Article
Immunology
Sabrina de Oliveira Emerick, Thais Vieira de Carvalho, Bianca Meirelles Miranda, Adriana Carneiro da Silva, Thais Viana Fialho Martins, Leandro Licursi de Oliveira, Eduardo de Almeida Marques-da-Silva
Summary: The study evaluated the immunization using different vaccines and adjuvants against L. chagasi infection, and found that the LPG3-SAP vaccine significantly reduced parasite load in both spleen and liver in mice, inducing Th1/Th17 response and IL-10 production.
Review
Microbiology
Carolina Ferreira, Jerome Estaquier, Ricardo Silvestre
Summary: Leishmania manipulates host metabolic pathways to evade the immune response, facilitating long-term survival and altering the metabolism of infected macrophages, which is linked to infection resistance. Studying the interactions between metabolism and innate immune cell function holds promise for therapeutic or prophylactic interventions.
CURRENT OPINION IN MICROBIOLOGY
(2021)
Article
Infectious Diseases
Geovanna Vioti, Mariana Dantas da Silva, Fredy Galvis-Ovallos, Maria Luana Alves, Diogo Tiago da Silva, Joao Augusto Franco Leonel, Nuno Wolfgang Balbini Pereira, Julia Cristina Benassi, Julio Cesar Pereira Spada, Carla Maia, Eunice Aparecida Bianchi Galati, Wilma Aparecida Starke-Buzetti, Tricia Maria Ferreira de Sousa Oliveira
Summary: The study demonstrates that naturally infected cats are capable of transmitting L. infantum to sand flies. Through clinical evaluation and diagnosis of 240 cats, the research examined the role of cats in the transmission of visceral leishmaniasis.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Review
Immunology
Katiuska Passelli, Oaklyne Billion, Fabienne Tacchini-Cottier
Summary: Leishmania parasites, transmitted by infected sand flies, cause a range of diseases in mammals. Neutrophils are crucial in the defense against these parasites, although some Leishmania species have developed ways to survive within them. Neutrophils also play a role in shaping the skin microenvironment during infection, influencing the adaptive immune response and disease outcome.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Marco Antonio Cabrera Gonzalez, Ana Alice Maia Goncalves, Jennifer Ottino, Jaqueline Costa Leite, Lucilene Aparecida Resende, Otoni Alves Melo-Junior, Patricia Silveira, Mariana Santos Cardoso, Ricardo Toshio Fujiwara, Lilian Lacerda Bueno, Renato Lima Santos, Tatiane Furtado de Carvalho, Giani Martins Garcia, Paulo Ricardo de Oliveira Paes, Alexsandro Sobreira Galdino, Miguel Angel Chavez-Fumagalli, Marilia Martins Melo, Denise Silveira-Lemos, Olindo Assis Martins-Filho, Walderez Ornelas Dutra, Vanessa Carla Furtado Mosqueira, Rodolfo Cordeiro Giunchetti
Summary: Visceral leishmaniasis (VL) is a fatal disease caused by Leishmania infantum, and dogs are the main reservoirs. A vaccine against canine visceral leishmaniasis (CVL) is important in controlling human and CVL infections by reducing L. infantum infection. This study evaluated the potential of two polymeric nanoformulations loaded with Leishmania amazonensis antigens as a VL vaccine using golden hamsters as a model. The results showed that the vaccines had no adverse reactions and significantly reduced the parasitic load in the liver and spleen. These vaccines may be promising candidates for a VL vaccine.
Review
Parasitology
Taylon Felipe Silva, Fernanda Tomiotto-Pellissier, Aline Kuhn Sbruzzi Pasquali, Fernanda Pinto-Ferreira, Wander Rogerio Pavanelli, Ivete Conchon-Costa, Italmar Teodorico Navarro, Eloiza Teles Caldart
Summary: The study revealed that the exact mechanism leading to different clinical manifestations among strains of the same species is still uncertain, and future studies are needed to better elucidate this phenomenon.
