Varespladib (LY315920) Appears to Be a Potent, Broad-Spectrum, Inhibitor of Snake Venom Phospholipase A2 and a Possible Pre-Referral Treatment for Envenomation

From Fangs to Pharmacology: The Future of Snakebite Envenoming Therapy

(2016) Andreas Laustsen et al.   CURRENT PHARMACEUTICAL DESIGN

Integrative characterization of the venom of the coral snake Micrurus dumerilii (Elapidae) from Colombia: Proteome, toxicity, and cross-neutralization by antivenom

(2016) Paola Rey-Suárez et al.   Journal of Proteomics

Preclinical evaluation of three polyspecific antivenoms against the venom of Echis ocellatus: Neutralization of toxic activities and antivenomics

(2016) Juan J. Calvete et al.   TOXICON

NETosis and lack of DNase activity are key factors in Echis carinatus venom-induced tissue destruction

(2016) Gajanan D. Katkar et al.   Nature Communications

Cost-Effectiveness of Antivenoms for Snakebite Envenoming in 16 Countries in West Africa

(2016) Muhammad Hamza et al.   PLoS Neglected Tropical Diseases

Biodistribution and Lymphatic Tracking of the Main Neurotoxin of Micrurus fulvius Venom by Molecular Imaging

(2016) Irene Vergara et al.   Toxins

Snake (Vipera berus) bite: The cause of severe anaphylactic shock and hepatocellular injury

(2015) K Pałgan et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Virtual analysis of structurally diverse synthetic analogs as inhibitors of snake venom secretory phospholipase A2

(2015) V. Sivaramakrishnan et al.   JOURNAL OF MOLECULAR RECOGNITION

Venomics and antivenomics of Bothrops erythromelas from five geographic populations within the Caatinga ecoregion of northeastern Brazil

(2015) Roberta Jeane B. Jorge et al.   Journal of Proteomics

Structural Basis for the Inhibition of a Phospholipase A2-Like Toxin by Caffeic and Aristolochic Acids

(2015) Carlos A. H. Fernandes et al.   PLoS One

Inhibitory potential of three zinc chelating agents against the proteolytic, hemorrhagic, and myotoxic activities of Echis carinatus venom

(2015) Ankanahalli N Nanjaraj Urs et al.   TOXICON

Evaluation of the preclinical efficacy of four antivenoms, distributed in sub-Saharan Africa, to neutralize the venom of the carpet viper, Echis ocellatus, from Mali, Cameroon, and Nigeria

(2015) Laura V. Sánchez et al.   TOXICON

Antivenoms for Snakebite Envenoming: What Is in the Research Pipeline?

(2015) Emilie Alirol et al.   PLoS Neglected Tropical Diseases

Population Pharmacokinetics of an Indian F(ab')2 Snake Antivenom in Patients with Russell's Viper (Daboia russelii) Bites

(2015) Geoffrey K. Isbister et al.   PLoS Neglected Tropical Diseases

Varespladib and Cardiovascular Events in Patients With an Acute Coronary Syndrome

(2014) Stephen J. Nicholls et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Identification of potent inhibitors against snake venom metalloproteinase (SVMP) using molecular docking and molecular dynamics studies

(2014) Sathishkumar Chinnasamy et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Medically important differences in snake venom composition are dictated by distinct postgenomic mechanisms

(2014) N. R. Casewell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intravascular hemolysis induced by the venom of the Eastern coral snake, Micrurus fulvius, in a mouse model: Identification of directly hemolytic phospholipases A2

(2014) Ruth Arce-Bejarano et al.   TOXICON

Point-of-care derived INR does not reliably detect significant coagulopathy following Australian snakebite

(2013) Kacey M. O’Rourke et al.   THROMBOSIS RESEARCH

Neurotoxicity in Snakebite—The Limits of Our Knowledge

(2013) Udaya K. Ranawaka et al.   PLoS Neglected Tropical Diseases

Micrurus snake venoms activate human complement system and generate anaphylatoxins

(2012) Gabriela D Tanaka et al.   BMC IMMUNOLOGY

Comparative proteomic analysis of the venom of the taipan snake, Oxyuranus scutellatus, from Papua New Guinea and Australia: Role of neurotoxic and procoagulant effects in venom toxicity

(2012) María Herrera et al.   Journal of Proteomics

Effect of Australian elapid venoms on blood coagulation: Australian Snakebite Project (ASP-17)

(2012) Abhishek Gulati et al.   TOXICON

Varespladib

(2011) &NA;   American Journal of Cardiovascular Drugs

Anti-Inflammatory Effects of Varespladib Methyl in Diabetic Patients with Acute Coronary Syndrome

(2011) Robert S. Rosenson et al.   CARDIOVASCULAR DRUGS AND THERAPY

Phospholipase A2Enzymes: Physical Structure, Biological Function, Disease Implication, Chemical Inhibition, and Therapeutic Intervention

(2011) Edward A. Dennis et al.   CHEMICAL REVIEWS

Evolutionary Analysis of Novel Serine Proteases in the Venom Gland Transcriptome of Bitis gabonica rhinoceros

(2011) Sakthivel Vaiyapuri et al.   PLoS One

Venom of Bothrops asper from Mexico and Costa Rica: Intraspecific variation and cross-neutralization by antivenoms

(2011) Álvaro Segura et al.   TOXICON

Snakebite Mortality in India: A Nationally Representative Mortality Survey

(2011) Bijayeeni Mohapatra et al.   PLoS Neglected Tropical Diseases

High resolution analysis of snake venom metalloproteinase (SVMP) peptide bond cleavage specificity using proteome based peptide libraries and mass spectrometry

(2010) Adriana F. Paes Leme et al.   Journal of Proteomics

First clinical experiences about the neurotoxic envenomings inflicted by lowland populations of the Balkan adder, Vipera berus bosniensis

(2010) Tamás Malina et al.   NEUROTOXICOLOGY

Purification and Functional Characterisation of Rhinocerase, a Novel Serine Protease from the Venom of Bitis gabonica rhinoceros

(2010) Sakthivel Vaiyapuri et al.   PLoS One

Snakebite Doesn't Cause Disseminated Intravascular Coagulation: Coagulopathy and Thrombotic Microangiopathy in Snake Envenoming

(2010) Geoffrey Isbister   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Proximal lower limb vein thrombosis following vipera berus hand bite

(2010) Gary et al.   Vasa-European Journal of Vascular Medicine

Effects of bites by the European adder (Vipera berus) in seven Swedish horses

(2010) K. G. Anlen   VETERINARY RECORD

Diversity of Micrurus Snake Species Related to Their Venom Toxic Effects and the Prospective of Antivenom Neutralization

(2010) Gabriela D. Tanaka et al.   PLoS Neglected Tropical Diseases

The Toxicogenomic Multiverse: Convergent Recruitment of Proteins Into Animal Venoms

(2009) Bryan G. Fry et al.   Annual Review of Genomics and Human Genetics