Article
Rheumatology
Zhibo Song, Xuerong Deng, Wenhui Xie, Borui Li, Zhuoli Zhang
Summary: Among Chinese patients with psoriatic arthritis, polyarticular involvement was the most common, while ultrasound significantly increased the identification of peripheral enthesitis. Active PsA patients were more likely to have comorbidities.
RHEUMATOLOGY AND THERAPY
(2021)
Article
Rheumatology
Naveen Ravichandran, Shivika Guleria, Namita Mohindra, Amita Aggarwal
Summary: This study assessed the long-term functional outcomes in ERA patients from China and found that delay in diagnosis was the sole predictor of poor functional outcome.
Article
Rheumatology
Serife Gul Karadag, Taner Coskuner, Fatma Gul Demirkan, Hafize Emine Sonmez, Semanur Ozdel, Mustafa Cakan, Gulcin Otar Yener, Kubra Ozturk, Ferhat Demir, Betul Sozeri, Nuray Aktay Ayaz
Summary: This study describes the clinical features and treatment outcomes of children with juvenile psoriatic arthritis (JPsA) and compares the different patterns of the disease between early-onset and late-onset age groups. The study found that about one-third of JPsA patients do not have psoriasis at the time of diagnosis, and children with PsA seem to display two different phenotypes.
Article
Medicine, General & Internal
Alberto Lo Gullo, Andrea Becciolini, Simone Parisi, Patrizia Del Medico, Antonella Farina, Elisa Visalli, Ylenia Dal Bosco, Aldo Biagio Molica Colella, Federica Lumetti, Rosalba Caccavale, Palma Scolieri, Romina Andracco, Francesco Girelli, Elena Bravi, Matteo Colina, Alessandro Volpe, Aurora Ianniello, Maria Chiara Ditto, Valeria Nucera, Veronica Franchina, Ilaria Plate, Eleonora Di Donato, Giorgio Amato, Carlo Salvarani, Simone Bernardi, Gianluca Lucchini, Francesco De Lucia, Francesco Molica Colella, Daniele Santilli, Natalia Mansueto, Giulio Ferrero, Antonio Marchetta, Eugenio Arrigoni, Rosario Foti, Gilda Sandri, Vincenzo Bruzzese, Marino Paroli, Enrico Fusaro, Alarico Ariani
Summary: The aim of this study is to evaluate the improvement in enthesitis and dactylitis activity in Psoriatic Arthritis (PsA) patients treated with apremilast. Results showed that PsA patients treated with apremilast experienced significant improvement in enthesitis and dactylitis activity, with over one-third of patients achieving remission after 1 year.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Rheumatology
Iain B. McInnes, Laura M. Sawyer, Kristen Markus, Corinne LeReun, Celia Sabry-Grant, Philip S. Helliwell
Summary: This study compared the efficacy and safety of different types of drugs in treating PsA, and found that IL-17A and IL-17RA inhibitors and guselkumab were more effective than TNF inhibitors in treating skin manifestations, and had similar efficacy for other symptoms such as enthesitis and dactylitis.
Article
Rheumatology
Jelena Vojinovic, Ivan Foeldvari, Joke Dehoorne, Violeta Panaviene, Gordana Susic, Gerd Horneff, Valda Stanevicha, Katarzyna Kobusinska, Zbigniew Zuber, Bogna Dobrzyniecka, Jonathan Akikusa, Tadej Avcin, Cecilia Borlenghi, Edmund Arthur, Svitlana Y. Tatulych, Chuanbo Zang, Vassilis Tsekouras, Bonnie Vlahos, Alberto Martini, Nicolino Ruperto
Summary: CLIPPER2 is an 8-year study on the safety and efficacy of etanercept in patients with juvenile idiopathic arthritis (JIA). The study found that etanercept treatment was well tolerated and effective in these patients.
Review
Medicine, General & Internal
Nicolo Girolimetto, Ivan Giovannini, Gloria Crepaldi, Gabriele De Marco, Ilaria Tinazzi, Niccolo Possemato, Pierluigi Macchioni, Rebecca McConnell, Dennis McGonagle, Annamaria Iagnocco, Alen Zabotti
Summary: Dactylitis, a common feature of PsA, is characterized by swelling of the digits and involvement of various anatomical structures. Imaging plays an important role in managing dactylitis in PsA patients and uncovering underlying mechanisms of its onset and chronicity.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biology
Sydney Moore McIntosh, Christian Kerut, Payton P. Hollenshead, Dorothy H. Askins, Kasra Mansourian, Zachary R. Palowsky, Varsha Allampalli, Shahab Ahmadzadeh, Sahar Shekoohi, Alan D. Kaye
Summary: Psoriatic arthritis is a chronic autoimmune condition with unique cutaneous manifestations. Tumor necrosis factor inhibitors, such as golimumab, have become a hallmark treatment option. Multiple studies have shown the efficacy of golimumab in both juvenile and adult-onset psoriatic arthritis.