Article
Medicine, General & Internal
Tammy Yu, Jie Tang
Summary: This case report describes an unusual case of hypercalcemia in a patient with acquired immunodeficiency syndrome and visceral leishmaniasis during the initiation of antiviral therapy. The patient developed de novo hypercalcemia and acute kidney injury, which was ultimately attributed to immune reconstitution inflammatory syndrome. Treatment with intravenous volume expansion, bisphosphonates, and oral corticosteroids resulted in complete resolution of the hypercalcemia. This case highlights the atypical presentation of immune reconstitution inflammatory syndrome and the potential role of proinflammatory cytokines in driving hypercalcemia.
Article
Public, Environmental & Occupational Health
Ilka Grewe, Thomas Theo Brehm, Benno Kreuels, Oliver M. Steinmetz, Bernhard Dumoulin, Anne Marie Asemissen, Dennis Tappe, Michael Ramharter, Stefan Schmiedel
Summary: We report a case of Leishmania infantum reactivation in an immunocompetent patient who developed visceral leishmaniasis with secondary IgA nephropathy nine years after an initial episode of mucosal leishmaniasis, which had been treated with liposomal amphotericin B.
JOURNAL OF TRAVEL MEDICINE
(2022)
Article
Microbiology
Felipe Gaitan-Albarracin, Monica Losada-Barragan, Nathalia Pinho, Renata Azevedo, Jonathan Duraes, Juan Sebastian Arcila-Barrera, Rodrigo C. Menezes, Fernanda N. Morgado, Vinicius de Frias Carvalho, Adriana Umana-Perez, Patricia Cuervo
Summary: Malnutrition may result in structural and immunological changes in the gut mucosae, leading to impaired immune response to Leishmania infantum infection. Pre-infection malnutrition exacerbates intestinal pathological alterations post-infection, promoting parasite proliferation in lymphoid tissues.
Article
Microbiology
Patricia de Almeida Machado, Pollyanna Stephanie Gomes, Victor Midlej, Elaine Soares Coimbra, Herbert Leonel de Matos Guedes
Summary: The study revealed the potential antileishmanial effect of PF-429242, which induces various cellular alterations in the parasite, such as mitochondrial damage, neutral lipids accumulation, oxidative stress, and autophagy leading to the death of L. infantum. Additionally, PF-429242 treatment modulated host cellular responses that favor the development of an immune response against the parasite.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Parasitology
Barrack O. Owino, Jackline Milkah Mwangi, Steve Kiplagat, Hannah Njiriku Mwangi, Johnstone M. Ingonga, Alphine Chebet, Philip M. Ngumbi, Jandouwe Villinger, Daniel K. Masiga, Damaris Matoke-Muhia
Summary: The study investigated transmission, vector abundance, distribution, and reservoir hosts of Leishmania in Merti sub-County, Kenya. Findings suggest potential involvement of Sergentomyia sand flies in Leishmania transmission, questioning the exclusively Phlebotomus sand flies' role in human leishmaniases. The presence of Trypanosoma DNA indicates possible mechanical transmission and the preference for different blood meal hosts was observed.
PARASITES & VECTORS
(2021)
Review
Infectious Diseases
Anurag Kumar Kushwaha, Breanna M. Scorza, Om Prakash Singh, Edgar Rowton, Phillip Lawyer, Shyam Sundar, Christine A. Petersen
Summary: Leishmania donovani is the causative agent of visceral leishmaniasis on the Indian subcontinent, transmitted by sand flies which have been shown to feed on domestic animals in addition to humans. Understanding the role of non-human reservoirs in transmission is critical for sustainable elimination goals. Efforts towards VL elimination in the region may be hindered by the presence of animal reservoirs.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Medicine, General & Internal
Juliana B. T. Carnielli, Anuja Dave, Audrey Romano, Sarah Forrester, Pedro R. de Faria, Renata Monti-Rocha, Carlos H. N. Costa, Reynaldo Dietze, Ian A. Graham, Jeremy C. Mottram
Summary: In Brazil, miltefosine treatment failure in visceral leishmaniasis has been linked to the deletion of the miltefosine susceptibility locus (MSL) in Leishmania infantum. CRISPR-Cas9 was used to investigate the role of NUC1, NUC2, HLP, and TEI in miltefosine resistance mechanisms. Findings suggest that the absence of NUC1 and NUC2 from the MSL contributes to natural resistance to miltefosine in L. infantum.
