Review: Genetics and the Classification of Arthritis in Adults and Children

Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis

(2017) Deepak A. Rao et al.   NATURE

Genome-Wide Association Meta-Analysis Reveals Novel Juvenile Idiopathic Arthritis Susceptibility Loci

(2017) Laura A. McIntosh et al.   Arthritis & Rheumatology

Fine-mapping the MHC locus in juvenile idiopathic arthritis (JIA) reveals genetic heterogeneity corresponding to distinct adult inflammatory arthritic diseases

(2016) A Hinks et al.   ANNALS OF THE RHEUMATIC DISEASES

Genetic architecture distinguishes systemic juvenile idiopathic arthritis from other forms of juvenile idiopathic arthritis: clinical and therapeutic implications

(2016) Michael J Ombrello et al.   ANNALS OF THE RHEUMATIC DISEASES

Predicting Which Children with Juvenile Idiopathic Arthritis Will Have a Severe Disease Course: Results from the ReACCh-Out Cohort

(2016) Jaime Guzman et al.   JOURNAL OF RHEUMATOLOGY

A method to decipher pleiotropy by detecting underlying heterogeneity driven by hidden subgroups applied to autoimmune and neuropsychiatric diseases

(2016) Buhm Han et al.   NATURE GENETICS

Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci

(2016) David Ellinghaus et al.   NATURE GENETICS

C13orf31 (FAMIN) is a central regulator of immunometabolic function

(2016) M Zaeem Cader et al.   NATURE IMMUNOLOGY

The Rheumatoid Arthritis Risk Variant CCR6DNP Regulates CCR6 via PARP-1

(2016) Gang Li et al.   PLoS Genetics

Genome-wide Association Analysis of Psoriatic Arthritis and Cutaneous Psoriasis Reveals Differences in Their Genetic Architecture

(2015) Philip E. Stuart et al.   AMERICAN JOURNAL OF HUMAN GENETICS

PTPN22 is associated with susceptibility to psoriatic arthritis but not psoriasis: evidence for a further PsA-specific risk locus

(2015) John Bowes et al.   ANNALS OF THE RHEUMATIC DISEASES

Immunogenetics of juvenile idiopathic arthritis: A comprehensive review

(2015) Aimee O. Hersh et al.   JOURNAL OF AUTOIMMUNITY

Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers

(2015) Suna Onengut-Gumuscu et al.   NATURE GENETICS

Genetic architectures of seropositive and seronegative rheumatic diseases

(2015) Yohei Kirino et al.   Nature Reviews Rheumatology

Secukinumab, an Interleukin-17A Inhibitor, in Ankylosing Spondylitis

(2015) Dominique Baeten et al.   NEW ENGLAND JOURNAL OF MEDICINE

Enthesitis as a component of dactylitis in psoriatic juvenile idiopathic arthritis: histology of an established clinical entity

(2015) Katherine Tuttle et al.   Pediatric Rheumatology

Gene-expression analysis of adult-onset Still’s disease and systemic juvenile idiopathic arthritis is consistent with a continuum of a single disease entity

(2015) Nanguneri Nirmala et al.   Pediatric Rheumatology

Autoinflammation and autoimmunity in systemic juvenile idiopathic arthritis

(2015) Peter A. Nigrovic   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HLA-DRB1*11and variants of the MHC class II locus are strong risk factors for systemic juvenile idiopathic arthritis

(2015) Michael J. Ombrello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clinical Outcomes and Progression to Orthopedic Surgery in Juvenile- Versus Adult-Onset Ankylosing Spondylitis

(2015) Deepak R. Jadon et al.   ARTHRITIS CARE & RESEARCH

Anti-citrullinated peptide/protein antibody (ACPA)-negative RA shares a large proportion of susceptibility loci with ACPA-positive RA: a meta-analysis of genome-wide association study in a Japanese population

