A synthetic lethal screen identifies the Vitamin D receptor as a novel gemcitabine sensitizer in pancreatic cancer cells

Chemoresistance to gemcitabine in hepatoma cells induces epithelial-mesenchymal transition and involves activation of PDGF-D pathway

(2015) Qiong Wu et al.   Oncotarget

Inhibition of glucose turnover by 3-bromopyruvate counteracts pancreatic cancer stem cell features and sensitizes cells to gemcitabine

(2015) Orkhan Isayev et al.   Oncotarget

Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma

(2014) Andrew D. Rhim et al.   CANCER CELL

HuR Posttranscriptionally Regulates WEE1: Implications for the DNA Damage Response in Pancreatic Cancer Cells

(2014) S. Lal et al.   CANCER RESEARCH

Sensitization of human cancer cells to gemcitabine by the Chk1 inhibitor MK-8776: cell cycle perturbation and impact of administration schedule in vitro and in vivo

(2013) Ryan Montano et al.   BMC CANCER

Centromere fragmentation is a common mitotic defect of S and G2checkpoint override

(2013) Neil Beeharry et al.   CELL CYCLE

Increased Survival in Pancreatic Cancer with nab-Paclitaxel plus Gemcitabine

(2013) Daniel D. Von Hoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

The novel ATR inhibitor VE-821 increases sensitivity of pancreatic cancer cells to radiation and chemotherapy

(2012) Remko Prevo et al.   CANCER BIOLOGY & THERAPY

The Pancreas Cancer Microenvironment

(2012) C. Feig et al.   CLINICAL CANCER RESEARCH

Potent 19-norvitamin D analogs for prostate and liver cancer therapy

(2012) Atsushi Kittaka et al.   Future Medicinal Chemistry

Impact of FOLFIRINOX Compared With Gemcitabine on Quality of Life in Patients With Metastatic Pancreatic Cancer: Results From the PRODIGE 4/ACCORD 11 Randomized Trial

(2012) Sophie Gourgou-Bourgade et al.   JOURNAL OF CLINICAL ONCOLOGY

PIAS4 represses vitamin D receptor-mediated signaling and acts as an E3-SUMO ligase towards vitamin D receptor

(2012) Sarita Jena et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

FOLFIRINOX for locally advanced and metastatic pancreatic cancer: single institution retrospective review of efficacy and toxicity

(2012) Krishna S. Gunturu et al.   MEDICAL ONCOLOGY

The Role of the Vitamin D Receptor and ERp57 in Photoprotection by 1α,25-Dihydroxyvitamin D3

(2012) Vanessa B. Sequeira et al.   MOLECULAR ENDOCRINOLOGY

Differential analysis of gene regulation at transcript resolution with RNA-seq

(2012) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

Dose Dependent Effects on Cell Cycle Checkpoints and DNA Repair by Bendamustine

(2012) Neil Beeharry et al.   PLoS One

CBP and p300 Histone Acetyltransferases Contribute to Homologous Recombination by Transcriptionally Activating the BRCA1 and RAD51 Genes

(2012) Hideaki Ogiwara et al.   PLoS One

Combination of calcitriol and dietary soy exhibits enhanced anticancer activity and increased hypercalcemic toxicity in a mouse xenograft model of prostate cancer

(2012) Jennifer Y. Wang et al.   PROSTATE

The Role of Vitamin D in Cancer Prevention and Treatment

(2012) Aruna V. Krishnan et al.   RHEUMATIC DISEASE CLINICS OF NORTH AMERICA

The potential therapeutic benefits of vitamin D in the treatment of estrogen receptor positive breast cancer

(2012) Aruna V. Krishnan et al.   STEROIDS

Vitamin D and cancer: Clinical aspects

(2011) Anna Woloszynska-Read et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

A Positive Feedback Signaling Loop between ATM and the Vitamin D Receptor Is Critical for Cancer Chemoprevention by Vitamin D

