Dynamic Changes in the Nigrostriatal Pathway in the MPTP Mouse Model of Parkinson’s Disease

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Glial Cells and Their Function in the Adult Brain: A Journey through the History of Their Ablation

(2017) Sarah Jäkel et al.   Frontiers in Cellular Neuroscience

Pathogenic Upregulation of Glial Lipocalin-2 in the Parkinsonian Dopaminergic System

(2016) B.-W. Kim et al.   JOURNAL OF NEUROSCIENCE

Parkinson's disease: 4 big questions

(2016) Sarah Deweerdt   NATURE

Two hundred steps

(2016) Liam Drew   NATURE

New Transgenic Mouse Lines for Selectively Targeting Astrocytes and Studying Calcium Signals in Astrocyte Processes In Situ and In Vivo

(2016) Rahul Srinivasan et al.   NEURON

Dopamine Controls Systemic Inflammation through Inhibition of NLRP3 Inflammasome

(2015) Yiqing Yan et al.   CELL

Evidence for a role of adaptive immune response in the disease pathogenesis of the MPTP mouse model of Parkinson's disease

(2015) Heather L. Martin et al.   GLIA

Genetic Cell Ablation Reveals Clusters of Local Self-Renewing Microglia in the Mammalian Central Nervous System

(2015) Julia Bruttger et al.   IMMUNITY

Changes in Neuronal Dopamine Homeostasis following 1-Methyl-4-phenylpyridinium (MPP+) Exposure

(2015) Se Joon Choi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NRSF is an essential mediator for the neuroprotection of trichostatin A in the MPTP mouse model of Parkinson's disease

(2015) Haiyun Suo et al.   NEUROPHARMACOLOGY

Genetic control of astrocyte function in neural circuits

(2015) Hannah M. Jahn et al.   Frontiers in Cellular Neuroscience

Tiagabine Protects Dopaminergic Neurons against Neurotoxins by Inhibiting Microglial Activation

(2015) Jie Liu et al.   Scientific Reports

Neuroinflammation in Parkinson’s disease and its potential as therapeutic target

(2015) Qinqin Wang et al.   Translational Neurodegeneration

Heart failure having little effect on the progression of Parkinson's disease: Direct evidence from mouse model

(2014) Jing Xu et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain

(2014) Monica R.P. Elmore et al.   NEURON

Wnt/β-Catenin Signaling Is Required to Rescue Midbrain Dopaminergic Progenitors and Promote Neurorepair in Ageing Mouse Model of Parkinson's Disease

(2014) Francesca L'Episcopo et al.   STEM CELLS

Neuron-Microglia Interaction in Neuroinflammation

(2013) Akio Suzumura   CURRENT PROTEIN & PEPTIDE SCIENCE

The innate and adaptive immunological aspects in neurodegenerative diseases

(2013) Maria C.O. Rodrigues et al.   JOURNAL OF NEUROIMMUNOLOGY

MPTP-induced dopamine neuron degeneration and glia activation is potentiated in MDMA-pretreated mice

(2013) Giulia Costa et al.   MOVEMENT DISORDERS

Inflammation and Adaptive Immunity in Parkinson's Disease

(2013) R. L. Mosley et al.   Cold Spring Harbor Perspectives in Medicine

S100B is increased in Parkinson’s disease and ablation protects against MPTP-induced toxicity through the RAGE and TNF-α pathway

(2012) Kinnari Sathe et al.   BRAIN

Plasticity of Subventricular Zone Neuroprogenitors in MPTP (1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine) Mouse Model of Parkinson's Disease Involves Cross Talk between Inflammatory and Wnt/ -Catenin Signaling Pathways: Functional Consequences for Neuroprotection and Repair

(2012) F. L'Episcopo et al.   JOURNAL OF NEUROSCIENCE

Suppression of neuroinflammation by astrocytic dopamine D2 receptors via αB-crystallin

(2012) Wei Shao et al.   NATURE

NRSF/REST neuronal deficient mice are more vulnerable to the neurotoxin MPTP

(2012) Mei Yu et al.   NEUROBIOLOGY OF AGING

Molecular effects of activated BV-2 microglia by mitochondrial toxin 1-methyl-4-phenylpyridinium

(2012) Meihua Jin et al.   NEUROTOXICOLOGY

Overexpression of Parkin Ameliorates Dopaminergic Neurodegeneration Induced by 1- Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine in Mice

(2012) Minjuan Bian et al.   PLoS One

Cold water stress attenuates dopaminergic neurotoxicity induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice

(2011) M. Xia et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Fluoxetine prevents MPTP-induced loss of dopaminergic neurons by inhibiting microglial activation

(2011) Young C. Chung et al.   NEUROPHARMACOLOGY

Neurotoxin-based models of Parkinson's disease

(2011) J. Bové et al.   NEUROSCIENCE

Physiology of Microglia

(2011) Helmut Kettenmann et al.   PHYSIOLOGICAL REVIEWS

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

Genetic Animal Models of Parkinson's Disease

(2010) Ted M. Dawson et al.   NEURON

Functions of astrocytes and their potential as therapeutic targets

(2010) Harold K. Kimelberg et al.   Neurotherapeutics

Elevated interleukin-1β induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine aggravating dopaminergic neurodegeneration in old male mice

(2009) Min-juan Bian et al.   BRAIN RESEARCH

A Nurr1/CoREST Pathway in Microglia and Astrocytes Protects Dopaminergic Neurons from Inflammation-Induced Death

(2009) Kaoru Saijo et al.   CELL

Differences between subacute and chronic MPTP mice models: investigation of dopaminergic neuronal degeneration and α-synuclein inclusions

(2009) Claire Gibrat et al.   JOURNAL OF NEUROCHEMISTRY

Lipocalin-2 Is an Autocrine Mediator of Reactive Astrocytosis

(2009) S. Lee et al.   JOURNAL OF NEUROSCIENCE

Neuroprotective Effect of Ghrelin in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Mouse Model of Parkinson’s Disease by Blocking Microglial Activation

(2009) Minho Moon et al.   NEUROTOXICITY RESEARCH

Expression of Cbl-interacting protein of 85 kDa in MPTP mouse model of Parkinson's disease and 1-methyl-4-phenyl-pyridinium ion-treated dopaminergic SH-SY5Y cells

(2008) Minjuan Bian et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Functional imaging of interleukin 1 beta expression in inflammatory process using bioluminescence imaging in transgenic mice

(2008) Limei Li et al.   BMC IMMUNOLOGY

Modelling Parkinson-like neurodegeneration via osmotic minipump delivery of MPTP and probenecid

(2008) Daniel Alvarez-Fischer et al.   JOURNAL OF NEUROCHEMISTRY

A neuroprotective agent, T-817MA (1-{3-[2-(1-benzothiophen-5-yl)ethoxy]propyl} azetidin-3-ol maleate), prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in mice

(2008) Toshiyuki Kawasaki et al.   NEUROPHARMACOLOGY