Article
Multidisciplinary Sciences
Wandayi Emmanuel Amlabu, Cynthia Mmalebna Amisigo, Christine Achiaa Antwi, Gordon Akanzuwine Awandare, Theresa Manful Gwira
Summary: Leishmaniasis, closely associated with poverty, is a disease that requires new chemotherapeutic approaches. This study evaluated the antileishmanial potency of eighteen compounds and found that some of them exhibited cytotoxic effects on the parasites, affecting their biology. Further in vivo studies are recommended to validate the findings.
Article
Immunology
Arthur Dujardin, Arnaud de La Blanchardiere, Julia Dina, Karl Stefic, Christophe Ravel, Julie Bonhomme, Renaud Verdon, Anna Lucie Fournier
Summary: This case report describes a severe visceral leishmaniasis in a patient with an acute primary HIV-1 infection, presenting with acute febrile psychotic disorder and hemophagocytic lymphohistiocytosis. The patient was successfully treated with intravenous liposomal amphotericin B, highlighting the complex interaction between HIV infection and visceral leishmaniasis in clinical presentation.
FRONTIERS IN IMMUNOLOGY
(2021)
Letter
Respiratory System
Eva Van Braeckel, Iain Page, Jesper Romhild Davidsen, Christian B. Laursen, Ritesh Agarwal, Ana Alastruey-Izquierdo, Aleksandra Barac, Jacques Cadranel, Arunaloke Chakrabarti, Oliver A. Cornely, David W. Denning, Holger Flick, Jean-Pierre Gangneux, Cendrine Godet, Yuta Hayashi, Christophe Hennequin, Martin Hoenigl, Muhammed Irfan, Koichi Izumikawa, Won-Jun Koh, Chris Kosmidis, Christoph Lange, Bernd Lamprecht, Francois Laurent, Oxana Munteanu, Rita Oladele, Thomas F. Patterson, Akira Watanabe, Helmut J. F. Salzer
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Microbiology
Stephane Bretagne, Karine Sitbon, Marie Desnos-Ollivier, Dea Garcia-Hermoso, Valerie Letscher-Bru, Sophie Cassaing, Laurence Millon, Florent Morio, Jean-Pierre Gangneux, Lilia Hasseine, Loic Favennec, Estelle Cateau, Eric Bailly, Maxime Moniot, Julie Bonhomme, Nicole Desbois-Nogard, Taieb Chouaki, Andre Paugam, Bernard Bouteille, Marc Pihet, Frederic Dalle, Odile Eloy, Milene Sasso, Magalie Demar, Patricia Mariani-Kurkdjian, Vincent Robert, Olivier Lortholary, Francoise Dromer
Summary: The epidemiology of invasive fungal diseases (IFDs) is difficult to determine due to diagnostic challenges. This study emphasizes the importance of active surveillance by mycologists and clinicians to understand global incidence and main IFDs. The findings show an increase in yeast fungemia and a higher prevalence of IFDs in older individuals. Despite advancements in diagnostic tools and antifungal drugs, global survival rates for IFDs have not improved.
Article
Microbiology
Sylvie Buffet-Bataillon, Guillaume Rizk, Vincent Cattoir, Mohamed Sassi, Vincent Thibault, Jennifer Del Giudice, Jean-Pierre Gangneux
Summary: Metagenomics analysis is widely used for clinical diagnosis, but we need confidence in interpreting the results. In this study, we propose a methodology for taxon identification and abundance assessment of microbiota data, with a focus on quality control and the introduction of an external positive control. The use of multiple complementary classifiers greatly improves the reliability of the analysis results.