(2015) Chikashi Terao et al.   ARTHRITIS RESEARCH & THERAPY

Fine Mapping Seronegative and Seropositive Rheumatoid Arthritis to Shared and Distinct HLA Alleles by Adjusting for the Effects of Heterogeneity

(2014) Buhm Han et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Disease progression into adulthood and predictors of long-term active disease in juvenile idiopathic arthritis

(2014) Anne M Selvaag et al.   ANNALS OF THE RHEUMATIC DISEASES

Cytokine profiling at disease onset: support for classification of young antinuclear antibody-positive patients as a separate category of juvenile idiopathic arthritis

(2014) Theo van den Broek et al.   ANNALS OF THE RHEUMATIC DISEASES

Familial aggregation of arthritis-related diseases in seropositive and seronegative rheumatoid arthritis: a register-based case-control study in Sweden

(2014) Thomas Frisell et al.   ANNALS OF THE RHEUMATIC DISEASES

An update on the contribution of the MHC to as susceptibility

(2014) John D. Reveille   CLINICAL RHEUMATOLOGY

Risk for ACPA-positive rheumatoid arthritis is driven by shared HLA amino acid polymorphisms in Asian and European populations

(2014) Yukinori Okada et al.   HUMAN MOLECULAR GENETICS

Adult-Onset Still Disease

(2014) Mathieu Gerfaud-Valentin et al.   MEDICINE

The Biologic Basis of Clinical Heterogeneity in Juvenile Idiopathic Arthritis

(2014) Simon W. M. Eng et al.   Arthritis & Rheumatology

Association of a Mutation inLACC1With a Monogenic Form of Systemic Juvenile Idiopathic Arthritis

(2014) Salma M. Wakil et al.   Arthritis & Rheumatology

Brief Report: Susceptibility to Childhood-Onset Rheumatoid Arthritis: Investigation of a Weighted Genetic Risk Score That Integrates Cumulative Effects of Variants at Five Genetic Loci

(2013) Sampath Prahalad et al.   ARTHRITIS AND RHEUMATISM

Familial Risks and Heritability of Rheumatoid Arthritis: Role of Rheumatoid Factor/Anti-Citrullinated Protein Antibody Status, Number and Type of Affected Relatives, Sex, and Age

(2013) Thomas Frisell et al.   ARTHRITIS AND RHEUMATISM

A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis

(2013) Stephen W. Scally et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Patients with Very Early-onset Systemic Juvenile Idiopathic Arthritis Exhibit More Inflammatory Features and a Worse Outcome

(2013) R. A. G. RUSSO et al.   JOURNAL OF RHEUMATOLOGY

Genetics of rheumatoid arthritis contributes to biology and drug discovery

(2013) Yukinori Okada et al.   NATURE

Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis

(2013) Anne Hinks et al.   NATURE GENETICS

Validating therapeutic targets through human genetics

(2013) Robert M. Plenge et al.   NATURE REVIEWS DRUG DISCOVERY

Genetics and epigenetics of rheumatoid arthritis

(2013) Sebastien Viatte et al.   Nature Reviews Rheumatology

Update on Juvenile Spondyloarthritis

(2013) Anusha Ramanathan et al.   RHEUMATIC DISEASE CLINICS OF NORTH AMERICA

Genetic markers of rheumatoid arthritis susceptibility in anti-citrullinated peptide antibody negative patients

(2012) Sebastien Viatte et al.   ANNALS OF THE RHEUMATIC DISEASES

It is time to rethink juvenile idiopathic arthritis classification and nomenclature

(2012) Alberto Martini   ANNALS OF THE RHEUMATIC DISEASES

Comprehensive assessment of rheumatoid arthritis susceptibility loci in a large psoriatic arthritis cohort

(2012) John Bowes et al.   ANNALS OF THE RHEUMATIC DISEASES

Serum S100A8/A9, But Not Follistatin-like Protein 1 and Interleukin 18, May Be a Useful Biomarker of Disease Activity in Adult-onset Still’s Disease

