Article
Medicine, General & Internal
Ewa Zelnio, Mihra Taljanovic, Malgorzata Manczak, Iwona Sudol-Szopinska
Summary: The hand and wrist are frequently involved in rheumatic diseases, and this study aimed to identify the distinguishing radiographic characteristics of psoriatic arthritis (PsA), seropositive rheumatoid arthritis (RA), and seronegative RA, especially in the early stages. The analysis of radiographic hand findings on 180 seropositive RA patients, 154 PsA patients, and 36 seronegative RA patients revealed that symmetric distribution of lesions was more suggestive of seropositive or seronegative RA, while lesions affecting PIP joints, wrist, or styloid process of the radius were more common in patients with seropositive RA. PsA was more likely to be suggested by DIP joints' involvement and proliferative bone changes. Furthermore, there were differences in the types of bone lesions and their distribution between seropositive RA, seronegative RA, and PsA, with ulnar styloid involvement more commonly seen in seronegative RA patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Hemi Luan, Wanjian Gu, Hua Li, Zi Wang, Lu Lu, Mengying Ke, Jiawei Lu, Wenjun Chen, Zhangzhang Lan, Yanlin Xiao, Jinyue Xu, Yi Zhang, Zongwei Cai, Shijia Liu, Wenyong Zhang
Summary: A panel of 26 serum markers from omics profiles was selected to build a machine-learning-based prediction model for diagnosing seronegative RA patients, achieving 90.2% accuracy in the validation set. Co-occurrence network analysis revealed significant associations between inflammation and immune activity markers, and abnormal metabolism of energy, lipids, and amino acids.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Medicine, General & Internal
Natalia Carbonell-Bobadilla, Carina Soto-Fajardo, Luis M. Amezcua-Guerra, Ana Beatriz Batres-Marroquin, Tania Vargas, Adrian Hernandez-Diazcouder, Valentin Jimenez-Rojas, Ana Cristina Medina-Garcia, Carlos Pineda, Luis H. Silveira
Summary: Seronegative rheumatoid arthritis patients have a milder disease compared to seropositive patients, with later onset age and lower requirement for antirheumatic therapies. On ultrasound evaluation, seropositive patients show more severe joint damage.
FRONTIERS IN MEDICINE
(2022)
Article
Multidisciplinary Sciences
Xiao-Hong He, Yun-Ting Xiao, Wen-Ying Chen, Mao-Jie Wang, Xiao-Dong Wu, Li-Yan Mei, Kai-Xin Gao, Qing-Chun Huang, Run-Yue Huang, Xiu-Min Chen
Summary: This study profiled serum miRNAs in seronegative RA patients, seropositive RA patients, and healthy controls. The expression levels of certain miRNAs were found to be different between the groups. The target genes and molecular pathways regulated by miRNAs in seronegative and seropositive RA were found to be similar, indicating the involvement of miRNAs in the immune system in the development of these diseases. The findings of this study provide potential biomarkers and targets for the diagnosis and treatment of seronegative and seropositive RA.
Review
Immunology
J. N. Pouw, E. F. A. Leijten, J. M. van Laar, M. Boes
Summary: Autoimmune rheumatic diseases are categorized based on the presence of specific autoreactive antibodies as seropositive or seronegative. Autoantibody-based diagnostics are helpful for patient care, and recent research indicates that AIRD patients may develop autoantibodies beyond the original classification.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2021)
Article
Medical Laboratory Technology
Yujue He, Junyu Lin, Jifeng Tang, Ziqing Yu, Qishui Ou, Jinpiao Lin
Summary: Differential protein expression in the sera of seropositive rheumatoid arthritis (SPRA) and seronegative rheumatoid arthritis (SNRA) patients was identified in this study, with 14 proteins showing significant differences. ELISA validation confirmed elevated levels of SAA1 in SPRA and SNRA patients, and increased levels of PSME1 in SPRA patients.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Rheumatology
Luis M. Amezcua-Guerra, Natalia Carbonell-Bobadilla, Carina Soto-Fajardo, Angelica Vargas, Ana B. Batres-Marroquin, Tania Vargas, Ana C. Medina-Garcia, Adrian Hernandez-Diazcouder, Valentin Jimenez-Rojas, Carlos Pineda, Luis H. Silveira
Summary: This study investigates the significance of anti-carbamylated protein (anti-CarP) antibodies in rheumatoid arthritis (RA) and seronegative disease (SNRA). The results show that anti-CarP antibodies are associated with increased disease activity but not with increased erosive joint damage in both RA and SNRA patients.
