Novel Evasion Mechanisms of the Classical Complement Pathway

Uncoupling complement C1s activation from C1q binding in apoptotic cell phagocytosis and immunosuppressive capacity

(2016) Lucrezia Colonna et al.   CLINICAL IMMUNOLOGY

Inhibition of the classical pathway of the complement system by saliva of Amblyomma cajennense (Acari: Ixodidae)

(2016) Paula F. Franco et al.   EXPERIMENTAL PARASITOLOGY

Anti-complement activity of the Ixodes scapularis salivary protein Salp20

(2016) Dennis E. Hourcade et al.   MOLECULAR IMMUNOLOGY

Schizophrenia risk from complex variation of complement component 4

(2016) Aswin Sekar et al.   NATURE

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

AnIxodes ricinusTick Salivary Lectin Pathway Inhibitor ProtectsBorrelia burgdorferisensu lato from Human Complement

(2016) Alex Wagemakers et al.   VECTOR-BORNE AND ZOONOTIC DISEASES

Borrelia burgdorferi BBK32 Inhibits the Classical Pathway by Blocking Activation of the C1 Complement Complex

(2016) Brandon L. Garcia et al.   PLoS Pathogens

SALO, a novel classical pathway complement inhibitor from saliva of the sand fly Lutzomyia longipalpis

(2016) Viviana P. Ferreira et al.   Scientific Reports

An Anti-C1s Monoclonal, TNT003, Inhibits Complement Activation Induced by Antibodies Against HLA

(2015) K. A. Thomas et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Roles of Complement C1q in Pneumococcus-Host Interactions

(2015) Vaibhav Agarwal et al.   CRITICAL REVIEWS IN IMMUNOLOGY

Complement inhibitors to treat IgM-mediated autoimmune hemolysis

(2015) D. Wouters et al.   HAEMATOLOGICA

The Group BStreptococcus–Secreted Protein CIP Interacts with C4, Preventing C3b Deposition via the Lectin and Classical Complement Pathways

(2015) Giampiero Pietrocola et al.   JOURNAL OF IMMUNOLOGY

Staphylococcal manipulation of host immune responses

(2015) Vilasack Thammavongsa et al.   NATURE REVIEWS MICROBIOLOGY

Tsetse GmmSRPN10 Has Anti-complement Activity and Is Important for Successful Establishment of Trypanosome Infections in the Fly Midgut

(2015) Cher-Pheng Ooi et al.   PLoS Neglected Tropical Diseases

Complement inhibitors to treat IgM-mediated autoimmune hemolysis

(2015) D. Wouters et al.   HAEMATOLOGICA

Peptide Inhibitor of Complement C1 (PIC1) Rapidly Inhibits Complement Activation after Intravascular Injection in Rats

(2015) Julia A. Sharp et al.   PLoS One

New anti-complement drugs: not so far away

(2014) Joshua M. Thurman   BLOOD

TNT003, an inhibitor of the serine protease C1s, prevents complement activation induced by cold agglutinins

(2014) J. Shi et al.   BLOOD

Binding ofStreptococcus pneumoniaeEndopeptidase O (PepO) to Complement Component C1q Modulates the Complement Attack and Promotes Host Cell Adherence

(2014) Vaibhav Agarwal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A New Map of Glycosaminoglycan and C3b Binding Sites on Factor H

(2014) C. Q. Schmidt et al.   JOURNAL OF IMMUNOLOGY

The Extracellular Adherence Protein fromStaphylococcus aureusInhibits the Classical and Lectin Pathways of Complement by Blocking Formation of the C3 Proconvertase

(2014) Jordan L. Woehl et al.   JOURNAL OF IMMUNOLOGY

Trypanosoma cruzi calreticulin inhibits the complement lectin pathway activation by direct interaction with L-Ficolin

(2014) Eduardo Sosoniuk et al.   MOLECULAR IMMUNOLOGY

Staphylococcus aureus secretes a unique class of neutrophil serine protease inhibitors

(2014) D. A. C. Stapels et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complement Is Activated by IgG Hexamers Assembled at the Cell Surface

(2014) C. A. Diebolder et al.   SCIENCE

Staphylococcus aureus: The multi headed hydra resists and controls human complement response in multiple ways

(2013) Peter F. Zipfel et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Collagen-binding Microbial Surface Components Recognizing Adhesive Matrix Molecule (MSCRAMM) of Gram-positive Bacteria Inhibit Complement Activation via the Classical Pathway

(2013) Mingsong Kang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Molecular Switch Governs the Interaction between the Human Complement Protease C1s and Its Substrate, Complement C4

(2013) Andrew J. Perry et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Alternative Role of C1q in Bacterial Infections: Facilitating Streptococcus pneumoniae Adherence and Invasion of Host Cells

(2013) V. Agarwal et al.   JOURNAL OF IMMUNOLOGY

Complement in Immune and Inflammatory Disorders: Pathophysiological Mechanisms

(2013) D. Ricklin et al.   JOURNAL OF IMMUNOLOGY

Complement in Immune and Inflammatory Disorders: Therapeutic Interventions

(2013) D. Ricklin et al.   JOURNAL OF IMMUNOLOGY

Human complement control and complement evasion by pathogenic microbes – Tipping the balance

(2013) Peter F. Zipfel et al.   MOLECULAR IMMUNOLOGY

Structural basis of the C1q/C1s interaction and its central role in assembly of the C1 complex of complement activation

(2013) Umakhanth Venkatraman Girija et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phagocytosis Escape by a Staphylococcus aureus Protein That Connects Complement and Coagulation Proteins at the Bacterial Surface