Article
Environmental Sciences
Anais Colas, Alexandre Baudet, Pierre Le Cann, Olivier Blanchard, Jean-Pierre Gangneux, Estelle Baures, Arnaud Florentin
Summary: This study conducted a health risk assessment of the chronic inhalation of chemical compounds by workers in healthcare and elderly care facilities. The findings suggest that the health risk from most investigated compounds does not appear to be of concern, but corrective actions may be necessary for some compounds to reduce the risk.
Article
Environmental Sciences
Alexandre Baudet, Estelle Baures, Olivier Blanchard, Pierre Le Cann, Jean-Pierre Gangneux, Arnaud Florentin
Summary: Poor indoor air quality can have adverse effects on human health. The concentrations of carbon dioxide, fine particulate matter, and total volatile organic compounds were found to be higher in private healthcare and elderly care facilities, especially in dental offices. Increasing ventilation can help reduce pollutant concentrations and maintain good indoor air quality.
Editorial Material
Allergy
Jean-Pierre Gangneux, Cendrine Godet, David W. Denning
Article
Microbiology
Brice Autier, Jean-Pierre Gangneux, Florence Robert-Gangneux
Summary: The diagnosis of intestinal parasitic infections commonly relies on microscopic examination, but the ParaFlo(R) assays offer improved reliability and ease of use. When compared to routine methods, ParaFlo(R) showed similar performance in protozoa detection but slightly poorer performance in helminth detection.
Article
Infectious Diseases
Victor Mercier, Valerie Letscher-Bru, Marie-Elisabeth Bougnoux, Laurence Delhaes, Francoise Botterel, Daniele Maubon, Frederic Dalle, Alexandre Alanio, Sandrine Houze, Eric Dannaoui, Carole Cassagne, Sophie Cassaing, Marie-Fleur Durieux, Arnaud Fekkar, Jean-Philippe Bouchara, Jean-Pierre Gangneux, Julie Bonhomme, Damien Dupont, Damien Costa, Boualem Sendid, Taieb Chouaki, Nathalie Bourgeois, Antoine Huguenin, Sophie Brun, Caroline Mahinc, Lilia Hasseine, Solene Le Gal, Anne-Pauline Bellanger, Eric Bailly, Florent Morio, Celine Nourrisson, Nicole Desbois-Nogard, Estelle Perraud-Cateau, Anne Debourgogne, Helene Yera, Laurence Lachaud, Milene Sasso
Summary: The study aimed to determine the epidemiological cut-off values (ECVs) of ten antifungal agents in a wide range of yeasts and Aspergillus spp. using gradient concentration strips. Retrospective collection of minimum inhibitory concentrations for various antifungal agents was done from 35 French microbiology laboratories between 2002 and 2020. The calculated ECVs can aid in interpreting minimum inhibitory concentrations and identifying non-wild type isolates.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Environmental Sciences
M. Cogliati, S. Arikan-Akdagli, A. Barac, A. C. Bostanaru, S. Brito, N. Cerikcioglu, M. A. Efstratiou, C. Ergin, M. C. Esposto, M. Frenkel, J. P. Gungneux, A. Gitto, C. I. Goncalves, H. Guegan, N. Gunde-Cimerman, M. Guran, E. Jonikaite, M. Katarzyte, L. Klingspor, M. Mares, W. G. Meijer, W. J. G. Melchers, J. Meletiadis, V. Nastasa, M. Novak Babic, D. Ogunc, B. Ozhak, A. Prigitano, S. Ranque, L. Romano, R. O. Rusu, R. Sabino, A. Sampaio, S. Silva, J. H. Stephens, M. Tehupeiory-Kooreman, A. Velegraki, C. Verissimo, E. Segal, J. Brandao
Summary: The study used data from the Mycosands survey to investigate the factors affecting the distribution of yeasts and molds along European shores. Environmental factors such as climate, soil properties, and water conditions were analyzed using species distribution modelling. The results showed that yeasts and molds have different distributions along European shores, with yeasts being more tolerant of low temperatures and molds showing affinity with specific soil compositions and water conditions.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Immunology