(2012) HYOUN-AH KIM et al.   JOURNAL OF RHEUMATOLOGY

Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis

(2012) Soumya Raychaudhuri et al.   NATURE GENETICS

Ongoing disease activity and changing categories in a long-term nordic cohort study of juvenile idiopathic arthritis

(2011) Ellen Nordal et al.   ARTHRITIS AND RHEUMATISM

Hierarchy of risk of childhood-onset rheumatoid arthritis conferred by HLA-DRB1 alleles encoding the shared epitope

(2011) Sampath Prahalad et al.   ARTHRITIS AND RHEUMATISM

Genome-Wide Meta-Analysis of Psoriatic Arthritis Identifies Susceptibility Locus at REL

(2011) Eva Ellinghaus et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility

(2011) David M Evans et al.   NATURE GENETICS

Predictors of poor response to methotrexate in polyarticular-course juvenile idiopathic arthritis: analysis of the PRINTO methotrexate trial

(2010) I. Vilca et al.   ANNALS OF THE RHEUMATIC DISEASES

Early disease onset is predicted by a higher genetic risk for lupus and is associated with a more severe phenotype in lupus patients

(2010) R. Webb et al.   ANNALS OF THE RHEUMATIC DISEASES

Biologic similarities based on age at onset in oligoarticular and polyarticular subtypes of juvenile idiopathic arthritis

(2010) Michael G. Barnes et al.   ARTHRITIS AND RHEUMATISM

Antinuclear antibody-positive patients should be grouped as a separate category in the classification of juvenile idiopathic arthritis

(2010) Angelo Ravelli et al.   ARTHRITIS AND RHEUMATISM

Juvenile idiopathic arthritis and HLA Class I and Class II interactions and age-at-onset effects

(2010) Jill A. Hollenbach et al.   ARTHRITIS AND RHEUMATISM

Clinical Manifestations but not Cytokine Profiles Differentiate Adult-onset Still's Disease and Sepsis

(2010) M. RAU et al.   JOURNAL OF RHEUMATOLOGY

Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci

(2010) John D Reveille et al.   NATURE GENETICS

Common variants at TRAF3IP2 are associated with susceptibility to psoriatic arthritis and psoriasis

(2010) Ulrike Hüffmeier et al.   NATURE GENETICS

The development of Assessment of SpondyloArthritis international Society classification criteria for axial spondyloarthritis (part II): validation and final selection

(2009) M Rudwaleit et al.   ANNALS OF THE RHEUMATIC DISEASES

The development of Assessment of SpondyloArthritis international Society classification criteria for axial spondyloarthritis (part I): classification of paper patients by expert opinion including uncertainty appraisal

(2009) M Rudwaleit et al.   ANNALS OF THE RHEUMATIC DISEASES

Comparison of clinical versus ultrasound-determined synovitis in juvenile idiopathic arthritis

(2009) Silvia Magni-Manzoni et al.   ARTHRITIS AND RHEUMATISM

Quantitative heritability of anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis

(2009) Diane van der Woude et al.   ARTHRITIS AND RHEUMATISM

Juvenile Psoriatic Arthritis: Bathwater or Baby?

(2009) P. A. NIGROVIC   JOURNAL OF RHEUMATOLOGY

Epidemiology and Course of Disease in Childhood Uveitis

(2009) Janine A. Smith et al.   OPHTHALMOLOGY

Comparison of clinical and radiographic severity of juvenile-onset versus adult-onset ankylosing spondylitis

(2008) F D O'Shea et al.   ANNALS OF THE RHEUMATIC DISEASES

Arthritis induced by posttranslationally modified (citrullinated) fibrinogen in DR4-IE transgenic mice

(2008) Jonathan A. Hill et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans

(2008) Sekar Kathiresan et al.   NATURE GENETICS