RHEUMATOLOGY INTERNATIONAL
(2023)
Article
Rheumatology
Kirsi Paalanen, Kari Puolakka, Elena Nikiphorou, Pekka Hannonen, Tuulikki Sokka
Summary: This study found that 10.4% of seronegative RA patients had their diagnosis changed to SpA within 15 years, particularly with a higher proportion related to PsA and axial SpA. It highlights the importance of vigilance in diagnosing RA and considering the possibility of SpA diagnosis, especially in cases with atypical presentations.
Article
Medicine, General & Internal
Misako Higashida-Konishi, Keisuke Izumi, Satoshi Hama, Hiroshi Takei, Hisaji Oshima, Yutaka Okano
Summary: The study compared the clinical characteristics of RS3PE and SNRA patients with and without malignancies, finding that RS3PE patients had higher inflammation levels and incidence of malignancy. Therefore, older age, male sex, presence of extremity edema, and RS3PE diagnosis should prompt screening for malignancies.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Rheumatology
Hyoungyoung Kim, Soo-Kyung Cho, Seongmi Choi, Seul Gi Im, Sun-Young Jung, Eun Jin Jang, Yoon-Kyoung Sung
Summary: Patients with seropositive rheumatoid arthritis (SPRA) utilized more methotrexate and biologic agents, had higher number of RA-related outpatient visits, and incurred higher annual medical costs compared to those with seronegative RA (SNRA). The incremental cost of seropositivity on total medical costs of RA patients increased as costs approached the upper quantile. Direct medical costs for both groups increased between 2012 and 2016, with a higher percentage increase in the SNRA group.
THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE
(2021)
Article
Medicine, General & Internal
Misako Higashida-Konishi, Keisuke Izumi, Satoshi Hama, Hiroshi Takei, Hisaji Oshima, Yutaka Okano
Summary: The study compared the clinical characteristics and malignancy-related factors between RS3PE and SNRA patients, finding that RS3PE patients had higher levels of inflammation and a higher incidence of malignancy.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Benedicte Delcoigne, Sella A. Provan, Eirik K. Kristianslund, Johan Askling, Lotta Ljung
Summary: This study aimed to estimate the short-term risks of acute coronary syndrome (ACS) in patients with rheumatoid arthritis (RA) based on their current disease activity, including remission. The results showed that failure to reach remission is associated with an increased risk of ACS, highlighting the importance of optimizing cardiovascular risk factors in these patients.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Immunology
Alzahraa Abdelwahab, Sanna Palosaari, Soha Abdelkawy Abdelwahab, Rehab Ahmed Rifaai, Nashwa Fathy El-Tahawy, Entesar Ali Saber, Tomi Nousiainen, Maarit Valkealahti, Johanna Huhtakangas, Tuomo J. Karttunen, Petri Lehenkari
Summary: Research on synovial tissue expression of Toll-like receptors (TLRs) in rheumatoid arthritis (RA) showed differences between seropositive and seronegative RA, potentially impacting disease outcomes. High expression of specific TLRs in seropositive RA may prime the synovium for reactions to citrullinated proteins and nucleic acids, which could contribute to inflammation.
Article
Immunology
Razvan M. Chirila, Florentina Berianu, Andy Abril, Ronald R. Butendieck
Summary: Extra-articular involvement (EAI) in rheumatoid arthritis (RA) can present as severe manifestations even in the absence of typical joint symptoms, emphasizing the importance of early diagnosis for guiding specific therapy and preventing complications.
IMMUNITY INFLAMMATION AND DISEASE
(2021)
Article
Rheumatology
Lukas Folle, Sara Bayat, Arnd Kleyer, Filippo Fagni, Lorenz A. Kapsner, Maja Schlereth, Timo Meinderink, Katharina Breininger, Koray Tacilar, Gerhard Kroenke, Michael Uder, Michael Sticherling, Sebastian Bickelhaupt, Georg Schett, Andreas Maier, Frank Roemer, David Simon
Summary: This study evaluated whether neural networks could differentiate seropositive rheumatoid arthritis (RA), seronegative RA, and psoriatic arthritis (PsA) based on inflammatory patterns from hand MRIs. The results showed that neural networks could successfully classify these types of inflammation based on MRI data.