(2011) H.-J. Ting et al.   CANCER RESEARCH

Therapeutic targeting of Chk1 in NSCLC stem cells during chemotherapy

(2011) M Bartucci et al.   CELL DEATH AND DIFFERENTIATION

MK-1775, a Potent Wee1 Inhibitor, Synergizes with Gemcitabine to Achieve Tumor Regressions, Selectively in p53-Deficient Pancreatic Cancer Xenografts

(2011) N. V. Rajeshkumar et al.   CLINICAL CANCER RESEARCH

Overexpression of Hedgehog Signaling Is Associated with Epidermal Tumor Formation in Vitamin D Receptor–Null Mice

(2011) Arnaud E. Teichert et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks

(2010) Samuel F. Bunting et al.   CELL

Calcitriol enhances gemcitabine antitumor activity in vitro and in vivo by promoting apoptosis in a human pancreatic carcinoma model system

(2010) Wei-Dong Yu et al.   CELL CYCLE

Curcumin: a novel nutritionally derived ligand of the vitamin D receptor with implications for colon cancer chemoprevention

(2010) Leonid Bartik et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Down-Regulation of Rad51 Expression Overcomes Drug Resistance to Gemcitabine in Human Non-Small-Cell Lung Cancer Cells

(2010) M.-S. Tsai et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation

(2010) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

TopHat: discovering splice junctions with RNA-Seq

(2009) Cole Trapnell et al.   BIOINFORMATICS

Involvement of Vitamin D Receptor in the Intestinal Induction of Human ABCB1

(2009) S. Tachibana et al.   DRUG METABOLISM AND DISPOSITION

Effects of Resin or Charcoal Treatment on Fetal Bovine Serum and Bovine Calf Serum

(2009) Zhimin Cao et al.   ENDOCRINE RESEARCH

In vitromodels of pancreatic cancer for translational oncology research

(2009) Georg Feldmann et al.   Expert Opinion on Drug Discovery

Synthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancer

(2009) David O Azorsa et al.   Journal of Translational Medicine

H2AX Is Required for Cell Cycle Arrest via the p53/p21 Pathway

(2009) M. Fragkos et al.   MOLECULAR AND CELLULAR BIOLOGY

Gemcitabine sensitization by checkpoint kinase 1 inhibition correlates with inhibition of a Rad51 DNA damage response in pancreatic cancer cells

(2009) L. A. Parsels et al.   MOLECULAR CANCER THERAPEUTICS

Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

(2009) K. P. Olive et al.   SCIENCE

Vitamin D Receptor Expression in Normal, Premalignant, and Malignant Human Lung Tissue

(2008) R. J. Menezes et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Sonic Hedgehog Promotes Desmoplasia in Pancreatic Cancer

(2008) J. M. Bailey et al.   CLINICAL CANCER RESEARCH

RAD51 foci formation in response to DNA damage is modulated by TIP49

(2008) Anastas Gospodinov et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Biopositive Effects of Low-Dose UVB on Epidermis: Coordinate Upregulation of Antimicrobial Peptides and Permeability Barrier Reinforcement

(2008) Seung P. Hong et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Breaching the DNA damage checkpoint via PF-00477736, a novel small-molecule inhibitor of checkpoint kinase 1

(2008) A. Blasina et al.   MOLECULAR CANCER THERAPEUTICS

AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies

(2008) S. D. Zabludoff et al.   MOLECULAR CANCER THERAPEUTICS

Vitamin D receptor: molecular signaling and actions of nutritional ligands in disease prevention

(2008) Mark R Haussler et al.   NUTRITION REVIEWS

Cancer Proliferation Gene Discovery Through Functional Genomics

(2008) M. R. Schlabach et al.   SCIENCE

Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

(2008) S. Jones et al.   SCIENCE

A pervasive role of histone acetyltransferases and deacetylases in an NF-κB-signaling code

(2008) Miriam Calao et al.   TRENDS IN BIOCHEMICAL SCIENCES