Lamine Alaoui, Javiera Villar, Renaud Leclere, Simon Le Gallou, Francis Relouzat, Henri-Alexandre Michaud, Karin Tarte, Natacha Teissier, Benoit Favier, Mikael Roussel, Elodie Segura
Summary: This study characterizes the phenotype, transcriptome, life cycle, and function of human tonsil macrophages, and identifies three subtypes with distinct features. CD36(hi) macrophages are related to monocytes, CD36(lo) macrophages have features of embryonic origin, and CD36(int) macrophages display mixed characteristics. Functionally, CD36(hi) macrophages are specialized in stimulating T follicular helper cells by producing Activin A. Stromal cell-derived TNF-alpha is identified as the inducer of Activin A secretion.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Cell & Tissue Engineering
Severine Loisel, Pauline Lansiaux, Delphine Rossille, Cedric Menard, Joelle Dulong, Celine Monvoisin, Nadege Bescher, Isabelle Bezier, Maelle Latour, Audrey Cras, Dominique Farge, Karin Tarte
Summary: Initial overexpression of profibrotic factors by B cells is associated with a lack of clinical response to MSCs in severe SSc patients. Increase of regulatory B cells is a marker of clinical response to MSCs in SSc patients. MSCs directly upregulate IL-10 production by activated B cells in vitro.
STEM CELLS TRANSLATIONAL MEDICINE
(2023)
Article
Microbiology
Brice Autier, Christelle Manuel, Britta Lundstroem-Stadelmann, Jean-Philippe Girard, Bruno Gottstein, Jean-Pierre Gangneux, Michel Samson, Florence Robert-Gangneux, Sarah Dion
Summary: Infection with Echinococcus multilocularis can lead to alveolar echinococcosis, a severe parasitic disease. This study found that the release of IL-33, a signaling molecule, is associated with the development of the disease. IL-33 promotes the growth of the parasite and the progression of the disease, making individuals more susceptible to infection or disease. Understanding the role of IL-33 could provide new insights for the management and treatment of alveolar echinococcosis.
MICROBIOLOGY SPECTRUM
(2023)
Review
Infectious Diseases
Yared Mulu Gelaw, Yonas Deressa Guracho, Florence Robert-Gangneux, Getu Degu Alene, Jean-Pierre Gangneux
Summary: Pneumocystis pneumonia (PCP) is a major cause of death among AIDS patients worldwide, but its burden in low- and middle-income countries like Ethiopia is difficult to estimate. This systematic review aimed to estimate the prevalence of PCP in Ethiopia, the second most densely populated country in Africa. Thirteen studies with a total of 4847 HIV-infected individuals were included in the analysis, and the pooled prevalence of PCP was found to be 5.65% with high heterogeneity. The study also found significant variations in PCP prevalence based on diagnostic methods, publication year, study design, and geographical region.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2023)
Review
Infectious Diseases
Jon Salmanton-Garcia, Martin Hoenigl, Jean-Pierre Gangneux, Esther Segal, Ana Alastruey-Izquierdo, Sevtap Arikan Akdagli, Katrien Lagrou, Volkan oezenci, Antonio Vena, Oliver A. Cornely
Summary: The diagnostic capacity for invasive fungal infections in Europe is generally good, but there are limitations in access to certain diagnostic tools and antifungal drugs. These limitations need to be addressed to ensure optimal diagnosis and treatment for all patients.
Article
Infectious Diseases
Candida Driemeyer, Diego R. Falci, Martin Hoenigl, Oliver A. Cornely, Arunaloke Chakrabarti, Jean Pierre Gangneux, Esther Segal, Marika Jurna-Ellam, Tadeja Matos, Jacques F. Meis, John R. Perfect, Valentina Arsic Arsenijevic, Mihai Mares, Daniela Elena Serban, Alessandro C. Pasqualotto
Summary: This study examines the availability of diagnostic and treatment tools related to fungal infections in Eastern and South-Eastern Europe. Such surveys are important for understanding gaps and highlighting fungal infections as a global health issue.