Article
Endocrinology & Metabolism
Jessica Edstorp, Yuxia Wei, Emma Ahlqvist, Lars Alfredsson, Valdemar Grill, Leif Groop, Bahareh Rasouli, Elin P. Sorgjerd, Per M. Thorsby, Tiinamaija Tuomi, Bjorn O. Asvold, Sofia Carlsson
Summary: The study reveals that smoking and snus use are associated with a higher risk of LADA and type 2 diabetes, and smoking acts synergistically with HLA high-risk genotypes in the development of LADA.
Article
Rheumatology
Viktor Molander, Hannah Bower, Thomas Frisell, Benedicte Delcoigne, Daniela Di Giuseppe, Johan Askling
Summary: Patients with rheumatoid arthritis (RA) treated with Janus kinase inhibitors (JAKi) have a higher incidence of venous thromboembolism (VTE) compared to those treated with other biological disease modifying antirheumatic drugs (bDMARDs), especially in terms of pulmonary embolism (PE).
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Bowen Tang, Qianwen Liu, Anna Ilar, Pernilla Wiebert, Sara Hagg, Leonid Padyukov, Lars Klareskog, Lars Alfredsson, Xia Jiang
Summary: This study examined the effects of occupational inhalable exposures on the development of rheumatoid arthritis (RA) and their interactions with smoking and RA-risk genes, specifically in relation to the presence of anticitrullinated protein antibodies (ACPA). The results showed that exposure to any occupational inhalable agents was associated with an increased risk for ACPA-positive RA. Furthermore, there was a significantly elevated risk for ACPA-positive RA among individuals who were exposed to occupational inhalable agents, smoked, and had a high genetic risk score (GRS). Significant interactions were found between occupational inhalable agents and smoking/genetic factors (high GRS or HLA-SE) in ACPA-positive RA.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Bruno Raposo, Marcelo Afonso, Lena Israelsson, Heidi Waehaemaa, Ragnhild Stalesen, Fredrik Wermeling, Aase Haj Hensvold, Caroline Groenwall, Bence Rethi, Lars Klareskog, Vivianne Malmstrom
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Public, Environmental & Occupational Health
Sven Cnattingius, Karin Kallen, Anna Sandstrom, Henny Rydberg, Helena Mansson, Olof Stephansson, Thomas Frisell, Jonas F. Ludvigsson
Summary: The Swedish Medical Birth Register (MBR) provides high-quality pregnancy-related information on over 5 million births during five decades. It is an important resource for understanding the health of mothers and offspring in both the short and long term.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Clinical Neurology
Chiara Starvaggi Cucuzza, Elisa Longinetti, Nicolas Ruffin, Bjoern Evertsson, Ingrid Kockum, Maja Jagodic, Faiez Al Nimer, Thomas Frisell, Fredrik Piehl
Summary: This study aimed to determine the clinical and neuroradiologic disease activity, as well as B-cell repopulation dynamics, after implementing extended rituximab dosing in RRMS. The results showed that extended dosing intervals did not increase the risk of relapse in RRMS, and the dynamics of total B-cell and memory B-cell repopulation varied considerably.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2023)
Article
Rheumatology
Matilda Morin, Thomas Frisell, Olof Stephansson, Karin Hellgren
Summary: This study aimed to assess the risks of adverse pregnancy outcomes in women with axial spondyloarthritis and investigate how the outcomes varied over time and with anti-rheumatic treatment. The results showed increased risks of preterm birth, pre-eclampsia, elective caesarean delivery, and serious infant infection in women with axial spondyloarthritis compared to the general population. However, there was a trend of improvement in pregnancy outcomes over time, coinciding with increased use of biological DMARDs.