(2013) Ya-Ping Ko et al.   PLoS Pathogens

A Structurally Dynamic N-terminal Helix Is a Key Functional Determinant in Staphylococcal Complement Inhibitor (SCIN) Proteins

(2012) Brandon L. Garcia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeted Protein Engineering Provides Insights into Binding Mechanism and Affinities of Bacterial Collagen Adhesins

(2012) Caná L. Ross et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel Scabies Mite Serpins Inhibit the Three Pathways of the Human Complement System

(2012) Angela Mika et al.   PLoS One

Structural basis for activation of the complement system by component C4 cleavage

(2012) R. T. Kidmose et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Tick Mannose-Binding Lectin Inhibitor Interferes with the Vertebrate Complement Cascade to Enhance Transmission of the Lyme Disease Agent

(2011) Tim J. Schuijt et al.   Cell Host & Microbe

The Sbi Protein Is a Multifunctional Immune Evasion Factor of Staphylococcus aureus

(2011) Emma Jane Smith et al.   INFECTION AND IMMUNITY

Diversity in the C3b Convertase Contact Residues and Tertiary Structures of the Staphylococcal Complement Inhibitor (SCIN) Protein Family

(2011) Brandon L. Garcia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pseudomonas aeruginosa Alkaline Protease Blocks Complement Activation via the Classical and Lectin Pathways

(2011) A. J. Laarman et al.   JOURNAL OF IMMUNOLOGY

The Herpes Simplex Virus 1 IgG Fc Receptor Blocks Antibody-Mediated Complement Activation and Antibody-Dependent Cellular Cytotoxicity In Vivo

(2011) J. M. Lubinski et al.   JOURNAL OF VIROLOGY

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(2011) Christian Ehrnthaller et al.   MOLECULAR MEDICINE

Entry of Bacillus anthracis spores into epithelial cells is mediated by the spore surface protein BclA, integrin α2β1 and complement component C1q

(2010) Qiong Xue et al.   CELLULAR MICROBIOLOGY

Convertase Inhibitory Properties of Staphylococcal Extracellular Complement-binding Protein

(2010) Ilse Jongerius et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Intercommunication between the Complement and Coagulation Systems

(2010) U. Amara et al.   JOURNAL OF IMMUNOLOGY

Selective Inhibition of the Lectin Pathway of Complement with Phage Display Selected Peptides against Mannose-Binding Lectin-Associated Serine Protease (MASP)-1 and -2: Significant Contribution of MASP-1 to Lectin Pathway Activation

(2010) A. Kocsis et al.   JOURNAL OF IMMUNOLOGY

Molecular Basis for Complement Recognition and Inhibition Determined by Crystallographic Studies of the Staphylococcal Complement Inhibitor (SCIN) Bound to C3c and C3b

(2010) Brandon L. Garcia et al.   JOURNAL OF MOLECULAR BIOLOGY

Complement inhibition by gram-positive pathogens: molecular mechanisms and therapeutic implications

(2010) Alexander Laarman et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Molecular mechanisms involved in the inactivation of the first component of human complement by Trypanosoma cruzi calreticulin

(2010) Carolina Valck et al.   MOLECULAR IMMUNOLOGY

Potent inhibition of the classical pathway of complement by a novel C1q-binding peptide derived from the human astrovirus coat protein

(2010) Jenny Q. Gronemus et al.   MOLECULAR IMMUNOLOGY

Complement control protein factor H: The good, the bad, and the inadequate

(2010) Viviana P. Ferreira et al.   MOLECULAR IMMUNOLOGY

Molecular mechanisms of complement evasion: learning from staphylococci and meningococci

(2010) Davide Serruto et al.   NATURE REVIEWS MICROBIOLOGY

Allosteric inhibition of complement function by a staphylococcal immune evasion protein

(2010) Hui Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The structure of C2b, a fragment of complement component C2 produced during C3 convertase formation

(2009) Vengadesan Krishnan et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Paths reunited: Initiation of the classical and lectin pathways of complement activation

(2009) Russell Wallis et al.   IMMUNOBIOLOGY

Analogous Interactions in Initiating Complexes of the Classical and Lectin Pathways of Complement

(2009) A. E. Phillips et al.   JOURNAL OF IMMUNOLOGY

Stringent regulation of complement lectin pathway C3/C5 convertase by C4b-binding protein (C4BP)

(2009) Nenoo Rawal et al.   MOLECULAR IMMUNOLOGY

Complement evasion strategies of pathogens—Acquisition of inhibitors and beyond

(2009) Anna M. Blom et al.   MOLECULAR IMMUNOLOGY

Human astrovirus coat protein binds C1q and MBL and inhibits the classical and lectin pathways of complement activation

(2009) Pamela S. Hair et al.   MOLECULAR IMMUNOLOGY

Structural and functional implications of the alternative complement pathway C3 convertase stabilized by a staphylococcal inhibitor

(2009) Suzan H M Rooijakkers et al.   NATURE IMMUNOLOGY

The Role of Salivary and Intestinal Complement System Inhibitors in the Midgut Protection of Triatomines and Mosquitoes

(2009) Veruska Cavalcanti Barros et al.   PLoS One

Complement evasion by human pathogens

(2008) John D. Lambris et al.   NATURE REVIEWS MICROBIOLOGY

Solution insights into the structure of the Efb/C3 complement inhibitory complex as revealed by lysine acetylation and mass spectrometry

(2007) Hui Chen et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

The tick-over theory revisited: Formation and regulation of the soluble alternative complement C3 convertase (C3(H2O)Bb)

(2007) Fredrik Bexborn et al.   MOLECULAR IMMUNOLOGY