environment and its applications in genetic programming and machine learning

(2015) Steve O’Hagan et al.   Genetic Programming and Evolvable Machines

Direct In Vivo Human Intestinal Permeability (Peff) Determined with Different Clinical Perfusion and Intubation Methods

(2015) David Dahlgren et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Engineered CRISPR-Cas9 nucleases with altered PAM specificities

(2015) Benjamin P. Kleinstiver et al.   NATURE

Membrane transporter engineering in industrial biotechnology and whole cell biocatalysis

(2015) Douglas B. Kell et al.   TRENDS IN BIOTECHNOLOGY

Quantifying the impact of transporters on cellular drug permeability

(2015) Pär Matsson et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Fitting Transporter Activities to Cellular Drug Concentrations and Fluxes: Why the Bumblebee Can Fly

(2015) Pedro Mendes et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

What would be the observable consequences if phospholipid bilayer diffusion of drugs into cells is negligible?

(2015) Douglas B. Kell   TRENDS IN PHARMACOLOGICAL SCIENCES

Understanding the foundations of the structural similarities between marketed drugs and endogenous human metabolites

(2015) Steve O'Hagan et al.   Frontiers in Pharmacology

Applications of a 7-day Caco-2 cell model in drug discovery and development

(2014) Ying Peng et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

In vitroandin vivoapproaches to characterize transporter-mediated disposition in drug discovery

(2014) Bo Feng et al.   Expert Opinion on Drug Discovery

A ‘rule of 0.5’ for the metabolite-likeness of approved pharmaceutical drugs

(2014) Steve O′Hagan et al.   Metabolomics

High-throughput screening of a CRISPR/Cas9 library for functional genomics in human cells

(2014) Yuexin Zhou et al.   NATURE

The solute carrier SLC35F2 enables YM155-mediated DNA damage toxicity

(2014) Georg E Winter et al.   Nature Chemical Biology

What do drug transporters really do?

(2014) Sanjay K. Nigam   NATURE REVIEWS DRUG DISCOVERY

How drugs get into cells: tested and testable predictions to help discriminate between transporter-mediated uptake and lipoidal bilayer diffusion

(2014) Douglas B. Kell et al.   Frontiers in Pharmacology

Membrane transporters in a human genome-scale metabolic knowledgebase and their implications for disease

(2014) Swagatika Sahoo et al.   Frontiers in Physiology

KNIME-CDK: Workflow-driven cheminformatics

(2013) Stephan Beisken et al.   BMC BIOINFORMATICS

Drug Discovery Applications for KNIME: An Open Source Data Mining Platform

(2013) Michael P. Mazanetz et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Metabolomics and systems pharmacology: why and how to model the human metabolic network for drug discovery

(2013) Douglas B. Kell et al.   DRUG DISCOVERY TODAY

Finding novel pharmaceuticals in the systems biology era using multiple effective drug targets, phenotypic screening and knowledge of transporters: where drug discovery went wrong and how to fix it

(2013) Douglas B. Kell   FEBS Journal

An analysis of a ‘community-driven’ reconstruction of the human metabolic network

(2013) Neil Swainston et al.   Metabolomics

A community-driven global reconstruction of human metabolism

(2013) Ines Thiele et al.   NATURE BIOTECHNOLOGY

CRISPR RNA–guided activation of endogenous human genes

(2013) Morgan L Maeder et al.   NATURE METHODS

DrugBank 4.0: shedding new light on drug metabolism

(2013) Vivian Law et al.   NUCLEIC ACIDS RESEARCH

Genetic Screens in Human Cells Using the CRISPR-Cas9 System

(2013) Tim Wang et al.   SCIENCE

Open-source platform to benchmark fingerprints for ligand-based virtual screening

(2013) Sereina Riniker et al.   Journal of Cheminformatics

Genome-wide assessment of the carriers involved in the cellular uptake of drugs: a model system in yeast

(2012) Karin Lanthaler et al.   BMC BIOLOGY

The promiscuous binding of pharmaceutical drugs and their transporter-mediated uptake into cells: what we (need to) know and how we can do so

(2012) Douglas B. Kell et al.   DRUG DISCOVERY TODAY

Cell-basedin vitromodels for predicting drug permeability

(2012) Bruno Sarmento et al.   Expert Opinion on Drug Metabolism & Toxicology

QSAR-based permeability model for drug-like compounds

(2011) Rafael Gozalbes et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Pharmaceutical drug transport: the issues and the implications that it is essentially carrier-mediated only

(2011) Douglas B. Kell et al.   DRUG DISCOVERY TODAY

Drug-permeability and transporter assays in Caco-2 and MDCK cell lines

(2011) Donna A Volpe   Future Medicinal Chemistry

KNIME Workflow to Assess PAINS Filters in SMARTS Format. Comparison of RDKit and Indigo Cheminformatics Libraries

(2011) Simon Saubern et al.   Molecular Informatics

Extensive In Vivo Metabolite-Protein Interactions Revealed by Large-Scale Systematic Analyses

(2010) Xiyan Li et al.   CELL

Recent advances in asymmetric oxidative coupling of 2-naphthol and its derivatives

(2010) Hui Wang   CHIRALITY

Attenuation of Intestinal Absorption by Major Efflux Transporters: Quantitative Tools and Strategies Using a Caco-2 Model

(2010) X. Lin et al.   DRUG METABOLISM AND DISPOSITION

Towards Prediction of In Vivo Intestinal Absorption Using a 96-Well Caco-2 Assay

(2010) Suzanne Skolnik et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Membrane transporters in drug development

(2010)   NATURE REVIEWS DRUG DISCOVERY

Implications of the Dominant Role of Transporters in Drug Uptake by Cells (Supplementary Material)

(2009) Paul Dobson et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Conciliating binding efficiency and polypharmacology

(2009) Jordi Mestres et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

‘Metabolite-likeness’ as a criterion in the design and selection of pharmaceutical drug libraries

(2008) Paul D. Dobson et al.   DRUG DISCOVERY TODAY

Transport of Dicationic Drugs Pentamidine and Furamidine by Human Organic Cation Transporters

(2008) X. Ming et al.   DRUG METABOLISM AND DISPOSITION

Comparison of drug transporter gene expression and functionality in Caco-2 cells from 10 different laboratories

(2008) Rose Hayeshi et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

The Caco-2 cell monolayer: usefulness and limitations

(2008) Huadong Sun et al.   Expert Opinion on Drug Metabolism & Toxicology

Carrier-mediated cellular uptake of pharmaceutical drugs: an exception or the rule?

(2008) Paul D. Dobson et al.   NATURE REVIEWS DRUG DISCOVERY

Array-based evolution of DNA aptamers allows modelling of an explicit sequence-fitness landscape

(2008) Christopher G. Knight et al.   NUCLEIC ACIDS RESEARCH

A modified fast (4 day) 96-well plate Caco-2 permeability assay

(2008) Masashi Uchida et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS