Secreted Phospholipases A2 from Animal Venoms in Pain and Analgesia

Articular inflammation induced by an enzymatically-inactive Lys49 phospholipase A2: activation of endogenous phospholipases contributes to the pronociceptive effect

(2017) Renata Gonçalves Dias et al.   JOURNAL OF VENOMOUS ANIMALS AND TOXINS INCLUDING TROPICAL DISEASES

Structural determinants of the hyperalgesic activity of myotoxic Lys49-phospholipase A2

(2017) Vanessa Olzon Zambelli et al.   JOURNAL OF VENOMOUS ANIMALS AND TOXINS INCLUDING TROPICAL DISEASES

Lys49 myotoxin from the Brazilian lancehead pit viper elicits pain through regulated ATP release

(2017) Chuchu Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Articular cartilage repair: Current needs, methods and research directions

(2017) Diego Correa et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Neuromuscular paralysis by the basic phospholipase A 2 subunit of crotoxin from Crotalus durissus terrificus snake venom needs its acid chaperone to concurrently inhibit acetylcholine release and produce muscle blockage

(2017) Walter L.G. Cavalcante et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Pancreatic and snake venom presynaptically active phospholipases A2 inhibit nicotinic acetylcholine receptors

(2017) Catherine A. Vulfius et al.   PLoS One

Biophysical studies suggest a new structural arrangement of crotoxin and provide insights into its toxic mechanism

(2017) Carlos A. H. Fernandes et al.   Scientific Reports

2-Oxoesters: A Novel Class of Potent and Selective Inhibitors of Cytosolic Group IVA Phospholipase A2

(2017) Maroula G. Kokotou et al.   Scientific Reports

Possibilities for preventive treatment in rheumatoid arthritis? Lessons from experimental animal models of arthritis: a systematic literature review and meta-analysis

(2016) J S Dekkers et al.   ANNALS OF THE RHEUMATIC DISEASES

An investigation into the inhibitory function of serotonin in diffuse noxious inhibitory controls in the neuropathic rat

(2016) K. Bannister et al.   EUROPEAN JOURNAL OF PAIN

Rattlesnake Phospholipase A2 Increases CFTR-Chloride Channel Current and Corrects ∆F508CFTR Dysfunction: Impact in Cystic Fibrosis

(2016) Grazyna Faure et al.   JOURNAL OF MOLECULAR BIOLOGY

Walker 256 Tumor Growth Suppression by Crotoxin Involves Formyl Peptide Receptors and Lipoxin A4

(2016) Patrícia Brigatte et al.   MEDIATORS OF INFLAMMATION

Isolation, structural and functional characterization of a new Lys49 phospholipase A 2 homologue from Bothrops neuwiedi urutu with bactericidal potential

(2016) Edailson A. Corrêa et al.   TOXICON

Neurotoxic phospholipase A2 from rattlesnake as a new ligand and new regulator of prokaryotic receptor GLIC (proton-gated ion channel from G. violaceus)

(2016) Maciej Ostrowski et al.   TOXICON

Comparative analysis of local effects caused by Bothrops alternatus and Bothrops moojeni snake venoms: enzymatic contributions and inflammatory modulations

(2016) Carla Cristine Neves Mamede et al.   TOXICON

TMEM16F Regulates Spinal Microglial Function in Neuropathic Pain States

(2016) Laura Batti et al.   Cell Reports

Preventive Effects of Bee Venom Derived Phospholipase A2 on Oxaliplatin-Induced Neuropathic Pain in Mice

(2016) Dongxing Li et al.   Toxins

Varespladib (LY315920) Appears to Be a Potent, Broad-Spectrum, Inhibitor of Snake Venom Phospholipase A2 and a Possible Pre-Referral Treatment for Envenomation

(2016) Matthew Lewin et al.   Toxins

Oral administration of cytosolic PLA2 inhibitor arachidonyl trifluoromethyl ketone ameliorates cauda equina compression injury in rats

(2015) Mushfiquddin Khan et al.   Journal of Neuroinflammation

Structural Basis for the Inhibition of a Phospholipase A2-Like Toxin by Caffeic and Aristolochic Acids

(2015) Carlos A. H. Fernandes et al.   PLoS One

Analgesic Effects of Bee Venom Derived Phospholipase A2 in a Mouse Model of Oxaliplatin-Induced Neuropathic Pain

(2015) Dongxing Li et al.   Toxins

Centipede Venoms and Their Components: Resources for Potential Therapeutic Applications

(2015) Md Hakim et al.   Toxins

A structure-based proposal for a comprehensive myotoxic mechanism of phospholipase A2-like proteins from viperid snake venoms

(2014) Carlos A.H. Fernandes et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Serotonergic mechanism of the relieving effect of bee venom acupuncture on oxaliplatin-induced neuropathic cold allodynia in rats

(2014) Ji-Hye Lee et al.   BMC Complementary and Alternative Medicine

Emerging targets in neuroinflammation-driven chronic pain

(2014) Ru-Rong Ji et al.   NATURE REVIEWS DRUG DISCOVERY

Aldehyde dehydrogenase-2 regulates nociception in rodent models of acute inflammatory pain

(2014) V. O. Zambelli et al.   Science Translational Medicine

Toxins and drug discovery

(2014) Alan L. Harvey   TOXICON

Crotoxin from Crotalus durissus terrificus snake venom induces the release of glutamate from cerebrocortical synaptosomes via N and P/Q calcium channels

(2014) Rosangela da Silva Lomeo et al.   TOXICON

Epidural Dexamethasone Decreased Inflammatory Hyperalgesia and Spinal cPLA2Expression in a Rat Formalin Test

(2014) Sam-Hong Min et al.   YONSEI MEDICAL JOURNAL

Structural bases for a complete myotoxic mechanism: Crystal structures of two non-catalytic phospholipases A2-like from Bothrops brazili venom

(2013) Carlos A.H. Fernandes et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Inhibition of inducible nitric oxide synthase-derived nitric oxide as a therapeutical target for acute pancreatitis induced by secretory phospholipase A2

(2013) E.A. Camargo et al.   EUROPEAN JOURNAL OF PAIN

Antinociceptive activity of crotoxin in the central nervous system: A functional Magnetic Resonance Imaging study

(2013) S. Wolz-Richter et al.   TOXICON

Snake venomics: From the inventory of toxins to biology

(2013) Juan J. Calvete   TOXICON

Phospholipase A2Enzymes: Physical Structure, Biological Function, Disease Implication, Chemical Inhibition, and Therapeutic Intervention

(2011) Edward A. Dennis et al.   CHEMICAL REVIEWS

Prostanoid Receptors

(2011) Takako Hirata et al.   CHEMICAL REVIEWS

Abdominal hyperalgesia in secretory phospholipase A2-induced rat pancreatitis: Distinct roles of NK1receptors

(2011) Enilton A. Camargol et al.   EUROPEAN JOURNAL OF PAIN

Crystal Structure of Crotoxin Reveals Key Residues Involved in the Stability and Toxicity of This Potent Heterodimeric β-Neurotoxin

(2011) Grazyna Faure et al.   JOURNAL OF MOLECULAR BIOLOGY

Rheumatoid arthritis therapy: Advances from bench to bedside

(2010) Soo-In Choi et al.   AUTOIMMUNITY

Therapeutic opportunities in fibroblasts in inflammatory arthritis

(2010) Marianne Niedermeier et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

The platelet activating factor (PAF) signaling cascade in systemic inflammatory responses

(2010) Christian C. Yost et al.   BIOCHIMIE

Nociceptors: the sensors of the pain pathway

(2010) Adrienne E. Dubin et al.   JOURNAL OF CLINICAL INVESTIGATION

Comparison between apo and complexed structures of bothropstoxin-I reveals the role of Lys122 and Ca2+-binding loop region for the catalytically inactive Lys49-PLA2s

(2010) Carlos A.H. Fernandes et al.   JOURNAL OF STRUCTURAL BIOLOGY

Bothrops snake myotoxins induce a large efflux of ATP and potassium with spreading of cell damage and pain

(2010) M. Cintra-Francischinelli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crotoxin: Novel activities for a classic β-neurotoxin

(2010) Sandra C. Sampaio et al.   TOXICON

Identification of continuous interaction sites in PLA2-based protein complexes by peptide arrays

(2009) Consuelo Latorre Fortes-Dias et al.   BIOCHIMIE

Cellular and Molecular Mechanisms of Pain

(2009) Allan I. Basbaum et al.   CELL

Genetic diversity in populations of the viper Bothrops moojeni Hoge, 1966 in Central Brazil using RAPD markers

(2009) N.C.L. Dutra et al.   GENETICS AND MOLECULAR RESEARCH

Role of Substance P and Bradykinin in Acute Pancreatitis Induced by Secretory Phospholipase A2

(2009) Enilton A. Camargo et al.   PANCREAS

Lysophosphatidic acid (LPA) receptors: Signaling properties and disease relevance

(2009) Mu-En Lin et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Influence of Quaternary Conformation on the Biological Activities of the Asp49-phospholipases A2s from Snake Venoms

(2009) Angelo Magro et al.   PROTEIN AND PEPTIDE LETTERS

Inflammation induced by Bothrops asper venom

(2009) Catarina Teixeira et al.   TOXICON

Interaction of Group IA Phospholipase A2with Metal Ions and Phospholipid Vesicles Probed with Deuterium Exchange Mass Spectrometry†

(2008) John E. Burke et al.   BIOCHEMISTRY

Pathological and protective roles of glia in chronic pain

(2008) Erin D. Milligan et al.   NATURE REVIEWS NEUROSCIENCE

Inhibition of spinal cytosolic phospholipase A2 expression by an antisense oligonucleotide attenuates tissue injury-induced hyperalgesia

(2008) D.H. Kim et al.   NEUROSCIENCE

Pancreatic Pain: A Mini Review

(2008) Ricardo A. Cruciani et al.   PANCREATOLOGY

The analgesic effect of crotoxin on neuropathic pain is mediated by central muscarinic receptors and 5-lipoxygenase-derived mediators

(2008) Francisco de Sousa Nogueira-Neto et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Insights into the role of oligomeric state on the biological activities of crotoxin: Crystal structure of a tetrameric phospholipase A2 formed by two isoforms of crotoxin B from Crotalus durissus terrificus venom

(2008) Daniela P. Marchi-Salvador et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Inhibitory effect of crotoxin on the pain-evoked discharge of neurons in thalamic parafascicular nucleus in rats

(2007) Qi Zhu et al.   TOXICON