Review
Medicine, General & Internal
Shi Huan Tay, Joo Guan Yeo, Jing Yao Leong, Salvatore Albani, Thaschawee Arkachaisri
Summary: Juvenile spondyloarthritis (JSpA) is a diverse spectrum of immune-mediated inflammatory arthritides that typically onset in late childhood and adolescence. It is characterized by a strong association with HLA-B27, enthesitis, and bone resorption.
FRONTIERS IN MEDICINE
(2021)
Article
Medicine, General & Internal
Fan Yang, Chaofan Lu, Huilan Liu, Lei Dou, Yanhong Wang, Hongbin Li, Xinwang Duan, Lijun Wu, Yongfu Wang, Xiuying Zhang, Jian Xu, Jinmei Su, Dong Xu, Jiuliang Zhao, Qingjun Wu, Mengtao Li, Xiaomei Leng, Xiaofeng Zeng
Summary: Enthesitis is common in Chinese patients with PsA, and it is important to evaluate both peripheral and axial sites. Compared with other cohorts, Chinese patients with enthesitis tend to be younger, have a lower body mass index, a higher rate of positive HLA-B27, more frequent dactylitis, and a higher proportion of csDMARDs use.
CHINESE MEDICAL JOURNAL
(2023)
Review
Immunology
Arash Maleki, Priya D. D. Patel, C. Steven Foster
Summary: Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatologic disease in children, with uveitis being the most common extra-articular manifestation. This review covers the epidemiology, risk factors, clinical presentation, laboratory tests, treatment options, and complications of JIA and JIA-associated uveitis. The discussion also includes the course of the disease, functional outcome, and quality of life for patients with JIA and JIA-associated uveitis.
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
(2023)
Review
Rheumatology
Patricia Harkins, Eoghan Burke, Catherine Swales, Alan Silman, Richard Conway
Summary: This study evaluated the safety and efficacy of Janus kinase inhibitors (JAKi) in the management of key clinical domains of Psoriatic arthritis (PsA). The results demonstrated that JAKi were more effective than placebo in improving outcomes such as peripheral arthritis, psoriasis, enthesitis, and dactylitis. However, JAKi treatment was associated with an increased risk of adverse events, including infections.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Review
Immunology
Mads Bruner, Anders Dige, Anne Gitte Loft, Trine Bay Laurberg, Jorgen Steen Agnholt, Kare Clemmensen, Iain McInnes, Rik Lories, Lars Iversen, Kasper Fjellhaugen Hjuler, Tue Wenzel Kragstrup
Summary: This article discusses the distinct group of axial spondyloarthritis, psoriatic arthritis, psoriasis, inflammatory bowel disease, and noninfectious uveitis, and reviews new targeted pharmacological treatment options for these diseases. It highlights the efficacy of different drugs, such as TNF inhibitors and specific inhibitors for certain inflamed tissues, and aims to assist clinicians in making stratified treatment decisions for patients with this disease spectrum.
AUTOIMMUNITY REVIEWS
(2021)
Article
Rheumatology
Emilio Filippucci, Gianluca Smerilli, Andrea Di Matteo, Walter Grassi
Summary: Enthesitis plays a crucial role in the diagnosis and management of patients with spondyloarthritis and psoriatic arthritis, but clinical assessment is often inaccurate due to poor specificity. Ultrasound has the potential to improve the evaluation of enthesitis and enhance patient management in this context. Reviewing the OMERACT definitions for ultrasound enthesitis can help identify current limitations and their potential implications for rheumatology research and clinical practice.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Review
Medicine, General & Internal
Roberta Naddei, Ana Rebollo-Gimenez, Marco Burrone, Valentina Natoli, Silvia Rosina, Alessandro Consolaro, Angelo Ravelli
Summary: Juvenile psoriatic arthritis (JPsA) is a controversial subset of juvenile idiopathic arthritis (JIA), accounting for 1-7% of cases. There has been debate about whether JPsA should be classified as a distinct category within JIA. Studies have shown that children with JPsA can be divided into two subgroups based on their clinical features and genetic determinants. The ongoing discussion has prompted the revision of the current classification of JPsA.
JOURNAL OF CLINICAL MEDICINE
(2023)