LANCET RHEUMATOLOGY
(2023)
Article
Rheumatology
Thomas Frisell, Hannah Bower, Matilda Morin, Eva Baecklund, Daniela Di Giuseppe, Benedicte Delcoigne, Nils Feltelius, Helena Forsblad-d'Elia, Elisabet Lindqvist, Ulf Lindstroem, Johan Askling
Summary: The objective of this study was to assess and compare the incidence rates of key safety outcomes for individual targeted synthetic or biological disease-modifying antirheumatic drugs (b/ts DMARDs) in rheumatoid arthritis (RA). The study found that the b/tsDMARDs currently used to treat RA have acceptable and largely similar safety profiles, but differences exist in particular concerning tolerability and specific infection risks.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Viking Huss, Hannah Bower, Karin Hellgren, Thomas Frisell, Johan Askling, ARTIS grp
Summary: This study assessed the cancer risks associated with Janus kinase inhibitors (JAKi) compared to biological disease-modifying antirheumatic drugs (bDMARDs) in clinical practice. The results showed that, in patients with rheumatoid arthritis (RA) and psoriatic arthritis (PsA), the short-term risk of cancers other than non-melanoma skin cancer (NMSC) was not higher with JAKi compared to tumor necrosis factor inhibitors (TNFi), but there was evidence of an increased risk for NMSC.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Clinical Neurology
Katharina Fink, Agnes Gorczyca, Peter Alping, Simon Englund, Susan Farmand, Annette M. Langer-Gould, Fredrik Piehl, Kyla McKay, Thomas Frisell, Neda Razaz
Summary: This study aimed to investigate the association between multiple sclerosis (MS) in mothers and the risks of adverse pregnancy and perinatal outcomes. A population-based retrospective cohort study in Sweden showed that mothers with MS had a higher risk of obstetric complications and their newborns had an increased risk of preterm birth and being small for gestational age compared to MS-free mothers. However, exposure to disease-modifying therapy (DMT) during pregnancy did not lead to major adverse outcomes.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Review
Genetics & Heredity
Anna S. E. Cuomo, Aparna Nathan, Soumya Raychaudhuri, Daniel G. MacArthur, Joseph E. Powell
Summary: In this Review, the authors discuss the field of single-cell genetics, which combines single-cell genomics with human genetics. They highlight the importance of single-cell expression quantitative trait loci studies in linking genetic variation to cellular processes in human biology and disease. The authors also mention the potential implications of this field for disease diagnosis, risk prediction, and therapeutic development, and emphasize the need for advances in data generation and analysis methods to fully utilize single-cell genomic data.
NATURE REVIEWS GENETICS
(2023)
Article
Rheumatology
Andrei Barbulescu, Arvid Sjolander, Benedicte Delcoigne, Johan Askling, Thomas Frisell
Summary: This study compared the incidence of serious infections between different oral glucocorticoid dose patterns in patients with rheumatoid arthritis. The results showed that higher doses and recent exposure to glucocorticoids are associated with an increased risk of serious infections. This study provides an explanation for the conflicting results in observational studies.
Letter
Pediatrics
Georgios Karamanis, Thomas Frisell, Mats Holmberg, Maria Halldin, Sara Sylven, Alkistis Skalkidou, Fotios C. Papadopoulos
Summary: This study investigates the occurrence of idiopathic intracranial hypertension (IHH) in individuals in Sweden who are undergoing gonadotropin-releasing hormone analogue (GnRHa) treatment for gender dysphoria.
Article
Biochemistry & Molecular Biology
Alexandre Xavier, Vicki E. Maltby, Ewoud Ewing, Maria Pia Campagna, Sean M. Burnard, Jesper N. Tegner, Mark Slee, Helmut Butzkueven, Ingrid Kockum, Lara Kular, Vilija G. Jokubaitis, Trevor Kilpatrick, Lars Alfredsson, Maja Jagodic, Anne-Louise Ponsonby, Bruce V. Taylor, Rodney J. Scott, Rodney A. Lea, Jeannette Lechner-Scott
Summary: This study reveals that DNA methylation differences in multiple sclerosis (MS) occur independently of known genetic risk loci. It shows that these differences more effectively differentiate the disease compared to known genetic risk loci. The study also indicates that the methylation differences in MS predominantly occur in B cells and monocytes, involving cell-specific biological pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Lars Klareskog, Lars Alfredsson
Summary: In the case of rheumatoid arthritis, the focus has mostly been on treating the established disease rather than preventing it. This review argues that prevention should become a major part of research and clinical practice, and describes the basis for broad public health-based prevention as well as a precision prevention strategy for individuals at high risk. The potential effectiveness of precision prevention will depend on the development of specific and long-lasting tolerance therapy.
IMMUNOTHERAPY ADVANCES
(2023)